Why will it never be known if convalescent plasma is effective for COVID-19

High expectations have been set around convalescent plasma (CP) for the treatment of COVID-19. However, none of the randomized controlled trials (RCTs) conducted so far have reached their primary endpoints. Herein we report that RCTs of CP disclose a high methodological variability in inclusion crit...

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Autores:
Tipo de recurso:
Article of investigation
Fecha de publicación:
2020
Institución:
Universidad de Bogotá Jorge Tadeo Lozano
Repositorio:
Expeditio: repositorio UTadeo
Idioma:
eng
OAI Identifier:
oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/15584
Acceso en línea:
https://doi.org/10.1016/j.jtauto.2020.100069
http://hdl.handle.net/20.500.12010/15584
Palabra clave:
Coronavirus
COVID-19
SARS-Cov-2
Convalescent plasma
Clinical trials
Randomized
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
Rights
License
Abierto (Texto Completo)
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repository_id_str
dc.title.spa.fl_str_mv Why will it never be known if convalescent plasma is effective for COVID-19
title Why will it never be known if convalescent plasma is effective for COVID-19
spellingShingle Why will it never be known if convalescent plasma is effective for COVID-19
Coronavirus
COVID-19
SARS-Cov-2
Convalescent plasma
Clinical trials
Randomized
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
title_short Why will it never be known if convalescent plasma is effective for COVID-19
title_full Why will it never be known if convalescent plasma is effective for COVID-19
title_fullStr Why will it never be known if convalescent plasma is effective for COVID-19
title_full_unstemmed Why will it never be known if convalescent plasma is effective for COVID-19
title_sort Why will it never be known if convalescent plasma is effective for COVID-19
dc.subject.spa.fl_str_mv Coronavirus
COVID-19
SARS-Cov-2
Convalescent plasma
Clinical trials
Randomized
topic Coronavirus
COVID-19
SARS-Cov-2
Convalescent plasma
Clinical trials
Randomized
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
dc.subject.lemb.spa.fl_str_mv Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
description High expectations have been set around convalescent plasma (CP) for the treatment of COVID-19. However, none of the randomized controlled trials (RCTs) conducted so far have reached their primary endpoints. Herein we report that RCTs of CP disclose a high methodological variability in inclusion criteria, outcomes, appropriate selection of donors, dosage, concentration of neutralizing antibodies and times of transfusion. Therefore, at this time there is insufficient evidence to recommend for or against the use of CP as a treatment for COVID-19.
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2020-11-10T14:02:49Z
dc.date.available.none.fl_str_mv 2020-11-10T14:02:49Z
dc.date.created.none.fl_str_mv 2020
dc.type.local.spa.fl_str_mv Artículo
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
format http://purl.org/coar/resource_type/c_2df8fbb1
dc.identifier.other.spa.fl_str_mv https://doi.org/10.1016/j.jtauto.2020.100069
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12010/15584
dc.identifier.doi.spa.fl_str_mv https://doi.org/10.1016/j.jtauto.2020.100069
url https://doi.org/10.1016/j.jtauto.2020.100069
http://hdl.handle.net/20.500.12010/15584
dc.language.iso.spa.fl_str_mv eng
language eng
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.local.spa.fl_str_mv Abierto (Texto Completo)
rights_invalid_str_mv Abierto (Texto Completo)
http://purl.org/coar/access_right/c_abf2
dc.format.extent.spa.fl_str_mv 19 páginas
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Journal of Translational Autoimmunity
dc.source.spa.fl_str_mv reponame:Expeditio Repositorio Institucional UJTL
instname:Universidad de Bogotá Jorge Tadeo Lozano
instname_str Universidad de Bogotá Jorge Tadeo Lozano
institution Universidad de Bogotá Jorge Tadeo Lozano
reponame_str Expeditio Repositorio Institucional UJTL
collection Expeditio Repositorio Institucional UJTL
bitstream.url.fl_str_mv https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/15584/2/license.txt
https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/15584/3/Why-will-it-never-be-known-if-convalescent-plas_2020_Journal-of-Translationa.pdf.jpg
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bitstream.checksumAlgorithm.fl_str_mv MD5
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repository.name.fl_str_mv Repositorio Institucional - Universidad Jorge Tadeo Lozano
repository.mail.fl_str_mv expeditio@utadeo.edu.co
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spelling 2020-11-10T14:02:49Z2020-11-10T14:02:49Z2020https://doi.org/10.1016/j.jtauto.2020.100069http://hdl.handle.net/20.500.12010/15584https://doi.org/10.1016/j.jtauto.2020.100069High expectations have been set around convalescent plasma (CP) for the treatment of COVID-19. However, none of the randomized controlled trials (RCTs) conducted so far have reached their primary endpoints. Herein we report that RCTs of CP disclose a high methodological variability in inclusion criteria, outcomes, appropriate selection of donors, dosage, concentration of neutralizing antibodies and times of transfusion. Therefore, at this time there is insufficient evidence to recommend for or against the use of CP as a treatment for COVID-19.19 páginasapplication/pdfengJournal of Translational Autoimmunityreponame:Expeditio Repositorio Institucional UJTLinstname:Universidad de Bogotá Jorge Tadeo LozanoCoronavirusCOVID-19SARS-Cov-2Convalescent plasmaClinical trialsRandomizedSíndrome respiratorio agudo graveCOVID-19SARS-CoV-2CoronavirusWhy will it never be known if convalescent plasma is effective for COVID-19Artículohttp://purl.org/coar/resource_type/c_2df8fbb1Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2Rojas, ManuelAnaya, Juan-ManuelLICENSElicense.txtlicense.txttext/plain; charset=utf-82938https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/15584/2/license.txtabceeb1c943c50d3343516f9dbfc110fMD52open accessTHUMBNAILWhy-will-it-never-be-known-if-convalescent-plas_2020_Journal-of-Translationa.pdf.jpgWhy-will-it-never-be-known-if-convalescent-plas_2020_Journal-of-Translationa.pdf.jpgIM Thumbnailimage/jpeg11659https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/15584/3/Why-will-it-never-be-known-if-convalescent-plas_2020_Journal-of-Translationa.pdf.jpg96c73b7ece8b3230affe4aecc4cff185MD53open access20.500.12010/15584oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/155842021-03-12 17:05:07.092metadata only accessRepositorio Institucional - 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