Anatomical Pathology of the Umbilical Cord and Its Maternal and Fetal Clinical Associations in 434 Newborns

Introduction: Umbilical cord (UC) abnormalities and their clinical relations in 434 newborns were analyzed. We had previously reported on clinical associations of long and short UCs with any kind of malformation. This study focuses on other UC features (insertion, vessels, entanglements, coiling, and knots) and their associations with clinical characteristics and neonatal prognosis. Methods: An observational analytic study was performed on placentas from consecutive deliveries. Ordered logistic regression with bivariate and multivariate analysis was performed to evaluate the relationship between variables of interest concerning UC abnormalities. Results: A total of 434 placentas made up the study. UC abnormalities were abnormal insertion, 82 (18.86%); coiling (hypo and hypercoiled), 177 (40.78%); single umbilical artery (SUA), 4 (0.92%); entanglements, 8 (1.84%); true knots, 3 (0.69%); webs in UC base, 9 (2.07%); and right twist, 68 (15.67%). After analyzing maternal and fetal complications during pregnancy, multivariate analysis confirmed the recognized association between malformations and SUA and male gender; further confirmation was also made between hypertensive disorders of pregnancy and true knots. Discussion: UC abnormalities associated with undesirable outcomes are varied and should be recognized and described. Clinical factors associated with anatomical UC abnormalities are not completely understood and justify forthcoming studies. © 2018, Society for Pediatric Pathology All rights reserved.

• Fecha de publicación: 2018
• Institución: Universidad Tecnológica de Bolívar
• Repositorio: Repositorio Institucional UTB
• Idioma: eng
• OAI Identifier: oai:repositorio.utb.edu.co:20.500.12585/8870
• Acceso en línea: https://hdl.handle.net/20.500.12585/8870
• Palabra clave: Coiling index; Cord accident; Placenta; Single umbilical artery; Stillbirth; Umbilical cord; Ubiquitin; Antemortem skin biopsy; Archicortex; Article; Aspiration pneumonia; Autopsy; Brain ventricle dilatation; Bronchiolitis; Case report; Caudate nucleus; Cause of death; Cell loss; Central nervous system; Cerebellum atrophy; Child; Clarke column; Clinical article; Convulsion; Copy number variation; Corpus striatum; Cortical gliosis; Degenerative disease; Dentate nucleus; Developmental disorder; Dyskinesia; Electron microscopy; Female; Fever; Gray matter; Hereditary motor sensory neuropathy; Histology; Hospital admission; Human; Human cell; Human tissue; Microarray analysis; Muscle atrophy; Muscle biopsy; Neocortex; Nuronal intranuclear inclusion disease; Nuclear magnetic resonance imaging; Pathogenesis; Pathology; Preschool child; Priority journal; Purkinje cell; Recurrent disease; Seizure; Skin biopsy; Substantia nigra; Walking difficulty; Adolescent; Adult; Male; Newborn; Pathology; Placenta; Pregnancy; Stillbirth; Umbilical cord; Young Adult; Adolescent; Adult; Female; Humans; Infant, Newborn; Male; Placenta; Pregnancy; Stillbirth; Umbilical Cord; Young Adult
• Rights: restrictedAccess
• License: http://creativecommons.org/licenses/by-nc-nd/4.0/