Two Case Reports of Neuropsychological Functioning in Congenital Insensitivity to Pain with Anhidrosis (CIPA)
Individuals with congenital insensitivity to pain with anhidrosis (CIPA) are reported to have intellectual disability but to our knowledge, no detailed study about neuropsychological functioning of this condition has ever been published. The present study assessed neuropsychological outcomes of two...
- Autores:
-
Santoya-Montes, Yanin
Gutiérrez-Ruíz, Karol
Zequeira Cotes, Rodrigo
Puentes Rozo, Pedro
- Tipo de recurso:
- Fecha de publicación:
- 2020
- Institución:
- Universidad Tecnológica de Bolívar
- Repositorio:
- Repositorio Institucional UTB
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.utb.edu.co:20.500.12585/9567
- Acceso en línea:
- https://hdl.handle.net/20.500.12585/9567
https://www.tandfonline.com/doi/abs/10.1080/87565641.2020.1825719
- Palabra clave:
- Neuropsychology
CIPA
Neuropsychological tests
Congenital Insensitivity to Pain with Anhidrosis (CIPA)
- Rights
- closedAccess
- License
- http://purl.org/coar/access_right/c_14cb
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Two Case Reports of Neuropsychological Functioning in Congenital Insensitivity to Pain with Anhidrosis (CIPA) |
| title |
Two Case Reports of Neuropsychological Functioning in Congenital Insensitivity to Pain with Anhidrosis (CIPA) |
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Two Case Reports of Neuropsychological Functioning in Congenital Insensitivity to Pain with Anhidrosis (CIPA) Neuropsychology CIPA Neuropsychological tests Congenital Insensitivity to Pain with Anhidrosis (CIPA) |
| title_short |
Two Case Reports of Neuropsychological Functioning in Congenital Insensitivity to Pain with Anhidrosis (CIPA) |
| title_full |
Two Case Reports of Neuropsychological Functioning in Congenital Insensitivity to Pain with Anhidrosis (CIPA) |
| title_fullStr |
Two Case Reports of Neuropsychological Functioning in Congenital Insensitivity to Pain with Anhidrosis (CIPA) |
| title_full_unstemmed |
Two Case Reports of Neuropsychological Functioning in Congenital Insensitivity to Pain with Anhidrosis (CIPA) |
| title_sort |
Two Case Reports of Neuropsychological Functioning in Congenital Insensitivity to Pain with Anhidrosis (CIPA) |
| dc.creator.fl_str_mv |
Santoya-Montes, Yanin Gutiérrez-Ruíz, Karol Zequeira Cotes, Rodrigo Puentes Rozo, Pedro |
| dc.contributor.author.none.fl_str_mv |
Santoya-Montes, Yanin Gutiérrez-Ruíz, Karol Zequeira Cotes, Rodrigo Puentes Rozo, Pedro |
| dc.subject.keywords.spa.fl_str_mv |
Neuropsychology CIPA Neuropsychological tests Congenital Insensitivity to Pain with Anhidrosis (CIPA) |
| topic |
Neuropsychology CIPA Neuropsychological tests Congenital Insensitivity to Pain with Anhidrosis (CIPA) |
| description |
Individuals with congenital insensitivity to pain with anhidrosis (CIPA) are reported to have intellectual disability but to our knowledge, no detailed study about neuropsychological functioning of this condition has ever been published. The present study assessed neuropsychological outcomes of two children with CIPA using standardized neuropsychological tests. The neuropsychological assessment revealed difficulties in a wide range of cognitive, executive, and integrative functions, such as a behavioral and adaptive level. Both children with CIPA functioned in the intellectual disability range with symptoms related to an executive dysfunction and negative-oriented personal emotional processing, and limitations in academic and self-care skills. |
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2020 |
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2020-11-06T12:35:08Z |
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2020-11-06T12:35:08Z |
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2020-09-27 |
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2020-11-05 |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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Yanin Santoya-Montes, Karol Gutiérrez-Ruiz, Rodrigo Zequeira Cotes & Pedro Puentes Rozo (2020) Two Case Reports of Neuropsychological Functioning in Congenital Insensitivity to Pain with Anhidrosis (CIPA), Developmental Neuropsychology, 45:6, 414-430, DOI: 10.1080/87565641.2020.1825719 |
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https://hdl.handle.net/20.500.12585/9567 |
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https://www.tandfonline.com/doi/abs/10.1080/87565641.2020.1825719 |
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10.1080/87565641.2020.1825719 |
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Universidad Tecnológica de Bolívar |
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Repositorio Universidad Tecnológica de Bolívar |
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Yanin Santoya-Montes, Karol Gutiérrez-Ruiz, Rodrigo Zequeira Cotes & Pedro Puentes Rozo (2020) Two Case Reports of Neuropsychological Functioning in Congenital Insensitivity to Pain with Anhidrosis (CIPA), Developmental Neuropsychology, 45:6, 414-430, DOI: 10.1080/87565641.2020.1825719 10.1080/87565641.2020.1825719 Universidad Tecnológica de Bolívar Repositorio Universidad Tecnológica de Bolívar |
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https://hdl.handle.net/20.500.12585/9567 https://www.tandfonline.com/doi/abs/10.1080/87565641.2020.1825719 |
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eng |
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16 páginas |
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Santoya-Montes, Yanin6975de80-529e-4596-b137-c840566a8fa6Gutiérrez-Ruíz, Karol2f673086-6084-498c-9a66-9a8d2c02e7d1Zequeira Cotes, Rodrigo6615d18b-db73-4036-a231-644e760e77aePuentes Rozo, Pedroe2cdf7fe-56b7-4718-a0f3-d23948fff79e2020-11-06T12:35:08Z2020-11-06T12:35:08Z2020-09-272020-11-05Yanin Santoya-Montes, Karol Gutiérrez-Ruiz, Rodrigo Zequeira Cotes & Pedro Puentes Rozo (2020) Two Case Reports of Neuropsychological Functioning in Congenital Insensitivity to Pain with Anhidrosis (CIPA), Developmental Neuropsychology, 45:6, 414-430, DOI: 10.1080/87565641.2020.1825719https://hdl.handle.net/20.500.12585/9567https://www.tandfonline.com/doi/abs/10.1080/87565641.2020.182571910.1080/87565641.2020.1825719Universidad Tecnológica de BolívarRepositorio Universidad Tecnológica de BolívarIndividuals with congenital insensitivity to pain with anhidrosis (CIPA) are reported to have intellectual disability but to our knowledge, no detailed study about neuropsychological functioning of this condition has ever been published. The present study assessed neuropsychological outcomes of two children with CIPA using standardized neuropsychological tests. The neuropsychological assessment revealed difficulties in a wide range of cognitive, executive, and integrative functions, such as a behavioral and adaptive level. Both children with CIPA functioned in the intellectual disability range with symptoms related to an executive dysfunction and negative-oriented personal emotional processing, and limitations in academic and self-care skills.16 páginasapplication/pdfengJournal Developmental Neuropsychology Volume 45, 2020 - Issue 6Two Case Reports of Neuropsychological Functioning in Congenital Insensitivity to Pain with Anhidrosis (CIPA)info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85NeuropsychologyCIPANeuropsychological testsCongenital Insensitivity to Pain with Anhidrosis (CIPA)info:eu-repo/semantics/closedAccesshttp://purl.org/coar/access_right/c_14cbCartagena de IndiasPúblico generalAlbuja, B. , Alvear, M. , & Ordoñez, C. (2014). Congenital insensitivity to pain with anhidrosis. Clinical diagnosis, evolution and complications. Case report. Archivos Argentinos de Pediatría , 112(5), e200–e205. doi:dx.doi.10.5546/aap.2014.e200 [PubMed], [Web of Science ®]Altassan, R. , Saud, H. , Masoodi, T. , Dosssari, H. , Khalifa, O. , Al-Zaidan, H. , … Wakil, S. (2017). Exome sequencing identifies novel NTRK1 mutations in patients with HSAN-IV phenotype. American Journal of Medical Genetics Part A , 173(4), 1009–1016. doi:10.1002/ajmg.a.38120Alvarán, L. , Sánchez, D. , & Restrepo-Ochoa, D. A. (2016). Neuropsicología de la inteligencia limítrofe. Cuadernos de Neuropsicología , 10(2), 129–141. doi:10.7714/CNPS/10.2.207American Educational Research Association, American Psychological Association, and the National Council on Measurement in Education . (2014). Standards for educational and psychological testing . Washington, DC: AERA.Arango-Lasprilla, J. C. (2020). Spanish-speaking pediatric neuropsychology: Recent research and new frontiers. Developmental Neuropsychology , 45(4), 1–2. doi:10.1080/87565641.2020.1775233Ardila, A. (2019). Executive functions brain functional system. In A.Ardila, S.Fatima, & M.Rosselli (Eds.), Dysexecutive syndromes (pp. 29–41). Cham: Springer. doi:10.1007/978-3-030-25077-5_2Ashwin, D. , Jasleen, H. , Rajkumar, G. , Rudresh, K. , & Prashanth, R. (2015). Hereditary sensory and autosomal peripheral neuropathy-type IV: Case series and review of literature. Oral and Maxillofacial Surgery , 19(2), 117–123. doi:10.1007/s10006-015-0486-5Ballinger, E. C. , Ananth, M. , Talmage, D. A. , & Role, L. W. (2016). Basal forebrain cholinergic circuits and signaling in cognition and cognitive decline. Neuron , 91(6), 1199–1218. doi:10.1016/j.neuron.2016.09.006Bar-On, E. , Weigl, D. , Parvari, R. , Katz, K. , & Weitz, R. (2002). Congenital insensitivity to pain, orthopaedic manifestations. Journal of Bone and Joint Surgery , 84-B(2), 252–257. doi:10.1302/0301-620X.84B2.11939Blank, A. , Frush Holt, R. , Pisoni, D. B. , & Kronenberger, W. G. (2020). Associations between parenting stress, language comprehension, and inhibitory control in children with hearing loss. Journal of Speech, Language, and Hearing Research , 63(1), 321–333. doi:10.1044/2019_JSLHR-19-00230Campos, A. , Martinez, J. , & De la Riva, V. (2012). Insensibilidad congénita al dolor con anhidrosis asociado a osteomielitis mandibular. Asociación Mexicana De Cirugia Bucal Y Maxilofacial , 8(1), 18–22.Cervigni, M. A. , Stelzer, F. , Mazzoni, C. C. , Gómez, C. D. , & Martino, P. (2012). Funcionamiento ejecutivo y TDAH. Aportes teóricos para un diagnóstico diferenciado entre una población infantil y adulta. Interamerican Journal of Psychology , 46(2), 271–276. http://www.redalyc.org/pdf/284/28425280009.pdfCuello, A. C. , Pentz, R. , & Hall, H. (2019). The brain NGF metabolic pathway in health and in Alzheimer’s pathology. Frontiers in Neuroscience , 13, 62. doi:10.3389/fnins.2019.00062Damasio, A. R. (1994). Descartes’ error: Emotion, reason, and the human brain . New York, NY: Putnam.Daneshjou, K. , Jafarieh, H. , & Raaeskarami, S.-R. (2012). Congenital insensitivity to pain and anhydrosis (CIPA) syndrome; A report of 4 cases. Iran Journal Pediatric , 22(3), 412–416.Danziger, N. , Prkachin, K. , & Willer, J. (2006). Is pain the price of empathy? The perception of others´ pain in patients with congenital insensitivity to pain. Brain , 129(9), 2494–2507. doi:10.1093/brain/awl155Dyck, P. , Mellinger, J. , Reagan, T. , Horowitz, S. , McDonald, J. , Litchy, W. , … Lambert, E. (1983). Not “Indifference to pain” but varieties of hereditary sensory and autonomic neuropathy. Brain , 106(2), 373–390. doi:http://dx.doi.10.1093/brain/106.2.373Elliott, R. (2003). Executive functions and their disorders: Imaging in clinical neuroscience. British Medical Bulletin , 65(1), 49–59. doi:10.1093/bmb/65.1.49Franco, N. , Pérez, M. , & De Dios, M. (2014). Relación entre los estilos de crianza parental y el desarrollo de ansiedad y conductas disruptivas en niños de 3 a 6 años. Revista de Psicología Clínica con Niños y Adolescentes , 1(2), 149–156. Obtenido de http://www.revistapcna.com/sites/default/files/6-rpcna_vol.2.pdfGligorović, M. , & Buha Ð Urovi C´, N. (2010). Executive functions and achievements in art education in children with mild intellectual disability. Specijalna Edukacija I Rehabilitacija , 9, 225–244.Gligorović, M. , & Buha, N. (2013). Conceptual abilities of children with mild intellectual disability: Analysis of Wisconsin card sorting test performance. Journal of Intellectual and Developmental Disability , 38(2), 134–140. doi:10.3109/13668250.2013.772956Haga, N. , Kubota, M. , & Miwa, Z. (2014). Hereditary sensory and autonomic neuropathy types IV and V in Japan. Pediatrics International , 57(1), 30–36. doi:10.1111/ped.12538Halloran, E. C. (2020). Positive approaches to parenting and discipline: Evidence-based, century old ideas still not used enough. In M.Knox (Ed.), Clinician’s toolkit for children’s behavioral health (pp. 21–55). London, United Kingdom: Academic Press.Heaton, R. K. , Chelune, G. J. , Talley, J. L. , Kay, G. G. , & Curtiss, G. (2001). WCST: Test de clasificación de tarjetas de Wisconsin . Madrid, Spain: TEA.Henry, L. , & Gudjonsson, G. (2003). Eyewitness memory, suggestibility, and repeated recall sessions in children with mild and moderate intellectual disabilities. Law and Human Behavior , 27(5), 481–505. doi:dx.doi.10.1023/A:1025434022699Heshmati, M. , Christoffel, D. J. , LeClair, K. , Cathomas, F. , Golden, S. A. , Aleyasin, H. , … Russo, S. J. (2020). Depression and social defeat stress are associated with inhibitory synaptic changes in the nucleus accumbens. Journal of Neuroscience , 40(32), 6228–6233. doi:10.1523/JNEUROSCI.2568-19.2020Iftikhar, S. , & Athar, M. (2013). Seeing is not always believing: Congenital insensitivity to pain with anhidrosis mimicking leprosy. Mayo Clinic Proceedings , 88(12), e153–e154. doi:http://dx.doi.10.1016/j.mayocp.2013.02.018Indo, Y. (2002). Genetics of congenital insensitivity to pain with anhidrosis (CIPA) or hereditary sensory and autonomic neuropathy type IV. Clinical, biological and molecular aspects of mutations in TRKA(NTRK1) gene encoding the receptor tyrosine kinase for nerve growth factor. Clinical Autonomic Research , 12(Suppl. 1), I20–I32. doi:10.1007/s102860200016Indo, Y. (2012). Nerve growth factor and the physiology of pain: Lessons from congenital insensitivity to pain with anhidrosis. Clinical Genetics , 82(4), 341–350. doi:10.1111/j.1399-0004.2012.01943.xIndo, Y. (2014). Neurobiology of pain, interoception and emotional response: Lessons from nerve growth factor‐dependent neurons. European Journal of Neuroscience , 39(3), 375–391. doi:10.1111/ejn.12448Indo, Y. (2018). NGF-dependent neurons and neurobiology of emotions and feelings: Lessons from congenital insensitivity to pain with anhidrosis. Neuroscience & Biobehavioral Reviews , 87, 1–16. doi:10.1016/j.neubiorev.2018.01.013Kucukdurmaz, F. , Imren, Y. , Uruc, V. , & Sen, C. (2015). PainCongenital insensitivity to pain with anhidrosis (CIPA) manifested with chronic osteomyelitis. Journal of Clinical and Analytical Medicine , 6(2), 230–232. doi:10.4328/JCAM.912Levy, D. , Levy, J. , Friger, M. , Aharoni-Mayer, Y. , Cohen-Iluz, M. , & Goldstein, E. (2010). Assessment of cognitive and adaptive behaviour among individuals with congenital insensitivity to pain and anhidrosis. Developmental Medicine & Child Neurology , 52(6), 559–562. doi:10.1111/j.1469-8749.2009.03567.xManga, D. , & Ramos, F. (2000). Batería Luria-DNA. Diagnóstico Neuropsicologico de Adultos . Madrid, Spain: Tea S.A.Masri, A. , Shboul, M. , Khasawneh, A. , Jadallah, R. , ALmustafa, A. , Escande-Beillard, N. , … Reversade, B. (2020). Congenital insensitivity to pain with anhidrosis syndrome: A series from Jordan. Clinical Neurology and Neurosurgery , 189, 105636. doi:10.1016/j.clineuro.2019.105636Mesulam, M. (2004). The cholinergic lesion of Alzheimer’s disease: Pivotal factor or side show? Learning & Memory , 11(1), 43–49. doi:10.1101/lm.69204Norcliffe-Kaufmann, L. , Katz, S. D. , Axelrod, F. , & Kaufmann, H. (2015). Norepinephrine deficiency with normal blood pressure control in congenital insensitivity to pain with anhidrosis. Annals of Neurology , 77(5), 743–752. doi:10.1002/ana.24377O’Callaghan, G. , & Stringaris, A. (2019). Reward processing in adolescent depression across neuroimaging modalities. Zeitschrift für Kinder-und Jugendpsychiatrie und Psychotherapie , 47(6), 535–541. doi:10.1024/1422-4917/a000663Ofluoğlu, D. , Altın, N. , Yaman, E. , Tuna, E. , Aytepe, Z. , & Tanyeri, H. (2016). Oral manifestations and prosthetic rehabilitation in hereditary sensory and autonomic neuropathy (hsan) type IV: A case report. Journal of Istanbul University Faculty of Dentistry , 50(2), 49–53. doi:10.17096/jiufd.44532Orlandi, M. (2003). Hiperhidrosis: Una patología con solución. Folia Dermatológica Peruana , 14(3), 35–38.Pan, P. M. , Sato, J. R. , Salum, G. A. , Rohde, L. A. , Gadelha, A. , Zugman, A. , … Pine, D. S. (2017). Ventral striatum functional connectivity as a predictor of adolescent depressive disorder in a longitudinal community-based sample. American Journal of Psychiatry , 174(11), 1112–1119. doi:10.1176/appi.ajp.2017.17040430Pérez-López, L. M. , Cabrera-González, M. , la Iglesia, G.-D. , Ricart, D. , & Knörr-Giménez, G. (2015). Update review and clinical presentation in congenital insensitivity to pain and anhidrosis. Case Reports in Pediatrics , 2015, 1–7. doi:10.1155/2015/589852Pineda, D. A. , Kamphaus, R. W. , Mora, O. , Restrepo, M. A. , Puerta, I. C. , Palacio, L. G. , … Jiménez, M. E. (1999). Sistema de evaluación multidimensional de la conducta. Escala para padres de niños de 6 a 11 años, versión colombiana. Revista de neurología , 28(7), 672–681. doi:10.33588/rn.2807.99011Pinsky, L. , & DiGeorge, A. M. (1966). Congenital familial sensory neuropathy with anhidrosis. Journal of Pediatrics , 68(1), 1–13. doi:10.1016/S0022-3476(66)80417-1Reynolds, C. R. (1992). BASC. Behavioral assessment system for children. Manual . Circle Pines, MN: American Guidance Service.Santoya-Montes, Y. , Cotes, R. Z. , & Gutiérrez-Ruiz, K. (2018). Estudio de Caso Funcionamiento Cognitivo Global y Conducta Adaptativa en dos Niñas con Neuropatía Sensitiva Autonómica Hereditaria Tipo IV. Revista Chilena De Neuropsicología , 13(2), 46–51. doi:10.5839/rcnp.2018.13.02.08Sayyahfar, S. , Chavoshzadeh, Z. , Khaledi, M. , Madadi, F. , Hassas, M. , Sawamura, D. , … Rezaei, N. (2013). Congenital insensitivity to pain with anhidrosis presenting with palmoplantar keratoderma. Pediatric Dermatology , 30(6), 754–756. doi:10.1111/j.1525-1470.2012.01833.xSebnem, S. , Ozturk, R. , Sarisozen, B. , Rotthier, A. , Baets, J. , & Timmerman, V. (2009). Humoral inmunodeficiency in congenital insensitivity to pain with anhidrosis. Neurogenetics , 10(2), 161–165. doi:10.1007/s10048-008-0165-xSergeant, J. A. , Geurts, H. , Huijbregts, S. , Scheres, A. , & Oosterlaan, J. (2003). The top and the bottom of ADHD: A neuropsychological perspective. Neuroscience & Biobehavioral Reviews , 27(7), 583–592. doi:10.1016/j.neubiorev.2003.08.004Sonuga-Barke, E. J. (2005). Causal models of attention-deficit/hyperactivity disorder: From common simple deficits to multiple developmental pathways. Biological Psychiatry , 57(11), 1231–1238. doi:10.1016/j.biopsych.2004.09.008Swanson, A. G. (1963). Congenital insensitivity to pain with anhydrosis. A unique syndrome in two male siblings. Archives of Neurology , 8(3), 299–306. doi:10.1001/archneur.1963.00460030083008Tanaka, T. , Satoh, T. , Tanaka, A. , & Yokozeki, H. (2012). Congenital insensitivity to pain with anhidrosis: A case with preserved itch sensation to histamine and partial pain. British Journal of Dermatology , 166(4), 888–891. doi:10.1111/j.1365-2133.2011.10706.xVan Den Bosch, G. , Baartmans, M. , Vos, P. , Dokter, J. , White, T. , & Tibboel, D. (2014). Pain insensitivity syndrome misinterpreted as inflicted burns. Pediatrics , 133(5), 1381–1388. doi:10.1542/peds.2013-2015Warner-Schmidt, J. L. , Schmidt, E. F. , Marshall, J. J. , Rubin, A. J. , Arango-Lievano, M. , Kaplitt, M. G. , … Greengard, P. (2012). Cholinergic interneurons in the nucleus accumbens regulate depression-like behavior. Proceedings of the National Academy of Sciences , 109(28), 11360–11365. doi:10.1073/pnas.1209293109Wechsler, D. (2007). Escala Wechsler de inteligencia para niños-IV . Mexico, D.F., Mexico: Manual modernoWilliams, L. M. , Hermens, D. F. , Thein, T. , Clark, C. R. , Cooper, N. J. , Clarke, S. D. , … Kohn, M. R. (2010). Using brain-based cognitive measures to support clinical decisions in ADHD. Pediatric Neurology , 42(2), 118–126. doi:10.1016/j.pediatrneurol.2009.08.010Yang, L. , Ji, S. , Yue, R. , Cheng, J. , & Niu, J. (2013). Old fractures in two patients with congenital insensitivity to pain with anhidrosis: Radiological findings. Clinical Imaging , 37(4), 788–790. doi:10.1016/j.clinimag.2013.01.016Zelazo, P. D. , Müller, U. , Frye, D. , & Marcovitch, S. (2003). The development of executive function in early childhood. 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