Free DNA, a reason for severe COVID-19 infection?

The fast-growing outbreak of 2019 novel coronaviruses (SARS-CoV-2) reached all continents except the Antarctica in merely three months. Severe SARS-CoV-2 infection (COVID-19) has a bad clinical outcome, and some reports emphasized the role of cytokine storm and dysfunctions of multiple organs. Howev...

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Autores:
Tipo de recurso:
Article of journal
Fecha de publicación:
2020
Institución:
Universidad de Bogotá Jorge Tadeo Lozano
Repositorio:
Expeditio: repositorio UTadeo
Idioma:
eng
OAI Identifier:
oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12092
Acceso en línea:
https://doi.org/10.1016/j.mehy.2020.109812
http://hdl.handle.net/20.500.12010/12092
Palabra clave:
COVID-19
DNA
Infection
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
Rights
License
Acceso restringido
id UTADEO2_af78279db6df2a9fc00f4fd0c47b4908
oai_identifier_str oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12092
network_acronym_str UTADEO2
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repository_id_str
dc.title.spa.fl_str_mv Free DNA, a reason for severe COVID-19 infection?
title Free DNA, a reason for severe COVID-19 infection?
spellingShingle Free DNA, a reason for severe COVID-19 infection?
COVID-19
DNA
Infection
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
title_short Free DNA, a reason for severe COVID-19 infection?
title_full Free DNA, a reason for severe COVID-19 infection?
title_fullStr Free DNA, a reason for severe COVID-19 infection?
title_full_unstemmed Free DNA, a reason for severe COVID-19 infection?
title_sort Free DNA, a reason for severe COVID-19 infection?
dc.subject.spa.fl_str_mv COVID-19
DNA
Infection
topic COVID-19
DNA
Infection
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
dc.subject.lemb.spa.fl_str_mv Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
description The fast-growing outbreak of 2019 novel coronaviruses (SARS-CoV-2) reached all continents except the Antarctica in merely three months. Severe SARS-CoV-2 infection (COVID-19) has a bad clinical outcome, and some reports emphasized the role of cytokine storm and dysfunctions of multiple organs. However, the etiology of severe COVID-19 has been largely unknown. Similar as SARS-CoV and MERS-CoV, SARS-CoV-2 is also thought derived from bat coronaviruses. However, it is not pathogenic for bat at all, because free DNA in cytoplasm or blood cannot bring up violent immune response in bat; but it can produce severe inflammations in human. I hypothesized that the damage induced by free DNA is a reason for severe COVID-19, which can explain many symptoms of this disease, such as cytokine storm, acute respiratory distress syndrome (ARDS) and muscus plug, acute injuries of heart, liver and kidney, and some special symptoms of COVID-19. My hypothesis will be helpful for better understand the etiology of severe COVID-19.
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2020-08-21T16:41:18Z
dc.date.available.none.fl_str_mv 2020-08-21T16:41:18Z
dc.date.created.none.fl_str_mv 2020
dc.type.local.spa.fl_str_mv Artículo
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_6501
format http://purl.org/coar/resource_type/c_6501
dc.identifier.issn.spa.fl_str_mv 0306-9877
dc.identifier.other.spa.fl_str_mv https://doi.org/10.1016/j.mehy.2020.109812
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12010/12092
dc.identifier.doi.spa.fl_str_mv https://doi.org/10.1016/j.mehy.2020.109812
identifier_str_mv 0306-9877
url https://doi.org/10.1016/j.mehy.2020.109812
http://hdl.handle.net/20.500.12010/12092
dc.language.iso.spa.fl_str_mv eng
language eng
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_f1cf
dc.rights.local.spa.fl_str_mv Acceso restringido
rights_invalid_str_mv Acceso restringido
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dc.format.extent.spa.fl_str_mv 3 páginas
dc.format.mimetype.spa.fl_str_mv image/jepg
dc.publisher.spa.fl_str_mv Medical Hypotheses
dc.source.spa.fl_str_mv reponame:Expeditio Repositorio Institucional UJTL
instname:Universidad de Bogotá Jorge Tadeo Lozano
instname_str Universidad de Bogotá Jorge Tadeo Lozano
institution Universidad de Bogotá Jorge Tadeo Lozano
reponame_str Expeditio Repositorio Institucional UJTL
collection Expeditio Repositorio Institucional UJTL
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spelling 2020-08-21T16:41:18Z2020-08-21T16:41:18Z20200306-9877https://doi.org/10.1016/j.mehy.2020.109812http://hdl.handle.net/20.500.12010/12092https://doi.org/10.1016/j.mehy.2020.109812The fast-growing outbreak of 2019 novel coronaviruses (SARS-CoV-2) reached all continents except the Antarctica in merely three months. Severe SARS-CoV-2 infection (COVID-19) has a bad clinical outcome, and some reports emphasized the role of cytokine storm and dysfunctions of multiple organs. However, the etiology of severe COVID-19 has been largely unknown. Similar as SARS-CoV and MERS-CoV, SARS-CoV-2 is also thought derived from bat coronaviruses. However, it is not pathogenic for bat at all, because free DNA in cytoplasm or blood cannot bring up violent immune response in bat; but it can produce severe inflammations in human. I hypothesized that the damage induced by free DNA is a reason for severe COVID-19, which can explain many symptoms of this disease, such as cytokine storm, acute respiratory distress syndrome (ARDS) and muscus plug, acute injuries of heart, liver and kidney, and some special symptoms of COVID-19. My hypothesis will be helpful for better understand the etiology of severe COVID-19.3 páginasimage/jepgengMedical Hypothesesreponame:Expeditio Repositorio Institucional UJTLinstname:Universidad de Bogotá Jorge Tadeo LozanoCOVID-19DNAInfectionSíndrome respiratorio agudo graveCOVID-19SARS-CoV-2CoronavirusFree DNA, a reason for severe COVID-19 infection?Artículohttp://purl.org/coar/resource_type/c_6501Acceso restringidohttp://purl.org/coar/access_right/c_f1cfLiu, BinORIGINALCaptura.PNGCaptura.PNGVer portadaimage/png111837https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12092/1/Captura.PNG635f879e1408772b740085334b369011MD51open accessFree-DNA--a-reason-for-severe-COVID-19-infection-_2020_Medical-Hypotheses.pdfFree-DNA--a-reason-for-severe-COVID-19-infection-_2020_Medical-Hypotheses.pdfArtículo reservadoapplication/pdf395551https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12092/3/Free-DNA--a-reason-for-severe-COVID-19-infection-_2020_Medical-Hypotheses.pdfe0b1037027fedfd5da8c9a37384a3b98MD53embargoed access|||2200-08-21LICENSElicense.txtlicense.txttext/plain; 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