Efficacies of the original and modified WHO-recommended hand rub formulations

The WHO hand rub formulations have been in use around the world for at least the past ten years. The advent of COVID-19 has further enhanced their use. We reviewed published efficacy data for the original and modified formulations. Only efficacy data according to the European Norms (EN) were found....

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Autores:
Tipo de recurso:
Article of investigation
Fecha de publicación:
2020
Institución:
Universidad de Bogotá Jorge Tadeo Lozano
Repositorio:
Expeditio: repositorio UTadeo
Idioma:
eng
OAI Identifier:
oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12501
Acceso en línea:
https://doi.org/10.1016/j.jhin.2020.08.006
http://hdl.handle.net/20.500.12010/12501
Palabra clave:
WHO-recommended hand rub
Efficacy
Modified formulation
Glycerol
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
Rights
License
Acceso restringido
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oai_identifier_str oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12501
network_acronym_str UTADEO2
network_name_str Expeditio: repositorio UTadeo
repository_id_str
dc.title.spa.fl_str_mv Efficacies of the original and modified WHO-recommended hand rub formulations
title Efficacies of the original and modified WHO-recommended hand rub formulations
spellingShingle Efficacies of the original and modified WHO-recommended hand rub formulations
WHO-recommended hand rub
Efficacy
Modified formulation
Glycerol
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
title_short Efficacies of the original and modified WHO-recommended hand rub formulations
title_full Efficacies of the original and modified WHO-recommended hand rub formulations
title_fullStr Efficacies of the original and modified WHO-recommended hand rub formulations
title_full_unstemmed Efficacies of the original and modified WHO-recommended hand rub formulations
title_sort Efficacies of the original and modified WHO-recommended hand rub formulations
dc.subject.spa.fl_str_mv WHO-recommended hand rub
Efficacy
Modified formulation
Glycerol
topic WHO-recommended hand rub
Efficacy
Modified formulation
Glycerol
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
dc.subject.lemb.spa.fl_str_mv Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
description The WHO hand rub formulations have been in use around the world for at least the past ten years. The advent of COVID-19 has further enhanced their use. We reviewed published efficacy data for the original and modified formulations. Only efficacy data according to the European Norms (EN) were found. The bactericidal efficacy of the original formulations was under practical conditions partly insufficient (EN 1500, only effective in 60 s; EN 12791, efficacy too low in 5 min). The 1st modification with higher alcohol concentrations improves their efficacy as hygienic hand rub (effective in 30 s). The 2nd (0.725% glycerol) and 3rd (0.5% glycerol) modification improves their efficacy for surgical hand preparation (effective in 5 and 3 min). The original and 2nd modified formulations were tested and demonstrate activity against enveloped viruses including SARS-CoV-2 in 30 s. The ethanol-based formulation is also active against some non-enveloped test viruses in 60 s (suspension tests, EN 14476). In vivo data of the formulations would provide a more reliable result on the virucidal efficacy on contaminated hands but are currently not available. Nevertheless, the last modifications should be adopted for use in healthcare.
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2020-08-31T20:41:06Z
dc.date.available.none.fl_str_mv 2020-08-31T20:41:06Z
dc.date.created.none.fl_str_mv 2020
dc.type.local.spa.fl_str_mv Artículo
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
format http://purl.org/coar/resource_type/c_2df8fbb1
dc.identifier.issn.spa.fl_str_mv 0195-6701
dc.identifier.other.spa.fl_str_mv https://doi.org/10.1016/j.jhin.2020.08.006
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12010/12501
dc.identifier.doi.spa.fl_str_mv https://doi.org/10.1016/j.jhin.2020.08.006
identifier_str_mv 0195-6701
url https://doi.org/10.1016/j.jhin.2020.08.006
http://hdl.handle.net/20.500.12010/12501
dc.language.iso.spa.fl_str_mv eng
language eng
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_f1cf
dc.rights.local.spa.fl_str_mv Acceso restringido
rights_invalid_str_mv Acceso restringido
http://purl.org/coar/access_right/c_f1cf
dc.format.extent.spa.fl_str_mv 20 páginas
dc.format.mimetype.spa.fl_str_mv image/jepg
dc.publisher.spa.fl_str_mv Journal of Hospital Infection
dc.source.spa.fl_str_mv reponame:Expeditio Repositorio Institucional UJTL
instname:Universidad de Bogotá Jorge Tadeo Lozano
instname_str Universidad de Bogotá Jorge Tadeo Lozano
institution Universidad de Bogotá Jorge Tadeo Lozano
reponame_str Expeditio Repositorio Institucional UJTL
collection Expeditio Repositorio Institucional UJTL
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spelling 2020-08-31T20:41:06Z2020-08-31T20:41:06Z20200195-6701https://doi.org/10.1016/j.jhin.2020.08.006http://hdl.handle.net/20.500.12010/12501https://doi.org/10.1016/j.jhin.2020.08.006The WHO hand rub formulations have been in use around the world for at least the past ten years. The advent of COVID-19 has further enhanced their use. We reviewed published efficacy data for the original and modified formulations. Only efficacy data according to the European Norms (EN) were found. The bactericidal efficacy of the original formulations was under practical conditions partly insufficient (EN 1500, only effective in 60 s; EN 12791, efficacy too low in 5 min). The 1st modification with higher alcohol concentrations improves their efficacy as hygienic hand rub (effective in 30 s). The 2nd (0.725% glycerol) and 3rd (0.5% glycerol) modification improves their efficacy for surgical hand preparation (effective in 5 and 3 min). The original and 2nd modified formulations were tested and demonstrate activity against enveloped viruses including SARS-CoV-2 in 30 s. The ethanol-based formulation is also active against some non-enveloped test viruses in 60 s (suspension tests, EN 14476). In vivo data of the formulations would provide a more reliable result on the virucidal efficacy on contaminated hands but are currently not available. Nevertheless, the last modifications should be adopted for use in healthcare.20 páginasimage/jepgengJournal of Hospital Infectionreponame:Expeditio Repositorio Institucional UJTLinstname:Universidad de Bogotá Jorge Tadeo LozanoWHO-recommended hand rubEfficacyModified formulationGlycerolSíndrome respiratorio agudo graveCOVID-19SARS-CoV-2CoronavirusEfficacies of the original and modified WHO-recommended hand rub formulationsArtículohttp://purl.org/coar/resource_type/c_2df8fbb1Acceso restringidohttp://purl.org/coar/access_right/c_f1cfSuchomel, MirandaSteinmann, JochenKampf, GünterORIGINALCaptura.PNGCaptura.PNGVer portadaimage/png80105https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12501/1/Captura.PNG6786cd1721609a2188dd276770707065MD51open accessEfficacies-of-the-original-and-modified-WHO-recomme_2020_Journal-of-Hospital.pdfEfficacies-of-the-original-and-modified-WHO-recomme_2020_Journal-of-Hospital.pdfArtículo reservadoapplication/pdf540815https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12501/3/Efficacies-of-the-original-and-modified-WHO-recomme_2020_Journal-of-Hospital.pdf5978e75166554b8fcef3a29b3c7c2040MD53embargoed access|||2200-08-31LICENSElicense.txtlicense.txttext/plain; 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