Células somáticas y mejoramiento genético en bovinos: Una revisión de literatura

El recuento de células somáticas es un indicativo de infecciones en la ubre y la cantidad en la leche se utiliza para evaluar su sanidad. Además, también es un factor que es heredable, existiendo toros que transmiten altos o bajos niveles de células somáticas en la leche. Este valor no ha sido tenid...

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Autores:
Llano Sánchez, María Camila
Velásquez Buendía, Catalina
Tipo de recurso:
Trabajo de grado de pregrado
Fecha de publicación:
2022
Institución:
Universidad Tecnológica de Pereira
Repositorio:
Repositorio Institucional UTP
Idioma:
spa
OAI Identifier:
oai:repositorio.utp.edu.co:11059/14106
Acceso en línea:
https://hdl.handle.net/11059/14106
https://repositorio.utp.edu.co/home
Palabra clave:
010 - Bibliografía::016 - Bibliografías y catálogos de obras sobre temas específicos
Ganado bovino
Ganado de leche
Mastitis - Bovine
Leche
Mastitis
Producción lechera
Rights
openAccess
License
Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
id UTP2_3bc4eccced00be2c530a75b9254b72cd
oai_identifier_str oai:repositorio.utp.edu.co:11059/14106
network_acronym_str UTP2
network_name_str Repositorio Institucional UTP
repository_id_str
dc.title.spa.fl_str_mv Células somáticas y mejoramiento genético en bovinos: Una revisión de literatura
title Células somáticas y mejoramiento genético en bovinos: Una revisión de literatura
spellingShingle Células somáticas y mejoramiento genético en bovinos: Una revisión de literatura
010 - Bibliografía::016 - Bibliografías y catálogos de obras sobre temas específicos
Ganado bovino
Ganado de leche
Mastitis - Bovine
Leche
Mastitis
Producción lechera
title_short Células somáticas y mejoramiento genético en bovinos: Una revisión de literatura
title_full Células somáticas y mejoramiento genético en bovinos: Una revisión de literatura
title_fullStr Células somáticas y mejoramiento genético en bovinos: Una revisión de literatura
title_full_unstemmed Células somáticas y mejoramiento genético en bovinos: Una revisión de literatura
title_sort Células somáticas y mejoramiento genético en bovinos: Una revisión de literatura
dc.creator.fl_str_mv Llano Sánchez, María Camila
Velásquez Buendía, Catalina
dc.contributor.advisor.none.fl_str_mv Echeverry López, Juan Carlos
dc.contributor.author.none.fl_str_mv Llano Sánchez, María Camila
Velásquez Buendía, Catalina
dc.subject.ddc.none.fl_str_mv 010 - Bibliografía::016 - Bibliografías y catálogos de obras sobre temas específicos
topic 010 - Bibliografía::016 - Bibliografías y catálogos de obras sobre temas específicos
Ganado bovino
Ganado de leche
Mastitis - Bovine
Leche
Mastitis
Producción lechera
dc.subject.agrovocuri.none.fl_str_mv Ganado bovino
Ganado de leche
Mastitis - Bovine
dc.subject.proposal.spa.fl_str_mv Leche
Mastitis
Producción lechera
description El recuento de células somáticas es un indicativo de infecciones en la ubre y la cantidad en la leche se utiliza para evaluar su sanidad. Además, también es un factor que es heredable, existiendo toros que transmiten altos o bajos niveles de células somáticas en la leche. Este valor no ha sido tenido en cuenta por los ganaderos para la selección de los toros en programas de mejoramiento, seleccionando principalmente por cantidad de leche. Un elevado conteo de células somáticas afecta valores como la grasa y la proteína de la leche. Además, se acorta la vida útil del animal debido a problemas en la salud de la ubre. El uso de razas especializadas comparadas con razas criollas, ha mostrado que no hay diferencia en el número de células somáticas. Existen también factores externos que incrementan las células somáticas en la leche como ordeños ineficientes, estrés calórico y edad del animal. Se recomienda que los ganaderos enfoquen también la selección del semen a utilizar en el hato con base en el conteo de células somáticas y así se obtendrá mejor precio por litro de leche además de bajar costos por disminución de la tasa de reposición.
publishDate 2022
dc.date.accessioned.none.fl_str_mv 2022-05-16T20:02:45Z
dc.date.available.none.fl_str_mv 2022-05-16T20:02:45Z
dc.date.issued.none.fl_str_mv 2022
dc.type.none.fl_str_mv Trabajo de grado - Pregrado
dc.type.version.none.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_7a1f
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dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/11059/14106
dc.identifier.instname.none.fl_str_mv Universidad Tecnológica de Pereira
dc.identifier.reponame.none.fl_str_mv Repositorio institucional Universidad Tecnológica de Pereira
dc.identifier.repourl.none.fl_str_mv https://repositorio.utp.edu.co/home
url https://hdl.handle.net/11059/14106
https://repositorio.utp.edu.co/home
identifier_str_mv Universidad Tecnológica de Pereira
Repositorio institucional Universidad Tecnológica de Pereira
dc.language.iso.none.fl_str_mv spa
language spa
dc.relation.references.none.fl_str_mv Weigel KA, Shook GE. Genetic Selection for Mastitis Resistance. Vet Clin North Am - Food Anim Pract [Internet]. 2018;34(3):457–72. Available from: https://doi.org/10.1016/j.cvfa.2018.07.001
Miglior F, Fleming A, Malchiodi F, Brito LF, Martin P, Baes CF. A 100- Year Review: Identification and genetic selection of economically important traits in dairy cattle. J Dairy Sci [Internet]. 2017;100(12):10251– 71. Available from: http://dx.doi.org/10.3168/jds.2017-12968
Pérez-Méndez JA, Roibás D, Wall A. Somatic cell counts, reproduction indicators, and technical efficiency in milk production: A stochastic frontier analysis for Spanish dairy farms. J Dairy Sci. 2020;103(8):7141–54.
Martin P, Barkema HW, Brito LF, Narayana SG, Miglior F. Symposium review: Novel strategies to genetically improve mastitis resistance in dairy cattle. J Dairy Sci [Internet]. 2017;101(3):2724–36. Available from: http://dx.doi.org/10.3168/jds.2017-13554
Miles AM, Huson HJ. Time- and population-dependent genetic patterns underlie bovine milk somatic cell count. J Dairy Sci [Internet]. 2020;103(9):8292–304. Available from: http://dx.doi.org/10.3168/jds.2020- 18322
Bobbo T, Fiore E, Gianesella M, Morgante M, Gallo L, Ruegg PL, et al. Variation in blood serum proteins and association with somatic cell count in dairy cattle from multi-breed herds. Animal [Internet]. 2017;11(12):2309–19. Available from: http://dx.doi.org/10.1017/S1751731117001227
Sartori C, Guzzo N, Mantovani R. Genetic correlations of fighting ability with somatic cells and longevity in cattle. Animal [Internet]. 2020;14(1):13–21. Available from: http://dx.doi.org/10.1017/S175173111900168X
Capoferri R, Cremonesi P, Castiglioni B, Pisoni G, Roccabianca P, Riva F, et al. Comparison of the response of mammary gland tissue from two divergent lines of goat with high and low milk somatic cell scores to an experimental Staphylococcus aureus infection. Vet Immunol Immunopathol [Internet]. 2021;234(February):110208. Available from: https://doi.org/10.1016/j.vetimm.2021.110208
Albenzio M, Figliola L, Caroprese M, Marino R, Sevi A, Santillo A. Somatic cell count in sheep milk. Small Rumin Res [Internet]. 2019;176(March):24–30. Available from: https://doi.org/10.1016/j.smallrumres.2019.05.013
Ahlawat S, Arora R, Sharma U, Sharma A, Girdhar Y, Sharma R, et al. Comparative gene expression profiling of milk somatic cells of Sahiwal cattle and Murrah buffaloes. Gene [Internet]. 2021;764(March 2020):145101. Available from: https://doi.org/10.1016/j.gene.2020.145101
Wei C, Luo HP, Wang YC, Huang XX, Zhang MH, Zhang XX, et al. Analyses of the genetic relationships between lactose, somatic cell score, and growth traits in Simmental cattle. Animal. 2021;15(1).
Santana ML, Bignardi AB, Pereira RJ, Stefani G, El Faro L. Genetics of heat tolerance for milk yield and quality in Holsteins. Animal [Internet]. 2017;11(1):4–14. Available from: http://dx.doi.org/10.1017/S1751731116001725
Sehested J, Gaillard C, Lehmann JO, Maciel GM, Vestergaard M, Weisbjerg MR, et al. Review: extended lactation in dairy cattle. Animal [Internet]. 2019;13(S1):A65–74. Available from: http://dx.doi.org/10.1017/S1751731119000806
Kargo M, Clasen JB, Nielsen HM, Byskov K, Norberg E. Short communication: Heterosis and breed effects for milk production and udder health traits in crosses between Danish Holstein, Danish Red, and Danish Jersey. J Dairy Sci [Internet]. 2021;104(1):678–82. Available from: http://dx.doi.org/10.3168/jds.2019-17866
Szyda J, Mielczarek M, Fraȩszczak M, Minozzi G, Williams JL, Wojdak Maksymiec K. The genetic background of clinical mastitis in Holstein Friesian cattle. Animal. 2019;13(10):2156–63
Brito LF, Bedere N, Douhard F, Oliveira HR, Arnal M, Peñagaricano F, et al. Review: Genetic selection of high-yielding dairy cattle toward sustainable farming systems in a rapidly changing world. Animal [Internet]. 2021;100292. Available from: https://doi.org/10.1016/j.animal.2021.100292
Bieber A, Wallenbeck A, Spengler Neff A, Leiber F, Simantke C, Knierim U, et al. Comparison of performance and fitness traits in German Angler, Swedish Red and Swedish Polled with Holstein dairy cattle breeds under organic production. Animal [Internet]. 2020;14(3):609–16. Available from: http://dx.doi.org/10.1017/S1751731119001964
Nasralla NN, Gomah NH, Aly MM, Abdel-Aleem JA, Hammam ARA, Osman DM, et al. Compositional characteristics of dairy products and their potential nondairy applications after shelf-life. Curr Res Food Sci [Internet]. 2022;5:150–6. Available from: https://doi.org/10.1016/j.crfs.2021.12.017
Lindsay D, Robertson R, Fraser R, Engstrom S, Jordan K. Heat induced inactivation of microorganisms in milk and dairy products. Int Dairy J [Internet]. 2021;121:105096. Available from: https://doi.org/10.1016/j.idairyj.2021.105096
Sar T, Harirchi S, Ramezani M, Bulkan G, Akbas MY, Pandey A, et al. Potential utilization of dairy industries by-products and wastes through microbial processes: A critical review. Sci Total Environ. 2022;810:152253.
Adamczyk K, Jagusiak W, Węglarz A. Associations between the breeding values of Holstein-Friesian bulls and longevity and culling reasons of their daughters. Animal. 2021;15(5).
Guinn JM, Nolan DT, Krawczel PD, Petersson-Wolfe CS, Pighetti GM, Stone AE, et al. Comparing dairy farm milk yield and components, somatic cell score, and reproductive performance among United States regions using summer to winter ratios. J Dairy Sci [Internet]. 2019;102(12):11777–85. Available from: http://dx.doi.org/10.3168/jds.2018-16170
Mandal A, Baneh H, Koloi S, Bhakat C. Estimation of variance components and genetic parameters for lactation persistency indices in crossbred cattle using Bayesian and REML methods. Meta Gene [Internet]. 2020;26(August):100780. Available from: https://doi.org/10.1016/j.mgene.2020.100780
Gupta JP, Bhushan B, Asaf VNM, Kumar A, Ranjan S, Panigrahi M, et al. Association and expression analysis of single nucleotide polymorphisms of CD14 gene with somatic cell score in crossbred cattle. Gene Reports [Internet]. 2018;12(March):255–60. Available from: https://doi.org/10.1016/j.genrep.2018.07.011
Beaupied BL, Martinez H, Martenies S, McConnel CS, Pollack IB, Giardina D, et al. Cows as canaries: The effects of ambient air pollution exposure on milk production and somatic cell count in dairy cows. Environ Res [Internet]. 2021;(September):112197. Available from: https://doi.org/10.1016/j.envres.2021.112197
Soumri N, Carabaño MJ, González-Recio O, Bedhiaf-Romdhani S. Genetic parameters of somatic cell scores using random regression test day models with Legendre polynomials in Tunisian dairy cattle. Livest Sci [Internet]. 2020;241(July):104178. Available from: https://doi.org/10.1016/j.livsci.2020.104178
Cecchinato A, Macciotta NPP, Mele M, Tagliapietra F, Schiavon S, Bittante G, et al. Genetic and genomic analyses of latent variables related to the milk fatty acid profile, milk composition, and udder health in dairy cattle. J Dairy Sci [Internet]. 2019;102(6):5254–65. Available from: http://dx.doi.org/10.3168/jds.2018-15867
Moncur VS, Hardie LC, Dechow CD. Genetic analysis of daily milk yield variability in Holstein dairy cattle in an experimental herd. Livest Sci [Internet]. 2021;244:104397. Available from: https://doi.org/10.1016/j.livsci.2021.104397
Meyerholz MM, Rohmeier L, Eickhoff T, Hülsebusch A, Jander S, Linden M, et al. Genetic selection for bovine chromosome 18 haplotypes associated with divergent somatic cell score affects postpartum reproductive and metabolic performance. J Dairy Sci [Internet]. 2019;102(11):9983–94. Available from: http://dx.doi.org/10.3168/jds.2018- 16171
Piwczyński D, Sitkowska B, Ptak E. Genetic relationship among somatic cell score and some milking traits in Holstein-Friesian primiparous cows milked by an automated milking system. Animal. 2021;15(2).
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spelling Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)Manifiesto (Manifestamos) en este documento la voluntad de autorizar a la Biblioteca Jorge Roa Martínez de la Universidad Tecnológica de Pereira la publicación en el Repositorio institucional (http://biblioteca.utp.edu.co), la versión electrónica de la OBRA titulada: ________________________________________________________________________________________________ ________________________________________________________________________________________________ ________________________________________________________________________________________________ La Universidad Tecnológica de Pereira, entidad académica sin ánimo de lucro, queda por lo tanto facultada para ejercer plenamente la autorización anteriormente descrita en su actividad ordinaria de investigación, docencia y publicación. La autorización otorgada se ajusta a lo que establece la Ley 23 de 1982. Con todo, en mi (nuestra) condición de autor (es) me (nos) reservo (reservamos) los derechos morales de la OBRA antes citada con arreglo al artículo 30 dehttps://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessEcheverry López, Juan CarlosLlano Sánchez, María CamilaVelásquez Buendía, Catalina2022-05-16T20:02:45Z2022-05-16T20:02:45Z2022https://hdl.handle.net/11059/14106Universidad Tecnológica de PereiraRepositorio institucional Universidad Tecnológica de Pereirahttps://repositorio.utp.edu.co/homeEl recuento de células somáticas es un indicativo de infecciones en la ubre y la cantidad en la leche se utiliza para evaluar su sanidad. Además, también es un factor que es heredable, existiendo toros que transmiten altos o bajos niveles de células somáticas en la leche. Este valor no ha sido tenido en cuenta por los ganaderos para la selección de los toros en programas de mejoramiento, seleccionando principalmente por cantidad de leche. Un elevado conteo de células somáticas afecta valores como la grasa y la proteína de la leche. Además, se acorta la vida útil del animal debido a problemas en la salud de la ubre. El uso de razas especializadas comparadas con razas criollas, ha mostrado que no hay diferencia en el número de células somáticas. Existen también factores externos que incrementan las células somáticas en la leche como ordeños ineficientes, estrés calórico y edad del animal. Se recomienda que los ganaderos enfoquen también la selección del semen a utilizar en el hato con base en el conteo de células somáticas y así se obtendrá mejor precio por litro de leche además de bajar costos por disminución de la tasa de reposición.The somatic cell count is an indication of udder infections and the amount in the milk is used to assess udder health. In addition, it is also a factor that is heritable, with bulls that transmit high or low levels of somatic cells in milk. This value has not been taken into account by farmers for the selection of bulls in improvement programs, selecting mainly for the amount of milk. A high somatic cell count affects values such as milk fat and protein. In addition, the lifespan of the animal is shortened due to problems in the health of the udder. The use of specialized breeds compared to landraces has shown that there is no difference in the number of somatic cells. There are also external factors that increase somatic cells in milk such as inefficient milking, heat stress and age of the animal. It is recommended that farmers also focus on the selection of semen to be used in the herd based on the somatic cell count and thus obtain a better price per liter of milk in addition to lower costs due to a decrease in the replacement rate.PregradoMédico(a) Veterinario(a) y Zootecnista11 Páginasapplication/pdfspaUniversidad Tecnológica de PereiraMedicina Veterinaria y ZootecniaFacultad de Ciencias de la SaludPereira010 - Bibliografía::016 - Bibliografías y catálogos de obras sobre temas específicosGanado bovinoGanado de lecheMastitis - BovineLecheMastitisProducción lecheraCélulas somáticas y mejoramiento genético en bovinos: Una revisión de literaturaTrabajo de grado - Pregradoinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_7a1fTextinfo:eu-repo/semantics/bachelorThesisWeigel KA, Shook GE. Genetic Selection for Mastitis Resistance. Vet Clin North Am - Food Anim Pract [Internet]. 2018;34(3):457–72. Available from: https://doi.org/10.1016/j.cvfa.2018.07.001Miglior F, Fleming A, Malchiodi F, Brito LF, Martin P, Baes CF. A 100- Year Review: Identification and genetic selection of economically important traits in dairy cattle. J Dairy Sci [Internet]. 2017;100(12):10251– 71. Available from: http://dx.doi.org/10.3168/jds.2017-12968Pérez-Méndez JA, Roibás D, Wall A. Somatic cell counts, reproduction indicators, and technical efficiency in milk production: A stochastic frontier analysis for Spanish dairy farms. J Dairy Sci. 2020;103(8):7141–54.Martin P, Barkema HW, Brito LF, Narayana SG, Miglior F. Symposium review: Novel strategies to genetically improve mastitis resistance in dairy cattle. J Dairy Sci [Internet]. 2017;101(3):2724–36. Available from: http://dx.doi.org/10.3168/jds.2017-13554Miles AM, Huson HJ. Time- and population-dependent genetic patterns underlie bovine milk somatic cell count. J Dairy Sci [Internet]. 2020;103(9):8292–304. Available from: http://dx.doi.org/10.3168/jds.2020- 18322Bobbo T, Fiore E, Gianesella M, Morgante M, Gallo L, Ruegg PL, et al. Variation in blood serum proteins and association with somatic cell count in dairy cattle from multi-breed herds. Animal [Internet]. 2017;11(12):2309–19. Available from: http://dx.doi.org/10.1017/S1751731117001227Sartori C, Guzzo N, Mantovani R. Genetic correlations of fighting ability with somatic cells and longevity in cattle. Animal [Internet]. 2020;14(1):13–21. Available from: http://dx.doi.org/10.1017/S175173111900168XCapoferri R, Cremonesi P, Castiglioni B, Pisoni G, Roccabianca P, Riva F, et al. Comparison of the response of mammary gland tissue from two divergent lines of goat with high and low milk somatic cell scores to an experimental Staphylococcus aureus infection. Vet Immunol Immunopathol [Internet]. 2021;234(February):110208. Available from: https://doi.org/10.1016/j.vetimm.2021.110208Albenzio M, Figliola L, Caroprese M, Marino R, Sevi A, Santillo A. Somatic cell count in sheep milk. Small Rumin Res [Internet]. 2019;176(March):24–30. Available from: https://doi.org/10.1016/j.smallrumres.2019.05.013Ahlawat S, Arora R, Sharma U, Sharma A, Girdhar Y, Sharma R, et al. Comparative gene expression profiling of milk somatic cells of Sahiwal cattle and Murrah buffaloes. Gene [Internet]. 2021;764(March 2020):145101. Available from: https://doi.org/10.1016/j.gene.2020.145101Wei C, Luo HP, Wang YC, Huang XX, Zhang MH, Zhang XX, et al. Analyses of the genetic relationships between lactose, somatic cell score, and growth traits in Simmental cattle. Animal. 2021;15(1).Santana ML, Bignardi AB, Pereira RJ, Stefani G, El Faro L. Genetics of heat tolerance for milk yield and quality in Holsteins. Animal [Internet]. 2017;11(1):4–14. Available from: http://dx.doi.org/10.1017/S1751731116001725Sehested J, Gaillard C, Lehmann JO, Maciel GM, Vestergaard M, Weisbjerg MR, et al. Review: extended lactation in dairy cattle. Animal [Internet]. 2019;13(S1):A65–74. Available from: http://dx.doi.org/10.1017/S1751731119000806Kargo M, Clasen JB, Nielsen HM, Byskov K, Norberg E. Short communication: Heterosis and breed effects for milk production and udder health traits in crosses between Danish Holstein, Danish Red, and Danish Jersey. J Dairy Sci [Internet]. 2021;104(1):678–82. Available from: http://dx.doi.org/10.3168/jds.2019-17866Szyda J, Mielczarek M, Fraȩszczak M, Minozzi G, Williams JL, Wojdak Maksymiec K. The genetic background of clinical mastitis in Holstein Friesian cattle. Animal. 2019;13(10):2156–63Brito LF, Bedere N, Douhard F, Oliveira HR, Arnal M, Peñagaricano F, et al. Review: Genetic selection of high-yielding dairy cattle toward sustainable farming systems in a rapidly changing world. Animal [Internet]. 2021;100292. Available from: https://doi.org/10.1016/j.animal.2021.100292Bieber A, Wallenbeck A, Spengler Neff A, Leiber F, Simantke C, Knierim U, et al. Comparison of performance and fitness traits in German Angler, Swedish Red and Swedish Polled with Holstein dairy cattle breeds under organic production. Animal [Internet]. 2020;14(3):609–16. Available from: http://dx.doi.org/10.1017/S1751731119001964Nasralla NN, Gomah NH, Aly MM, Abdel-Aleem JA, Hammam ARA, Osman DM, et al. Compositional characteristics of dairy products and their potential nondairy applications after shelf-life. Curr Res Food Sci [Internet]. 2022;5:150–6. Available from: https://doi.org/10.1016/j.crfs.2021.12.017Lindsay D, Robertson R, Fraser R, Engstrom S, Jordan K. Heat induced inactivation of microorganisms in milk and dairy products. Int Dairy J [Internet]. 2021;121:105096. Available from: https://doi.org/10.1016/j.idairyj.2021.105096Sar T, Harirchi S, Ramezani M, Bulkan G, Akbas MY, Pandey A, et al. Potential utilization of dairy industries by-products and wastes through microbial processes: A critical review. Sci Total Environ. 2022;810:152253.Adamczyk K, Jagusiak W, Węglarz A. Associations between the breeding values of Holstein-Friesian bulls and longevity and culling reasons of their daughters. Animal. 2021;15(5).Guinn JM, Nolan DT, Krawczel PD, Petersson-Wolfe CS, Pighetti GM, Stone AE, et al. Comparing dairy farm milk yield and components, somatic cell score, and reproductive performance among United States regions using summer to winter ratios. J Dairy Sci [Internet]. 2019;102(12):11777–85. Available from: http://dx.doi.org/10.3168/jds.2018-16170Mandal A, Baneh H, Koloi S, Bhakat C. Estimation of variance components and genetic parameters for lactation persistency indices in crossbred cattle using Bayesian and REML methods. 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Animal. 2021;15(2).PublicationORIGINALTRABAJO DE GRADO.pdfTRABAJO DE GRADO.pdfapplication/pdf82193https://dspace7-utp.metabuscador.org/bitstreams/6ea0b4d4-156f-473b-93aa-c23c72073fae/download65978d66fff6e6e08536f29d6ffc5363MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-814828https://dspace7-utp.metabuscador.org/bitstreams/87930280-aebf-426b-b5c6-bd64ca3ec365/download2f9959eaf5b71fae44bbf9ec84150c7aMD52TEXTTRABAJO DE GRADO.pdf.txtTRABAJO DE GRADO.pdf.txtExtracted texttext/plain24027https://dspace7-utp.metabuscador.org/bitstreams/f31c6065-bb9d-48da-b79c-2a24df78ed00/downloadfbbb26e2934f859742ec610a458a70a2MD53THUMBNAILTRABAJO DE GRADO.pdf.jpgTRABAJO DE GRADO.pdf.jpgGenerated Thumbnailimage/jpeg13712https://dspace7-utp.metabuscador.org/bitstreams/94aea07d-8558-406a-b77c-def547391160/download3af51891b2aca2ff299dc5c22c0489e6MD5411059/14106oai:dspace7-utp.metabuscador.org:11059/141062024-09-05 17:05:56.969https://creativecommons.org/licenses/by-nc-nd/4.0/Manifiesto (Manifestamos) en este documento la voluntad de autorizar a la Biblioteca Jorge Roa Martínez de la Universidad Tecnológica de Pereira la publicación en el Repositorio institucional (http://biblioteca.utp.edu.co), la versión electrónica de la OBRA titulada: ________________________________________________________________________________________________ ________________________________________________________________________________________________ ________________________________________________________________________________________________ La Universidad Tecnológica de Pereira, entidad académica sin ánimo de lucro, queda por lo tanto facultada para ejercer plenamente la autorización anteriormente descrita en su actividad ordinaria de investigación, docencia y publicación. La autorización otorgada se ajusta a lo que establece la Ley 23 de 1982. Con todo, en mi (nuestra) condición de autor (es) me (nos) reservo (reservamos) los derechos morales de la OBRA antes citada con arreglo al artículo 30 deopen.accesshttps://dspace7-utp.metabuscador.orgRepositorio de la Universidad Tecnológica de 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