Molecularly imprinted polymer based electrochemical biosensors: overcoming the challenges of detecting vital biomarkers and speeding up diagnosis

Electrochemical biosensors for the detection of vital biomarkers is a well-established technology that utilises a transducer and recognition element in tandem to determine the presence of an analyte. There is growing interest in using Molecularly Imprinted Polymers (MIPs) as recognition elements in...

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Autores:
Tipo de recurso:
Article of investigation
Fecha de publicación:
2020
Institución:
Universidad de Bogotá Jorge Tadeo Lozano
Repositorio:
Expeditio: repositorio UTadeo
Idioma:
eng
OAI Identifier:
oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/15308
Acceso en línea:
https://doi.org/10.1016/j.talo.2020.100018
http://hdl.handle.net/20.500.12010/15308
Palabra clave:
Molecularly Imprinted Polymers (MIPs)
Biosensors
Biomarkers
Sepsis
Cardiovascular Disease
Acute Myocardial Infarction
Cancer
Electrochemistry
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
Rights
License
Abierto (Texto Completo)
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network_acronym_str UTADEO2
network_name_str Expeditio: repositorio UTadeo
repository_id_str
dc.title.spa.fl_str_mv Molecularly imprinted polymer based electrochemical biosensors: overcoming the challenges of detecting vital biomarkers and speeding up diagnosis
title Molecularly imprinted polymer based electrochemical biosensors: overcoming the challenges of detecting vital biomarkers and speeding up diagnosis
spellingShingle Molecularly imprinted polymer based electrochemical biosensors: overcoming the challenges of detecting vital biomarkers and speeding up diagnosis
Molecularly Imprinted Polymers (MIPs)
Biosensors
Biomarkers
Sepsis
Cardiovascular Disease
Acute Myocardial Infarction
Cancer
Electrochemistry
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
title_short Molecularly imprinted polymer based electrochemical biosensors: overcoming the challenges of detecting vital biomarkers and speeding up diagnosis
title_full Molecularly imprinted polymer based electrochemical biosensors: overcoming the challenges of detecting vital biomarkers and speeding up diagnosis
title_fullStr Molecularly imprinted polymer based electrochemical biosensors: overcoming the challenges of detecting vital biomarkers and speeding up diagnosis
title_full_unstemmed Molecularly imprinted polymer based electrochemical biosensors: overcoming the challenges of detecting vital biomarkers and speeding up diagnosis
title_sort Molecularly imprinted polymer based electrochemical biosensors: overcoming the challenges of detecting vital biomarkers and speeding up diagnosis
dc.subject.spa.fl_str_mv Molecularly Imprinted Polymers (MIPs)
Biosensors
Biomarkers
Sepsis
Cardiovascular Disease
Acute Myocardial Infarction
Cancer
Electrochemistry
topic Molecularly Imprinted Polymers (MIPs)
Biosensors
Biomarkers
Sepsis
Cardiovascular Disease
Acute Myocardial Infarction
Cancer
Electrochemistry
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
dc.subject.lemb.spa.fl_str_mv Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
description Electrochemical biosensors for the detection of vital biomarkers is a well-established technology that utilises a transducer and recognition element in tandem to determine the presence of an analyte. There is growing interest in using Molecularly Imprinted Polymers (MIPs) as recognition elements in a wide range of sensing devices due to their economic viability and scalability. The inherent properties of polymer platforms, alongside the vast array of monomeric options, synthetic routes and incorporation strategies allow for the production of a multitude of sensitive and selective recognition elements that have significant advantages over classically utilised biological entities. MIPs exhibit superior chemical and thermal stability offering a wider variety of immobilization/incorporation strategies, virtually unlimited ambient shelf-life and a longer product lifetime, whilst the vast array of monomers available offer flexibility to their synthesis. Even though some sensor platforms have been reported for the detection of vital biomarkers, the use of MIPs has a number of challenges and drawbacks that need to be overcome in order to produce sensing platforms with the required sensitivity and specificity for clinical use. In this review, we will provide an overview of the reasoning behind using MIPs as recognition elements in electrochemical biosensors for vital biomarkers, discuss the problems synergizing MIPs and electrochemical read-out strategies and offer insights into the future perspectives of this promising and innovative technology.
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2020-11-04T15:28:56Z
dc.date.available.none.fl_str_mv 2020-11-04T15:28:56Z
dc.date.created.none.fl_str_mv 2020
dc.type.local.spa.fl_str_mv Artículo
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format http://purl.org/coar/resource_type/c_2df8fbb1
dc.identifier.issn.spa.fl_str_mv 2666-8319(
dc.identifier.other.spa.fl_str_mv https://doi.org/10.1016/j.talo.2020.100018
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12010/15308
dc.identifier.doi.spa.fl_str_mv https://doi.org/10.1016/j.talo.2020.100018
identifier_str_mv 2666-8319(
url https://doi.org/10.1016/j.talo.2020.100018
http://hdl.handle.net/20.500.12010/15308
dc.language.iso.spa.fl_str_mv eng
language eng
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.local.spa.fl_str_mv Abierto (Texto Completo)
rights_invalid_str_mv Abierto (Texto Completo)
http://purl.org/coar/access_right/c_abf2
dc.format.extent.spa.fl_str_mv 34 páginas
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dc.publisher.spa.fl_str_mv Talanta Open
dc.source.spa.fl_str_mv reponame:Expeditio Repositorio Institucional UJTL
instname:Universidad de Bogotá Jorge Tadeo Lozano
instname_str Universidad de Bogotá Jorge Tadeo Lozano
institution Universidad de Bogotá Jorge Tadeo Lozano
reponame_str Expeditio Repositorio Institucional UJTL
collection Expeditio Repositorio Institucional UJTL
bitstream.url.fl_str_mv https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/15308/2/license.txt
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spelling 2020-11-04T15:28:56Z2020-11-04T15:28:56Z20202666-8319(https://doi.org/10.1016/j.talo.2020.100018http://hdl.handle.net/20.500.12010/15308https://doi.org/10.1016/j.talo.2020.100018Electrochemical biosensors for the detection of vital biomarkers is a well-established technology that utilises a transducer and recognition element in tandem to determine the presence of an analyte. There is growing interest in using Molecularly Imprinted Polymers (MIPs) as recognition elements in a wide range of sensing devices due to their economic viability and scalability. The inherent properties of polymer platforms, alongside the vast array of monomeric options, synthetic routes and incorporation strategies allow for the production of a multitude of sensitive and selective recognition elements that have significant advantages over classically utilised biological entities. MIPs exhibit superior chemical and thermal stability offering a wider variety of immobilization/incorporation strategies, virtually unlimited ambient shelf-life and a longer product lifetime, whilst the vast array of monomers available offer flexibility to their synthesis. Even though some sensor platforms have been reported for the detection of vital biomarkers, the use of MIPs has a number of challenges and drawbacks that need to be overcome in order to produce sensing platforms with the required sensitivity and specificity for clinical use. In this review, we will provide an overview of the reasoning behind using MIPs as recognition elements in electrochemical biosensors for vital biomarkers, discuss the problems synergizing MIPs and electrochemical read-out strategies and offer insights into the future perspectives of this promising and innovative technology.34 páginasapplication/pdfengTalanta Openreponame:Expeditio Repositorio Institucional UJTLinstname:Universidad de Bogotá Jorge Tadeo LozanoMolecularly Imprinted Polymers (MIPs)BiosensorsBiomarkersSepsisCardiovascular DiseaseAcute Myocardial InfarctionCancerElectrochemistrySíndrome respiratorio agudo graveCOVID-19SARS-CoV-2CoronavirusMolecularly imprinted polymer based electrochemical biosensors: overcoming the challenges of detecting vital biomarkers and speeding up diagnosisArtículohttp://purl.org/coar/resource_type/c_2df8fbb1Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2Crapnell, Robert D.Dempsey-Hibbert, Nina C.Peeters, MarloesTridente, AscanioBanks, Craig E.LICENSElicense.txtlicense.txttext/plain; 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