Efficacies of the original and modified WHO-recommended hand rub formulations
The WHO hand rub formulations have been in use around the world for at least the past ten years. The advent of COVID-19 has further enhanced their use. We reviewed published efficacy data for the original and modified formulations. Only efficacy data according to the European Norms (EN) were found....
- Autores:
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2020
- Institución:
- Universidad de Bogotá Jorge Tadeo Lozano
- Repositorio:
- Expeditio: repositorio UTadeo
- Idioma:
- eng
- OAI Identifier:
- oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12501
- Acceso en línea:
- https://doi.org/10.1016/j.jhin.2020.08.006
http://hdl.handle.net/20.500.12010/12501
- Palabra clave:
- WHO-recommended hand rub
Efficacy
Modified formulation
Glycerol
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
- Rights
- License
- Acceso restringido
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|
dc.title.spa.fl_str_mv |
Efficacies of the original and modified WHO-recommended hand rub formulations |
title |
Efficacies of the original and modified WHO-recommended hand rub formulations |
spellingShingle |
Efficacies of the original and modified WHO-recommended hand rub formulations WHO-recommended hand rub Efficacy Modified formulation Glycerol Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus |
title_short |
Efficacies of the original and modified WHO-recommended hand rub formulations |
title_full |
Efficacies of the original and modified WHO-recommended hand rub formulations |
title_fullStr |
Efficacies of the original and modified WHO-recommended hand rub formulations |
title_full_unstemmed |
Efficacies of the original and modified WHO-recommended hand rub formulations |
title_sort |
Efficacies of the original and modified WHO-recommended hand rub formulations |
dc.subject.spa.fl_str_mv |
WHO-recommended hand rub Efficacy Modified formulation Glycerol |
topic |
WHO-recommended hand rub Efficacy Modified formulation Glycerol Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus |
dc.subject.lemb.spa.fl_str_mv |
Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus |
description |
The WHO hand rub formulations have been in use around the world for at least the past ten years. The advent of COVID-19 has further enhanced their use. We reviewed published efficacy data for the original and modified formulations. Only efficacy data according to the European Norms (EN) were found. The bactericidal efficacy of the original formulations was under practical conditions partly insufficient (EN 1500, only effective in 60 s; EN 12791, efficacy too low in 5 min). The 1st modification with higher alcohol concentrations improves their efficacy as hygienic hand rub (effective in 30 s). The 2nd (0.725% glycerol) and 3rd (0.5% glycerol) modification improves their efficacy for surgical hand preparation (effective in 5 and 3 min). The original and 2nd modified formulations were tested and demonstrate activity against enveloped viruses including SARS-CoV-2 in 30 s. The ethanol-based formulation is also active against some non-enveloped test viruses in 60 s (suspension tests, EN 14476). In vivo data of the formulations would provide a more reliable result on the virucidal efficacy on contaminated hands but are currently not available. Nevertheless, the last modifications should be adopted for use in healthcare. |
publishDate |
2020 |
dc.date.accessioned.none.fl_str_mv |
2020-08-31T20:41:06Z |
dc.date.available.none.fl_str_mv |
2020-08-31T20:41:06Z |
dc.date.created.none.fl_str_mv |
2020 |
dc.type.local.spa.fl_str_mv |
Artículo |
dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
format |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.identifier.issn.spa.fl_str_mv |
0195-6701 |
dc.identifier.other.spa.fl_str_mv |
https://doi.org/10.1016/j.jhin.2020.08.006 |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/20.500.12010/12501 |
dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.1016/j.jhin.2020.08.006 |
identifier_str_mv |
0195-6701 |
url |
https://doi.org/10.1016/j.jhin.2020.08.006 http://hdl.handle.net/20.500.12010/12501 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_f1cf |
dc.rights.local.spa.fl_str_mv |
Acceso restringido |
rights_invalid_str_mv |
Acceso restringido http://purl.org/coar/access_right/c_f1cf |
dc.format.extent.spa.fl_str_mv |
20 páginas |
dc.format.mimetype.spa.fl_str_mv |
image/jepg |
dc.publisher.spa.fl_str_mv |
Journal of Hospital Infection |
dc.source.spa.fl_str_mv |
reponame:Expeditio Repositorio Institucional UJTL instname:Universidad de Bogotá Jorge Tadeo Lozano |
instname_str |
Universidad de Bogotá Jorge Tadeo Lozano |
institution |
Universidad de Bogotá Jorge Tadeo Lozano |
reponame_str |
Expeditio Repositorio Institucional UJTL |
collection |
Expeditio Repositorio Institucional UJTL |
bitstream.url.fl_str_mv |
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2020-08-31T20:41:06Z2020-08-31T20:41:06Z20200195-6701https://doi.org/10.1016/j.jhin.2020.08.006http://hdl.handle.net/20.500.12010/12501https://doi.org/10.1016/j.jhin.2020.08.006The WHO hand rub formulations have been in use around the world for at least the past ten years. The advent of COVID-19 has further enhanced their use. We reviewed published efficacy data for the original and modified formulations. Only efficacy data according to the European Norms (EN) were found. The bactericidal efficacy of the original formulations was under practical conditions partly insufficient (EN 1500, only effective in 60 s; EN 12791, efficacy too low in 5 min). The 1st modification with higher alcohol concentrations improves their efficacy as hygienic hand rub (effective in 30 s). The 2nd (0.725% glycerol) and 3rd (0.5% glycerol) modification improves their efficacy for surgical hand preparation (effective in 5 and 3 min). The original and 2nd modified formulations were tested and demonstrate activity against enveloped viruses including SARS-CoV-2 in 30 s. The ethanol-based formulation is also active against some non-enveloped test viruses in 60 s (suspension tests, EN 14476). In vivo data of the formulations would provide a more reliable result on the virucidal efficacy on contaminated hands but are currently not available. Nevertheless, the last modifications should be adopted for use in healthcare.20 páginasimage/jepgengJournal of Hospital Infectionreponame:Expeditio Repositorio Institucional UJTLinstname:Universidad de Bogotá Jorge Tadeo LozanoWHO-recommended hand rubEfficacyModified formulationGlycerolSíndrome respiratorio agudo graveCOVID-19SARS-CoV-2CoronavirusEfficacies of the original and modified WHO-recommended hand rub formulationsArtículohttp://purl.org/coar/resource_type/c_2df8fbb1Acceso restringidohttp://purl.org/coar/access_right/c_f1cfSuchomel, MirandaSteinmann, JochenKampf, GünterORIGINALCaptura.PNGCaptura.PNGVer portadaimage/png80105https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12501/1/Captura.PNG6786cd1721609a2188dd276770707065MD51open accessEfficacies-of-the-original-and-modified-WHO-recomme_2020_Journal-of-Hospital.pdfEfficacies-of-the-original-and-modified-WHO-recomme_2020_Journal-of-Hospital.pdfArtículo reservadoapplication/pdf540815https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12501/3/Efficacies-of-the-original-and-modified-WHO-recomme_2020_Journal-of-Hospital.pdf5978e75166554b8fcef3a29b3c7c2040MD53embargoed access|||2200-08-31LICENSElicense.txtlicense.txttext/plain; charset=utf-82938https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12501/2/license.txtabceeb1c943c50d3343516f9dbfc110fMD52open accessTHUMBNAILCaptura.PNGCaptura.PNGPortadaimage/png80105https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12501/4/Captura.PNG6786cd1721609a2188dd276770707065MD54open accessEfficacies-of-the-original-and-modified-WHO-recomme_2020_Journal-of-Hospital.pdf.jpgEfficacies-of-the-original-and-modified-WHO-recomme_2020_Journal-of-Hospital.pdf.jpgIM Thumbnailimage/jpeg12254https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12501/5/Efficacies-of-the-original-and-modified-WHO-recomme_2020_Journal-of-Hospital.pdf.jpg5cb56ac868b4f35fcbc5c9618b49bd35MD55open access20.500.12010/12501oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/125012020-08-31 15:41:06.564open accessRepositorio Institucional - Universidad Jorge Tadeo Lozanoexpeditio@utadeo.edu.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 |