Diagnosis of COVID-19: Facts and challenges

At the end of 2019, the novel coronavirus disease 2019 (COVID-19) emerged in Wuhan, China, and then spread rapidly across the country and throughout the world. The causative agent is severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2); according to the International Committee on Taxonomy of...

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Autores:
Tipo de recurso:
Article of investigation
Fecha de publicación:
2020
Institución:
Universidad de Bogotá Jorge Tadeo Lozano
Repositorio:
Expeditio: repositorio UTadeo
Idioma:
eng
OAI Identifier:
oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/13890
Acceso en línea:
https://doi.org/10.1016/j.nmni.2020.100761
http://hdl.handle.net/20.500.12010/13890
Palabra clave:
SARS-CoV-2
COVID-19
lateral flow immunoassay
ELISA
PCR
LAMP
CRISPR
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
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License
Abierto (Texto Completo)
Description
Summary:At the end of 2019, the novel coronavirus disease 2019 (COVID-19) emerged in Wuhan, China, and then spread rapidly across the country and throughout the world. The causative agent is severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2); according to the International Committee on Taxonomy of Viruses, this virus has a nucleic acid sequence that is different from other known coronaviruses but has some similarity to the beta coronavirus identified in bats. Coronaviruses are a large virus group of enveloped positive-sense single-stranded RNA. They are divided into four genera—alpha, beta, delta, and gamma—and alpha and beta coronaviruses are known to infect humans. Rapid and early diagnosis of COVID-19 is a challenging issue for physicians and other health care personnel. The sensitivity and specificity of the clinical, radiological, and laboratory tests used to diagnose COVID-19 are variable and largely differ in efficacy depending on the patient’s stage of presentation.