Clinical characteristics and risk assessment of newborns born to mothers with COVID-19

Background Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is causing an outbreak of pneumonia in Wuhan, Hubei Province, China, and other international areas. Objective Here, we report the clinical characteristics of the newborns delivered by SARS-CoV-2 infected pregnant women. Methods We prospectively collected and analyzed the clinical features, laboratory data and outcomes of 7 newborns delivered by SARS-CoV-2 infected pregnant women in Zhongnan Hospital of Wuhan University during January 20 to January 29, 2020. Results 4 of the 7 newborns were late preterm with gestational age between 36 weeks and 37 weeks, and the other 3 were full-term infants. The average birth weight was 2096 ± 660 g. All newborns were born without asphyxia. 2 premature infants performed mild grunting after birth, but relieved rapidly with non-invasive continuous positive airway pressure (nCPAP) ventilation. 3 cases had chest X-ray, 1 was normal and 2 who were supported by nCPAP presented mild neonatal respiratory distress syndrome (NRDS). Samples of pharyngeal swab in 6 cases, amniotic fluid and umbilical cord blood in 4 cases were tested by qRT-PCR, and there was no positive result of SARS-CoV-2 nucleic acid in all cases. Conclusions The current data show that the infection of SARS-CoV-2 in late pregnant women does not cause adverse outcomes in their newborns, however, it is necessary to separate newborns from mothers immediately to avoid the potential threats.

• Tipo de recurso: Article of journal
• Fecha de publicación: 2020
• Institución: Universidad de Bogotá Jorge Tadeo Lozano
• Repositorio: Expeditio: repositorio UTadeo
• Idioma: eng
• OAI Identifier: oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12267
• Acceso en línea: https://www.sciencedirect.com/science/article/pii/S1386653220300986?via%3Dihub; http://hdl.handle.net/20.500.12010/12267; https://doi.org/10.1016/j.jcv.2020.104356
• Palabra clave: Mujeres embarazadas; Síndrome respiratorio agudo grave; COVID-19; SARS-CoV-2; Coronavirus; Pregnant woman; Newborn; Clinical features; Mother-to-child vertical transmission
• License: Acceso restringido