Role of VEGF in the differential growth between the fetal and placental ends of the umbilical cord
INTRODUCTION: The umbilical cord (UC) is a vital structure; its alterations affect the newborn and neurological impact can be permanent. Paradoxically, factors that determine it remain unknown. We explore the differential VEGF protein expression in the UC's proximal and distal portions in relat...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2019
- Institución:
- Universidad Tecnológica de Bolívar
- Repositorio:
- Repositorio Institucional UTB
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.utb.edu.co:20.500.12585/9192
- Acceso en línea:
- https://hdl.handle.net/20.500.12585/9192
- Palabra clave:
- Stillbirth
Umbilical cord
Umbilical cord length
VEGF
Vasculotropin
Vasculotropin A
VEGFA protein, human
Acidosis
Amnion
Article
Clinical article
Congenital heart malformation
Diaphragm hernia
Disease association
Endothelium
Female
Fetus growth
Gestational age
Human
Human cell
Hypoglycemia
Immunohistochemistry
Intrauterine growth retardation
Male
Maternal hypertension
Neonatal respiratory distress syndrome
Newborn
Newborn jaundice
Observational study
Placenta
Placenta development
Pregnancy diabetes mellitus
Premature fetus membrane rupture
Priority journal
Protein expression
Protein function
Stroma cell
Umbilical cord
Urinary tract infection
Cell proliferation
Controlled study
Fetus
Gene expression regulation
Growth, development and aging
Metabolism
Physiology
Pregnancy
Randomized controlled trial
Umbilical cord
Cell proliferation
Female
Fetus
Gene Expression Regulation, Developmental
Humans
Infant, Newborn
Placenta
Pregnancy
Umbilical Cord
Vascular Endothelial Growth Factor A
- Rights
- restrictedAccess
- License
- http://creativecommons.org/licenses/by-nc-nd/4.0/
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Role of VEGF in the differential growth between the fetal and placental ends of the umbilical cord |
| title |
Role of VEGF in the differential growth between the fetal and placental ends of the umbilical cord |
| spellingShingle |
Role of VEGF in the differential growth between the fetal and placental ends of the umbilical cord Stillbirth Umbilical cord Umbilical cord length VEGF Vasculotropin Vasculotropin A VEGFA protein, human Acidosis Amnion Article Clinical article Congenital heart malformation Diaphragm hernia Disease association Endothelium Female Fetus growth Gestational age Human Human cell Hypoglycemia Immunohistochemistry Intrauterine growth retardation Male Maternal hypertension Neonatal respiratory distress syndrome Newborn Newborn jaundice Observational study Placenta Placenta development Pregnancy diabetes mellitus Premature fetus membrane rupture Priority journal Protein expression Protein function Stroma cell Umbilical cord Urinary tract infection Cell proliferation Controlled study Fetus Gene expression regulation Growth, development and aging Metabolism Physiology Pregnancy Randomized controlled trial Umbilical cord Cell proliferation Female Fetus Gene Expression Regulation, Developmental Humans Infant, Newborn Placenta Pregnancy Umbilical Cord Vascular Endothelial Growth Factor A |
| title_short |
Role of VEGF in the differential growth between the fetal and placental ends of the umbilical cord |
| title_full |
Role of VEGF in the differential growth between the fetal and placental ends of the umbilical cord |
| title_fullStr |
Role of VEGF in the differential growth between the fetal and placental ends of the umbilical cord |
| title_full_unstemmed |
Role of VEGF in the differential growth between the fetal and placental ends of the umbilical cord |
| title_sort |
Role of VEGF in the differential growth between the fetal and placental ends of the umbilical cord |
| dc.subject.keywords.none.fl_str_mv |
Stillbirth Umbilical cord Umbilical cord length VEGF Vasculotropin Vasculotropin A VEGFA protein, human Acidosis Amnion Article Clinical article Congenital heart malformation Diaphragm hernia Disease association Endothelium Female Fetus growth Gestational age Human Human cell Hypoglycemia Immunohistochemistry Intrauterine growth retardation Male Maternal hypertension Neonatal respiratory distress syndrome Newborn Newborn jaundice Observational study Placenta Placenta development Pregnancy diabetes mellitus Premature fetus membrane rupture Priority journal Protein expression Protein function Stroma cell Umbilical cord Urinary tract infection Cell proliferation Controlled study Fetus Gene expression regulation Growth, development and aging Metabolism Physiology Pregnancy Randomized controlled trial Umbilical cord Cell proliferation Female Fetus Gene Expression Regulation, Developmental Humans Infant, Newborn Placenta Pregnancy Umbilical Cord Vascular Endothelial Growth Factor A |
| topic |
Stillbirth Umbilical cord Umbilical cord length VEGF Vasculotropin Vasculotropin A VEGFA protein, human Acidosis Amnion Article Clinical article Congenital heart malformation Diaphragm hernia Disease association Endothelium Female Fetus growth Gestational age Human Human cell Hypoglycemia Immunohistochemistry Intrauterine growth retardation Male Maternal hypertension Neonatal respiratory distress syndrome Newborn Newborn jaundice Observational study Placenta Placenta development Pregnancy diabetes mellitus Premature fetus membrane rupture Priority journal Protein expression Protein function Stroma cell Umbilical cord Urinary tract infection Cell proliferation Controlled study Fetus Gene expression regulation Growth, development and aging Metabolism Physiology Pregnancy Randomized controlled trial Umbilical cord Cell proliferation Female Fetus Gene Expression Regulation, Developmental Humans Infant, Newborn Placenta Pregnancy Umbilical Cord Vascular Endothelial Growth Factor A |
| description |
INTRODUCTION: The umbilical cord (UC) is a vital structure; its alterations affect the newborn and neurological impact can be permanent. Paradoxically, factors that determine it remain unknown. We explore the differential VEGF protein expression in the UC's proximal and distal portions in relation to the hypothesis that the UC has differential growth and that VEGF plays a role in it. METHODS: An observational analytical study was performed. One UC segment was taken proximal to fetus and another distal; both were randomly processed; VEGF immunohistochemical analysis was performed; two blinded pathologists read results. RESULTS: Forty-eight newborns were included. Protein expression between the two edges of the umbilical cord, in any kind of cells, was interpreted. Endothelium, amnion, and stromal cells expressed VEGF; the first two were not different between opposite ends. Stromal cells had differential expression: higher in the proximal to the fetus portion. CONCLUSION: Knowledge of molecular factors is necessary. UC cells widely expressed VEGF, possibly contributing to UC growth. Even though stromal cell expression was different, the interaction with activity close to the fetus must be explored. © 2019 - IOS Press and the authors. All rights reserved. |
| publishDate |
2019 |
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2019 |
| dc.date.accessioned.none.fl_str_mv |
2020-03-26T16:33:11Z |
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2020-03-26T16:33:11Z |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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info:eu-repo/semantics/article |
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Artículo |
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publishedVersion |
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Journal of Neonatal-Perinatal Medicine; Vol. 12, Núm. 1; pp. 47-56 |
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19345798 |
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https://hdl.handle.net/20.500.12585/9192 |
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10.3233/NPM-1795 |
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Universidad Tecnológica de Bolívar |
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Repositorio UTB |
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56461296300 57208213035 57208205059 6504810639 53871077300 57194148507 |
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Journal of Neonatal-Perinatal Medicine; Vol. 12, Núm. 1; pp. 47-56 19345798 10.3233/NPM-1795 Universidad Tecnológica de Bolívar Repositorio UTB 56461296300 57208213035 57208205059 6504810639 53871077300 57194148507 |
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https://hdl.handle.net/20.500.12585/9192 |
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eng |
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eng |
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Recurso electrónico |
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application/pdf |
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IOS Press |
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IOS Press |
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2020-03-26T16:33:11Z2020-03-26T16:33:11Z2019Journal of Neonatal-Perinatal Medicine; Vol. 12, Núm. 1; pp. 47-5619345798https://hdl.handle.net/20.500.12585/919210.3233/NPM-1795Universidad Tecnológica de BolívarRepositorio UTB56461296300572082130355720820505965048106395387107730057194148507INTRODUCTION: The umbilical cord (UC) is a vital structure; its alterations affect the newborn and neurological impact can be permanent. Paradoxically, factors that determine it remain unknown. We explore the differential VEGF protein expression in the UC's proximal and distal portions in relation to the hypothesis that the UC has differential growth and that VEGF plays a role in it. METHODS: An observational analytical study was performed. One UC segment was taken proximal to fetus and another distal; both were randomly processed; VEGF immunohistochemical analysis was performed; two blinded pathologists read results. RESULTS: Forty-eight newborns were included. Protein expression between the two edges of the umbilical cord, in any kind of cells, was interpreted. Endothelium, amnion, and stromal cells expressed VEGF; the first two were not different between opposite ends. Stromal cells had differential expression: higher in the proximal to the fetus portion. CONCLUSION: Knowledge of molecular factors is necessary. UC cells widely expressed VEGF, possibly contributing to UC growth. Even though stromal cell expression was different, the interaction with activity close to the fetus must be explored. © 2019 - IOS Press and the authors. All rights reserved.vasculotropin, 127464-60-2; vasculotropin A, 489395-96-2; Vascular Endothelial Growth Factor A; VEGFA protein, humanRecurso electrónicoapplication/pdfengIOS Presshttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/restrictedAccessAtribución-NoComercial 4.0 Internacionalhttp://purl.org/coar/access_right/c_16echttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85064122819&doi=10.3233%2fNPM-1795&partnerID=40&md5=ebf42be72c3f52fa638593f373ce838fRole of VEGF in the differential growth between the fetal and placental ends of the umbilical cordinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1StillbirthUmbilical cordUmbilical cord lengthVEGFVasculotropinVasculotropin AVEGFA protein, humanAcidosisAmnionArticleClinical articleCongenital heart malformationDiaphragm herniaDisease associationEndotheliumFemaleFetus growthGestational ageHumanHuman cellHypoglycemiaImmunohistochemistryIntrauterine growth retardationMaleMaternal hypertensionNeonatal respiratory distress syndromeNewbornNewborn jaundiceObservational studyPlacentaPlacenta developmentPregnancy diabetes mellitusPremature fetus membrane rupturePriority journalProtein expressionProtein functionStroma cellUmbilical cordUrinary tract infectionCell proliferationControlled studyFetusGene expression regulationGrowth, development and agingMetabolismPhysiologyPregnancyRandomized controlled trialUmbilical cordCell proliferationFemaleFetusGene Expression Regulation, DevelopmentalHumansInfant, NewbornPlacentaPregnancyUmbilical CordVascular Endothelial Growth Factor AOlaya-C M.Michael F.Fabian G.Luis Silva J.Bernal J.E.Garzon A.L.Collins, J.H., Collins, C.L.C.C., (2011) Silent risk: Issues about the human umbilical cordTantbirojn, P., Saleemuddin, A., Sirois, K., Gross abnormalities of the umbilical cord: Related placental histology and clinical significance (2009) Placenta., 30 (12), pp. 1083-1088Saleemuddin, A., Tantbirojn, P., Sirois, K., Obstetric and perinatal complications in placentas with fetal thrombotic vasculopathy (2010) Pediatr Dev Pathol., 13 (6), pp. 459-464Horn, L.-C., Langner, A., Stiehl, P., Wittekind, C., Faber, R., Identification of the causes of intrauterine death during 310 consecutive autopsies (2004) Eur J Obstet Gynecol Reprod Biol., 113 (2), pp. 134-138Redline, R.W., Classification of placental lesions (2015) AmJ Obstet Gynecol, 213 (4), pp. S21-S28Olaya-C, M., Fritsch, M., Bernal, J.E., Immunohistochemical protein expression profiling of growth-and apoptoticrelated factors in relation to umbilical cord length (2015) Early Hum Dev., 91 (5), pp. 291-297Jurasz, P., Yurkova, N., Kirshenbaum, L., Stewart, D.J., VEGF masks BNIP3-mediated apoptosis of hypoxic endothelial cells (2011) Angiogenesis., 14 (2), pp. 199-207Zeisler, H., Llurba, E., Chantraine, F., Predictive value of the sFlt-1: PlGF Ratio in women with suspected preeclampsia (2016) N Engl J Med., 374 (1), pp. 13-22Andraweera, P.H., Dekker, G.A., Roberts, C.T., The vascular endothelial growth factor family in adverse pregnancy outcomes (2012) Hum Reprod Update., 18, pp. 436-457Olaya-C, M., Silva, J.L., Bernal, J.E., Implementation of a simple method to measure total umbilical cord length (2014) J Neonatal Perinatal Med., 7 (4), pp. 269-272Kaplan, C., Normal values for placentas (2007) Color Atlas of Gross Placental Pathology, pp. 119-122. , In: Springer, editor. Color Atlas of Gross Placental Pathology. Second. New YorkProctor, L.K., Fitzgerald, B., Whittle, W.L., Umbilical cord diameter percentile curves and their correlation to birth weight and placental pathology (2013) Placenta., 34, pp. 62-66Olaya-C, M., Salcedo, J., Salazar, A., Silva, J., Bernal, J., Anatomical pathology of the umbilical cord and its maternal and fetal clinical associations in 434 newborns (2018) Pediatr Dev Pathol., p. 58204Redline, R.W., O'Riordan, M.A., Placental lesions associated with cerebral palsy and neurologic impairment following term birth (2000) Arch Pathol Lab Med., 124 (12), pp. 1785-1791Blackburn, W., Umbilical cord (2006) Human Malformation and Related Anomalies, pp. 1413-1495. , Oxford University Press, editor. First. New YorkStefos, T., Sotiriadis, A., Vasilios, D., Umbilical cord length and parity-the Greek experience (2003) Eur J Obstet Gynecol Reprod Biol., 107 (1), pp. 41-44Olaya, M., Bernal, J.E., Umbilical cord abnormalities in fetal and neonatal pathology in Bogota (2014) J Perinat Med., 20 (1), pp. 22-27Olaya-C, M., Bernal, J.E., Clinical associations to abnormal umbilical cord length in Latin American newborns (2015) J Neonatal Perinatal Med., 8 (3), pp. 251-256Olaya-C, M., Salcedo-Betancourt, J., Galvis, S.H., Ortiz, A.M., Gutierrez, S., Bernal, J.E., Umbilical cord and preeclampsia (2016) J Neonatal Perinatal Med., 9 (1), pp. 49-57Sovio, U., Gaccioli, F., Cook, E., Hund, M., Charnock-Jones, D.S., Smith, G.C.S., Prediction of preeclampsia using the soluble fms-like tyrosine kinase 1 to placental growth factor ratio: A Prospective cohort study of unselected nulliparous women (2017) Hypertension., 69 (4), pp. 731-738Sandrim, V.C., Palei, A.C.T., Cavalli, R.C., Vascular endothelial growth factor genotypes and haplotypes are associated with pre-eclampsia but not with gestational hypertension (2009) Mol Hum Reprod, 15 (2), pp. 115-120Wu, K.H., Zhou, B., Lu, S.H., In vitro and in vivo differentiation of human umbilical cord derived stem cells into endothelial cells (2007) J Cell Biochem., 100 (3), pp. 608-616Taki, A., Abe, M., Komaki, M., Expression of angiogenesis-related factors and inflammatory cytokines in placenta and umbilical vessels in pregnancies with preeclampsia and chorioamnionitis/funisitis (2012) Congenit Anom (Kyoto)., 52 (2), pp. 97-103Bader, A.M., Klose, K., Bieback, K., Hypoxic Preconditioning increases survival and pro-angiogenic capacity of human cord blood mesenchymal stromal cells in vitro (2015) PLoS One., 10 (9), p. e0138477http://purl.org/coar/resource_type/c_6501THUMBNAILMiniProdInv.pngMiniProdInv.pngimage/png23941https://repositorio.utb.edu.co/bitstream/20.500.12585/9192/1/MiniProdInv.png0cb0f101a8d16897fb46fc914d3d7043MD5120.500.12585/9192oai:repositorio.utb.edu.co:20.500.12585/91922021-02-02 15:21:04.476Repositorio Institucional UTBrepositorioutb@utb.edu.co |