Ferritina como predictor de morbimortalidad en pacientes hipertensos hospitalizados con COVID severo comparada con valores de Dímero D: Una revisión sistemática

ilustraciones, gráficos, tablas

Autores:
Castaño Ospina, Juan Camilo
Tipo de recurso:
Trabajo de grado de pregrado
Fecha de publicación:
2024
Institución:
Unidad Central del Valle del Cauca
Repositorio:
Repositorio Institucional - Unidad Central del Valle del Cauca
Idioma:
spa
OAI Identifier:
oai:repositorio.uceva.edu.co:20.500.12993/4471
Acceso en línea:
http://hdl.handle.net/20.500.12993/4471
Palabra clave:
COVID-19
Ferritina
Productos de degradación de fibrina-fibrinógeno
Pronóstico
Revisión sistemática (DeCS)
COVID-19
Ferritin
Fibrinogen-fibrin degradation products
Prognosis
Systematic review (DeCS)
Rights
openAccess
License
Derechos reservados - Unidad Central del Valle del Cauca
id Uceva2_f767163da0daeea972a26704894c5110
oai_identifier_str oai:repositorio.uceva.edu.co:20.500.12993/4471
network_acronym_str Uceva2
network_name_str Repositorio Institucional - Unidad Central del Valle del Cauca
repository_id_str
dc.title.spa.fl_str_mv Ferritina como predictor de morbimortalidad en pacientes hipertensos hospitalizados con COVID severo comparada con valores de Dímero D: Una revisión sistemática
dc.title.titleenglish.spa.fl_str_mv Ferritin as a predictor of morbidity and mortality in hospitalized hypertensive patients with severe COVID compared to D-dimer levels: A systematic review
title Ferritina como predictor de morbimortalidad en pacientes hipertensos hospitalizados con COVID severo comparada con valores de Dímero D: Una revisión sistemática
spellingShingle Ferritina como predictor de morbimortalidad en pacientes hipertensos hospitalizados con COVID severo comparada con valores de Dímero D: Una revisión sistemática
COVID-19
Ferritina
Productos de degradación de fibrina-fibrinógeno
Pronóstico
Revisión sistemática (DeCS)
COVID-19
Ferritin
Fibrinogen-fibrin degradation products
Prognosis
Systematic review (DeCS)
title_short Ferritina como predictor de morbimortalidad en pacientes hipertensos hospitalizados con COVID severo comparada con valores de Dímero D: Una revisión sistemática
title_full Ferritina como predictor de morbimortalidad en pacientes hipertensos hospitalizados con COVID severo comparada con valores de Dímero D: Una revisión sistemática
title_fullStr Ferritina como predictor de morbimortalidad en pacientes hipertensos hospitalizados con COVID severo comparada con valores de Dímero D: Una revisión sistemática
title_full_unstemmed Ferritina como predictor de morbimortalidad en pacientes hipertensos hospitalizados con COVID severo comparada con valores de Dímero D: Una revisión sistemática
title_sort Ferritina como predictor de morbimortalidad en pacientes hipertensos hospitalizados con COVID severo comparada con valores de Dímero D: Una revisión sistemática
dc.creator.fl_str_mv Castaño Ospina, Juan Camilo
dc.contributor.advisor.none.fl_str_mv Giraldo Ospina, Beatriz
López Muñóz, Diego Fernando
dc.contributor.author.none.fl_str_mv Castaño Ospina, Juan Camilo
dc.contributor.orcid.spa.fl_str_mv https://orcid.org/0000-0001-8015-3223
dc.contributor.orcid.none.fl_str_mv https://orcid.org/0009-0001-3130-2613
https://orcid.org/0000-0001-6156-1619
dc.subject.proposal.spa.fl_str_mv COVID-19
Ferritina
Productos de degradación de fibrina-fibrinógeno
Pronóstico
Revisión sistemática (DeCS)
topic COVID-19
Ferritina
Productos de degradación de fibrina-fibrinógeno
Pronóstico
Revisión sistemática (DeCS)
COVID-19
Ferritin
Fibrinogen-fibrin degradation products
Prognosis
Systematic review (DeCS)
dc.subject.keywords.spa.fl_str_mv COVID-19
Ferritin
Fibrinogen-fibrin degradation products
Prognosis
Systematic review (DeCS)
description ilustraciones, gráficos, tablas
publishDate 2024
dc.date.accessioned.none.fl_str_mv 2024-06-26T13:43:21Z
dc.date.available.none.fl_str_mv 2024-06-26T13:43:21Z
dc.date.issued.none.fl_str_mv 2024
dc.type.spa.fl_str_mv bachelor thesis
dc.type.local.spa.fl_str_mv Tesis/Trabajo de grado - Monografía - Pregrado
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_7a1f
dc.type.content.spa.fl_str_mv Text
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/bachelorThesis
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
format http://purl.org/coar/resource_type/c_7a1f
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12993/4471
dc.identifier.instname.spa.fl_str_mv Instname:Unidad Central del Valle del Cauca
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional Unidad Central del Valle del Cauca
dc.identifier.repourl.none.fl_str_mv repourl:https://repositorio.uceva.edu.co/
url http://hdl.handle.net/20.500.12993/4471
identifier_str_mv Instname:Unidad Central del Valle del Cauca
reponame:Repositorio Institucional Unidad Central del Valle del Cauca
repourl:https://repositorio.uceva.edu.co/
dc.language.iso.spa.fl_str_mv spa
language spa
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spelling Giraldo Ospina, BeatrizLópez Muñóz, Diego FernandoCastaño Ospina, Juan Camilohttps://orcid.org/0000-0001-8015-3223https://orcid.org/0009-0001-3130-2613https://orcid.org/0000-0001-6156-1619Tulua, Valle del Cauca, ColombiaTuluá2024-06-26T13:43:21Z2024-06-26T13:43:21Z2024http://hdl.handle.net/20.500.12993/4471Instname:Unidad Central del Valle del Caucareponame:Repositorio Institucional Unidad Central del Valle del Caucarepourl:https://repositorio.uceva.edu.co/ilustraciones, gráficos, tablasIntroducción: La infección por COVID-19 presentó una severidad variable, siendo especialmente grave en pacientes hipertensos debido a los mecanismos asociados al receptor ACE2. La ferritina y el dímero D, biomarcadores inflamatorios, se relacionaron con la gravedad de la enfermedad y variaron significativamente en pacientes hipertensos con COVID-19 severo. El objetivo de este estudio fue evaluar la ferritina como predictor de morbimortalidad en pacientes hipertensos con COVID-19 severo, comparándola con el dímero D. Método: Se realizó una revisión sistemática siguiendo los lineamientos de la estrategia PRISMA (2020). La búsqueda de literatura se llevó a cabo en las bases de datos PubMed (MedLine), Scopus, Science Direct y Web of Science, incluyendo estudios observacionales de población adulta hipertensa hospitalizada por COVID-19 severo que evaluaron la ferritina y el dímero D como predictores de morbimortalidad entre 2019 y 2023. Los hallazgos se describieron cualitativamente, utilizando la lista de verificación PRISMA (2020) y apoyándose en la plataforma Rayyan AI para la selección de estudios. Resultados: Se obtuvo información detallada sobre la utilidad de la ferritina como predictor de morbimortalidad en comparación con el dímero D. Los datos de los estudios seleccionados incluyeron edad, niveles de ferritina y dímero D. La búsqueda inicial arrojó 4586 resultados, de los cuales se seleccionaron 27 estudios para análisis cuantitativo. El análisis reveló que los pacientes adultos hipertensos hospitalizados por COVID-19 severo presentaron incrementos significativos en los niveles de ferritina y dímero D, indicando su relevancia como biomarcadores. Conclusiones: Esta revisión sistemática proporcionó información crucial sobre el valor pronóstico de la ferritina en pacientes hipertensos con COVID-19 severo. Los resultados sugieren que la ferritina podría ser un biomarcador útil para mejorar el manejo clínico de estos pacientes, complementando la información proporcionada por el dímero D. Palabras clave: COVID-19, ferritina, Productos de Degradación de Fibrina-Fibrinógeno, pronóstico, revisión sistemática. (DeCS)Resumen / Abstract / 1. Planteamiento del problema / 1.1 Justificación / 2. Objetivos / 3. Marco teórico / 4. Métodos / 4.1 Bases de datos y criterios de búsqueda / 4.2 Proceso de selección de estudios / 4.3 Evaluación de la calidad y riesgo de sesgo / 4.4 Extracción y análisis de datos / 4.5 Síntesis y comparación de resultados / 5. Resultados / 5.1 Análisis de datos / 5.2 Resultados clave / 5.3 Implicaciones clínicas / 6. Discusión / 6.1 Hipertensión arterial y mortalidad por COVID-19 / 6.2 Ferritina como predictor de mortalidad / 6.3 Dímero D como Predictor de Mortalidad / 6.4 Comparación entre Ferritina y Dímero D / 6.5 Limitaciones de la revisión / 6.6 Implicaciones clínicas y futuras investigaciones / 7. Conclusiones / 7.1 Recomendaciones para futuros estudiosMedicoPregradoIntroduction: COVID-19 infection exhibited variable severity, being particularly severe in hypertensive patients due to mechanisms associated with the ACE2 receptor. Ferritin and D- dimer, inflammatory biomarkers, were related to disease severity and varied significantly in hypertensive patients with severe COVID-19. This study aimed to evaluate ferritin as a predictor of morbidity and mortality in hypertensive patients with severe COVID-19, comparing it with D-dimer. Method: A systematic review was conducted following the PRISMA (2020) guidelines. The literature search was performed in the databases PubMed (MedLine), Scopus, Science Direct, and Web of Science, including observational studies of adult hypertensive populations hospitalized with severe COVID-19 that evaluated ferritin and D-dimer as predictors of morbidity and mortality between 2019 and 2023. The findings were described qualitatively, using the PRISMA (2020) checklist and supported by the Rayyan AI platform for study selection. Results: Detailed information was obtained on the utility of ferritin as a predictor of morbidity and mortality compared to D-dimer. Data from the selected studies included age, ferritin levels, and D-dimer levels. The initial search yielded 4586 results, from which 27 studies were selected for quantitative analysis. The analysis revealed that adult hypertensive patients hospitalized with severe COVID-19 showed significant increases in ferritin and D- dimer levels, indicating their relevance as biomarkers. Conclusions: This systematic review provided crucial information on the prognostic value of ferritin in hypertensive patients with severe COVID-19. The results suggest that ferritin could be a useful biomarker for improving the clinical management of these patients, complementing the information provided by D-dimer. Keywords: COVID-19, ferritin, Fibrinogen-Fibrin Degradation Products, prognosis, systematic review. (DeCS)PDF25 páginasapplication/pdfspaDerechos reservados - Unidad Central del Valle del Caucahttp://creativecommons.org/licenses/by-nc-nd/4.0Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)info:eu-repo/semantics/openAccessAbierto (Texto Completo)http://purl.org/coar/access_right/c_abf2Ferritina como predictor de morbimortalidad en pacientes hipertensos hospitalizados con COVID severo comparada con valores de Dímero D: Una revisión sistemáticaFerritin as a predictor of morbidity and mortality in hospitalized hypertensive patients with severe COVID compared to D-dimer levels: A systematic reviewbachelor thesisTesis/Trabajo de grado - Monografía - Pregradohttp://purl.org/coar/resource_type/c_7a1fTextinfo:eu-repo/semantics/bachelorThesisinfo:eu-repo/semantics/acceptedVersionMedicinaFacultad de Ciencias de la SaludCOVID-19FerritinaProductos de degradación de fibrina-fibrinógenoPronósticoRevisión sistemática (DeCS)COVID-19FerritinFibrinogen-fibrin degradation productsPrognosisSystematic review (DeCS)Akyüz, A., Işık, F., Aslan, B., Çap, M., Kaya, İ., Atlı, Ö., İnci, Ü., Taştan, E., Aktan, A., Bilge, Ö., Okşul, M., Aydın, E., Karahan, Z., Altıntaş, D. 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