Neuronal Mechanics and Transport

Understanding the underlying mechanisms of how axons and dendrites develop is a fundamental problem in neuroscience and a main goal of research on nervous system development and regeneration. Previous studies have provided a tremendous amount of information on signaling and cytoskeletal proteins reg...

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Autores:
Tipo de recurso:
Book
Fecha de publicación:
2016
Institución:
Universidad de Bogotá Jorge Tadeo Lozano
Repositorio:
Expeditio: repositorio UTadeo
Idioma:
eng
OAI Identifier:
oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/15049
Acceso en línea:
https://www.frontiersin.org/research-topics/3186/neuronal-mechanics-and-transport
http://hdl.handle.net/20.500.12010/15049
Palabra clave:
Neurología
Mecánica neuronal
Desarrollo neuronal
Transporte neuronal
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License
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dc.title.spa.fl_str_mv Neuronal Mechanics and Transport
title Neuronal Mechanics and Transport
spellingShingle Neuronal Mechanics and Transport
Neurología
Mecánica neuronal
Desarrollo neuronal
Transporte neuronal
title_short Neuronal Mechanics and Transport
title_full Neuronal Mechanics and Transport
title_fullStr Neuronal Mechanics and Transport
title_full_unstemmed Neuronal Mechanics and Transport
title_sort Neuronal Mechanics and Transport
dc.subject.spa.fl_str_mv Neurología
topic Neurología
Mecánica neuronal
Desarrollo neuronal
Transporte neuronal
dc.subject.lemb.spa.fl_str_mv Mecánica neuronal
Desarrollo neuronal
Transporte neuronal
description Understanding the underlying mechanisms of how axons and dendrites develop is a fundamental problem in neuroscience and a main goal of research on nervous system development and regeneration. Previous studies have provided a tremendous amount of information on signaling and cytoskeletal proteins regulating axonal and dendritic growth and guidance. However, relatively little is known about the relative contribution and role of cytoskeletal dynamics, transport of organelles and cytoskeletal components, and force generation to axonal elongation. Advancing the knowledge of these biomechanical processes is critical to better understand the development of the nervous system, the pathological progression of neurodegenerative diseases, acute traumatic injury, and for designing novel approaches to promote neuronal regeneration following disease, stroke, or trauma. Mechanical properties and forces shape the development of the nervous system from the cellular up to the organ level. Recent advances in quantitative live cell imaging, biophysical, and nanotechnological methods such as traction force microscopy, optical tweezers, and atomic force microscopy have enabled researchers to gain better insights into how cytoskeletal dynamics and motor-driven transport, membrane-dynamics, adhesion, and substrate rigidity influence axonal elongation. Given the complexity and mechanical nature of this problem, mathematical modeling contributes significantly to our understanding of neuronal mechanics. Nonetheless, there has been limited direct interaction and discussions between experimentalists and theoreticians in this research area. The purpose of this Frontiers Research Topic is to highlight exciting and important work that is currently developing in the fields of neuronal cell biology, neuronal mechanics, intracellular transport, and mathematical modeling in the form of primary research articles, reviews, perspectives, and commentaries.
publishDate 2016
dc.date.created.none.fl_str_mv 2016-01-19
dc.date.accessioned.none.fl_str_mv 2020-10-28T22:46:49Z
dc.date.available.none.fl_str_mv 2020-10-28T22:46:49Z
dc.type.local.spa.fl_str_mv Libro
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_2f33
format http://purl.org/coar/resource_type/c_2f33
dc.identifier.isbn.none.fl_str_mv 978-2-889-19823-8
dc.identifier.issn.none.fl_str_mv 1664-8714
dc.identifier.other.none.fl_str_mv https://www.frontiersin.org/research-topics/3186/neuronal-mechanics-and-transport
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12010/15049
dc.identifier.doi.none.fl_str_mv 10.3389/978-2-88919-823-8
identifier_str_mv 978-2-889-19823-8
1664-8714
10.3389/978-2-88919-823-8
url https://www.frontiersin.org/research-topics/3186/neuronal-mechanics-and-transport
http://hdl.handle.net/20.500.12010/15049
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.references.spa.fl_str_mv Suter, D. M., Miller, K. E., eds. (2016). Neuronal Mechanics and Transport. Lausanne: Frontiers Media. doi: 10.3389/978-2-88919-823-8
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rights_invalid_str_mv Abierto (Texto Completo)
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dc.format.extent.spa.fl_str_mv 214 páginas
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Frontiers Media SA
institution Universidad de Bogotá Jorge Tadeo Lozano
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spelling 2020-10-28T22:46:49Z2020-10-28T22:46:49Z2016-01-19978-2-889-19823-81664-8714https://www.frontiersin.org/research-topics/3186/neuronal-mechanics-and-transporthttp://hdl.handle.net/20.500.12010/1504910.3389/978-2-88919-823-8214 páginasapplication/pdfengFrontiers Media SANeurologíaMecánica neuronalDesarrollo neuronalTransporte neuronalNeuronal Mechanics and TransportLibrohttp://purl.org/coar/resource_type/c_2f33Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2Suter, D. M., Miller, K. E., eds. (2016). Neuronal Mechanics and Transport. Lausanne: Frontiers Media. doi: 10.3389/978-2-88919-823-8Understanding the underlying mechanisms of how axons and dendrites develop is a fundamental problem in neuroscience and a main goal of research on nervous system development and regeneration. Previous studies have provided a tremendous amount of information on signaling and cytoskeletal proteins regulating axonal and dendritic growth and guidance. However, relatively little is known about the relative contribution and role of cytoskeletal dynamics, transport of organelles and cytoskeletal components, and force generation to axonal elongation. Advancing the knowledge of these biomechanical processes is critical to better understand the development of the nervous system, the pathological progression of neurodegenerative diseases, acute traumatic injury, and for designing novel approaches to promote neuronal regeneration following disease, stroke, or trauma. Mechanical properties and forces shape the development of the nervous system from the cellular up to the organ level. Recent advances in quantitative live cell imaging, biophysical, and nanotechnological methods such as traction force microscopy, optical tweezers, and atomic force microscopy have enabled researchers to gain better insights into how cytoskeletal dynamics and motor-driven transport, membrane-dynamics, adhesion, and substrate rigidity influence axonal elongation. Given the complexity and mechanical nature of this problem, mathematical modeling contributes significantly to our understanding of neuronal mechanics. Nonetheless, there has been limited direct interaction and discussions between experimentalists and theoreticians in this research area. The purpose of this Frontiers Research Topic is to highlight exciting and important work that is currently developing in the fields of neuronal cell biology, neuronal mechanics, intracellular transport, and mathematical modeling in the form of primary research articles, reviews, perspectives, and commentaries.Suter, Daniel M.Miller, Kyle E.ORIGINALNeuronal Mechanics and Transport_100.PDFNeuronal Mechanics and Transport_100.PDFVer documentoapplication/pdf31654751https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/15049/1/Neuronal%20Mechanics%20and%20Transport_100.PDFfd6cbf034aa73c4480d34d259fb26e83MD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-82938https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/15049/2/license.txtabceeb1c943c50d3343516f9dbfc110fMD52open accessTHUMBNAILNeuronal Mechanics and Transport_100.PDF.jpgNeuronal Mechanics and Transport_100.PDF.jpgIM Thumbnailimage/jpeg12810https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/15049/3/Neuronal%20Mechanics%20and%20Transport_100.PDF.jpga46522568802cf6a820f72aea2234568MD53open access20.500.12010/15049oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/150492020-11-11 22:45:39.094open accessRepositorio Institucional - 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