Ecotoxicological assessment of perchlorate using in vitro and in vivo assays
Perchlorate is an inorganic ion widespread in the environment, generated as a natural and anthropogenic pollutant, with known endocrine disruption properties in the thyroid gland. Nonetheless, there are few reports of its ecotoxicological impact on wildlife. The aim of this study was to evaluate the...
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- Biological models
Biota
Ecotoxicology
Effects
Endocrine disruption
Toxicity
Alga
Anthropogenic source
Assay
Assessment method
Bacterium
Biota
Crustacean
Earthworm
Ecological modeling
Ecotoxicology
Endocrine disruptor
Freshwater environment
Perchlorate
Pollution effect
Algae
Crustacea
Daphnia magna
Eisenia fetida
Selenastrum capricornutum
Vibrio fischeri
Perchlorate
Animal
Animal model
Bioassay
Drug effect
Ecotoxicology
Environmental monitoring
Human
Oligochaeta
Pollutant
Procedures
Species difference
Toxicity
Animals
Biological Assay
Ecotoxicology
Environmental monitoring
Environmental Pollutants
Humans
Models, Animal
Oligochaeta
Perchlorates
Species Specificity
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Ecotoxicological assessment of perchlorate using in vitro and in vivo assays |
| title |
Ecotoxicological assessment of perchlorate using in vitro and in vivo assays |
| spellingShingle |
Ecotoxicological assessment of perchlorate using in vitro and in vivo assays Biological models Biota Ecotoxicology Effects Endocrine disruption Toxicity Alga Anthropogenic source Assay Assessment method Bacterium Biota Crustacean Earthworm Ecological modeling Ecotoxicology Endocrine disruptor Freshwater environment Perchlorate Pollution effect Algae Crustacea Daphnia magna Eisenia fetida Selenastrum capricornutum Vibrio fischeri Perchlorate Animal Animal model Bioassay Drug effect Ecotoxicology Environmental monitoring Human Oligochaeta Pollutant Procedures Species difference Toxicity Animals Biological Assay Ecotoxicology Environmental monitoring Environmental Pollutants Humans Models, Animal Oligochaeta Perchlorates Species Specificity |
| title_short |
Ecotoxicological assessment of perchlorate using in vitro and in vivo assays |
| title_full |
Ecotoxicological assessment of perchlorate using in vitro and in vivo assays |
| title_fullStr |
Ecotoxicological assessment of perchlorate using in vitro and in vivo assays |
| title_full_unstemmed |
Ecotoxicological assessment of perchlorate using in vitro and in vivo assays |
| title_sort |
Ecotoxicological assessment of perchlorate using in vitro and in vivo assays |
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Biological models Biota Ecotoxicology Effects Endocrine disruption Toxicity Alga Anthropogenic source Assay Assessment method Bacterium Biota Crustacean Earthworm Ecological modeling Ecotoxicology Endocrine disruptor Freshwater environment Perchlorate Pollution effect Algae Crustacea Daphnia magna Eisenia fetida Selenastrum capricornutum Vibrio fischeri Perchlorate Animal Animal model Bioassay Drug effect Ecotoxicology Environmental monitoring Human Oligochaeta Pollutant Procedures Species difference Toxicity Animals Biological Assay Ecotoxicology Environmental monitoring Environmental Pollutants Humans Models, Animal Oligochaeta Perchlorates Species Specificity |
| topic |
Biological models Biota Ecotoxicology Effects Endocrine disruption Toxicity Alga Anthropogenic source Assay Assessment method Bacterium Biota Crustacean Earthworm Ecological modeling Ecotoxicology Endocrine disruptor Freshwater environment Perchlorate Pollution effect Algae Crustacea Daphnia magna Eisenia fetida Selenastrum capricornutum Vibrio fischeri Perchlorate Animal Animal model Bioassay Drug effect Ecotoxicology Environmental monitoring Human Oligochaeta Pollutant Procedures Species difference Toxicity Animals Biological Assay Ecotoxicology Environmental monitoring Environmental Pollutants Humans Models, Animal Oligochaeta Perchlorates Species Specificity |
| description |
Perchlorate is an inorganic ion widespread in the environment, generated as a natural and anthropogenic pollutant, with known endocrine disruption properties in the thyroid gland. Nonetheless, there are few reports of its ecotoxicological impact on wildlife. The aim of this study was to evaluate the adverse effects of KClO4 exposure on different cell lines, HEK, N2a, and 3T3, as well as in ecological models such as Vibrio fischeri, Pseudokirchneriella subcapitata, Daphnia magna, and Eisenia fetida. Perchlorate exhibited similar toxicity against tested cell lines, with LC50 values of 19, 15, and 19 mM for HEK, N2a, and 3T3, respectively; whereas in V. fischeri, the toxicity, examined as bioluminescence reduction, was considerably lower (EC50 = 715 mM). The survival of the freshwater algae P. subcapitata was significatively impaired by perchlorate (LC50 = 72 mM), and its effect on the lethality in the crustacean D. magna was prominent (LC50 = 5 mM). For the earthworm E. fetida, the LC50 was 56 mM in soil. In this organism, perchlorate induced avoidance behavior, weight loss, and decreased egg production and hatchling, as well as morphological and histopathological effects, such as malformations, dwarfism, and necrosis. In conclusion, perchlorate toxicity varies according to the species, although E. fetida is a sensitive model to generate information regarding the toxicological impact of KClO4 on biota. © 2018, Springer-Verlag GmbH Germany, part of Springer Nature. |
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2018 |
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2018 |
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2020-03-26T16:32:33Z |
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2020-03-26T16:32:33Z |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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Environmental Science and Pollution Research; Vol. 25, Núm. 14; pp. 13697-13708 |
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09441344 |
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https://hdl.handle.net/20.500.12585/8882 |
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10.1007/s11356-018-1565-6 |
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Universidad Tecnológica de Bolívar |
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Environmental Science and Pollution Research; Vol. 25, Núm. 14; pp. 13697-13708 09441344 10.1007/s11356-018-1565-6 Universidad Tecnológica de Bolívar Repositorio UTB 56674579200 57200990599 9736353600 |
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2020-03-26T16:32:33Z2020-03-26T16:32:33Z2018Environmental Science and Pollution Research; Vol. 25, Núm. 14; pp. 13697-1370809441344https://hdl.handle.net/20.500.12585/888210.1007/s11356-018-1565-6Universidad Tecnológica de BolívarRepositorio UTB56674579200572009905999736353600Perchlorate is an inorganic ion widespread in the environment, generated as a natural and anthropogenic pollutant, with known endocrine disruption properties in the thyroid gland. Nonetheless, there are few reports of its ecotoxicological impact on wildlife. The aim of this study was to evaluate the adverse effects of KClO4 exposure on different cell lines, HEK, N2a, and 3T3, as well as in ecological models such as Vibrio fischeri, Pseudokirchneriella subcapitata, Daphnia magna, and Eisenia fetida. Perchlorate exhibited similar toxicity against tested cell lines, with LC50 values of 19, 15, and 19 mM for HEK, N2a, and 3T3, respectively; whereas in V. fischeri, the toxicity, examined as bioluminescence reduction, was considerably lower (EC50 = 715 mM). The survival of the freshwater algae P. subcapitata was significatively impaired by perchlorate (LC50 = 72 mM), and its effect on the lethality in the crustacean D. magna was prominent (LC50 = 5 mM). For the earthworm E. fetida, the LC50 was 56 mM in soil. In this organism, perchlorate induced avoidance behavior, weight loss, and decreased egg production and hatchling, as well as morphological and histopathological effects, such as malformations, dwarfism, and necrosis. In conclusion, perchlorate toxicity varies according to the species, although E. fetida is a sensitive model to generate information regarding the toxicological impact of KClO4 on biota. © 2018, Springer-Verlag GmbH Germany, part of Springer Nature.perchlorate, 14797-73-0; Environmental Pollutants; perchlorate; PerchloratesRecurso electrónicoapplication/pdfengSpringer Verlaghttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/restrictedAccessAtribución-NoComercial 4.0 Internacionalhttp://purl.org/coar/access_right/c_16echttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85042767977&doi=10.1007%2fs11356-018-1565-6&partnerID=40&md5=5b305b162b9438486ee8f2659e4314baEcotoxicological assessment of perchlorate using in vitro and in vivo assaysinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1Biological modelsBiotaEcotoxicologyEffectsEndocrine disruptionToxicityAlgaAnthropogenic sourceAssayAssessment methodBacteriumBiotaCrustaceanEarthwormEcological modelingEcotoxicologyEndocrine disruptorFreshwater environmentPerchloratePollution effectAlgaeCrustaceaDaphnia magnaEisenia fetidaSelenastrum capricornutumVibrio fischeriPerchlorateAnimalAnimal modelBioassayDrug effectEcotoxicologyEnvironmental monitoringHumanOligochaetaPollutantProceduresSpecies differenceToxicityAnimalsBiological AssayEcotoxicologyEnvironmental monitoringEnvironmental PollutantsHumansModels, AnimalOligochaetaPerchloratesSpecies SpecificityAcevedo Barrios, RosaSabater-Marco C.Olivero-Verbel J.Abbondanzi, F., Cachada, A., Campisi, T., Guerra, R., Raccagni, M., Iacondini, A., Optimisation of a microbial bioassay for contaminated soil monitoring: bacterial inoculum standardisation and comparison with Microtox® assay (2003) Chemosphere, 53 (8), pp. 889-897Acevedo-Barrios, R., Bertel-Sevilla, A., Alonso-Molina, J., Olivero-Verbel, J., Perchlorate tolerant bacteria from saline environments at the Caribbean region of Colombia (2016) Toxicol Lett (259), p. 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