Recent trends in protein and peptide-based biomaterials for advanced drug delivery

Abstract: Engineering protein and peptide-based materials for drug delivery applications has gained momentum due to their favorable biochemical and biophysical properties over synthetic materials, including biocompatibility, ease of synthesis and purification, tunability, scalability, and lack of toxicity. These biomolecules have been used to develop a host of drug delivery platforms, such as peptide- and protein-drug conjugates, injectable particles, and drug depots to deliver small molecule drugs, therapeutic proteins, and nucleic acids. In this review, we discuss progress in engineering the architecture and biological functions of peptide-based biomaterials —naturally derived, chemically synthesized and recombinant— with a focus on the molecular features that modulate their structure-function relationships for drug delivery

• Tipo de recurso: Article of investigation
• Fecha de publicación: 2020
• Institución: Universidad de Bogotá Jorge Tadeo Lozano
• Repositorio: Expeditio: repositorio UTadeo
• Idioma: eng
• OAI Identifier: oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12738
• Acceso en línea: https://doi.org/10.1016/j.addr.2020.08.008; http://hdl.handle.net/20.500.12010/12738
• Palabra clave: Drug delivery; Polypeptides; Recombinant proteins; Bioinspired materials; Hierarchical self-assembly; Síndrome respiratorio agudo grave; COVID-19; SARS-CoV-2; Coronavirus
• License: Acceso restringido