Relationship between red complex microorganisms and Aggregatibacter actinomycetemcomitans isolation and Down’s syndrome. Systematic review and meta-analysis.

Background: Patients with Down’s Syndrome (DS) are frequently diagnosed with periodontal disease (PD). However, a direct relation between both conditions hasn’t been found yet and the burden in oral health of periodontal pathogens of these patients is currently unknown. Methods: A systematic review...

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Fecha de publicación:: 2022

Institución:: Pontificia Universidad Javeriana Cali

Repositorio:: Vitela

Idioma:: spa

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oai_identifier_str	oai:vitela.javerianacali.edu.co:11522/449
network_acronym_str	Vitela2
network_name_str	Vitela
repository_id_str
dc.title.en-US.fl_str_mv	Relationship between red complex microorganisms and Aggregatibacter actinomycetemcomitans isolation and Down’s syndrome. Systematic review and meta-analysis.
dc.title.es-ES.fl_str_mv	Relación entre la presencia de microorganismos del complejo rojo y Aggregatibacter actinomycetemcomitans y síndrome de Down. Revisión sistemática y metanálisis.
title	Relationship between red complex microorganisms and Aggregatibacter actinomycetemcomitans isolation and Down’s syndrome. Systematic review and meta-analysis.
spellingShingle	Relationship between red complex microorganisms and Aggregatibacter actinomycetemcomitans isolation and Down’s syndrome. Systematic review and meta-analysis. Jiménez-Galeano, Vanessa Síndrome de Down Gingivitis Periodontitis Aggregatibacter actinomycetemcomitans Down syndrome Gingivitis Periodontitis Aggregatibacter actinomycetemcomitans
title_short	Relationship between red complex microorganisms and Aggregatibacter actinomycetemcomitans isolation and Down’s syndrome. Systematic review and meta-analysis.
title_full	Relationship between red complex microorganisms and Aggregatibacter actinomycetemcomitans isolation and Down’s syndrome. Systematic review and meta-analysis.
title_fullStr	Relationship between red complex microorganisms and Aggregatibacter actinomycetemcomitans isolation and Down’s syndrome. Systematic review and meta-analysis.
title_full_unstemmed	Relationship between red complex microorganisms and Aggregatibacter actinomycetemcomitans isolation and Down’s syndrome. Systematic review and meta-analysis.
title_sort	Relationship between red complex microorganisms and Aggregatibacter actinomycetemcomitans isolation and Down’s syndrome. Systematic review and meta-analysis.
dc.creator.none.fl_str_mv	Jiménez-Galeano, Vanessa Tamayo-Cardona, Julián Andrés Jaramillo-Echeverry, Adriana
author	Jiménez-Galeano, Vanessa
author_facet	Jiménez-Galeano, Vanessa Tamayo-Cardona, Julián Andrés Jaramillo-Echeverry, Adriana
author_role	author
author2	Tamayo-Cardona, Julián Andrés Jaramillo-Echeverry, Adriana
author2_role	author author
dc.subject.es-ES.fl_str_mv	Síndrome de Down Gingivitis Periodontitis Aggregatibacter actinomycetemcomitans
topic	Síndrome de Down Gingivitis Periodontitis Aggregatibacter actinomycetemcomitans Down syndrome Gingivitis Periodontitis Aggregatibacter actinomycetemcomitans
dc.subject.en-US.fl_str_mv	Down syndrome Gingivitis Periodontitis Aggregatibacter actinomycetemcomitans
description	Background: Patients with Down’s Syndrome (DS) are frequently diagnosed with periodontal disease (PD). However, a direct relation between both conditions hasn’t been found yet and the burden in oral health of periodontal pathogens of these patients is currently unknown. Methods: A systematic review was performed to find out the relationship between prevalence of Red Complex (RC) microorganisms and Aggregatibacter actinomycetemcomitans (Aa) and DS in patients with periodontal disease. Studies published between 2000 and 2019 were selected by two independent authors in PubMed and Embase databases, the quality of the articles was evaluated with the Newcastle-Ottawa scale, the funnel plot and the Egger test were performed to analyze the homogeneity and asymmetry of the results and the calculation of the OR and its confidence intervals, using the Forest Plot. Results: Seven studies were selected for qualitative analysis, and 3 case-control studies were included for meta-analysis. Prevalence of CR microorganisms and Aa was assessed in patients with periodontitis, both with and without DS: P. gingivalis OR 1,07 (95%CI 0,56 - 2,07), T. forsythia OR 1,19 (95%CI 0,38 - 3,75), T. denticola OR 1,07 (95%CI 0,56 - 2,07), Aa OR 0,90 (95%CI 0,44 - 1,84). Included studies were found homogeneous in the analysis that were performed, with I2 tests of 0%, excluding T. forsythia where heterogeneity was found with I2 test of 80%. Conclusion: An association between presence of RC microorganisms and Aa was not found in the current meta-analysis when comparing patients with periodontal disease, both with and without DS.
publishDate	2022
dc.date.accessioned.none.fl_str_mv	2023-10-11T04:34:55Z
dc.date.available.none.fl_str_mv	2023-10-11T04:34:55Z
dc.date.none.fl_str_mv	2022-09-30
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
dc.type.es-ES.fl_str_mv	Revisión sistemática de la literatura
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/643
dc.identifier.uri.none.fl_str_mv	https://vitela.javerianacali.edu.co/handle/11522/449
url	https://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/643 https://vitela.javerianacali.edu.co/handle/11522/449
dc.language.none.fl_str_mv	spa
language	spa
dc.relation.none.fl_str_mv	https://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/643/546
dc.rights.es-ES.fl_str_mv	Derechos de autor 2023 Salutem Scientia Spiritus https://creativecommons.org/licenses/by-nc-nd/4.0
rights_invalid_str_mv	Derechos de autor 2023 Salutem Scientia Spiritus https://creativecommons.org/licenses/by-nc-nd/4.0
dc.format.none.fl_str_mv	application/pdf
dc.publisher.es-ES.fl_str_mv	Pontificia Universidad Javeriana Cali
dc.source.en-US.fl_str_mv	Salutem Scientia Spiritus; Vol. 8 No. 3 (2022): Revista Salutem Scientia Spiritus; 33-40
dc.source.es-ES.fl_str_mv	Salutem Scientia Spiritus; Vol. 8 Núm. 3 (2022): Revista Salutem Scientia Spiritus; 33-40
dc.source.none.fl_str_mv	2463-1426
institution	Pontificia Universidad Javeriana Cali
repository.name.fl_str_mv	Repositorio Vitela
repository.mail.fl_str_mv	vitela.mail@javerianacali.edu.co
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spelling	Jiménez-Galeano, VanessaTamayo-Cardona, Julián AndrésJaramillo-Echeverry, Adriana2022-09-302023-10-11T04:34:55Z2023-10-11T04:34:55Zhttps://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/643https://vitela.javerianacali.edu.co/handle/11522/449Background: Patients with Down’s Syndrome (DS) are frequently diagnosed with periodontal disease (PD). However, a direct relation between both conditions hasn’t been found yet and the burden in oral health of periodontal pathogens of these patients is currently unknown. Methods: A systematic review was performed to find out the relationship between prevalence of Red Complex (RC) microorganisms and Aggregatibacter actinomycetemcomitans (Aa) and DS in patients with periodontal disease. Studies published between 2000 and 2019 were selected by two independent authors in PubMed and Embase databases, the quality of the articles was evaluated with the Newcastle-Ottawa scale, the funnel plot and the Egger test were performed to analyze the homogeneity and asymmetry of the results and the calculation of the OR and its confidence intervals, using the Forest Plot. Results: Seven studies were selected for qualitative analysis, and 3 case-control studies were included for meta-analysis. Prevalence of CR microorganisms and Aa was assessed in patients with periodontitis, both with and without DS: P. gingivalis OR 1,07 (95%CI 0,56 - 2,07), T. forsythia OR 1,19 (95%CI 0,38 - 3,75), T. denticola OR 1,07 (95%CI 0,56 - 2,07), Aa OR 0,90 (95%CI 0,44 - 1,84). Included studies were found homogeneous in the analysis that were performed, with I2 tests of 0%, excluding T. forsythia where heterogeneity was found with I2 test of 80%. Conclusion: An association between presence of RC microorganisms and Aa was not found in the current meta-analysis when comparing patients with periodontal disease, both with and without DS.Objetivo: Determinar si existe una relación entre la presencia de microorganismos del complejo rojo y Aggregatibacter actinomycetemcomitans (Aa) en pacientes con enfermedad periodontal y Síndrome de Down (SD). Métodos: Se realizó una revisión sistemática para buscar la relación entre la prevalencia de microorganismos del Complejo Rojo (CR), Aggregatibacter actinomycetemcomitans (Aa) y SD en pacientes con enfermedad periodontal. Se ejecutó la búsqueda y selección de artículos publicados entre 2000 y 2019 por parte de dos autores de manera independiente en las bases de datos PubMed y Embase, se evaluó la calidad de los artículos con la escala Newcastle-Ottawa, se realizó el gráfico de embudo y la prueba Egger para analizar la homogeneidad y asimetría de los resultados y el cálculo del OR y sus intervalos de confianza, mediante el Forest Plot. Resultados: Se incluyeron 7 estudios para el análisis cualitativo, y 3 estudios de casos y controles para el metanálisis. Se evaluó la relación de microorganismos de CR y Aa en pacientes con periodontitis, con y sin SD: P. gingivalis OR 1,07 (IC 95% 0,56 - 2.07), T. forsythia OR 1,19 (IC 95% 0,38 - 3,75), T. denticola OR 1,07 (IC 95% 0,56 - 2,07), Aa OR 0,90 (IC 95% 0,44 - 1,84). Los estudios incluidos fueron homogéneos con pruebas de I2 de 0%, a excepción de T. forsythia en donde se encontró heterogeneidad con I2 80%. Conclusión: No se encontró asociación entre la presencia de los microorganismos del complejo rojo ni Aa en pacientes con enfermedad periodontal, al comparar pacientes con y sin SD.application/pdfspaPontificia Universidad Javeriana Calihttps://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/643/546Derechos de autor 2023 Salutem Scientia Spiritushttps://creativecommons.org/licenses/by-nc-nd/4.0Salutem Scientia Spiritus; Vol. 8 No. 3 (2022): Revista Salutem Scientia Spiritus; 33-40Salutem Scientia Spiritus; Vol. 8 Núm. 3 (2022): Revista Salutem Scientia Spiritus; 33-402463-1426Síndrome de DownGingivitisPeriodontitisAggregatibacter actinomycetemcomitansDown syndromeGingivitisPeriodontitisAggregatibacter actinomycetemcomitansRelationship between red complex microorganisms and Aggregatibacter actinomycetemcomitans isolation and Down’s syndrome. Systematic review and meta-analysis.Relación entre la presencia de microorganismos del complejo rojo y Aggregatibacter actinomycetemcomitans y síndrome de Down. Revisión sistemática y metanálisis.info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRevisión sistemática de la literatura11522/449oai:vitela.javerianacali.edu.co:11522/4492024-06-25 05:12:42.388metadata.onlyhttps://vitela.javerianacali.edu.coRepositorio Vitelavitela.mail@javerianacali.edu.co

Relationship between red complex microorganisms and Aggregatibacter actinomycetemcomitans isolation and Down’s syndrome. Systematic review and meta-analysis.

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