Factors Associated with Urinary Tract Infection after Prostatectomy
Introduction and Objective Prostate surgery is a common procedure among older men. There are different techniques, and the choice depends on the pathology to be treated, the experience of the specialist, and the technical availability. Among its complications is urinary tract infection, which causes...
- Autores:
-
Paillier Gonzalez , Jaime Enrique
Rodríguez Piraquive , Miguel Sebastián
Paillier Gonzalez , Cecilia
Sfeir Moreno , Mario Andrés
Pérez Becerra , Nathalia María
- Tipo de recurso:
- Fecha de publicación:
- 2022
- Institución:
- Universidad Tecnológica de Bolívar
- Repositorio:
- Repositorio Institucional UTB
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.utb.edu.co:20.500.12585/12239
- Acceso en línea:
- https://hdl.handle.net/20.500.12585/12239
- Palabra clave:
- Antibiotic Prophylaxis;
Cystoscopy;
Anti-Bacterial Agents
LEMB
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc-nd/4.0/
| id |
UTB2_61248a46a83f7cd1e7d1802d9f6ae3d6 |
|---|---|
| oai_identifier_str |
oai:repositorio.utb.edu.co:20.500.12585/12239 |
| network_acronym_str |
UTB2 |
| network_name_str |
Repositorio Institucional UTB |
| repository_id_str |
|
| dc.title.spa.fl_str_mv |
Factors Associated with Urinary Tract Infection after Prostatectomy |
| dc.title.alternative.spa.fl_str_mv |
Factores asociados a infección de vías urinarias luego de una prostatectomía |
| title |
Factors Associated with Urinary Tract Infection after Prostatectomy |
| spellingShingle |
Factors Associated with Urinary Tract Infection after Prostatectomy Antibiotic Prophylaxis; Cystoscopy; Anti-Bacterial Agents LEMB |
| title_short |
Factors Associated with Urinary Tract Infection after Prostatectomy |
| title_full |
Factors Associated with Urinary Tract Infection after Prostatectomy |
| title_fullStr |
Factors Associated with Urinary Tract Infection after Prostatectomy |
| title_full_unstemmed |
Factors Associated with Urinary Tract Infection after Prostatectomy |
| title_sort |
Factors Associated with Urinary Tract Infection after Prostatectomy |
| dc.creator.fl_str_mv |
Paillier Gonzalez , Jaime Enrique Rodríguez Piraquive , Miguel Sebastián Paillier Gonzalez , Cecilia Sfeir Moreno , Mario Andrés Pérez Becerra , Nathalia María |
| dc.contributor.author.none.fl_str_mv |
Paillier Gonzalez , Jaime Enrique Rodríguez Piraquive , Miguel Sebastián Paillier Gonzalez , Cecilia Sfeir Moreno , Mario Andrés Pérez Becerra , Nathalia María |
| dc.subject.keywords.spa.fl_str_mv |
Antibiotic Prophylaxis; Cystoscopy; Anti-Bacterial Agents |
| topic |
Antibiotic Prophylaxis; Cystoscopy; Anti-Bacterial Agents LEMB |
| dc.subject.armarc.none.fl_str_mv |
LEMB |
| description |
Introduction and Objective Prostate surgery is a common procedure among older men. There are different techniques, and the choice depends on the pathology to be treated, the experience of the specialist, and the technical availability. Among its complications is urinary tract infection, which causes increased morbidity and mortality and costs for the health system. The main objective of the present study was to evaluate the factors related to the onset of urinary tract infection after prostate surgery. Materials and Methods A case-control study was conducted in a population of patients undergoing prostatectomy from 2018 to early 2020 in the city of Medellín, Colombia. The cases corresponded to patients who presented urinary tract infection up to 30 days after prostatectomy. The association between cases and controls was estimated by calculating the odds ratio (OR), which was adjusted with logistic regression and a multivariate generalized additive model. Results We identified 96 incident cases of urinary tract infection after prostatectomy, with a prevalence of 8.99%. The frequency of requests for preoperative urine culture was of 52.92% (95% confidence interval [95%CI]: 48.34-57.44). The independently associated variables were: request for preoperative urine culture, number of doses, and type of antibiotic used for prophylaxis. In particular, the use of aminoglycosides in prophylaxis schemes was found to be a protective factor. The main germs isolated were: Eschirichia coli, Pseudomonas aeruginosa, Klepsiella pneumoniae, Enterococos faecalis, and Serratia marcescens. Conclusion The present study shows that factors such as the preoperative request for urine culture and the use of aminoglycosides for surgical prophylaxis influence the probability of developing urinary tract infection after prostatectomy. © 2022. Sociedad Colombiana de Urología. All rights reserved. |
| publishDate |
2022 |
| dc.date.issued.none.fl_str_mv |
2022 |
| dc.date.accessioned.none.fl_str_mv |
2023-07-19T21:25:34Z |
| dc.date.available.none.fl_str_mv |
2023-07-19T21:25:34Z |
| dc.date.submitted.none.fl_str_mv |
2023 |
| dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.hasversion.spa.fl_str_mv |
info:eu-repo/semantics/draft |
| dc.type.spa.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
| status_str |
draft |
| dc.identifier.citation.spa.fl_str_mv |
Gonzalez, J. E. P., Piraquive, M. S. R., Gonzalez, C. P., Moreno, M. A. S., & Becerra, N. M. P. (2022). Factores asociados a infección de vías urinarias luego de una prostatectomía. Revista Urología Colombiana/Colombian Urology Journal, 31(01), e21-e27. |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/20.500.12585/12239 |
| dc.identifier.doi.none.fl_str_mv |
10.1055/s-0042-1743204 |
| dc.identifier.instname.spa.fl_str_mv |
Universidad Tecnológica de Bolívar |
| dc.identifier.reponame.spa.fl_str_mv |
Repositorio Universidad Tecnológica de Bolívar |
| identifier_str_mv |
Gonzalez, J. E. P., Piraquive, M. S. R., Gonzalez, C. P., Moreno, M. A. S., & Becerra, N. M. P. (2022). Factores asociados a infección de vías urinarias luego de una prostatectomía. Revista Urología Colombiana/Colombian Urology Journal, 31(01), e21-e27. 10.1055/s-0042-1743204 Universidad Tecnológica de Bolívar Repositorio Universidad Tecnológica de Bolívar |
| url |
https://hdl.handle.net/20.500.12585/12239 |
| dc.language.iso.spa.fl_str_mv |
spa |
| language |
spa |
| dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
| dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| dc.rights.accessrights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
| dc.rights.cc.*.fl_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
| rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://purl.org/coar/access_right/c_abf2 |
| eu_rights_str_mv |
openAccess |
| dc.format.extent.none.fl_str_mv |
7 páginas |
| dc.format.mimetype.spa.fl_str_mv |
application/pdf |
| dc.publisher.place.spa.fl_str_mv |
Cartagena de Indias |
| dc.source.spa.fl_str_mv |
Urologia Colombiana |
| institution |
Universidad Tecnológica de Bolívar |
| bitstream.url.fl_str_mv |
https://repositorio.utb.edu.co/bitstream/20.500.12585/12239/1/s-0042-1743204.pdf https://repositorio.utb.edu.co/bitstream/20.500.12585/12239/2/license_rdf https://repositorio.utb.edu.co/bitstream/20.500.12585/12239/3/license.txt https://repositorio.utb.edu.co/bitstream/20.500.12585/12239/4/s-0042-1743204.pdf.txt https://repositorio.utb.edu.co/bitstream/20.500.12585/12239/5/s-0042-1743204.pdf.jpg |
| bitstream.checksum.fl_str_mv |
b55e44d6300204e56cc2e05537d4c4ae 4460e5956bc1d1639be9ae6146a50347 e20ad307a1c5f3f25af9304a7a7c86b6 7b1b160ab75578b88d8c4b617eff3fe6 603d35055dea67c68547e847728039f0 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositorio Institucional UTB |
| repository.mail.fl_str_mv |
repositorioutb@utb.edu.co |
| _version_ |
1808397603319054336 |
| spelling |
Paillier Gonzalez , Jaime Enriquedb17901a-9ea2-4b0a-bc26-dd868bd18765Rodríguez Piraquive , Miguel Sebastiánce2046dc-32b6-4035-bc4f-b94c09bc8e9bPaillier Gonzalez , Ceciliabbb134ef-e474-43ea-9201-37df3cd609aaSfeir Moreno , Mario Andrés6086fa63-aefc-404d-b325-0ffac401a822Pérez Becerra , Nathalia Maríaed51e13c-2612-4dd9-a831-31b5bd1983242023-07-19T21:25:34Z2023-07-19T21:25:34Z20222023Gonzalez, J. E. P., Piraquive, M. S. R., Gonzalez, C. P., Moreno, M. A. S., & Becerra, N. M. P. (2022). Factores asociados a infección de vías urinarias luego de una prostatectomía. Revista Urología Colombiana/Colombian Urology Journal, 31(01), e21-e27.https://hdl.handle.net/20.500.12585/1223910.1055/s-0042-1743204Universidad Tecnológica de BolívarRepositorio Universidad Tecnológica de BolívarIntroduction and Objective Prostate surgery is a common procedure among older men. There are different techniques, and the choice depends on the pathology to be treated, the experience of the specialist, and the technical availability. Among its complications is urinary tract infection, which causes increased morbidity and mortality and costs for the health system. The main objective of the present study was to evaluate the factors related to the onset of urinary tract infection after prostate surgery. Materials and Methods A case-control study was conducted in a population of patients undergoing prostatectomy from 2018 to early 2020 in the city of Medellín, Colombia. The cases corresponded to patients who presented urinary tract infection up to 30 days after prostatectomy. The association between cases and controls was estimated by calculating the odds ratio (OR), which was adjusted with logistic regression and a multivariate generalized additive model. Results We identified 96 incident cases of urinary tract infection after prostatectomy, with a prevalence of 8.99%. The frequency of requests for preoperative urine culture was of 52.92% (95% confidence interval [95%CI]: 48.34-57.44). The independently associated variables were: request for preoperative urine culture, number of doses, and type of antibiotic used for prophylaxis. In particular, the use of aminoglycosides in prophylaxis schemes was found to be a protective factor. The main germs isolated were: Eschirichia coli, Pseudomonas aeruginosa, Klepsiella pneumoniae, Enterococos faecalis, and Serratia marcescens. Conclusion The present study shows that factors such as the preoperative request for urine culture and the use of aminoglycosides for surgical prophylaxis influence the probability of developing urinary tract infection after prostatectomy. © 2022. Sociedad Colombiana de Urología. All rights reserved.7 páginasapplication/pdfspahttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://purl.org/coar/access_right/c_abf2Urologia ColombianaFactors Associated with Urinary Tract Infection after ProstatectomyFactores asociados a infección de vías urinarias luego de una prostatectomíainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/drafthttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/version/c_b1a7d7d4d402bccehttp://purl.org/coar/resource_type/c_2df8fbb1Antibiotic Prophylaxis;Cystoscopy;Anti-Bacterial AgentsLEMBCartagena de IndiasCaro-Zapata, F.L., Vásquez-Franco, A., Correa-Galeano, É.D., García-Valencia, J. Postoperative infectious complications after open prostatectomy and transurethral resection of the prostate in patients with benign prostatic hyperplasia (2018) Iatreia, 31 (3), pp. 274-283. Cited 3 times. http://aprendeenlinea.udea.edu.co/revistas/index.php/iatreia/article/download/325348/20789687 doi: 10.17533/udea.iatreia.v31n3a05Khalil, M.I., Bhandari, N.R., Payakachat, N., Davis, R., Raheem, O.A., Kamel, M.H. Perioperative mortality and morbidity of outpatient versus inpatient robot-assisted radical prostatectomy: A propensity matched analysis (2020) Urologic Oncology: Seminars and Original Investigations, 38 (1), pp. 3.e1-3.e6. Cited 16 times. http://www.elsevier.com/locate/issn/10781439 doi: 10.1016/j.urolonc.2019.07.008Pérez Manzanares, V.M., Salinas González, F., García Vásquez, R.A., Arriaga Aguilar, J., Candia Plata, M.C. Comparative study of open and laparoscopic prostatic adenomectomy: Which offers the best results? (2016) Revista Mexicana de Urologia, 76 (2), pp. 99-103. http://www.journals.elsevier.com/revista-mexicana-de-urologia/ doi: 10.1016/j.uromx.2016.01.007Mohee, A.R., Gascoyne-Binzi, D., West, R., Bhattarai, S., Eardley, I., Sandoe, J.A.T. Bacteraemia during transurethral resection of the prostate: What are the risk factors and is it more common than we think? (2016) PLoS ONE, 11 (7), art. no. e0157864. Cited 18 times. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0157864 doi: 10.1371/journal.pone.0157864Hwang, E.C., Jung, S.I., Kwon, D.D., Lee, G., Bae, J.H., Na, Y.G., Min, S.K., (...), Chang, I.H. A prospective Korean multicenter study for infectious complications in patients undergoing prostate surgery: Risk factors and efficacy of antibiotic prophylaxis (Open Access) (2014) Journal of Korean Medical Science, 29 (9), pp. 1271-1277. Cited 10 times. http://www.jkms.org/Synapse/Data/PDFData/0063JKMS/jkms-29-1271.pdf doi: 10.3346/jkms.2014.29.9.1271Colau, A., Lucet, J.C., Rufat, P., Botto, H., Benoit, G., Jardin, A. Incidence and risk factors of bacteriuria after transurethral resection of the prostate (Open Access) (2001) European Urology, 39 (3), pp. 272-276. Cited 50 times. doi: 10.1159/000052452Cruz Arévalo, A., Cárdenas, A.M., Gómez, J.E., Reyes, J.C., Duarte, R.A. Predictive factors of infectious complications in patients undergoing prostatectomy (2017) Urologia Colombiana, 26 (2), pp. 81-86. Cited 3 times. https://www.thieme-connect.com/products/ejournals/journal/10.1055/s-00035331 doi: 10.1016/j.uroco.2016.06.003Gupta, K., Hooton, T.M., Naber, K.G., Wullt, B., Colgan, R., Miller, L.G., Moran, G.J., (...), Soper, D.E. International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: A 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases (2011) Clinical Infectious Diseases, 52 (5), pp. e103-e120. Cited 1917 times. doi: 10.1093/cid/ciq257De Cueto, M. Microbiological diagnosis of urinary tract infections (Open Access) (2005) Enfermedades Infecciosas y Microbiologia Clinica, 23 (SUPPL.4), pp. 9-14. Cited 7 times. http://external.doyma.es/prepdf/water.asp?pident_articulo=13091443&pident_usuario=797308&pident_revista=28&fichero=28v23nSupl.4a13091443pdf001.pdf&ty=25&accion=L&origen=doyma&web=www.doyma.es&lan=es doi: 10.1157/13091443Köves, B., Tenke, P., Tandogdu, Z., Cai, T., Bogenhard, F., Wullt, B., Naber, K., (...), Wagenlehner, F. Transurethral Resection of the Prostate: are We Following the Guidelines? - Outcomes from the Global Prevalence of Infections in Urology (GPIU) Study (2019) Journal of Chemotherapy, 31 (1), pp. 15-22. Cited 6 times. http://www.maneyonline.com/loi/joc doi: 10.1080/1120009X.2018.1542552Li, Y.-H., Li, G.-Q., Guo, S.-M., Che, Y.-N., Wang, X., Cheng, F.-T. Clinical analysis of urinary tract infection in patients undergoing transurethral resection of the prostate (Open Access) (2017) European review for medical and pharmacological sciences, 21 (20), pp. 4487-4492. Cited 10 times.Cai, T., Verze, P., Palmieri, A., Gacci, M., Lanzafame, P., Malossini, G., Nesi, G., (...), Johansen, T.E.B. Is Preoperative Assessment and Treatment of Asymptomatic Bacteriuria Necessary for Reducing the Risk of Postoperative Symptomatic Urinary Tract Infections After Urologic Surgical Procedures? (Open Access) (2017) Urology, 99, pp. 100-105. Cited 24 times. www.elsevier.com/locate/urology doi: 10.1016/j.urology.2016.10.016Gallegos Salazar, J., O'Brien, W., Strymish, J.M., Itani, K., Branch-Elliman, W., Gupta, K. Association of Screening and Treatment for Preoperative Asymptomatic Bacteriuria with Postoperative Outcomes among US Veterans (Open Access) (2019) JAMA Surgery, 154 (3), pp. 241-248. Cited 11 times. http://archsurg.jamanetwork.com/issues.aspx doi: 10.1001/jamasurg.2018.4759Lightner, D.J., Wymer, K., Sanchez, J., Kavoussi, L. Best Practice Statement on Urologic Procedures and Antimicrobial Prophylaxis (Open Access) (2020) Journal of Urology, 203 (2), pp. 351-356. Cited 130 times. https://www.auajournals.org/ doi: 10.1097/JU.0000000000000509Machado-Alba, J.E., González-Santos, D.M. Dispensing antibiotics to outpatients in a colombian population (Open Access) (2009) Revista de Salud Publica, 11 (5), pp. 734-744. Cited 13 times. http://www.scielosp.org/pdf/rsap/v11n5/v11n5a06.pdf doi: 10.1590/S0124-00642009000500006Erdem, H., Kiliç, S., Pahsa, A., Besirbellioglu, B.A. Gram-negative bacterial resistance to cephalosporins in community-acquired infections in Turkey (Open Access) (2005) Journal of Chemotherapy, 17 (1), pp. 61-65. Cited 8 times. http://www.maneyonline.com/loi/joc doi: 10.1179/joc.2005.17.1.61Hayward, R.S., Harding, J., Molloy, R., Land, L., Longcroft-Neal, K., Moore, D., Ross, J.D.C. Adverse effects of a single dose of gentamicin in adults: a systematic review (Open Access) (2018) British Journal of Clinical Pharmacology, 84 (2), pp. 223-238. Cited 64 times. http://www.bjcp-journal.com/ doi: 10.1111/bcp.13439Nielsen, D.V., Fedosova, M., Hjortdal, V., Jakobsen, C.-J. Is single-dose prophylactic gentamicin associated with acute kidney injury in patients undergoing cardiac surgery? A matched-pair analysis (2014) Journal of Thoracic and Cardiovascular Surgery, 148 (4), pp. 1634-1639. Cited 20 times. http://www.elsevier.com/inca/publications/store/6/2/3/1/5/1/index.htt doi: 10.1016/j.jtcvs.2014.05.090Schober, P., Vetter, T.R. Logistic Regression in Medical Research (Open Access) (2021) Anesthesia and Analgesia, 132 (2), pp. 365-366. Cited 53 times. http://journals.lww.com/anesthesia-analgesia/toc/publishahead doi: 10.1213/ANE.0000000000005247http://purl.org/coar/resource_type/c_6501ORIGINALs-0042-1743204.pdfs-0042-1743204.pdfapplication/pdf1009794https://repositorio.utb.edu.co/bitstream/20.500.12585/12239/1/s-0042-1743204.pdfb55e44d6300204e56cc2e05537d4c4aeMD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805https://repositorio.utb.edu.co/bitstream/20.500.12585/12239/2/license_rdf4460e5956bc1d1639be9ae6146a50347MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-83182https://repositorio.utb.edu.co/bitstream/20.500.12585/12239/3/license.txte20ad307a1c5f3f25af9304a7a7c86b6MD53TEXTs-0042-1743204.pdf.txts-0042-1743204.pdf.txtExtracted texttext/plain31601https://repositorio.utb.edu.co/bitstream/20.500.12585/12239/4/s-0042-1743204.pdf.txt7b1b160ab75578b88d8c4b617eff3fe6MD54THUMBNAILs-0042-1743204.pdf.jpgs-0042-1743204.pdf.jpgGenerated Thumbnailimage/jpeg6806https://repositorio.utb.edu.co/bitstream/20.500.12585/12239/5/s-0042-1743204.pdf.jpg603d35055dea67c68547e847728039f0MD5520.500.12585/12239oai:repositorio.utb.edu.co:20.500.12585/122392023-07-20 00:18:07.192Repositorio Institucional UTBrepositorioutb@utb.edu.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 |