Azithromycin: The first broad-spectrum therapeutic

The Strategic Plan for Biodefense Research by the U.S. Department of Health and Human Services demarcates the need for drugs which target multiple types of pathogens to prepare for infectious threats. Azithromycin is one such broad-spectrum therapeutic that is both included in the University of Oxfo...

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Autores:
Tipo de recurso:
Article of investigation
Fecha de publicación:
2020
Institución:
Universidad de Bogotá Jorge Tadeo Lozano
Repositorio:
Expeditio: repositorio UTadeo
Idioma:
eng
OAI Identifier:
oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12404
Acceso en línea:
https://doi.org/10.1016/j.ejmech.2020.112739
http://hdl.handle.net/20.500.12010/12404
Palabra clave:
Azithromycin
Broad-spectrum
COVID-19
Pneumonia
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
Rights
License
Acceso restringido
id UTADEO2_cc27a517a6e56c7115841b4aad974f55
oai_identifier_str oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12404
network_acronym_str UTADEO2
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repository_id_str
dc.title.spa.fl_str_mv Azithromycin: The first broad-spectrum therapeutic
title Azithromycin: The first broad-spectrum therapeutic
spellingShingle Azithromycin: The first broad-spectrum therapeutic
Azithromycin
Broad-spectrum
COVID-19
Pneumonia
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
title_short Azithromycin: The first broad-spectrum therapeutic
title_full Azithromycin: The first broad-spectrum therapeutic
title_fullStr Azithromycin: The first broad-spectrum therapeutic
title_full_unstemmed Azithromycin: The first broad-spectrum therapeutic
title_sort Azithromycin: The first broad-spectrum therapeutic
dc.subject.spa.fl_str_mv Azithromycin
Broad-spectrum
COVID-19
Pneumonia
topic Azithromycin
Broad-spectrum
COVID-19
Pneumonia
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
dc.subject.lemb.spa.fl_str_mv Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
description The Strategic Plan for Biodefense Research by the U.S. Department of Health and Human Services demarcates the need for drugs which target multiple types of pathogens to prepare for infectious threats. Azithromycin is one such broad-spectrum therapeutic that is both included in the University of Oxford’s RECOVERY and excluded from the World Health Organization’s SOLIDARITY trials. Here we review azithromycin’s broad antibiotic, antimalarial, antiviral pharmacology and contextualise it against a broader history as the most repositioned therapeutic of the macrolide class; we further evaluate azithromycin’s clinical and socio-economic propriety for respiratory pandemics and delineate a model for its combinatorial mechanism of action against COVID-19 pneumonia.
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2020-08-28T14:26:03Z
dc.date.available.none.fl_str_mv 2020-08-28T14:26:03Z
dc.date.created.none.fl_str_mv 2020
dc.type.local.spa.fl_str_mv Artículo
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format http://purl.org/coar/resource_type/c_2df8fbb1
dc.identifier.issn.spa.fl_str_mv 0223-5234
dc.identifier.other.spa.fl_str_mv https://doi.org/10.1016/j.ejmech.2020.112739
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12010/12404
dc.identifier.doi.spa.fl_str_mv https://doi.org/10.1016/j.ejmech.2020.112739
identifier_str_mv 0223-5234
url https://doi.org/10.1016/j.ejmech.2020.112739
http://hdl.handle.net/20.500.12010/12404
dc.language.iso.spa.fl_str_mv eng
language eng
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_f1cf
dc.rights.local.spa.fl_str_mv Acceso restringido
rights_invalid_str_mv Acceso restringido
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dc.format.extent.spa.fl_str_mv 45 páginas
dc.format.mimetype.spa.fl_str_mv image/jepg
dc.publisher.spa.fl_str_mv European Journal of Medicinal Chemistry
dc.source.spa.fl_str_mv reponame:Expeditio Repositorio Institucional UJTL
instname:Universidad de Bogotá Jorge Tadeo Lozano
instname_str Universidad de Bogotá Jorge Tadeo Lozano
institution Universidad de Bogotá Jorge Tadeo Lozano
reponame_str Expeditio Repositorio Institucional UJTL
collection Expeditio Repositorio Institucional UJTL
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spelling 2020-08-28T14:26:03Z2020-08-28T14:26:03Z20200223-5234https://doi.org/10.1016/j.ejmech.2020.112739http://hdl.handle.net/20.500.12010/12404https://doi.org/10.1016/j.ejmech.2020.112739The Strategic Plan for Biodefense Research by the U.S. Department of Health and Human Services demarcates the need for drugs which target multiple types of pathogens to prepare for infectious threats. Azithromycin is one such broad-spectrum therapeutic that is both included in the University of Oxford’s RECOVERY and excluded from the World Health Organization’s SOLIDARITY trials. Here we review azithromycin’s broad antibiotic, antimalarial, antiviral pharmacology and contextualise it against a broader history as the most repositioned therapeutic of the macrolide class; we further evaluate azithromycin’s clinical and socio-economic propriety for respiratory pandemics and delineate a model for its combinatorial mechanism of action against COVID-19 pneumonia.45 páginasimage/jepgengEuropean Journal of Medicinal Chemistryreponame:Expeditio Repositorio Institucional UJTLinstname:Universidad de Bogotá Jorge Tadeo LozanoAzithromycinBroad-spectrumCOVID-19PneumoniaSíndrome respiratorio agudo graveCOVID-19SARS-CoV-2CoronavirusAzithromycin: The first broad-spectrum therapeuticArtículohttp://purl.org/coar/resource_type/c_2df8fbb1Acceso restringidohttp://purl.org/coar/access_right/c_f1cfFirth, AntonPrathapan, PraveenORIGINALCaptura.PNGCaptura.PNGVer portadaimage/png70669https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12404/1/Captura.PNGd60abd516be6e4f237f995fd3c5be31cMD51open accessAzithromycin--The-First-Broad-spectrum-T_2020_European-Journal-of-Medicinal-.pdfAzithromycin--The-First-Broad-spectrum-T_2020_European-Journal-of-Medicinal-.pdfArtículo reservadoapplication/pdf5136935https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12404/3/Azithromycin--The-First-Broad-spectrum-T_2020_European-Journal-of-Medicinal-.pdf873ccb6c661d942b40b2c4cb96324bbaMD53embargoed access|||2200-08-08LICENSElicense.txtlicense.txttext/plain; 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