Targeting stress granules: A novel therapeutic strategy for human diseases
Stress granules (SGs) are assemblies of mRNA and proteins that form from mRNAs stalled in translation initiation in response to stress. Chronic stress might even induce formation of cytotoxic pathological SGs. SGs participate in various biological functions including response to apoptosis, inflammat...
- Autores:
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2020
- Institución:
- Universidad de Bogotá Jorge Tadeo Lozano
- Repositorio:
- Expeditio: repositorio UTadeo
- Idioma:
- eng
- OAI Identifier:
- oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12464
- Acceso en línea:
- https://doi.org/10.1016/j.phrs.2020.105143
http://hdl.handle.net/20.500.12010/12464
- Palabra clave:
- Herapeutic strategy
Human diseases
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
- Rights
- License
- Acceso restringido
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oai_identifier_str |
oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12464 |
network_acronym_str |
UTADEO2 |
network_name_str |
Expeditio: repositorio UTadeo |
repository_id_str |
|
dc.title.spa.fl_str_mv |
Targeting stress granules: A novel therapeutic strategy for human diseases |
title |
Targeting stress granules: A novel therapeutic strategy for human diseases |
spellingShingle |
Targeting stress granules: A novel therapeutic strategy for human diseases Herapeutic strategy Human diseases Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus |
title_short |
Targeting stress granules: A novel therapeutic strategy for human diseases |
title_full |
Targeting stress granules: A novel therapeutic strategy for human diseases |
title_fullStr |
Targeting stress granules: A novel therapeutic strategy for human diseases |
title_full_unstemmed |
Targeting stress granules: A novel therapeutic strategy for human diseases |
title_sort |
Targeting stress granules: A novel therapeutic strategy for human diseases |
dc.subject.spa.fl_str_mv |
Herapeutic strategy Human diseases |
topic |
Herapeutic strategy Human diseases Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus |
dc.subject.lemb.spa.fl_str_mv |
Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus |
description |
Stress granules (SGs) are assemblies of mRNA and proteins that form from mRNAs stalled in translation initiation in response to stress. Chronic stress might even induce formation of cytotoxic pathological SGs. SGs participate in various biological functions including response to apoptosis, inflammation, immune modulation, and signalling pathways; moreover, SGs are involved in pathogenesis of neurodegenerative diseases, viral infection, aging, cancers and many other diseases. Emerging evidence has shown that small molecules can affect SG dynamics, including assembly, disassembly, maintenance and clearance. Thus, targeting SGs is a potential therapeutic strategy for the treatment of human diseases and the promotion of health. The established methods for detecting SGs provided ready tools for largescale screening of agents that alter the dynamics of SGs. Here, we describe the effects of small molecules on SG assembly, disassembly, and their roles in the disease. Moreover, we provide perspective for the possible application of small molecules targeting SGs in the treatment of human diseases. |
publishDate |
2020 |
dc.date.accessioned.none.fl_str_mv |
2020-08-31T16:15:06Z |
dc.date.available.none.fl_str_mv |
2020-08-31T16:15:06Z |
dc.date.created.none.fl_str_mv |
2020 |
dc.type.local.spa.fl_str_mv |
Artículo |
dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
format |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.identifier.issn.spa.fl_str_mv |
1043-6618 |
dc.identifier.other.spa.fl_str_mv |
https://doi.org/10.1016/j.phrs.2020.105143 |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/20.500.12010/12464 |
dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.1016/j.phrs.2020.105143 |
identifier_str_mv |
1043-6618 |
url |
https://doi.org/10.1016/j.phrs.2020.105143 http://hdl.handle.net/20.500.12010/12464 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_f1cf |
dc.rights.local.spa.fl_str_mv |
Acceso restringido |
rights_invalid_str_mv |
Acceso restringido http://purl.org/coar/access_right/c_f1cf |
dc.format.extent.spa.fl_str_mv |
47 páginas |
dc.format.mimetype.spa.fl_str_mv |
image/jepg |
dc.publisher.spa.fl_str_mv |
Pharmacological Research |
dc.source.spa.fl_str_mv |
reponame:Expeditio Repositorio Institucional UJTL instname:Universidad de Bogotá Jorge Tadeo Lozano |
instname_str |
Universidad de Bogotá Jorge Tadeo Lozano |
institution |
Universidad de Bogotá Jorge Tadeo Lozano |
reponame_str |
Expeditio Repositorio Institucional UJTL |
collection |
Expeditio Repositorio Institucional UJTL |
bitstream.url.fl_str_mv |
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bitstream.checksum.fl_str_mv |
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bitstream.checksumAlgorithm.fl_str_mv |
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repository.name.fl_str_mv |
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repository.mail.fl_str_mv |
expeditio@utadeo.edu.co |
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1808495318600253440 |
spelling |
2020-08-31T16:15:06Z2020-08-31T16:15:06Z20201043-6618https://doi.org/10.1016/j.phrs.2020.105143http://hdl.handle.net/20.500.12010/12464https://doi.org/10.1016/j.phrs.2020.105143Stress granules (SGs) are assemblies of mRNA and proteins that form from mRNAs stalled in translation initiation in response to stress. Chronic stress might even induce formation of cytotoxic pathological SGs. SGs participate in various biological functions including response to apoptosis, inflammation, immune modulation, and signalling pathways; moreover, SGs are involved in pathogenesis of neurodegenerative diseases, viral infection, aging, cancers and many other diseases. Emerging evidence has shown that small molecules can affect SG dynamics, including assembly, disassembly, maintenance and clearance. Thus, targeting SGs is a potential therapeutic strategy for the treatment of human diseases and the promotion of health. The established methods for detecting SGs provided ready tools for largescale screening of agents that alter the dynamics of SGs. Here, we describe the effects of small molecules on SG assembly, disassembly, and their roles in the disease. Moreover, we provide perspective for the possible application of small molecules targeting SGs in the treatment of human diseases.47 páginasimage/jepgengPharmacological Researchreponame:Expeditio Repositorio Institucional UJTLinstname:Universidad de Bogotá Jorge Tadeo LozanoHerapeutic strategyHuman diseasesSíndrome respiratorio agudo graveCOVID-19SARS-CoV-2CoronavirusTargeting stress granules: A novel therapeutic strategy for human diseasesArtículohttp://purl.org/coar/resource_type/c_2df8fbb1Acceso restringidohttp://purl.org/coar/access_right/c_f1cfF, WangJ, LiS, FanZ, JinC, HuangORIGINALCaptura.PNGCaptura.PNGVer portadaimage/png93046https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12464/1/Captura.PNG9ce91f65b4b504b4c5e65ba04b5d1190MD51open accessTargeting-stress-granules--A-novel-therapeutic-strate_2020_Pharmacological-R.pdfTargeting-stress-granules--A-novel-therapeutic-strate_2020_Pharmacological-R.pdfArtículo reservadoapplication/pdf5009107https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12464/3/Targeting-stress-granules--A-novel-therapeutic-strate_2020_Pharmacological-R.pdfbccac8f3362df0be35f52644b158b2f9MD53embargoed access|||2200-08-31THUMBNAILCaptura.PNGCaptura.PNGPortadaimage/png93988https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12464/4/Captura.PNG771fda2f7af27c78dd20a9042d5686b7MD54open accessTargeting-stress-granules--A-novel-therapeutic-strate_2020_Pharmacological-R.pdf.jpgTargeting-stress-granules--A-novel-therapeutic-strate_2020_Pharmacological-R.pdf.jpgIM Thumbnailimage/jpeg6444https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12464/5/Targeting-stress-granules--A-novel-therapeutic-strate_2020_Pharmacological-R.pdf.jpgfc09867ced3304d272a4a22381d24741MD55open accessLICENSElicense.txtlicense.txttext/plain; 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