Single Cell Analysis in Biotechnology and Systems Biology

Cells are the most fundamental building blocks of most life forms and play a significant role in coordinating with each other to perform systematic functions in all living creatures. However, the behavior of cell to cell, or cell to the environment with their organelles and their intracellular physical and biological functions remains unknown. To better understand the physiological interactions among molecules, organelles, and cells ensemble average measurement of millions of cells together, cannot provide detailed information such as stem cell proliferation, differentiation, neural network coordination, and cardiomyocytes synchronization. Again, biological functions such as genomes, epigenomes and transcriptomes as a bulk population is informative, however it is not enough to understand the cellular heterogeneity characteristics in phenotypic behavior assays and dynamics of individual cells. Thus, single cells analysis (SCA) has evolved in frontier research.

• Tipo de recurso: Book
• Fecha de publicación: 2020
• Institución: Universidad de Bogotá Jorge Tadeo Lozano
• Repositorio: Expeditio: repositorio UTadeo
• Idioma: eng
• OAI Identifier: oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/14284
• Acceso en línea: https://www.mdpi.com/books/pdfview/book/197; http://hdl.handle.net/20.500.12010/14284; https://doi.org/10.3390/books978-3-03842-194-8
• Palabra clave: single cell heterogeneity; Micro/nano fluidic single cell analysis; Single cell cytometry; Microinjection; Optoporation; Metabolomics and fluxomics; Single cell in system biology; Single cell cultivation; Single cell manipulation; Single cell electroporation; Thermoporation and magnetoporation; Proteomics; Single cell diagnostic and imaging; Cellular complexity; Single cell perturbation; Separation; Detection; Single cell genomics
• License: Abierto (Texto Completo)