Relationship between red complex microorganisms and Aggregatibacter actinomycetemcomitans isolation and Down’s syndrome. Systematic review and meta-analysis.

Background: Patients with Down’s Syndrome (DS) are frequently diagnosed with periodontal disease (PD). However, a direct relation between both conditions hasn’t been found yet and the burden in oral health of periodontal pathogens of these patients is currently unknown. Methods: A systematic review...

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Fecha de publicación:: 2022

Institución:: Pontificia Universidad Javeriana Cali

Repositorio:: Vitela

Idioma:: spa

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Summary:	Background: Patients with Down’s Syndrome (DS) are frequently diagnosed with periodontal disease (PD). However, a direct relation between both conditions hasn’t been found yet and the burden in oral health of periodontal pathogens of these patients is currently unknown. Methods: A systematic review was performed to find out the relationship between prevalence of Red Complex (RC) microorganisms and Aggregatibacter actinomycetemcomitans (Aa) and DS in patients with periodontal disease. Studies published between 2000 and 2019 were selected by two independent authors in PubMed and Embase databases, the quality of the articles was evaluated with the Newcastle-Ottawa scale, the funnel plot and the Egger test were performed to analyze the homogeneity and asymmetry of the results and the calculation of the OR and its confidence intervals, using the Forest Plot. Results: Seven studies were selected for qualitative analysis, and 3 case-control studies were included for meta-analysis. Prevalence of CR microorganisms and Aa was assessed in patients with periodontitis, both with and without DS: P. gingivalis OR 1,07 (95%CI 0,56 - 2,07), T. forsythia OR 1,19 (95%CI 0,38 - 3,75), T. denticola OR 1,07 (95%CI 0,56 - 2,07), Aa OR 0,90 (95%CI 0,44 - 1,84). Included studies were found homogeneous in the analysis that were performed, with I2 tests of 0%, excluding T. forsythia where heterogeneity was found with I2 test of 80%. Conclusion: An association between presence of RC microorganisms and Aa was not found in the current meta-analysis when comparing patients with periodontal disease, both with and without DS.

Relationship between red complex microorganisms and Aggregatibacter actinomycetemcomitans isolation and Down’s syndrome. Systematic review and meta-analysis.

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