Drug induced toxic epidermal necrolysis. Case report

Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are considered two mucocutaneous disorders associated with rare drug reactions within clinical practice, whose severity depends on the extent of the lesions in both skin and mucous membranes, and the time elapsed from symptom onset...

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Autores:
Tipo de recurso:
Fecha de publicación:
2023
Institución:
Pontificia Universidad Javeriana Cali
Repositorio:
Vitela
Idioma:
spa
OAI Identifier:
oai:vitela.javerianacali.edu.co:11522/526
Acceso en línea:
https://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/1311
https://vitela.javerianacali.edu.co/handle/11522/526
Palabra clave:
Hipersensibilidad a drogas
Alergia
Inmunología
Inducida por medicamentos
Drug hypersensibility
Allergy
Immunology
Drug-induced
Rights
License
Derechos de autor 2023 Salutem Scientia Spiritus
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oai_identifier_str oai:vitela.javerianacali.edu.co:11522/526
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network_name_str Vitela
repository_id_str
spelling Solano-Dazzarola, Paola Andrea2023-03-302023-10-11T04:35:21Z2023-10-11T04:35:21Zhttps://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/1311https://vitela.javerianacali.edu.co/handle/11522/526Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are considered two mucocutaneous disorders associated with rare drug reactions within clinical practice, whose severity depends on the extent of the lesions in both skin and mucous membranes, and the time elapsed from symptom onset and prodrome to diagnosis. In recent decades, understanding of the disease pathogenesis has increased and the association between toxicity mediated by cytotoxic T lymphocytes and genes of human leukocyte antigens (HLA) has been described; however, many of the factors associated with the development of the disease remain under investigation, such as TEN induced by viral infections. The aim of this research is to document a case of TEN in an adult male patient with systemic involvement after starting treatment with amoxicillin.El Síndrome de Steven Jhonson (SSJ) y la Necrolisis Epidérmica Tóxica (NET) son considerados dos trastornos mucocutáneos asociados a reacciones adversas medicamentosas poco comunes dentro de la práctica clínica cuya gravedad depende de la extensión de las lesiones tanto en piel como en mucosas y del tiempo de evolución desde el inicio de la sintomatología y pródromo hasta el diagnóstico. En las últimas décadas el entendimiento de la patogénesis de la enfermedad ha incrementado y se encuentra descrito la asociación entre la toxicidad mediada por linfocitos T citotóxicos y relación con genes de antígenos leucocitarios humanos (HLA); sin embargo, muchos de los factores asociados al desarrollo de la enfermedad siguen siendo objeto de investigación; como la NET inducida por infecciones virales. El objetivo de esta investigación es documentar un caso de NET en un paciente masculino adulto con compromiso sistémico posterior al inicio de tratamiento con amoxicilina.application/pdfspaPontificia Universidad Javeriana Calihttps://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/1311/1152Derechos de autor 2023 Salutem Scientia Spiritushttps://creativecommons.org/licenses/by-nc-nd/4.0Salutem Scientia Spiritus; Vol. 9 No. 1 (2023): Revista Salutem Scientia Spiritus; 72-77Salutem Scientia Spiritus; Vol. 9 Núm. 1 (2023): Revista Salutem Scientia Spiritus; 72-772463-1426Hipersensibilidad a drogasAlergiaInmunologíaInducida por medicamentosDrug hypersensibilityAllergyImmunologyDrug-inducedDrug induced toxic epidermal necrolysis. Case reportNecrólisis epidérmica tóxica inducida por fármacos. Reporte de casoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionReporte de caso11522/526oai:vitela.javerianacali.edu.co:11522/5262024-06-25 05:12:43.621metadata.onlyhttps://vitela.javerianacali.edu.coRepositorio Vitelavitela.mail@javerianacali.edu.co
dc.title.en-US.fl_str_mv Drug induced toxic epidermal necrolysis. Case report
dc.title.es-ES.fl_str_mv Necrólisis epidérmica tóxica inducida por fármacos. Reporte de caso
title Drug induced toxic epidermal necrolysis. Case report
spellingShingle Drug induced toxic epidermal necrolysis. Case report
Solano-Dazzarola, Paola Andrea
Hipersensibilidad a drogas
Alergia
Inmunología
Inducida por medicamentos
Drug hypersensibility
Allergy
Immunology
Drug-induced
title_short Drug induced toxic epidermal necrolysis. Case report
title_full Drug induced toxic epidermal necrolysis. Case report
title_fullStr Drug induced toxic epidermal necrolysis. Case report
title_full_unstemmed Drug induced toxic epidermal necrolysis. Case report
title_sort Drug induced toxic epidermal necrolysis. Case report
dc.creator.none.fl_str_mv Solano-Dazzarola, Paola Andrea
author Solano-Dazzarola, Paola Andrea
author_facet Solano-Dazzarola, Paola Andrea
author_role author
dc.subject.es-ES.fl_str_mv Hipersensibilidad a drogas
Alergia
Inmunología
Inducida por medicamentos
topic Hipersensibilidad a drogas
Alergia
Inmunología
Inducida por medicamentos
Drug hypersensibility
Allergy
Immunology
Drug-induced
dc.subject.en-US.fl_str_mv Drug hypersensibility
Allergy
Immunology
Drug-induced
description Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are considered two mucocutaneous disorders associated with rare drug reactions within clinical practice, whose severity depends on the extent of the lesions in both skin and mucous membranes, and the time elapsed from symptom onset and prodrome to diagnosis. In recent decades, understanding of the disease pathogenesis has increased and the association between toxicity mediated by cytotoxic T lymphocytes and genes of human leukocyte antigens (HLA) has been described; however, many of the factors associated with the development of the disease remain under investigation, such as TEN induced by viral infections. The aim of this research is to document a case of TEN in an adult male patient with systemic involvement after starting treatment with amoxicillin.
publishDate 2023
dc.date.accessioned.none.fl_str_mv 2023-10-11T04:35:21Z
dc.date.available.none.fl_str_mv 2023-10-11T04:35:21Z
dc.date.none.fl_str_mv 2023-03-30
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
dc.type.es-ES.fl_str_mv Reporte de caso
status_str publishedVersion
dc.identifier.none.fl_str_mv https://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/1311
dc.identifier.uri.none.fl_str_mv https://vitela.javerianacali.edu.co/handle/11522/526
url https://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/1311
https://vitela.javerianacali.edu.co/handle/11522/526
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv https://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/1311/1152
dc.rights.es-ES.fl_str_mv Derechos de autor 2023 Salutem Scientia Spiritus
https://creativecommons.org/licenses/by-nc-nd/4.0
rights_invalid_str_mv Derechos de autor 2023 Salutem Scientia Spiritus
https://creativecommons.org/licenses/by-nc-nd/4.0
dc.format.none.fl_str_mv application/pdf
dc.publisher.es-ES.fl_str_mv Pontificia Universidad Javeriana Cali
dc.source.en-US.fl_str_mv Salutem Scientia Spiritus; Vol. 9 No. 1 (2023): Revista Salutem Scientia Spiritus; 72-77
dc.source.es-ES.fl_str_mv Salutem Scientia Spiritus; Vol. 9 Núm. 1 (2023): Revista Salutem Scientia Spiritus; 72-77
dc.source.none.fl_str_mv 2463-1426
institution Pontificia Universidad Javeriana Cali
repository.name.fl_str_mv Repositorio Vitela
repository.mail.fl_str_mv vitela.mail@javerianacali.edu.co
_version_ 1812095063902126080

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