The under-reported role of toxic substance exposures in the COVID-19 pandemic
Coronavirus disease 2019 (COVID-19) and previous pandemics have been viewed almost exclusively as virology problems, with toxicology problems mostly being ignored. This perspective is not supported by the evolution of COVID-19, where the impact of real-life exposures to multiple toxic stressors degr...
- Autores:
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2020
- Institución:
- Universidad de Bogotá Jorge Tadeo Lozano
- Repositorio:
- Expeditio: repositorio UTadeo
- Idioma:
- eng
- OAI Identifier:
- oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12457
- Palabra clave:
- Toxic substance
COVID-19
Pandemic
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
- Rights
- License
- Acceso restringido
id |
UTADEO2_bc90dfc1b48ddbf49fc72d82733722b5 |
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oai_identifier_str |
oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12457 |
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Expeditio: repositorio UTadeo |
repository_id_str |
|
dc.title.spa.fl_str_mv |
The under-reported role of toxic substance exposures in the COVID-19 pandemic |
title |
The under-reported role of toxic substance exposures in the COVID-19 pandemic |
spellingShingle |
The under-reported role of toxic substance exposures in the COVID-19 pandemic Toxic substance COVID-19 Pandemic Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus |
title_short |
The under-reported role of toxic substance exposures in the COVID-19 pandemic |
title_full |
The under-reported role of toxic substance exposures in the COVID-19 pandemic |
title_fullStr |
The under-reported role of toxic substance exposures in the COVID-19 pandemic |
title_full_unstemmed |
The under-reported role of toxic substance exposures in the COVID-19 pandemic |
title_sort |
The under-reported role of toxic substance exposures in the COVID-19 pandemic |
dc.subject.spa.fl_str_mv |
Toxic substance COVID-19 Pandemic |
topic |
Toxic substance COVID-19 Pandemic Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus |
dc.subject.lemb.spa.fl_str_mv |
Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus |
description |
Coronavirus disease 2019 (COVID-19) and previous pandemics have been viewed almost exclusively as virology problems, with toxicology problems mostly being ignored. This perspective is not supported by the evolution of COVID-19, where the impact of real-life exposures to multiple toxic stressors degrading the immune system is followed by the SARS-CoV-2 virus exploiting the degraded immune system to trigger a chain of events ultimately leading to COVID-19. This immune system degradation from multiple toxic stressors (chemical, physical, biological, psychosocial stressors) means that attribution of serious consequences from COVID-19 should be made to the virus-toxic stressors nexus, not to any of the nexus constituents in isolation. The leading toxic stressors (identified in this study as contributing to COVID-19) are pervasive, contributing to myriad chronic diseases as well as immune system degradation. They increase the likelihood for comorbidities and mortality associated with COVID-19. For the short-term, tactical/reactive virology-focused treatments are of higher priority than strategic/proactive toxicology-focused treatments, although both could be implemented in parallel to reinforce each other. However, for long-term pandemic prevention, toxicology-based approaches should be given higher priority than virology-based approaches. Since current COVID-19 treatments globally ignore the toxicology component almost completely, only limited benefits can be expected from these treatments. |
publishDate |
2020 |
dc.date.accessioned.none.fl_str_mv |
2020-08-31T15:21:52Z |
dc.date.available.none.fl_str_mv |
2020-08-31T15:21:52Z |
dc.date.created.none.fl_str_mv |
2020 |
dc.type.local.spa.fl_str_mv |
Artículo |
dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
format |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.identifier.issn.spa.fl_str_mv |
0278-6915 |
dc.identifier.other.spa.fl_str_mv |
https://doi.org/10.1016/j.fct.2020.111687 |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/20.500.12010/12457 |
dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.1016/j.fct.2020.111687 |
identifier_str_mv |
0278-6915 |
url |
https://doi.org/10.1016/j.fct.2020.111687 http://hdl.handle.net/20.500.12010/12457 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_f1cf |
dc.rights.local.spa.fl_str_mv |
Acceso restringido |
rights_invalid_str_mv |
Acceso restringido http://purl.org/coar/access_right/c_f1cf |
dc.format.extent.spa.fl_str_mv |
27 páginas |
dc.format.mimetype.spa.fl_str_mv |
image/jepg |
dc.publisher.spa.fl_str_mv |
Food and Chemical Toxicology |
dc.source.spa.fl_str_mv |
reponame:Expeditio Repositorio Institucional UJTL instname:Universidad de Bogotá Jorge Tadeo Lozano |
instname_str |
Universidad de Bogotá Jorge Tadeo Lozano |
institution |
Universidad de Bogotá Jorge Tadeo Lozano |
reponame_str |
Expeditio Repositorio Institucional UJTL |
collection |
Expeditio Repositorio Institucional UJTL |
bitstream.url.fl_str_mv |
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2020-08-31T15:21:52Z2020-08-31T15:21:52Z20200278-6915https://doi.org/10.1016/j.fct.2020.111687http://hdl.handle.net/20.500.12010/12457https://doi.org/10.1016/j.fct.2020.111687Coronavirus disease 2019 (COVID-19) and previous pandemics have been viewed almost exclusively as virology problems, with toxicology problems mostly being ignored. This perspective is not supported by the evolution of COVID-19, where the impact of real-life exposures to multiple toxic stressors degrading the immune system is followed by the SARS-CoV-2 virus exploiting the degraded immune system to trigger a chain of events ultimately leading to COVID-19. This immune system degradation from multiple toxic stressors (chemical, physical, biological, psychosocial stressors) means that attribution of serious consequences from COVID-19 should be made to the virus-toxic stressors nexus, not to any of the nexus constituents in isolation. The leading toxic stressors (identified in this study as contributing to COVID-19) are pervasive, contributing to myriad chronic diseases as well as immune system degradation. They increase the likelihood for comorbidities and mortality associated with COVID-19. For the short-term, tactical/reactive virology-focused treatments are of higher priority than strategic/proactive toxicology-focused treatments, although both could be implemented in parallel to reinforce each other. However, for long-term pandemic prevention, toxicology-based approaches should be given higher priority than virology-based approaches. Since current COVID-19 treatments globally ignore the toxicology component almost completely, only limited benefits can be expected from these treatments.27 páginasimage/jepgengFood and Chemical Toxicologyreponame:Expeditio Repositorio Institucional UJTLinstname:Universidad de Bogotá Jorge Tadeo LozanoToxic substanceCOVID-19PandemicSíndrome respiratorio agudo graveCOVID-19SARS-CoV-2CoronavirusThe under-reported role of toxic substance exposures in the COVID-19 pandemicArtículohttp://purl.org/coar/resource_type/c_2df8fbb1Acceso restringidohttp://purl.org/coar/access_right/c_f1cfKostoff, Ronald N.Briggs, Michael B.Porter, Alan L.Hernández, Antonio F.Abdollahi, MohammadAschner, MichaelTsatsakis, AristidisORIGINALCaptura.PNGCaptura.PNGVer portadaimage/png84977https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12457/1/Captura.PNG865958515677634429818b0985061db7MD51open accessThe-Under-Reported-Role-of-Toxic-Substance-Exposures_2020_Food-and-Chemical-.pdfThe-Under-Reported-Role-of-Toxic-Substance-Exposures_2020_Food-and-Chemical-.pdfArtículo reservadoapplication/pdf795308https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12457/3/The-Under-Reported-Role-of-Toxic-Substance-Exposures_2020_Food-and-Chemical-.pdffe69a4bd057b6bdabf6958cd437c264cMD53embargoed access|||2200-08-31LICENSElicense.txtlicense.txttext/plain; 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