The under-reported role of toxic substance exposures in the COVID-19 pandemic

Coronavirus disease 2019 (COVID-19) and previous pandemics have been viewed almost exclusively as virology problems, with toxicology problems mostly being ignored. This perspective is not supported by the evolution of COVID-19, where the impact of real-life exposures to multiple toxic stressors degr...

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Autores:
Tipo de recurso:
Article of investigation
Fecha de publicación:
2020
Institución:
Universidad de Bogotá Jorge Tadeo Lozano
Repositorio:
Expeditio: repositorio UTadeo
Idioma:
eng
OAI Identifier:
oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12457
Acceso en línea:
https://doi.org/10.1016/j.fct.2020.111687
http://hdl.handle.net/20.500.12010/12457
Palabra clave:
Toxic substance
COVID-19
Pandemic
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
Rights
License
Acceso restringido
id UTADEO2_bc90dfc1b48ddbf49fc72d82733722b5
oai_identifier_str oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12457
network_acronym_str UTADEO2
network_name_str Expeditio: repositorio UTadeo
repository_id_str
dc.title.spa.fl_str_mv The under-reported role of toxic substance exposures in the COVID-19 pandemic
title The under-reported role of toxic substance exposures in the COVID-19 pandemic
spellingShingle The under-reported role of toxic substance exposures in the COVID-19 pandemic
Toxic substance
COVID-19
Pandemic
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
title_short The under-reported role of toxic substance exposures in the COVID-19 pandemic
title_full The under-reported role of toxic substance exposures in the COVID-19 pandemic
title_fullStr The under-reported role of toxic substance exposures in the COVID-19 pandemic
title_full_unstemmed The under-reported role of toxic substance exposures in the COVID-19 pandemic
title_sort The under-reported role of toxic substance exposures in the COVID-19 pandemic
dc.subject.spa.fl_str_mv Toxic substance
COVID-19
Pandemic
topic Toxic substance
COVID-19
Pandemic
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
dc.subject.lemb.spa.fl_str_mv Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
description Coronavirus disease 2019 (COVID-19) and previous pandemics have been viewed almost exclusively as virology problems, with toxicology problems mostly being ignored. This perspective is not supported by the evolution of COVID-19, where the impact of real-life exposures to multiple toxic stressors degrading the immune system is followed by the SARS-CoV-2 virus exploiting the degraded immune system to trigger a chain of events ultimately leading to COVID-19. This immune system degradation from multiple toxic stressors (chemical, physical, biological, psychosocial stressors) means that attribution of serious consequences from COVID-19 should be made to the virus-toxic stressors nexus, not to any of the nexus constituents in isolation. The leading toxic stressors (identified in this study as contributing to COVID-19) are pervasive, contributing to myriad chronic diseases as well as immune system degradation. They increase the likelihood for comorbidities and mortality associated with COVID-19. For the short-term, tactical/reactive virology-focused treatments are of higher priority than strategic/proactive toxicology-focused treatments, although both could be implemented in parallel to reinforce each other. However, for long-term pandemic prevention, toxicology-based approaches should be given higher priority than virology-based approaches. Since current COVID-19 treatments globally ignore the toxicology component almost completely, only limited benefits can be expected from these treatments.
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2020-08-31T15:21:52Z
dc.date.available.none.fl_str_mv 2020-08-31T15:21:52Z
dc.date.created.none.fl_str_mv 2020
dc.type.local.spa.fl_str_mv Artículo
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format http://purl.org/coar/resource_type/c_2df8fbb1
dc.identifier.issn.spa.fl_str_mv 0278-6915
dc.identifier.other.spa.fl_str_mv https://doi.org/10.1016/j.fct.2020.111687
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12010/12457
dc.identifier.doi.spa.fl_str_mv https://doi.org/10.1016/j.fct.2020.111687
identifier_str_mv 0278-6915
url https://doi.org/10.1016/j.fct.2020.111687
http://hdl.handle.net/20.500.12010/12457
dc.language.iso.spa.fl_str_mv eng
language eng
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dc.rights.local.spa.fl_str_mv Acceso restringido
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dc.format.extent.spa.fl_str_mv 27 páginas
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dc.publisher.spa.fl_str_mv Food and Chemical Toxicology
dc.source.spa.fl_str_mv reponame:Expeditio Repositorio Institucional UJTL
instname:Universidad de Bogotá Jorge Tadeo Lozano
instname_str Universidad de Bogotá Jorge Tadeo Lozano
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reponame_str Expeditio Repositorio Institucional UJTL
collection Expeditio Repositorio Institucional UJTL
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spelling 2020-08-31T15:21:52Z2020-08-31T15:21:52Z20200278-6915https://doi.org/10.1016/j.fct.2020.111687http://hdl.handle.net/20.500.12010/12457https://doi.org/10.1016/j.fct.2020.111687Coronavirus disease 2019 (COVID-19) and previous pandemics have been viewed almost exclusively as virology problems, with toxicology problems mostly being ignored. This perspective is not supported by the evolution of COVID-19, where the impact of real-life exposures to multiple toxic stressors degrading the immune system is followed by the SARS-CoV-2 virus exploiting the degraded immune system to trigger a chain of events ultimately leading to COVID-19. This immune system degradation from multiple toxic stressors (chemical, physical, biological, psychosocial stressors) means that attribution of serious consequences from COVID-19 should be made to the virus-toxic stressors nexus, not to any of the nexus constituents in isolation. The leading toxic stressors (identified in this study as contributing to COVID-19) are pervasive, contributing to myriad chronic diseases as well as immune system degradation. They increase the likelihood for comorbidities and mortality associated with COVID-19. For the short-term, tactical/reactive virology-focused treatments are of higher priority than strategic/proactive toxicology-focused treatments, although both could be implemented in parallel to reinforce each other. However, for long-term pandemic prevention, toxicology-based approaches should be given higher priority than virology-based approaches. Since current COVID-19 treatments globally ignore the toxicology component almost completely, only limited benefits can be expected from these treatments.27 páginasimage/jepgengFood and Chemical Toxicologyreponame:Expeditio Repositorio Institucional UJTLinstname:Universidad de Bogotá Jorge Tadeo LozanoToxic substanceCOVID-19PandemicSíndrome respiratorio agudo graveCOVID-19SARS-CoV-2CoronavirusThe under-reported role of toxic substance exposures in the COVID-19 pandemicArtículohttp://purl.org/coar/resource_type/c_2df8fbb1Acceso restringidohttp://purl.org/coar/access_right/c_f1cfKostoff, Ronald N.Briggs, Michael B.Porter, Alan L.Hernández, Antonio F.Abdollahi, MohammadAschner, MichaelTsatsakis, AristidisORIGINALCaptura.PNGCaptura.PNGVer portadaimage/png84977https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12457/1/Captura.PNG865958515677634429818b0985061db7MD51open accessThe-Under-Reported-Role-of-Toxic-Substance-Exposures_2020_Food-and-Chemical-.pdfThe-Under-Reported-Role-of-Toxic-Substance-Exposures_2020_Food-and-Chemical-.pdfArtículo reservadoapplication/pdf795308https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12457/3/The-Under-Reported-Role-of-Toxic-Substance-Exposures_2020_Food-and-Chemical-.pdffe69a4bd057b6bdabf6958cd437c264cMD53embargoed access|||2200-08-31LICENSElicense.txtlicense.txttext/plain; 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