A roadmap to engineering antiviral natural products synthesis in microbes
Natural products continue to be the inspirations for us to discover and acquire new drugs. The seemingly unstoppable viruses have kept records high to threaten human health and well-being. The diversity and complexity of natural products (NPs) offer remarkable efficacy and specificity to target vira...
- Autores:
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2020
- Institución:
- Universidad de Bogotá Jorge Tadeo Lozano
- Repositorio:
- Expeditio: repositorio UTadeo
- Idioma:
- eng
- OAI Identifier:
- oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12259
- Acceso en línea:
- https://doi.org/10.1016/j.copbio.2020.07.008
http://hdl.handle.net/20.500.12010/12259
- Palabra clave:
- Engineering antiviral
Natural products
Microbes
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
- Rights
- License
- Abierto (Texto Completo)
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| dc.title.spa.fl_str_mv |
A roadmap to engineering antiviral natural products synthesis in microbes |
| title |
A roadmap to engineering antiviral natural products synthesis in microbes |
| spellingShingle |
A roadmap to engineering antiviral natural products synthesis in microbes Engineering antiviral Natural products Microbes Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus |
| title_short |
A roadmap to engineering antiviral natural products synthesis in microbes |
| title_full |
A roadmap to engineering antiviral natural products synthesis in microbes |
| title_fullStr |
A roadmap to engineering antiviral natural products synthesis in microbes |
| title_full_unstemmed |
A roadmap to engineering antiviral natural products synthesis in microbes |
| title_sort |
A roadmap to engineering antiviral natural products synthesis in microbes |
| dc.subject.spa.fl_str_mv |
Engineering antiviral Natural products Microbes |
| topic |
Engineering antiviral Natural products Microbes Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus |
| dc.subject.lemb.spa.fl_str_mv |
Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus |
| description |
Natural products continue to be the inspirations for us to discover and acquire new drugs. The seemingly unstoppable viruses have kept records high to threaten human health and well-being. The diversity and complexity of natural products (NPs) offer remarkable efficacy and specificity to target viral infection steps and serve as excellent source for antiviral agents. The discovery and production of antiviral NPs remain challenging due to low abundance in their native hosts. Reconstruction of NP biosynthetic pathways in microbes is a promising solution to overcome this limitation. In this review, we surveyed 23 most prominent NPs (from more than 200 antiviral NP candidates) with distinct antiviral mode of actions and summarized the recent metabolic engineering effort to produce these compounds in various microbial hosts. We envision that the scalable and low-cost production of novel antiviral NPs, enabled by metabolic engineering, may light the hope to control and eradicate the deadliest viruses that plague our society and humanity. |
| publishDate |
2020 |
| dc.date.accessioned.none.fl_str_mv |
2020-08-25T20:45:54Z |
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2020-08-25T20:45:54Z |
| dc.date.created.none.fl_str_mv |
2020 |
| dc.type.local.spa.fl_str_mv |
Artículo |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.identifier.issn.spa.fl_str_mv |
0958-1669 |
| dc.identifier.other.spa.fl_str_mv |
https://doi.org/10.1016/j.copbio.2020.07.008 |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/20.500.12010/12259 |
| dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.1016/j.copbio.2020.07.008 |
| identifier_str_mv |
0958-1669 |
| url |
https://doi.org/10.1016/j.copbio.2020.07.008 http://hdl.handle.net/20.500.12010/12259 |
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eng |
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eng |
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http://purl.org/coar/access_right/c_abf2 |
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Abierto (Texto Completo) |
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Abierto (Texto Completo) http://purl.org/coar/access_right/c_abf2 |
| dc.format.extent.spa.fl_str_mv |
10 páginas |
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application/pdf |
| dc.publisher.spa.fl_str_mv |
Current Opinion in Biotechnology |
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reponame:Expeditio Repositorio Institucional UJTL instname:Universidad de Bogotá Jorge Tadeo Lozano |
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Expeditio Repositorio Institucional UJTL |
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2020-08-25T20:45:54Z2020-08-25T20:45:54Z20200958-1669https://doi.org/10.1016/j.copbio.2020.07.008http://hdl.handle.net/20.500.12010/12259https://doi.org/10.1016/j.copbio.2020.07.008Natural products continue to be the inspirations for us to discover and acquire new drugs. The seemingly unstoppable viruses have kept records high to threaten human health and well-being. The diversity and complexity of natural products (NPs) offer remarkable efficacy and specificity to target viral infection steps and serve as excellent source for antiviral agents. The discovery and production of antiviral NPs remain challenging due to low abundance in their native hosts. Reconstruction of NP biosynthetic pathways in microbes is a promising solution to overcome this limitation. In this review, we surveyed 23 most prominent NPs (from more than 200 antiviral NP candidates) with distinct antiviral mode of actions and summarized the recent metabolic engineering effort to produce these compounds in various microbial hosts. We envision that the scalable and low-cost production of novel antiviral NPs, enabled by metabolic engineering, may light the hope to control and eradicate the deadliest viruses that plague our society and humanity.10 páginasapplication/pdfengCurrent Opinion in Biotechnologyreponame:Expeditio Repositorio Institucional UJTLinstname:Universidad de Bogotá Jorge Tadeo LozanoEngineering antiviralNatural productsMicrobesSíndrome respiratorio agudo graveCOVID-19SARS-CoV-2CoronavirusA roadmap to engineering antiviral natural products synthesis in microbesArtículohttp://purl.org/coar/resource_type/c_2df8fbb1Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2Ma, JingboGu, YangXu, PengORIGINAL1-s2.0-S0958166920300963-main.pdf1-s2.0-S0958166920300963-main.pdfVer artículoapplication/pdf1851323https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12259/1/1-s2.0-S0958166920300963-main.pdf653ba6cabb7c5b7a272c116f8211c7b9MD51open accessTHUMBNAIL1-s2.0-S0958166920300963-main.pdf.jpg1-s2.0-S0958166920300963-main.pdf.jpgIM Thumbnailimage/jpeg27034https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12259/3/1-s2.0-S0958166920300963-main.pdf.jpg21d6212a5671eec97f6916b91c8dc252MD53open accessLICENSElicense.txtlicense.txttext/plain; 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