COVID-19: Impact in endothelial function and therapy with Mesenchymal Stromal Cells

The new pandemic of SARS-CoV-2 Betacoronavirus, has spread worldwide, and infected millions of individuals causing the disease denominated of COVID-19. Further on flu symptoms, due to the high tropism of virus, has most been observed in the COVID-19 pathophysiology: acute heart failure, thromboembol...

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Autores:
Longo de Freitas, Carla
Okochi Alves da silva, Priscilla Yuri
Pinho Franco, Maria do Carmo
de Almeida, Danilo Candido
Tipo de recurso:
Fecha de publicación:
2021
Institución:
Unidad Central del Valle del Cauca
Repositorio:
Repositorio Institucional - Unidad Central del Valle del Cauca
Idioma:
spa
OAI Identifier:
oai:repositorio.uceva.edu.co:20.500.12993/2312
Acceso en línea:
http://revistas.uceva.edu.co/index.php/magnascientia/article/view/2
https://doi.org/10.54502/msuceva.v1n1a2
Palabra clave:
COVID-19 pathophysiology
Endothelial disfunction
Immune cells
Mesenchymal Stromal Cells
Pathogenesis
Rights
openAccess
License
Derechos de autor 2021 Magna Scientia UCEVA
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network_acronym_str Uceva2
network_name_str Repositorio Institucional - Unidad Central del Valle del Cauca
repository_id_str
spelling Longo de Freitas, CarlaOkochi Alves da silva, Priscilla YuriPinho Franco, Maria do Carmode Almeida, Danilo Candido2021-12-01http://revistas.uceva.edu.co/index.php/magnascientia/article/view/210.54502/msuceva.v1n1a2https://doi.org/10.54502/msuceva.v1n1a2The new pandemic of SARS-CoV-2 Betacoronavirus, has spread worldwide, and infected millions of individuals causing the disease denominated of COVID-19. Further on flu symptoms, due to the high tropism of virus, has most been observed in the COVID-19 pathophysiology: acute heart failure, thromboembolism events, acute renal failure, neurological and liver damage, and multiple organ failure, with special attention to endothelial disfunction. Hence, elucidate whether virus target the endothelium is a crucial step to understand COVID-19 pathogenesis. However, the permissiveness of blood vessels during SARS-CoV-2 infection remains unclear, but regardless endothelial infection, the vascular disfunction may occurred in response to molecular inflammatory signaling triggered by immune cells that attempt to limit infection. Thus, alternative therapies using mesenchymal stromal cells (MSCs) can change this scenario and help critically ill patients. In this reflection, we attempt to discuss COVID-19 pathophysiology with impact in endothelial function and explore the applicability of MSC-based therapies as alternative treatment.  PDFapplication/pdfspaUnidad Central del Valle del CaucaUnidad Central del Valle del Cauca Revista Magna ScientiaMagna Scientia UCEVA; Vol. 1 Núm. 1 (2021); 6-10http://revistas.uceva.edu.co/index.php/magnascientia/article/view/2/1https://doi.org/10.54502/msuceva.v1n1a2Magna ScientiaDerechos de autor 2021 Magna Scientia UCEVAhttps://creativecommons.org/licenses/by-nc-nd/4.0/http://creativecommons.org/licenses/by-nc-nd/4.0deed.esAtribución-NoComercial-SinDerivadas 4.0 Internacionalinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf22805-67012805-6884COVID-19: Impact in endothelial function and therapy with Mesenchymal Stromal CellsArtículo de RevisiónTextinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1COVID-19 pathophysiologyEndothelial disfunctionImmune cellsMesenchymal Stromal CellsPathogenesisTHUMBNAILCovid19.jpgCovid19.jpgIM Thumbnailimage/jpeg164496https://repositorio.uceva.edu.co/bitstream/20.500.12993/2312/1/Covid19.jpg55e88c43f307b9a49803371943c6d96cMD51open access20.500.12993/2312oai:repositorio.uceva.edu.co:20.500.12993/23122023-11-16 16:52:07.314metadata only accessRepositorio Institucional Unidad Central del Valle del Caucabiblioteca@uceva.edu.co
dc.title.none.fl_str_mv COVID-19: Impact in endothelial function and therapy with Mesenchymal Stromal Cells
title COVID-19: Impact in endothelial function and therapy with Mesenchymal Stromal Cells
spellingShingle COVID-19: Impact in endothelial function and therapy with Mesenchymal Stromal Cells
COVID-19 pathophysiology
Endothelial disfunction
Immune cells
Mesenchymal Stromal Cells
Pathogenesis
title_short COVID-19: Impact in endothelial function and therapy with Mesenchymal Stromal Cells
title_full COVID-19: Impact in endothelial function and therapy with Mesenchymal Stromal Cells
title_fullStr COVID-19: Impact in endothelial function and therapy with Mesenchymal Stromal Cells
title_full_unstemmed COVID-19: Impact in endothelial function and therapy with Mesenchymal Stromal Cells
title_sort COVID-19: Impact in endothelial function and therapy with Mesenchymal Stromal Cells
dc.creator.fl_str_mv Longo de Freitas, Carla
Okochi Alves da silva, Priscilla Yuri
Pinho Franco, Maria do Carmo
de Almeida, Danilo Candido
dc.contributor.author.none.fl_str_mv Longo de Freitas, Carla
Okochi Alves da silva, Priscilla Yuri
Pinho Franco, Maria do Carmo
de Almeida, Danilo Candido
dc.subject.proposal.none.fl_str_mv COVID-19 pathophysiology
Endothelial disfunction
Immune cells
Mesenchymal Stromal Cells
Pathogenesis
topic COVID-19 pathophysiology
Endothelial disfunction
Immune cells
Mesenchymal Stromal Cells
Pathogenesis
description The new pandemic of SARS-CoV-2 Betacoronavirus, has spread worldwide, and infected millions of individuals causing the disease denominated of COVID-19. Further on flu symptoms, due to the high tropism of virus, has most been observed in the COVID-19 pathophysiology: acute heart failure, thromboembolism events, acute renal failure, neurological and liver damage, and multiple organ failure, with special attention to endothelial disfunction. Hence, elucidate whether virus target the endothelium is a crucial step to understand COVID-19 pathogenesis. However, the permissiveness of blood vessels during SARS-CoV-2 infection remains unclear, but regardless endothelial infection, the vascular disfunction may occurred in response to molecular inflammatory signaling triggered by immune cells that attempt to limit infection. Thus, alternative therapies using mesenchymal stromal cells (MSCs) can change this scenario and help critically ill patients. In this reflection, we attempt to discuss COVID-19 pathophysiology with impact in endothelial function and explore the applicability of MSC-based therapies as alternative treatment.  
publishDate 2021
dc.date.issued.none.fl_str_mv 2021-12-01
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.local.none.fl_str_mv Artículo de Revisión
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10.54502/msuceva.v1n1a2
dc.identifier.uri.none.fl_str_mv https://doi.org/10.54502/msuceva.v1n1a2
url http://revistas.uceva.edu.co/index.php/magnascientia/article/view/2
https://doi.org/10.54502/msuceva.v1n1a2
identifier_str_mv 10.54502/msuceva.v1n1a2
dc.language.iso.none.fl_str_mv spa
language spa
dc.relation.ispartof.none.fl_str_mv Unidad Central del Valle del Cauca Revista Magna Scientia
dc.relation.ispartofseries.none.fl_str_mv Magna Scientia UCEVA; Vol. 1 Núm. 1 (2021); 6-10
dc.relation.uri.none.fl_str_mv http://revistas.uceva.edu.co/index.php/magnascientia/article/view/2/1
https://doi.org/10.54502/msuceva.v1n1a2
dc.relation.ispartofjournal.none.fl_str_mv Magna Scientia
dc.rights.none.fl_str_mv Derechos de autor 2021 Magna Scientia UCEVA
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.uri.*.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0deed.es
dc.rights.license.*.fl_str_mv Atribución-NoComercial-SinDerivadas 4.0 Internacional
dc.rights.accessrights.none.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv Derechos de autor 2021 Magna Scientia UCEVA
https://creativecommons.org/licenses/by-nc-nd/4.0/
http://creativecommons.org/licenses/by-nc-nd/4.0deed.es
Atribución-NoComercial-SinDerivadas 4.0 Internacional
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv PDF
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Unidad Central del Valle del Cauca
publisher.none.fl_str_mv Unidad Central del Valle del Cauca
dc.source.none.fl_str_mv 2805-6701
2805-6884
institution Unidad Central del Valle del Cauca
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repository.name.fl_str_mv Repositorio Institucional Unidad Central del Valle del Cauca
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