Admission high-sensitivity cardiac troponin versus a biochemical score for predicting mortality in patients with COVID-19
Emerging evidence indicates a role for cardiac troponin testing, specifically high-sensitivity cardiac troponin (hs-cTn) in hospitalized patients with COVID-19(1). Undetectable levels of hscTn in patients with (and without) COVID-19 may be helpful in identifying a low-risk subgroup, with higher leve...
- Autores:
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2020
- Institución:
- Universidad de Bogotá Jorge Tadeo Lozano
- Repositorio:
- Expeditio: repositorio UTadeo
- Idioma:
- eng
- OAI Identifier:
- oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/14596
- Acceso en línea:
- https://doi.org/10.1016/j.cjco.2020.10.008
http://hdl.handle.net/20.500.12010/14596
- Palabra clave:
- Predicting mortality
COVID-19
High-sensitivity cardiac troponin
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
- Rights
- License
- Abierto (Texto Completo)
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oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/14596 |
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dc.title.spa.fl_str_mv |
Admission high-sensitivity cardiac troponin versus a biochemical score for predicting mortality in patients with COVID-19 |
title |
Admission high-sensitivity cardiac troponin versus a biochemical score for predicting mortality in patients with COVID-19 |
spellingShingle |
Admission high-sensitivity cardiac troponin versus a biochemical score for predicting mortality in patients with COVID-19 Predicting mortality COVID-19 High-sensitivity cardiac troponin Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus |
title_short |
Admission high-sensitivity cardiac troponin versus a biochemical score for predicting mortality in patients with COVID-19 |
title_full |
Admission high-sensitivity cardiac troponin versus a biochemical score for predicting mortality in patients with COVID-19 |
title_fullStr |
Admission high-sensitivity cardiac troponin versus a biochemical score for predicting mortality in patients with COVID-19 |
title_full_unstemmed |
Admission high-sensitivity cardiac troponin versus a biochemical score for predicting mortality in patients with COVID-19 |
title_sort |
Admission high-sensitivity cardiac troponin versus a biochemical score for predicting mortality in patients with COVID-19 |
dc.subject.spa.fl_str_mv |
Predicting mortality COVID-19 High-sensitivity cardiac troponin |
topic |
Predicting mortality COVID-19 High-sensitivity cardiac troponin Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus |
dc.subject.lemb.spa.fl_str_mv |
Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus |
description |
Emerging evidence indicates a role for cardiac troponin testing, specifically high-sensitivity cardiac troponin (hs-cTn) in hospitalized patients with COVID-19(1). Undetectable levels of hscTn in patients with (and without) COVID-19 may be helpful in identifying a low-risk subgroup, with higher levels useful in identifying patients at high-risk for hospital death(1,2). Further improvements in risk-stratification for emergency department or hospitalized patients may be achieved by adding clinical chemistry tests, such as glucose and creatinine [i.e., estimated glomerular filtration rate (eGFR)] to generate a clinical chemistry score (CCS)(2,3). For patients with COVID-19, additional biochemical tests may have important prognostic roles such as urea which is already a component of the CURB-65 score (confusion, urea, respiratory rate, blood pressure, age ≥65y) used to risk stratify patients presenting to hospital with pneumonia(4). We performed a retrospective chart review of COVID-19 patients admitted to hospitals in the city of Hamilton in order to explore the performance characteristics of hs-cTn levels, the CCS and the CCS with urea (CCUS) to predict in-hospital death. This review included the first 26-weeks of this pandemic (ethics-approval:#11425-C). |
publishDate |
2020 |
dc.date.accessioned.none.fl_str_mv |
2020-10-19T20:34:41Z |
dc.date.available.none.fl_str_mv |
2020-10-19T20:34:41Z |
dc.date.created.none.fl_str_mv |
2020 |
dc.type.local.spa.fl_str_mv |
Artículo |
dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
format |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.identifier.issn.spa.fl_str_mv |
2589-790X |
dc.identifier.other.spa.fl_str_mv |
https://doi.org/10.1016/j.cjco.2020.10.008 |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/20.500.12010/14596 |
dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.1016/j.cjco.2020.10.008 |
identifier_str_mv |
2589-790X |
url |
https://doi.org/10.1016/j.cjco.2020.10.008 http://hdl.handle.net/20.500.12010/14596 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.local.spa.fl_str_mv |
Abierto (Texto Completo) |
rights_invalid_str_mv |
Abierto (Texto Completo) http://purl.org/coar/access_right/c_abf2 |
dc.format.extent.spa.fl_str_mv |
7 páginas |
dc.format.mimetype.spa.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
CJC Open |
dc.source.spa.fl_str_mv |
reponame:Expeditio Repositorio Institucional UJTL instname:Universidad de Bogotá Jorge Tadeo Lozano |
instname_str |
Universidad de Bogotá Jorge Tadeo Lozano |
institution |
Universidad de Bogotá Jorge Tadeo Lozano |
reponame_str |
Expeditio Repositorio Institucional UJTL |
collection |
Expeditio Repositorio Institucional UJTL |
bitstream.url.fl_str_mv |
https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/14596/3/Admission-high-sensitivity-cardiac-troponin-versus-a-biochemical-s_2020_CJC-.pdf.jpg https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/14596/2/license.txt |
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bitstream.checksumAlgorithm.fl_str_mv |
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repository.name.fl_str_mv |
Repositorio Institucional - Universidad Jorge Tadeo Lozano |
repository.mail.fl_str_mv |
expeditio@utadeo.edu.co |
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1814213495530455040 |
spelling |
2020-10-19T20:34:41Z2020-10-19T20:34:41Z20202589-790Xhttps://doi.org/10.1016/j.cjco.2020.10.008http://hdl.handle.net/20.500.12010/14596https://doi.org/10.1016/j.cjco.2020.10.008Emerging evidence indicates a role for cardiac troponin testing, specifically high-sensitivity cardiac troponin (hs-cTn) in hospitalized patients with COVID-19(1). Undetectable levels of hscTn in patients with (and without) COVID-19 may be helpful in identifying a low-risk subgroup, with higher levels useful in identifying patients at high-risk for hospital death(1,2). Further improvements in risk-stratification for emergency department or hospitalized patients may be achieved by adding clinical chemistry tests, such as glucose and creatinine [i.e., estimated glomerular filtration rate (eGFR)] to generate a clinical chemistry score (CCS)(2,3). For patients with COVID-19, additional biochemical tests may have important prognostic roles such as urea which is already a component of the CURB-65 score (confusion, urea, respiratory rate, blood pressure, age ≥65y) used to risk stratify patients presenting to hospital with pneumonia(4). We performed a retrospective chart review of COVID-19 patients admitted to hospitals in the city of Hamilton in order to explore the performance characteristics of hs-cTn levels, the CCS and the CCS with urea (CCUS) to predict in-hospital death. This review included the first 26-weeks of this pandemic (ethics-approval:#11425-C).7 páginasapplication/pdfengCJC Openreponame:Expeditio Repositorio Institucional UJTLinstname:Universidad de Bogotá Jorge Tadeo LozanoPredicting mortalityCOVID-19High-sensitivity cardiac troponinSíndrome respiratorio agudo graveCOVID-19SARS-CoV-2CoronavirusAdmission high-sensitivity cardiac troponin versus a biochemical score for predicting mortality in patients with COVID-19Artículohttp://purl.org/coar/resource_type/c_2df8fbb1Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2Kavsak, Peter A.Mondoux, Shawn E.Wit, Kerstin deRochwerg, BramMain, CherylYamamura, DeborahParé, GuillaumeMa, JinhuiPerri, DanSherbino, JonathanWorster, AndrewTHUMBNAILAdmission-high-sensitivity-cardiac-troponin-versus-a-biochemical-s_2020_CJC-.pdf.jpgAdmission-high-sensitivity-cardiac-troponin-versus-a-biochemical-s_2020_CJC-.pdf.jpgIM Thumbnailimage/jpeg10869https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/14596/3/Admission-high-sensitivity-cardiac-troponin-versus-a-biochemical-s_2020_CJC-.pdf.jpgcc3156744062e0e00e137ef795bb02cdMD53open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-82938https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/14596/2/license.txtabceeb1c943c50d3343516f9dbfc110fMD52open access20.500.12010/14596oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/145962021-03-12 18:27:46.866metadata only accessRepositorio Institucional - Universidad Jorge Tadeo Lozanoexpeditio@utadeo.edu.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 |