Estado actual del conocimiento sobre la rinotraqueitis infecciosa bovina

Incluye figuras y tablas.

Autores:
Vargas Bustos, Camilo Andrés
Tipo de recurso:
Trabajo de grado de pregrado
Fecha de publicación:
2018
Institución:
Universidad de los Llanos
Repositorio:
Repositorio Digital Universidad de los LLanos
Idioma:
spa
OAI Identifier:
oai:repositorio.unillanos.edu.co:001/3340
Acceso en línea:
https://repositorio.unillanos.edu.co/handle/001/3340
https://repositorio.unillanos.edu.co/
Palabra clave:
Rinotraqueitis infecciosa bovina
Vacunas
Erradicación
Monografía
Infectious bovine rhinotracheitis
Vaccine
Eradication
Monograph
Rights
openAccess
License
Derechos Reservados - Universidad de los Llanos, 2018
id Unillanos2_8d125ca8bc74d956c239e0e5e3d6d4aa
oai_identifier_str oai:repositorio.unillanos.edu.co:001/3340
network_acronym_str Unillanos2
network_name_str Repositorio Digital Universidad de los LLanos
repository_id_str
dc.title.spa.fl_str_mv Estado actual del conocimiento sobre la rinotraqueitis infecciosa bovina
title Estado actual del conocimiento sobre la rinotraqueitis infecciosa bovina
spellingShingle Estado actual del conocimiento sobre la rinotraqueitis infecciosa bovina
Rinotraqueitis infecciosa bovina
Vacunas
Erradicación
Monografía
Infectious bovine rhinotracheitis
Vaccine
Eradication
Monograph
title_short Estado actual del conocimiento sobre la rinotraqueitis infecciosa bovina
title_full Estado actual del conocimiento sobre la rinotraqueitis infecciosa bovina
title_fullStr Estado actual del conocimiento sobre la rinotraqueitis infecciosa bovina
title_full_unstemmed Estado actual del conocimiento sobre la rinotraqueitis infecciosa bovina
title_sort Estado actual del conocimiento sobre la rinotraqueitis infecciosa bovina
dc.creator.fl_str_mv Vargas Bustos, Camilo Andrés
dc.contributor.advisor.none.fl_str_mv Góngora Orjuela, Agustín
dc.contributor.author.none.fl_str_mv Vargas Bustos, Camilo Andrés
dc.subject.proposal.spa.fl_str_mv Rinotraqueitis infecciosa bovina
Vacunas
Erradicación
Monografía
topic Rinotraqueitis infecciosa bovina
Vacunas
Erradicación
Monografía
Infectious bovine rhinotracheitis
Vaccine
Eradication
Monograph
dc.subject.proposal.eng.fl_str_mv Infectious bovine rhinotracheitis
Vaccine
Eradication
Monograph
description Incluye figuras y tablas.
publishDate 2018
dc.date.issued.none.fl_str_mv 2018
dc.date.accessioned.none.fl_str_mv 2024-04-16T20:48:18Z
dc.date.available.none.fl_str_mv 2024-04-16T20:48:18Z
dc.type.spa.fl_str_mv Trabajo de grado - Pregrado
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/bachelorThesis
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_7a1f
dc.type.content.spa.fl_str_mv Text
dc.type.coarversion.spa.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
format http://purl.org/coar/resource_type/c_7a1f
status_str publishedVersion
dc.identifier.citation.spa.fl_str_mv Vargas Bustos, Camilo A. (2018). Estado actual del conocimiento sobre la rinotraqueitis infecciosa bovina [Trabajo de grado, Universidad de los Llanos]. Repositorio digital Universidad de los Llanos.
dc.identifier.uri.none.fl_str_mv https://repositorio.unillanos.edu.co/handle/001/3340
dc.identifier.instname.spa.fl_str_mv Universidad de los Llanos
dc.identifier.reponame.spa.fl_str_mv Repositorio digital Universidad de los Llanos
dc.identifier.repourl.spa.fl_str_mv https://repositorio.unillanos.edu.co/
identifier_str_mv Vargas Bustos, Camilo A. (2018). Estado actual del conocimiento sobre la rinotraqueitis infecciosa bovina [Trabajo de grado, Universidad de los Llanos]. Repositorio digital Universidad de los Llanos.
Universidad de los Llanos
Repositorio digital Universidad de los Llanos
url https://repositorio.unillanos.edu.co/handle/001/3340
https://repositorio.unillanos.edu.co/
dc.language.iso.spa.fl_str_mv spa
language spa
dc.relation.references.spa.fl_str_mv Ackermann M., Engels M. 2006. Pro and contra IBR-eradication. Vet. Microbiol. 113: 293-302.
Arenas N.M., Moreno F.G. 2015. Rinotraquitis Infecciosa Bovina en Colombia. Referencias para Consultorio MV. 40: 8-11.
Armengol R., Villalba D., Coma E., Porquet L., Jubert A., Nogareda C. 2017. Prevalence of individual and bulk tank milk antibodies of bovine herpesvirus type 1 and its relation to milk quality parameters on dairy farms in Catalonia (north-east Spain). Vet. Rec. Open. 4: e000203.
Barkema H.W., Green M.J., Bradley A.J., Zadoks R.N. 2009. Invited review: The role of contagious disease in udder health. J. Dairy Sci. 92: 4717-4729.
Beer M., König P., Schielke G., Trapp S. 2003. Marker diagnostic for the eradication of bovine herpesvirus type 1: Possibilities and limitations. Berl. Munch. Tierarztl. Wochenschr. 116: 183-91.
Bertolotti L., Muratore E., Nogarol C., Caruso C., Lucchese L., Profiti M., Anfossi L., Masoero L., Nardelli S., Rosati S. 2015. Development and validation of an indirect ELISA as a confirmatory test for surveillance of infectious bovine rhinotracheitis in vaccinated herds. BMC Vet. Res. 11: 300.
Betancur H C., González T M., Reza G. L. 2006. Seroepidemiología de la rinotraqueitis infecciosa bovina en el municipio de Montería, Colombia. Rev. MVZ Córdoba. 11: 830-836.
Bielanski A., Algire J., Lalonde A., Garceac A. 2013. Prevention of bovine herpesvirus-1 transmission by the transfer of embryos disinfected with recombinant bovine trypsin. Theriogenology. 80: 1104-1108.
Boelaert F., Speybroeck N., Kruif A.d., Aerts M., Burzykowski T., Molenberghs G., Berkvens D.L. 2005. Risk factors for bovine herpesvirus-1 seropositivity. Prev. Vet. Med. 69: 285-295.
Brower A., Homb K.M., Bochsler P., Porter R., Woods K., Ubl S., Krueger D., Cigel F., TooheyKurth K. 2008. Encephalitis in aborted bovine fetuses associated with Bovine herpesvirus 1 infection. J Vet Diagn Invest. 20: 297-303.
Camacho R., Carvajal L.Y., Castellanos-Dominguez Y.Z., Díaz W.F., Vásquez M.C. 2015. Presence of IgG antibodies against reproductive infections in breeding bulls of Magdalena Medio, Colombia. Rev Colomb Cienc Pecu. 28: 323-330.
Campos F.S., Franco A.C., Hübner S.O., Oliveira M.T., Silva A.D., Esteves P.A., Roehe P.M., Rijsewijk F.A.M. 2009. High prevalence of co-infections with bovine herpesvirus 1 and 5 found in cattle in southern Brazil. Vet. Microbiol. 139: 67-73.
Cedeño Quevedo D., Benavides B., Cárdenas G., Herrera C. 2011. Factores de riesgo asociados a la seroprevalencia de BHV-1 y DVB en hatos lecheros en Pasto, Colombia, en el 2011. Rev. Lasallista Investig. 8: 61-68.
CIAT - Centro Internacional de Agricultura Tropical. 1972 - 1975. Informe anual de salud animal; Bogotá.
Cordero Camacho C.P., Escobar Mármol L., Carrillo Borda E.F., Morantes Medina S.J., Aristizábal Gutiérrez F.A. 2011. Detection of seven viruses and Mycoplasma in fetal bovine serum by real time PCR. Rev Colomb Cienc Pecu. 24: 585-597.
Crane C.S., Lukas G.N., Watkins W.W. 1964. Infectious Bovine Rhinotracheitis abortion in California beef cattle. J Am Vet Med Assoc. 144: 13-8.
Cuddington B.P., Mossman K.L. 2015. Oncolytic bovine herpesvirus type 1 as a broad spectrum cancer therapeutic. Curr Opin Virol. 13: 11-16.
Chaparro J., Ramírez G., Vera V., Góngora A., Villamil L. 2002. Aislamiento de una cepa de campo del virus de la Rinotraqueítis Infecciosa Bovina de una explotación de ganado de carne en el Departamento del Meta. Orinoquía. 6: 100-107.
Chase C.C.L., Fulton R.W., O’Toole D., Gillette B., Daly R.F., Perry G., Clement T. 2017. Bovine herpesvirus 1 modified live virus vaccines for cattle reproduction: Balancing protection with undesired effects. Vet. Microbiol. 206: 69-77.
Díaz F. 2000. Reactividad serológica y aspectos epidemiológicos para Rinotraqueítis Bovina Infecciosa (IBR) mediante la prueba de seroneutralización viral en toros reproductores de la región central del departamento del Valle del Cauca. [Tesis de Maestría]. Bogotá: Facultad de Medicina Veterinaria y de Zootecnia. Universidad Nacional de Colombia.
Dias J.A., Alfieri A.A., Ferreira-Neto J.S., Gonçalves V.S.P., Muller E.E. 2013. Seroprevalence and Risk Factors of Bovine Herpesvirus 1 Infection in Cattle Herds in the State of Paraná, Brazil. Transbound Emerg Dis. 60: 39-47.
Eaglesome M.D., Garcia M.M. 1997. Disease risks to animal health from artificial insemination with bovine semen. Rev sci Tech. 16: 215-25.
Favier P.A., Marin M.S., Morán P.E., Odeón A.C., Verna A.E., Pérez S.E. 2014. Latency of bovine herpesvirus type 5 (BoHV-5) in tonsils and peripheral blood leukocytes. Vet. J. 202: 134-140.
Forschner E., Bunger I., Kuttler D., Mehrkens L. 1986. IBR/IPV serodiagnosis with ELISA methods in blood, single milk and bulk milk samples; control measures for maintaining normal cattle herds; eradication measures with reference to vaccination. DTW. Deutsche tierarztliche Wochenschrift. 93: 328-35.
Frizzo da Silva L. 2012. Bovine herpesvirus type 1 (BHV-1) regulates the innate immune system to promote productive infection and latency. ETD collection for University of Nebraska - Lincoln. AAI3503429.
Fulton R.W., d'Offay J.M., Eberle R., Moeller R.B., Campen H.V., O'Toole D., Chase C., Miller M.M., Sprowls R., Nydam D.V. 2015. Bovine herpesvirus-1: evaluation of genetic diversity of subtypes derived from field strains of varied clinical syndromes and their relationship to vaccine strains. Vaccine. 33: 549-58.
Fulton R.W., d’Offay J.M., Dubovi E.J., Eberle R. 2016. Bovine herpesvirus-1: Genetic diversity of field strains from cattle with respiratory disease, genital, fetal disease and systemic neonatal disease and their relationship to vaccine strains. Virus Res. 223: 115-121.
Fulton R.W., d’Offay J.M., Eberle R. 2013. Bovine herpesvirus-1: Comparison and differentiation of vaccine and field strains based on genomic sequence variation. Vaccine. 31: 1471-1479.
Geraghty T., O’Neill R., More S.J., O’Grady L. 2012. Dynamics of individual animal Bovine Herpes Virus-1 antibody status on 9 commercial dairy herds. Res Vet Sci. 93: 143-149.
Góngora A., Villamil L.C., Vera V.J., Parra J.L., Ramírez G., López G. 1995a. Aislamiento de un herpes virus bovino tipo-1 (hvb-1) de secreción nasal y esmegma prepucial en un toro reproductor. Rev. Med. Vet. Zoot. 43: 43-60.
Góngora A., Villamil L.C., Vera V.J., Ramírez G.C., Parra J.L. 1995b. Diagnóstico de las principales enfermedades reproductivas en toros de la sabana de Bogotá. Énfasis en rinotraqueitis infeccionesa bovina (RIB). Rev. Med. Vet. Zoot. 43: 37-42.
González-García M.A., Maldonado J.L., Gómez-Pacheco J.M., Arenas-Casas A., CarboneroMartínez A., Borges-Rodríguez C., García Bocanegra I., Perea-Remujo J.A. 2009. Seroprevalence and risk factors associated with bovine herpesvirus type 1 (BHV1) infection in non-vaccinated cattle herds in Andalusia (South of Spain). Span. J. Agric. Res. 7: 550-554.
Graham D.A. 2013. Bovine herpes virus-1 (BoHV-1) in cattle–a review with emphasis on reproductive impacts and the emergence of infection in Ireland and the United Kingdom. Ir Vet J. 66: 15.
Hulyanych M., Nedosekov V., Sobko Y. 2016. Determination of Cultural Conditions of Infectious Bovine Rhinotracheitis Virus Strain “BM”. Ann Agrar Sci. 14: 201-204.
Jones C., Chowdhury S. 2010. Bovine Herpesvirus Type 1 (BHV-1) is an Important Cofactor in the Bovine Respiratory Disease Complex. Vet Clin Food Anim. 26: 303-321.
Kaashoek M.J., Van Engelenburg F.A.C., Moerman A., Gielkens A.L.J., Rijsewijk F.A.M., van Oirschot J.T. 1996. Virulence and immunogenicity in calves of thymidine kinase- and glycoprotein E-negative bovine herpesvirus 1 mutants. Vet. Microbiol. 48: 143-153.
Kendrick J.W., McEntee K. 1967. The effect of artificial insemination with semen contaminated with IBR-IPV virus. Cornell Vet. 57: 3-11.
Kennedy P.C., Richards W.P.C. 1964. The Pathology of Abortion Caused by the Virus of Infectious Bovine Rhinotracheitis. Vet Pathol. 1: 7-17.
Kupferschmied H.U., Kihm U., Bachmann P., Müller K.H., Ackermann M. 1986. Transmission of IBR/IPV virus in bovine semen: A case report. Theriogenology. 25: 439-43.
Kutish G., Mainprize T., Rock D. 1990. Characterization of the latency-related transcriptionally active region of the bovine herpesvirus 1 genome. J Virol. 64: 5730-7.
Mahajan V., Banga H.S., Deka D., Filia G., Gupta A. 2013. Comparison of Diagnostic Tests for Diagnosis of Infectious Bovine Rhinotracheitis in Natural Cases of Bovine Abortion. J. Comp. Path. 149: 391-401.
Marin M.S., Leunda M.R., Verna A.E., Morán P.E., Odeón A.C., Pérez S.E. 2016. Distribution of bovine herpesvirus type 1 in the nervous system of experimentally infected calves. Vet J. 209: 82-86.
Meurens F., Schynts F., Keil G.M., Muylkens B., Vanderplasschen A., Gallego P., Thiry E. 2004. Superinfection prevents recombination of the alphaherpesvirus bovine herpesvirus 1. J. Virol. 78: 3872-3879.
Miller N.J. 1955. Infectious necrotic rhinotracheitis of cattle. JAVMA. 126: 463-7.
Molano D., Rodríguez J., Ramírez G., Villamil L. 1996. Caracterización electroforética e inmunológica de una cepa de campo del virus de la rinotraqueitis infecciosa bovina y su comparación con cepas de referencia. Rev. Med. Vet. Zoot. 44: 35-38.
Molina V., Risalde M.A., Sánchez-Cordón P.J., Pedrera M., Romero-Palomo F., Luzzago C., Gómez-Villamandos J.C. 2013. Effect of infection with BHV-1 on peripheral blood leukocytes and lymphocyte subpopulations in calves with subclinical BVD. Res Vet Sci. 95: 115-122.
Motta Giraldo J.L., Waltero García I., Abeledo M.A. 2013. Prevalencia de anticuerpos al virus de la diarrea viral bovina, Herpesvirus bovino 1 y Herpesvirus bovino 4 en bovinos y búfalos en el Departamento de Caquetá, Colombia. Rev. Salud Anim. 35: 174-181.
Muratore E., Bertolotti L., Nogarol C., Caruso C., Lucchese L., Iotti B., Ariello D., Moresco A., Masoero L., Nardelli S., Rosati S. 2017. Surveillance of Infectious Bovine Rhinotracheitis in marker-vaccinated dairy herds: Application of a recombinant gE ELISA on bulk milk samples. Vet Immunol Immunopathol. 185: 1-6.
Muylkens B., Meurens F., Schynts F., Farnir F., Pourchet A., Bardiau M., Gogev S., Thiry J., Cuisenaire A., Vanderplasschen A., Thiry E. 2006. Intraspecific bovine herpesvirus 1 recombinants carrying glycoprotein E deletion as a vaccine marker are virulent in cattle. J Gen Virol. 87: 2149-2154.
Muylkens B., Thiry J., Kirten P., Schynts F., Thiry E. 2007. Bovine herpesvirus 1 infection and infectious bovine rhinotracheitis. Vet. Res. 38: 181-209.
Nandi S., Kumar M., Manohar M., Chauhan R.S. 2009. Bovine herpes virus infections in cattle. Anim. Health Res Rev. 10: 85-98.
Narita M., Kimura K., Tanimura N., Arai S., Tsuboi T., Katsuda K. 2000. Immunohistochemical Characterization of Calf Pneumonia Produced by the Combined Endobronchial Administration of Bovine Herpesvirus 1 and Pasteurella haemolytica. J. Comp. Path. 123: 126-134.
Newcomer B.W., Givens D. 2016. Diagnosis and Control of Viral Diseases of Reproductive Importance: Infectious Bovine Rhinotracheitis and Bovine Viral Diarrhea. Vet Clin Food Anim. 32: 425-441.
Nuotio L., Neuvonen E., Hyytiäinen M. 2007. Epidemiology and eradication of infectious bovine rhinotracheitis/infectious pustular vulvovaginitis (IBR/IPV) virus in Finland. Acta Vet Scand. 49: 3.
Ochoa X., Orbegozo M., Manrique-Abril F., Pulido M M., Ospina J. 2012. Seroprevalencia de rinotraqueitis infecciosa bovina en hatos lecheros de Toca - Boyacá. Rev. MVZ Córdoba. 17: 2974-2982.
Oliveira M.T., Campos F.S., Dias M.M., Velho F.A., Freneau G.E., Brito W.M.E.D., Rijsewijk F.A.M., Franco A.C., Roehe P.M. 2011. Detection of bovine herpesvirus 1 and 5 in semen from Brazilian bulls. Theriogenology. 75: 1139-1145.
Parsonson I.M., Snowdon W.A. 1975. The effect of natural and artificial breeding using bulls infected with, or semen contaminated with, infectious bovine rhinotracheitis virus. Austral Vet J. 51: 365-9.
Patel J.R. 2005. Characteristics of live bovine herpesvirus-1 vaccines. Vet J. 169: 404-416.
Peña Joya M.A., Góngora A., Jiménez C. 2011. Infectious agents affecting fertility of bulls, and transmission risk through semen: Retrospective analysis of their sanitary status in Colombia. Rev Colomb Cienc Pecu. 24: 623-633.
Piedrahita D., Ramirez G., Vera V. 2005. Detección y caracterización por metodos moleculares de aislamientos colombianos de herpesvirus bovino tipo 1. Rev. Med. Vet. Zoot. 52: 120-127.
Piedrahita L.E., Montoya L.M., Pedraza F.J. 2010. Herpes Virus Bovino tipo 1 (BoHV-1) como posible causa de encefalitis en bovinos de la región del Magdalena Medio Colombiano: Estudio serológico y análisis epidemiológico. Rev Colomb Cienc Pecu. 23: 191-198.
Quinn, P.J.; Markey, B.K.; Carter, M.E.; Donnelly, W.J.C.; Leonard, F.C. 2005. Microbiología y Enfermedades Infecciosas Veterinarias. Acribia, S.A. España. Pag. 387-400.
Raaperi K., Nurmoja I., Orro T., Viltrop A. 2010. Seroepidemiology of bovine herpesvirus 1 (BHV1) infection among Estonian dairy herds and risk factors for the spread within herds. Prev Vet Med. 96: 74-81.
Raaperi K., Orro T., Viltrop A. 2014. Epidemiology and control of bovine herpesvirus 1 infection in Europe. Vet J. 201: 249-256.
Raaperi K., Orro T., Viltrop A. 2015. Effect of vaccination against bovine herpesvirus 1 with inactivated gE-negative marker vaccines on the health of dairy cattle herds. Prev Vet Med. 118: 467-476.
Ramírez Vásquez N.F., Villar Argaiz D., Fernández Silva J.A., Londoño Pino J., Chaparro Gutiérrez J.J., Olivera Ángel M.E. 2016. Seroprevalence and risk factors of several bovine viral diseases in dairy farms of San Pedro de los Milagros, Antioquia, Colombia. Rev CES Med Zootec. 11: 15-25.
Reber A., Reist M., Schwermer H. 2012. Cost-effectiveness of bulk-tank milk testing for surveys to demonstrate freedom from infectious bovine rhinotracheitis and bovine enzootic leucosis in Switzerland. Schweiz Arch Tierheilkd. 154: 189-97.
Rissi D.R., Pierezan F., Silva M.S.e., Flores E.F., de Barros C.S.L. 2008. Neurological Disease in Cattle in Southern Brazil Associated with Bovine Herpesvirus Infection. J Vet Diagn Invest. 20: 346-349.
Rock D., Lokensgard J., Lewis T., Kutish G. 1992. Characterization of dexamethasoneinduced reactivation of latent bovine herpesvirus 1. J Virol. 66: 2484-90.
Ruiz, A. 1977. Complejo Rinotraqueitis infecciosa bovina, Vulvovaginitis postular infecciosa. Enfermedades de los Bovinos. Dirección general de ganadería sub programa de Sanidad Animal. Santo Domingo. República Dominicana.
Ruiz-Saenz J., Jaime J., Ramirez G., Vera V. 2012. Molecular and in vitro characterization of field isolates of bovine herpesvirus-1. Virol. Sin. 27: 26-37.
Ruiz-Saenz J., Jaime J., Vera V. 2009. Vacunas contra el herpesvirus bovino-1: Una mirada desde el pasado hacia el futuro de la inmunización. Acta biol. Colomb. 14: 3-20.
Ruiz-Sáenz J., Jaime J., Vera V. 2013. An inactivated vaccine from a field strain of bovine herpesvirus-1 (BoHV-1) has high antigenic mass and induces strong efficacy in a rabbit model. Virol. Sin. 28: 36-42.
Ruiz-Saenz J., Jaime J., Víctor J., Vera V. 2010. Prevalencia serológica y aislamiento del Herpesvirus Bovino-1 (BHV-1) en hatos ganaderos de Antioquia y del Valle del Cauca. Rev Colomb Cienc Pecu. 23: 299-307.
Ruiz J., Jaime J., Vera V. 2008. Latencia Del Herpesvirus Bovino-1: El Papel De Los Transcritos Relacionados Con Latencia (Rl). Acta biol. Colomb. 13: 3-22.
Ruiz Sáenz J., Osorio J.E., Vera V.J. 2012. Desarrollo De Un Poxvirus Recombinante Que Expresa La Glicoproteína D Del Herpesvirus Bovino-1. Acta biol. Colomb. 17: 14.
Saravanajayam M., Kumanan K., Balasubramaniam A. 2015. Seroepidemiology of infectious bovine rhinotracheitis infection in unvaccinated cattle. Vet World. 8: 1416-1419.
Schroeder R.J., Moys M.D. 1954. An acute upper respiratory infection of dairy cattle. JAVMA. 125: 471-2.
Segura-Correa J.C., Zapata-Campos C.C., Jasso-Obregón J.O., Martinez-Burnes J., LópezZavala R. 2016. Seroprevalence and risk factors associated with bovine herpesvirus 1 and bovine viral diarrhea virus in North-Eastern Mexico. Open Vet. J. 6: 143-149.
Silva M.S., Brum M.C.S., Loreto E.L.S., Weiblen R., Flores E.F. 2007. Molecular and antigenic characterization of Brazilian bovine herpesvirus type 1 isolates recovered from the brain of cattle with neurological disease. Virus Res. 129: 191-199.
Straub O.C. 1975. Infectious bovine rhinotracheitis virus. History and recent developments. Developments in biological standardization. 28: 530-533.
Straub O.C. 2001. Advances in BHV1 (IBR) research. DTW. Deutsche tierarztliche Wochenschrift. 108: 419-422.
Strube W., Auer S., Block W., Heinen E., Kretzdorn D., Rodenbach C., Schmeer N. 1996. A gE deleted infectious bovine rhinotracheitis marker vaccine for use in improved bovine herpesvirus 1 control programs. Vet. Microbiol. 53: 181-189.
Thiry E., Muylkens B., Meurens F., Gogev S., Thiry J., Vanderplasschen A., Schynts F. 2006. Recombination in the alphaherpesvirus bovine herpesvirus 1. Vet. Microbiol. 113: 171-177.
Tignon M., De Baere M., Hanon J.-B., Goolaerts A., Houtain J.-Y., Delooz L., Cay A.B. 2017. Characterization of three commercial ELISA kits for detection of BOHV-1 gE specific antibodies in serum and milk samples and applicability of bulk milk for determination of herd status. J Virol Methods. 245: 66-72.
Trapp S., König P., Beer M. 2003. Conventional and marked BHV-1 vaccines in Germany: a brief review. Berl Munch Tierarztl Wochenschr. 116: 208-215.
Van Oirschot J.T., Kaashoek M.J., Rijsewijk F.A.M., Stegeman J.A. 1996. The use of marker vaccines in eradication of herpesviruses. J Biotechnol. 44: 75-81.
Vargas B D., Bohórquez G A., Parra A J., Jaime C J., Góngora O A. 2016. Serological evaluation of bovine herpesvirus 1 and 5 in cattle-breeding systems on Colombia's high plains. Rev. MVZ Córdoba. 21: 5381-5389.
Vera, V.; Ramírez, G.; Villamil, L. C.; De Sandino M.; Jaime, J. 2006. Biología Molecular, Epidemiologia y Control de IBR y de DVB. ISBN 958-701-708-8. Bogotá: Universidad Nacional de Colombia. 154p.
Vera, V.; Ramírez, G.; Barrera, J.; Villamil, L. C. 2000. Hablemos de Virología. Ed. Universidad Nacional de Colombia. Facultad de Medicina Veterinaria y Zootecnia. Bogotá.
Vicetti Miguel R.D., Sheridan B.S., Harvey S.A., Schreiner R.S., Hendricks R.L., Cherpes T.L. 2010. 17-beta estradiol promotion of herpes simplex virus type 1 reactivation is estrogen receptor dependent. J Virol. 84: 565-72.
Walz P.H., Givens M.D., Rodning S.P., Riddell K.P., Brodersen B.W., Scruggs D., Short T., Grotelueschen D. 2017. Evaluation of reproductive protection against bovine viral diarrhea virus and bovine herpesvirus-1 afforded by annual revaccination with modified-live viral or combination modified-live/killed viral vaccines after primary vaccination with modified-live viral vaccine. Vaccine. 35: 1046-1054.
Watters R.D., Wiltbank M.C., Guenther J.N., Brickner A.E., Rastani R.R., Fricke P.M., Grummer R.R. 2009. Effect of dry period length on reproduction during the subsequent lactation. J. Dairy Sci. 92: 3081-3090.
Yates W.D. 1982. A review of infectious bovine rhinotracheitis, shipping fever pneumonia and viral-bacterial synergism in respiratory disease of cattle. Can J Comp Med. 46: 225-263.
Zhu L., Yuan C., Zhang D., Ma Y., Ding X., Zhu G. 2016. BHV-1 induced oxidative stress contributes to mitochondrial dysfunction in MDBK cells. Vet. Res. 47: 1-6.
Zúñiga A., Ossa I., J.E Hincapie Nieto J.O. 1977. Prevalencia de rinotraqueitis infecciosa bovina en reproductores del Urabá antioqueño para 1977. Rev. Colomb Cienc Pecu. 1: 135148.
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spelling Góngora Orjuela, Agustín91971a3e6b0453b653040bf65920b520Vargas Bustos, Camilo Andrés7465894eac9534c661eafa91e7e68ba22024-04-16T20:48:18Z2024-04-16T20:48:18Z2018Vargas Bustos, Camilo A. (2018). Estado actual del conocimiento sobre la rinotraqueitis infecciosa bovina [Trabajo de grado, Universidad de los Llanos]. Repositorio digital Universidad de los Llanos.https://repositorio.unillanos.edu.co/handle/001/3340Universidad de los LlanosRepositorio digital Universidad de los Llanoshttps://repositorio.unillanos.edu.co/Incluye figuras y tablas.La Rinotraqueitis Infecciosa Bovina (IBR por su sigla en inglés) es una enfermedad de origen viral conocida clínicamente por el enrojecimiento de la nariz, el lagrimeo de los terneros, la vaginitis vesicular, el exantema coital; es una enfermedad altamente contagiosa que se manifiesta clínicamente de diferentes maneras dependiendo del serotipo implicado y del tejido infectado. La IBR es causada por el Herpesvirus bovino tipo 1 (HVB-1). Este virus es miembro del género Varicellovirus de la subfamilia Alphaherpesvirinae, que pertenece a la familia Herpesviridae. Siendo un herpesvirus tiene la capacidad de generar latencia en el animal infectado, convirtiéndolo en portador por toda la vida; haciéndolo susceptible a posteriores infecciones bacteriana y virales como ocurre en el complejo respiratorio bovino o “fiebre de embarque”. Es una enfermedad que se ha diseminado a nivel mundial, con reporte en el país desde el año 1972. En Colombia se han llevado a cabo diferentes estudios de seroprevalencia del HVB – 1 que varían entre 20 a 90%, lo que sugiere una presentación endémica de la enfermedad. Su importancia radica en los problemas reproductivos que provoca, entre ellos la repetición de servicios, orquitis, epididimitis, vaginitis, infección fetal, aborto, metritis postparto, anestro y algunos casos de mastitis que se ha asociado a la presencia del virus. Se cataloga como una de las afecciones que más pérdidas económicas genera en la ganadería mundial. Varios países de Europa han optado por el camino de la erradicación sin embargo son muy pocos los que han tenido éxito. La falta de técnicas diagnósticas eficientes y falencias en cuanto a la calidad y el uso de las vacunas han sido unos de los principales obstáculos a superar, además de los altos costos económicos que implica un programa de erradicación. Nuestro país no cuenta con medidas de control claras encaminadas a disminuir la alta seroprevalencia; siendo una de las principales tareas a lograr con el propósito de mitigar el impacto negativo en la ganadería colombiana. Estas estrategias deben abordarse integralmente involucrando a todas las partes implicadas en el proceso.Infectious Bovine Rhinotracheitis (IBR) is a disease of viral origin known clinically for nose reddening, tearing of calves, vesicular vaginitis, coital exanthema; it is a highly contagious disease that manifests clinically in different ways depending on the serotype involved and the infected tissue. IBR is caused by bovine Herpesvirus type 1 (BoHV – 1). This virus is a member of the genus Varicellovirus in the subfamily Alphaherpesvirinae, which belongs to the Herpesviridae family. Being a herpesvirus has the ability to generate latency in the infected animal, making it a carrier for life; making it susceptible to subsequent bacterial and viral infections such as occurs in the bovine respiratory complex or "boarding fever". It is a disease that has spread worldwide, with a report in the country since 1972. In Colombia, several BoHV-1 seroprevalence studies have been carried out, ranging from 20 to 90%, suggesting an endemic presentation of the disease. Its importance lies in the reproductive problems it causes, including the repetition of services, orchitis, epididymitis, vaginitis, fetal infection, abortion, postpartum metritis, anestrus and some cases of mastitis that has been associated with the presence of the virus. It is cataloged as one of the conditions that generates the most economic losses in the world cattle ranch. Several countries in Europe have chosen the path of eradication, but very few have succeeded. The lack of efficient diagnostic techniques and shortcomings in the quality and use of vaccines have been one of the main obstacles to overcome, in addition to the high economic costs involved in an eradication program. Our country does not have clear control measures aimed at reducing high seroprevalence; being one of the main tasks to achieve in order to mitigate the negative impact on Colombian livestock. These strategies must be comprehensively addressed by involving all parties involved in the process.Resumen. -- Abstract. -- Introducción. -- Justificación. -- Objetivos. -- Objetivo general. -- Objetivos específicos. -- Marco Teórico. -- Historia de la rinotraqueitis infecciosa bovina (IBR). -- Etiología. -- Clasificación. -- Epidemiologia. -- Latencia viral. -- Coinfecciones entre IBR y otros virus. -- Medidas de control de IBR y principales vacunas. -- Programa de erradicación de IBR. -- Historia y situación de la rinotraqueitis infecciosa bovina en Colombia. -- Conclusiones. -- Bibliografía.PregradoMedico(a) Veterinario(a) ZootecnistaMedicina Veterinaria y Zootecnia54 páginasapplication/pdfspaUniversidad de los LlanosFacultad de Ciencias Agropecuarias y Recursos NaturalesVillavicencioDerechos Reservados - Universidad de los Llanos, 2018https://creativecommons.org/licenses/by-nc/4.0/Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Estado actual del conocimiento sobre la rinotraqueitis infecciosa bovinaTrabajo de grado - Pregradoinfo:eu-repo/semantics/bachelorThesisinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_7a1fTexthttp://purl.org/coar/version/c_970fb48d4fbd8a85Ackermann M., Engels M. 2006. Pro and contra IBR-eradication. Vet. Microbiol. 113: 293-302.Arenas N.M., Moreno F.G. 2015. Rinotraquitis Infecciosa Bovina en Colombia. Referencias para Consultorio MV. 40: 8-11.Armengol R., Villalba D., Coma E., Porquet L., Jubert A., Nogareda C. 2017. Prevalence of individual and bulk tank milk antibodies of bovine herpesvirus type 1 and its relation to milk quality parameters on dairy farms in Catalonia (north-east Spain). Vet. Rec. Open. 4: e000203.Barkema H.W., Green M.J., Bradley A.J., Zadoks R.N. 2009. Invited review: The role of contagious disease in udder health. J. Dairy Sci. 92: 4717-4729.Beer M., König P., Schielke G., Trapp S. 2003. Marker diagnostic for the eradication of bovine herpesvirus type 1: Possibilities and limitations. Berl. Munch. Tierarztl. Wochenschr. 116: 183-91.Bertolotti L., Muratore E., Nogarol C., Caruso C., Lucchese L., Profiti M., Anfossi L., Masoero L., Nardelli S., Rosati S. 2015. Development and validation of an indirect ELISA as a confirmatory test for surveillance of infectious bovine rhinotracheitis in vaccinated herds. BMC Vet. Res. 11: 300.Betancur H C., González T M., Reza G. L. 2006. Seroepidemiología de la rinotraqueitis infecciosa bovina en el municipio de Montería, Colombia. Rev. MVZ Córdoba. 11: 830-836.Bielanski A., Algire J., Lalonde A., Garceac A. 2013. Prevention of bovine herpesvirus-1 transmission by the transfer of embryos disinfected with recombinant bovine trypsin. Theriogenology. 80: 1104-1108.Boelaert F., Speybroeck N., Kruif A.d., Aerts M., Burzykowski T., Molenberghs G., Berkvens D.L. 2005. Risk factors for bovine herpesvirus-1 seropositivity. Prev. Vet. Med. 69: 285-295.Brower A., Homb K.M., Bochsler P., Porter R., Woods K., Ubl S., Krueger D., Cigel F., TooheyKurth K. 2008. Encephalitis in aborted bovine fetuses associated with Bovine herpesvirus 1 infection. J Vet Diagn Invest. 20: 297-303.Camacho R., Carvajal L.Y., Castellanos-Dominguez Y.Z., Díaz W.F., Vásquez M.C. 2015. Presence of IgG antibodies against reproductive infections in breeding bulls of Magdalena Medio, Colombia. Rev Colomb Cienc Pecu. 28: 323-330.Campos F.S., Franco A.C., Hübner S.O., Oliveira M.T., Silva A.D., Esteves P.A., Roehe P.M., Rijsewijk F.A.M. 2009. High prevalence of co-infections with bovine herpesvirus 1 and 5 found in cattle in southern Brazil. Vet. Microbiol. 139: 67-73.Cedeño Quevedo D., Benavides B., Cárdenas G., Herrera C. 2011. Factores de riesgo asociados a la seroprevalencia de BHV-1 y DVB en hatos lecheros en Pasto, Colombia, en el 2011. Rev. Lasallista Investig. 8: 61-68.CIAT - Centro Internacional de Agricultura Tropical. 1972 - 1975. Informe anual de salud animal; Bogotá.Cordero Camacho C.P., Escobar Mármol L., Carrillo Borda E.F., Morantes Medina S.J., Aristizábal Gutiérrez F.A. 2011. Detection of seven viruses and Mycoplasma in fetal bovine serum by real time PCR. Rev Colomb Cienc Pecu. 24: 585-597.Crane C.S., Lukas G.N., Watkins W.W. 1964. Infectious Bovine Rhinotracheitis abortion in California beef cattle. J Am Vet Med Assoc. 144: 13-8.Cuddington B.P., Mossman K.L. 2015. Oncolytic bovine herpesvirus type 1 as a broad spectrum cancer therapeutic. Curr Opin Virol. 13: 11-16.Chaparro J., Ramírez G., Vera V., Góngora A., Villamil L. 2002. Aislamiento de una cepa de campo del virus de la Rinotraqueítis Infecciosa Bovina de una explotación de ganado de carne en el Departamento del Meta. Orinoquía. 6: 100-107.Chase C.C.L., Fulton R.W., O’Toole D., Gillette B., Daly R.F., Perry G., Clement T. 2017. Bovine herpesvirus 1 modified live virus vaccines for cattle reproduction: Balancing protection with undesired effects. Vet. Microbiol. 206: 69-77.Díaz F. 2000. Reactividad serológica y aspectos epidemiológicos para Rinotraqueítis Bovina Infecciosa (IBR) mediante la prueba de seroneutralización viral en toros reproductores de la región central del departamento del Valle del Cauca. [Tesis de Maestría]. Bogotá: Facultad de Medicina Veterinaria y de Zootecnia. Universidad Nacional de Colombia.Dias J.A., Alfieri A.A., Ferreira-Neto J.S., Gonçalves V.S.P., Muller E.E. 2013. Seroprevalence and Risk Factors of Bovine Herpesvirus 1 Infection in Cattle Herds in the State of Paraná, Brazil. Transbound Emerg Dis. 60: 39-47.Eaglesome M.D., Garcia M.M. 1997. Disease risks to animal health from artificial insemination with bovine semen. Rev sci Tech. 16: 215-25.Favier P.A., Marin M.S., Morán P.E., Odeón A.C., Verna A.E., Pérez S.E. 2014. Latency of bovine herpesvirus type 5 (BoHV-5) in tonsils and peripheral blood leukocytes. Vet. J. 202: 134-140.Forschner E., Bunger I., Kuttler D., Mehrkens L. 1986. IBR/IPV serodiagnosis with ELISA methods in blood, single milk and bulk milk samples; control measures for maintaining normal cattle herds; eradication measures with reference to vaccination. DTW. Deutsche tierarztliche Wochenschrift. 93: 328-35.Frizzo da Silva L. 2012. Bovine herpesvirus type 1 (BHV-1) regulates the innate immune system to promote productive infection and latency. ETD collection for University of Nebraska - Lincoln. AAI3503429.Fulton R.W., d'Offay J.M., Eberle R., Moeller R.B., Campen H.V., O'Toole D., Chase C., Miller M.M., Sprowls R., Nydam D.V. 2015. Bovine herpesvirus-1: evaluation of genetic diversity of subtypes derived from field strains of varied clinical syndromes and their relationship to vaccine strains. Vaccine. 33: 549-58.Fulton R.W., d’Offay J.M., Dubovi E.J., Eberle R. 2016. Bovine herpesvirus-1: Genetic diversity of field strains from cattle with respiratory disease, genital, fetal disease and systemic neonatal disease and their relationship to vaccine strains. Virus Res. 223: 115-121.Fulton R.W., d’Offay J.M., Eberle R. 2013. Bovine herpesvirus-1: Comparison and differentiation of vaccine and field strains based on genomic sequence variation. Vaccine. 31: 1471-1479.Geraghty T., O’Neill R., More S.J., O’Grady L. 2012. Dynamics of individual animal Bovine Herpes Virus-1 antibody status on 9 commercial dairy herds. Res Vet Sci. 93: 143-149.Góngora A., Villamil L.C., Vera V.J., Parra J.L., Ramírez G., López G. 1995a. Aislamiento de un herpes virus bovino tipo-1 (hvb-1) de secreción nasal y esmegma prepucial en un toro reproductor. Rev. Med. Vet. Zoot. 43: 43-60.Góngora A., Villamil L.C., Vera V.J., Ramírez G.C., Parra J.L. 1995b. Diagnóstico de las principales enfermedades reproductivas en toros de la sabana de Bogotá. Énfasis en rinotraqueitis infeccionesa bovina (RIB). Rev. Med. Vet. Zoot. 43: 37-42.González-García M.A., Maldonado J.L., Gómez-Pacheco J.M., Arenas-Casas A., CarboneroMartínez A., Borges-Rodríguez C., García Bocanegra I., Perea-Remujo J.A. 2009. Seroprevalence and risk factors associated with bovine herpesvirus type 1 (BHV1) infection in non-vaccinated cattle herds in Andalusia (South of Spain). Span. J. Agric. Res. 7: 550-554.Graham D.A. 2013. Bovine herpes virus-1 (BoHV-1) in cattle–a review with emphasis on reproductive impacts and the emergence of infection in Ireland and the United Kingdom. Ir Vet J. 66: 15.Hulyanych M., Nedosekov V., Sobko Y. 2016. Determination of Cultural Conditions of Infectious Bovine Rhinotracheitis Virus Strain “BM”. Ann Agrar Sci. 14: 201-204.Jones C., Chowdhury S. 2010. Bovine Herpesvirus Type 1 (BHV-1) is an Important Cofactor in the Bovine Respiratory Disease Complex. Vet Clin Food Anim. 26: 303-321.Kaashoek M.J., Van Engelenburg F.A.C., Moerman A., Gielkens A.L.J., Rijsewijk F.A.M., van Oirschot J.T. 1996. Virulence and immunogenicity in calves of thymidine kinase- and glycoprotein E-negative bovine herpesvirus 1 mutants. Vet. Microbiol. 48: 143-153.Kendrick J.W., McEntee K. 1967. The effect of artificial insemination with semen contaminated with IBR-IPV virus. Cornell Vet. 57: 3-11.Kennedy P.C., Richards W.P.C. 1964. The Pathology of Abortion Caused by the Virus of Infectious Bovine Rhinotracheitis. Vet Pathol. 1: 7-17.Kupferschmied H.U., Kihm U., Bachmann P., Müller K.H., Ackermann M. 1986. Transmission of IBR/IPV virus in bovine semen: A case report. Theriogenology. 25: 439-43.Kutish G., Mainprize T., Rock D. 1990. Characterization of the latency-related transcriptionally active region of the bovine herpesvirus 1 genome. J Virol. 64: 5730-7.Mahajan V., Banga H.S., Deka D., Filia G., Gupta A. 2013. Comparison of Diagnostic Tests for Diagnosis of Infectious Bovine Rhinotracheitis in Natural Cases of Bovine Abortion. J. Comp. Path. 149: 391-401.Marin M.S., Leunda M.R., Verna A.E., Morán P.E., Odeón A.C., Pérez S.E. 2016. Distribution of bovine herpesvirus type 1 in the nervous system of experimentally infected calves. Vet J. 209: 82-86.Meurens F., Schynts F., Keil G.M., Muylkens B., Vanderplasschen A., Gallego P., Thiry E. 2004. Superinfection prevents recombination of the alphaherpesvirus bovine herpesvirus 1. J. Virol. 78: 3872-3879.Miller N.J. 1955. Infectious necrotic rhinotracheitis of cattle. JAVMA. 126: 463-7.Molano D., Rodríguez J., Ramírez G., Villamil L. 1996. Caracterización electroforética e inmunológica de una cepa de campo del virus de la rinotraqueitis infecciosa bovina y su comparación con cepas de referencia. Rev. Med. Vet. Zoot. 44: 35-38.Molina V., Risalde M.A., Sánchez-Cordón P.J., Pedrera M., Romero-Palomo F., Luzzago C., Gómez-Villamandos J.C. 2013. Effect of infection with BHV-1 on peripheral blood leukocytes and lymphocyte subpopulations in calves with subclinical BVD. Res Vet Sci. 95: 115-122.Motta Giraldo J.L., Waltero García I., Abeledo M.A. 2013. Prevalencia de anticuerpos al virus de la diarrea viral bovina, Herpesvirus bovino 1 y Herpesvirus bovino 4 en bovinos y búfalos en el Departamento de Caquetá, Colombia. Rev. Salud Anim. 35: 174-181.Muratore E., Bertolotti L., Nogarol C., Caruso C., Lucchese L., Iotti B., Ariello D., Moresco A., Masoero L., Nardelli S., Rosati S. 2017. Surveillance of Infectious Bovine Rhinotracheitis in marker-vaccinated dairy herds: Application of a recombinant gE ELISA on bulk milk samples. Vet Immunol Immunopathol. 185: 1-6.Muylkens B., Meurens F., Schynts F., Farnir F., Pourchet A., Bardiau M., Gogev S., Thiry J., Cuisenaire A., Vanderplasschen A., Thiry E. 2006. Intraspecific bovine herpesvirus 1 recombinants carrying glycoprotein E deletion as a vaccine marker are virulent in cattle. J Gen Virol. 87: 2149-2154.Muylkens B., Thiry J., Kirten P., Schynts F., Thiry E. 2007. Bovine herpesvirus 1 infection and infectious bovine rhinotracheitis. Vet. Res. 38: 181-209.Nandi S., Kumar M., Manohar M., Chauhan R.S. 2009. Bovine herpes virus infections in cattle. Anim. Health Res Rev. 10: 85-98.Narita M., Kimura K., Tanimura N., Arai S., Tsuboi T., Katsuda K. 2000. Immunohistochemical Characterization of Calf Pneumonia Produced by the Combined Endobronchial Administration of Bovine Herpesvirus 1 and Pasteurella haemolytica. J. Comp. Path. 123: 126-134.Newcomer B.W., Givens D. 2016. Diagnosis and Control of Viral Diseases of Reproductive Importance: Infectious Bovine Rhinotracheitis and Bovine Viral Diarrhea. Vet Clin Food Anim. 32: 425-441.Nuotio L., Neuvonen E., Hyytiäinen M. 2007. Epidemiology and eradication of infectious bovine rhinotracheitis/infectious pustular vulvovaginitis (IBR/IPV) virus in Finland. Acta Vet Scand. 49: 3.Ochoa X., Orbegozo M., Manrique-Abril F., Pulido M M., Ospina J. 2012. Seroprevalencia de rinotraqueitis infecciosa bovina en hatos lecheros de Toca - Boyacá. Rev. MVZ Córdoba. 17: 2974-2982.Oliveira M.T., Campos F.S., Dias M.M., Velho F.A., Freneau G.E., Brito W.M.E.D., Rijsewijk F.A.M., Franco A.C., Roehe P.M. 2011. Detection of bovine herpesvirus 1 and 5 in semen from Brazilian bulls. Theriogenology. 75: 1139-1145.Parsonson I.M., Snowdon W.A. 1975. The effect of natural and artificial breeding using bulls infected with, or semen contaminated with, infectious bovine rhinotracheitis virus. Austral Vet J. 51: 365-9.Patel J.R. 2005. Characteristics of live bovine herpesvirus-1 vaccines. Vet J. 169: 404-416.Peña Joya M.A., Góngora A., Jiménez C. 2011. Infectious agents affecting fertility of bulls, and transmission risk through semen: Retrospective analysis of their sanitary status in Colombia. Rev Colomb Cienc Pecu. 24: 623-633.Piedrahita D., Ramirez G., Vera V. 2005. Detección y caracterización por metodos moleculares de aislamientos colombianos de herpesvirus bovino tipo 1. Rev. Med. Vet. Zoot. 52: 120-127.Piedrahita L.E., Montoya L.M., Pedraza F.J. 2010. Herpes Virus Bovino tipo 1 (BoHV-1) como posible causa de encefalitis en bovinos de la región del Magdalena Medio Colombiano: Estudio serológico y análisis epidemiológico. Rev Colomb Cienc Pecu. 23: 191-198.Quinn, P.J.; Markey, B.K.; Carter, M.E.; Donnelly, W.J.C.; Leonard, F.C. 2005. Microbiología y Enfermedades Infecciosas Veterinarias. Acribia, S.A. España. Pag. 387-400.Raaperi K., Nurmoja I., Orro T., Viltrop A. 2010. Seroepidemiology of bovine herpesvirus 1 (BHV1) infection among Estonian dairy herds and risk factors for the spread within herds. Prev Vet Med. 96: 74-81.Raaperi K., Orro T., Viltrop A. 2014. Epidemiology and control of bovine herpesvirus 1 infection in Europe. Vet J. 201: 249-256.Raaperi K., Orro T., Viltrop A. 2015. Effect of vaccination against bovine herpesvirus 1 with inactivated gE-negative marker vaccines on the health of dairy cattle herds. Prev Vet Med. 118: 467-476.Ramírez Vásquez N.F., Villar Argaiz D., Fernández Silva J.A., Londoño Pino J., Chaparro Gutiérrez J.J., Olivera Ángel M.E. 2016. Seroprevalence and risk factors of several bovine viral diseases in dairy farms of San Pedro de los Milagros, Antioquia, Colombia. Rev CES Med Zootec. 11: 15-25.Reber A., Reist M., Schwermer H. 2012. Cost-effectiveness of bulk-tank milk testing for surveys to demonstrate freedom from infectious bovine rhinotracheitis and bovine enzootic leucosis in Switzerland. Schweiz Arch Tierheilkd. 154: 189-97.Rissi D.R., Pierezan F., Silva M.S.e., Flores E.F., de Barros C.S.L. 2008. Neurological Disease in Cattle in Southern Brazil Associated with Bovine Herpesvirus Infection. J Vet Diagn Invest. 20: 346-349.Rock D., Lokensgard J., Lewis T., Kutish G. 1992. Characterization of dexamethasoneinduced reactivation of latent bovine herpesvirus 1. J Virol. 66: 2484-90.Ruiz, A. 1977. Complejo Rinotraqueitis infecciosa bovina, Vulvovaginitis postular infecciosa. Enfermedades de los Bovinos. Dirección general de ganadería sub programa de Sanidad Animal. Santo Domingo. República Dominicana.Ruiz-Saenz J., Jaime J., Ramirez G., Vera V. 2012. Molecular and in vitro characterization of field isolates of bovine herpesvirus-1. Virol. Sin. 27: 26-37.Ruiz-Saenz J., Jaime J., Vera V. 2009. Vacunas contra el herpesvirus bovino-1: Una mirada desde el pasado hacia el futuro de la inmunización. Acta biol. Colomb. 14: 3-20.Ruiz-Sáenz J., Jaime J., Vera V. 2013. An inactivated vaccine from a field strain of bovine herpesvirus-1 (BoHV-1) has high antigenic mass and induces strong efficacy in a rabbit model. Virol. Sin. 28: 36-42.Ruiz-Saenz J., Jaime J., Víctor J., Vera V. 2010. Prevalencia serológica y aislamiento del Herpesvirus Bovino-1 (BHV-1) en hatos ganaderos de Antioquia y del Valle del Cauca. Rev Colomb Cienc Pecu. 23: 299-307.Ruiz J., Jaime J., Vera V. 2008. Latencia Del Herpesvirus Bovino-1: El Papel De Los Transcritos Relacionados Con Latencia (Rl). Acta biol. Colomb. 13: 3-22.Ruiz Sáenz J., Osorio J.E., Vera V.J. 2012. Desarrollo De Un Poxvirus Recombinante Que Expresa La Glicoproteína D Del Herpesvirus Bovino-1. Acta biol. Colomb. 17: 14.Saravanajayam M., Kumanan K., Balasubramaniam A. 2015. Seroepidemiology of infectious bovine rhinotracheitis infection in unvaccinated cattle. Vet World. 8: 1416-1419.Schroeder R.J., Moys M.D. 1954. An acute upper respiratory infection of dairy cattle. JAVMA. 125: 471-2.Segura-Correa J.C., Zapata-Campos C.C., Jasso-Obregón J.O., Martinez-Burnes J., LópezZavala R. 2016. Seroprevalence and risk factors associated with bovine herpesvirus 1 and bovine viral diarrhea virus in North-Eastern Mexico. Open Vet. J. 6: 143-149.Silva M.S., Brum M.C.S., Loreto E.L.S., Weiblen R., Flores E.F. 2007. Molecular and antigenic characterization of Brazilian bovine herpesvirus type 1 isolates recovered from the brain of cattle with neurological disease. Virus Res. 129: 191-199.Straub O.C. 1975. Infectious bovine rhinotracheitis virus. History and recent developments. Developments in biological standardization. 28: 530-533.Straub O.C. 2001. Advances in BHV1 (IBR) research. DTW. Deutsche tierarztliche Wochenschrift. 108: 419-422.Strube W., Auer S., Block W., Heinen E., Kretzdorn D., Rodenbach C., Schmeer N. 1996. A gE deleted infectious bovine rhinotracheitis marker vaccine for use in improved bovine herpesvirus 1 control programs. Vet. Microbiol. 53: 181-189.Thiry E., Muylkens B., Meurens F., Gogev S., Thiry J., Vanderplasschen A., Schynts F. 2006. Recombination in the alphaherpesvirus bovine herpesvirus 1. Vet. Microbiol. 113: 171-177.Tignon M., De Baere M., Hanon J.-B., Goolaerts A., Houtain J.-Y., Delooz L., Cay A.B. 2017. Characterization of three commercial ELISA kits for detection of BOHV-1 gE specific antibodies in serum and milk samples and applicability of bulk milk for determination of herd status. J Virol Methods. 245: 66-72.Trapp S., König P., Beer M. 2003. Conventional and marked BHV-1 vaccines in Germany: a brief review. Berl Munch Tierarztl Wochenschr. 116: 208-215.Van Oirschot J.T., Kaashoek M.J., Rijsewijk F.A.M., Stegeman J.A. 1996. The use of marker vaccines in eradication of herpesviruses. J Biotechnol. 44: 75-81.Vargas B D., Bohórquez G A., Parra A J., Jaime C J., Góngora O A. 2016. Serological evaluation of bovine herpesvirus 1 and 5 in cattle-breeding systems on Colombia's high plains. Rev. MVZ Córdoba. 21: 5381-5389.Vera, V.; Ramírez, G.; Villamil, L. C.; De Sandino M.; Jaime, J. 2006. Biología Molecular, Epidemiologia y Control de IBR y de DVB. ISBN 958-701-708-8. Bogotá: Universidad Nacional de Colombia. 154p.Vera, V.; Ramírez, G.; Barrera, J.; Villamil, L. C. 2000. Hablemos de Virología. Ed. Universidad Nacional de Colombia. Facultad de Medicina Veterinaria y Zootecnia. Bogotá.Vicetti Miguel R.D., Sheridan B.S., Harvey S.A., Schreiner R.S., Hendricks R.L., Cherpes T.L. 2010. 17-beta estradiol promotion of herpes simplex virus type 1 reactivation is estrogen receptor dependent. J Virol. 84: 565-72.Walz P.H., Givens M.D., Rodning S.P., Riddell K.P., Brodersen B.W., Scruggs D., Short T., Grotelueschen D. 2017. Evaluation of reproductive protection against bovine viral diarrhea virus and bovine herpesvirus-1 afforded by annual revaccination with modified-live viral or combination modified-live/killed viral vaccines after primary vaccination with modified-live viral vaccine. Vaccine. 35: 1046-1054.Watters R.D., Wiltbank M.C., Guenther J.N., Brickner A.E., Rastani R.R., Fricke P.M., Grummer R.R. 2009. Effect of dry period length on reproduction during the subsequent lactation. J. Dairy Sci. 92: 3081-3090.Yates W.D. 1982. A review of infectious bovine rhinotracheitis, shipping fever pneumonia and viral-bacterial synergism in respiratory disease of cattle. Can J Comp Med. 46: 225-263.Zhu L., Yuan C., Zhang D., Ma Y., Ding X., Zhu G. 2016. BHV-1 induced oxidative stress contributes to mitochondrial dysfunction in MDBK cells. Vet. Res. 47: 1-6.Zúñiga A., Ossa I., J.E Hincapie Nieto J.O. 1977. Prevalencia de rinotraqueitis infecciosa bovina en reproductores del Urabá antioqueño para 1977. Rev. 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