Azithromycin: The first broad-spectrum therapeutic
The Strategic Plan for Biodefense Research by the U.S. Department of Health and Human Services demarcates the need for drugs which target multiple types of pathogens to prepare for infectious threats. Azithromycin is one such broad-spectrum therapeutic that is both included in the University of Oxfo...
- Autores:
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2020
- Institución:
- Universidad de Bogotá Jorge Tadeo Lozano
- Repositorio:
- Expeditio: repositorio UTadeo
- Idioma:
- eng
- OAI Identifier:
- oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12404
- Acceso en línea:
- https://doi.org/10.1016/j.ejmech.2020.112739
http://hdl.handle.net/20.500.12010/12404
- Palabra clave:
- Azithromycin
Broad-spectrum
COVID-19
Pneumonia
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
- Rights
- License
- Acceso restringido
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repository_id_str |
|
dc.title.spa.fl_str_mv |
Azithromycin: The first broad-spectrum therapeutic |
title |
Azithromycin: The first broad-spectrum therapeutic |
spellingShingle |
Azithromycin: The first broad-spectrum therapeutic Azithromycin Broad-spectrum COVID-19 Pneumonia Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus |
title_short |
Azithromycin: The first broad-spectrum therapeutic |
title_full |
Azithromycin: The first broad-spectrum therapeutic |
title_fullStr |
Azithromycin: The first broad-spectrum therapeutic |
title_full_unstemmed |
Azithromycin: The first broad-spectrum therapeutic |
title_sort |
Azithromycin: The first broad-spectrum therapeutic |
dc.subject.spa.fl_str_mv |
Azithromycin Broad-spectrum COVID-19 Pneumonia |
topic |
Azithromycin Broad-spectrum COVID-19 Pneumonia Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus |
dc.subject.lemb.spa.fl_str_mv |
Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus |
description |
The Strategic Plan for Biodefense Research by the U.S. Department of Health and Human Services demarcates the need for drugs which target multiple types of pathogens to prepare for infectious threats. Azithromycin is one such broad-spectrum therapeutic that is both included in the University of Oxford’s RECOVERY and excluded from the World Health Organization’s SOLIDARITY trials. Here we review azithromycin’s broad antibiotic, antimalarial, antiviral pharmacology and contextualise it against a broader history as the most repositioned therapeutic of the macrolide class; we further evaluate azithromycin’s clinical and socio-economic propriety for respiratory pandemics and delineate a model for its combinatorial mechanism of action against COVID-19 pneumonia. |
publishDate |
2020 |
dc.date.accessioned.none.fl_str_mv |
2020-08-28T14:26:03Z |
dc.date.available.none.fl_str_mv |
2020-08-28T14:26:03Z |
dc.date.created.none.fl_str_mv |
2020 |
dc.type.local.spa.fl_str_mv |
Artículo |
dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
format |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.identifier.issn.spa.fl_str_mv |
0223-5234 |
dc.identifier.other.spa.fl_str_mv |
https://doi.org/10.1016/j.ejmech.2020.112739 |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/20.500.12010/12404 |
dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.1016/j.ejmech.2020.112739 |
identifier_str_mv |
0223-5234 |
url |
https://doi.org/10.1016/j.ejmech.2020.112739 http://hdl.handle.net/20.500.12010/12404 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_f1cf |
dc.rights.local.spa.fl_str_mv |
Acceso restringido |
rights_invalid_str_mv |
Acceso restringido http://purl.org/coar/access_right/c_f1cf |
dc.format.extent.spa.fl_str_mv |
45 páginas |
dc.format.mimetype.spa.fl_str_mv |
image/jepg |
dc.publisher.spa.fl_str_mv |
European Journal of Medicinal Chemistry |
dc.source.spa.fl_str_mv |
reponame:Expeditio Repositorio Institucional UJTL instname:Universidad de Bogotá Jorge Tadeo Lozano |
instname_str |
Universidad de Bogotá Jorge Tadeo Lozano |
institution |
Universidad de Bogotá Jorge Tadeo Lozano |
reponame_str |
Expeditio Repositorio Institucional UJTL |
collection |
Expeditio Repositorio Institucional UJTL |
bitstream.url.fl_str_mv |
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expeditio@utadeo.edu.co |
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spelling |
2020-08-28T14:26:03Z2020-08-28T14:26:03Z20200223-5234https://doi.org/10.1016/j.ejmech.2020.112739http://hdl.handle.net/20.500.12010/12404https://doi.org/10.1016/j.ejmech.2020.112739The Strategic Plan for Biodefense Research by the U.S. Department of Health and Human Services demarcates the need for drugs which target multiple types of pathogens to prepare for infectious threats. Azithromycin is one such broad-spectrum therapeutic that is both included in the University of Oxford’s RECOVERY and excluded from the World Health Organization’s SOLIDARITY trials. Here we review azithromycin’s broad antibiotic, antimalarial, antiviral pharmacology and contextualise it against a broader history as the most repositioned therapeutic of the macrolide class; we further evaluate azithromycin’s clinical and socio-economic propriety for respiratory pandemics and delineate a model for its combinatorial mechanism of action against COVID-19 pneumonia.45 páginasimage/jepgengEuropean Journal of Medicinal Chemistryreponame:Expeditio Repositorio Institucional UJTLinstname:Universidad de Bogotá Jorge Tadeo LozanoAzithromycinBroad-spectrumCOVID-19PneumoniaSíndrome respiratorio agudo graveCOVID-19SARS-CoV-2CoronavirusAzithromycin: The first broad-spectrum therapeuticArtículohttp://purl.org/coar/resource_type/c_2df8fbb1Acceso restringidohttp://purl.org/coar/access_right/c_f1cfFirth, AntonPrathapan, PraveenORIGINALCaptura.PNGCaptura.PNGVer portadaimage/png70669https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12404/1/Captura.PNGd60abd516be6e4f237f995fd3c5be31cMD51open accessAzithromycin--The-First-Broad-spectrum-T_2020_European-Journal-of-Medicinal-.pdfAzithromycin--The-First-Broad-spectrum-T_2020_European-Journal-of-Medicinal-.pdfArtículo reservadoapplication/pdf5136935https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12404/3/Azithromycin--The-First-Broad-spectrum-T_2020_European-Journal-of-Medicinal-.pdf873ccb6c661d942b40b2c4cb96324bbaMD53embargoed access|||2200-08-08LICENSElicense.txtlicense.txttext/plain; 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