Features of dengue and chikungunya infections of colombian children under 24 months of age admitted to the emergency department

We aimed to assess clinical and laboratory differences between dengue and chikungunya in children <24 months of age in a comparative study. We collected retrospective clinical and laboratory data confirmed by NS1/IgM for dengue for 19 months (1 January 2013 to 17 August 2014). Prospective data fo...

Full description

Autores:
Tipo de recurso:
Fecha de publicación:
2018
Institución:
Universidad Tecnológica de Bolívar
Repositorio:
Repositorio Institucional UTB
Idioma:
eng
OAI Identifier:
oai:repositorio.utb.edu.co:20.500.12585/9239
Acceso en línea:
https://hdl.handle.net/20.500.12585/9239
Palabra clave:
Chikungunya
Children
Complications
Dengue
Severe dengue
Article
Chikungunya
Child
Clinical feature
Colombian
Controlled study
Dengue
Diagnostic test accuracy study
Differential diagnosis
Female
Human
Infant
Major clinical study
Male
Platelet count
Preschool child
Real time polymerase chain reaction
Retrospective study
Sensitivity and specificity
Algorithm
Chikungunya
Chikungunya virus
Colombia
Comparative study
Dengue
Dengue virus
Differential diagnosis
Hospital emergency service
Newborn
Prospective study
Statistics and numerical data
Algorithms
Chikungunya Fever
Chikungunya virus
Colombia
Dengue
Dengue virus
Diagnosis, Differential
Emergency Service, Hospital
Humans
Infant
Infant, Newborn
Prospective Studies
Retrospective studies
Sensitivity and specificity
Rights
openAccess
License
http://creativecommons.org/licenses/by-nc-nd/4.0/
Description
Summary:We aimed to assess clinical and laboratory differences between dengue and chikungunya in children <24 months of age in a comparative study. We collected retrospective clinical and laboratory data confirmed by NS1/IgM for dengue for 19 months (1 January 2013 to 17 August 2014). Prospective data for chikungunya confirmed by real-time polymerase chain reaction were collected for 4 months (22 September 2014-14 December 2014). Sensitivity and specificity [with 95% confidence interval (CI)] were reported for each disease diagnosis. A platelet count <150 000 cells/ml at emergency admission best characterized dengue, with a sensitivity of 67% (95% CI, 53-79) and specificity of 95% (95% CI, 82-99). The algorithm developed with classification and regression tree analysis showed a sensitivity of 93% (95% CI, 68-100) and specificity of 38% (95% CI, 9-76) to diagnose dengue. Our study provides potential differential characteristics between chikungunya and dengue in young children, especially low platelet counts. © The Author [2017].