COVID-19 and Sex Differences: Mechanisms and Biomarkers
Men are consistently overrepresented in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, and COVID (COrona- VIrus-Disease)-19 severe outcomes, including higher fatality rates. These differences are likely due to gender-specific behaviors, genetic and hormonal factors, and sex...
- Autores:
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2020
- Institución:
- Universidad de Bogotá Jorge Tadeo Lozano
- Repositorio:
- Expeditio: repositorio UTadeo
- Idioma:
- eng
- OAI Identifier:
- oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12552
- Acceso en línea:
- https://doi.org/10.1016/j.mayocp.2020.07.024
http://hdl.handle.net/20.500.12010/12552
- Palabra clave:
- COVID-19
SARS-Cov-2
Sex
Estrogen
Testosterone
Androgen
Biomarker
ACE2
TMPRSS2
Inflammation
Coagulation
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
- Rights
- License
- Acceso restringido
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COVID-19 and Sex Differences: Mechanisms and Biomarkers |
| title |
COVID-19 and Sex Differences: Mechanisms and Biomarkers |
| spellingShingle |
COVID-19 and Sex Differences: Mechanisms and Biomarkers COVID-19 SARS-Cov-2 Sex Estrogen Testosterone Androgen Biomarker ACE2 TMPRSS2 Inflammation Coagulation Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus |
| title_short |
COVID-19 and Sex Differences: Mechanisms and Biomarkers |
| title_full |
COVID-19 and Sex Differences: Mechanisms and Biomarkers |
| title_fullStr |
COVID-19 and Sex Differences: Mechanisms and Biomarkers |
| title_full_unstemmed |
COVID-19 and Sex Differences: Mechanisms and Biomarkers |
| title_sort |
COVID-19 and Sex Differences: Mechanisms and Biomarkers |
| dc.subject.spa.fl_str_mv |
COVID-19 SARS-Cov-2 Sex Estrogen Testosterone Androgen Biomarker ACE2 TMPRSS2 Inflammation Coagulation |
| topic |
COVID-19 SARS-Cov-2 Sex Estrogen Testosterone Androgen Biomarker ACE2 TMPRSS2 Inflammation Coagulation Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus |
| dc.subject.lemb.spa.fl_str_mv |
Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus |
| description |
Men are consistently overrepresented in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, and COVID (COrona- VIrus-Disease)-19 severe outcomes, including higher fatality rates. These differences are likely due to gender-specific behaviors, genetic and hormonal factors, and sex differences in biological pathways related to SARS-CoV-2 infection. Several social, behavioral and comorbid factors are implicated in the generally worse outcomes in men as compared with women. Underlying biological sex differences and their effects on COVID-19 outcomes, however, have received less attention. The present review summarizes the available literature regarding proposed molecular and cellular markers of COVID-19 infection, their associations with health outcomes, and any reported modification by sex. Biological sex differences characterized by such biomarkers exist within healthy populations and also differ with age- and sex-specific conditions, such as pregnancy and menopause. In the context of COVID-19, descriptive biomarker levels are often reported by sex, but data pertaining to the effect of patient sex on the relationship between biomarkers and COVID-19 disease severity/outcomes are scarce. Such biomarkers may offer plausible explanations for the worse COVID-19 outcomes seen in men. There is the need for larger studies with sex-specific reporting and robust analyses to elucidate how sex modifies cellular and molecular pathways associated with SARS-CoV-2. This will improve interpretation of biomarkers and clinical management of COVID-19 patients by facilitating a personalized medical approach to risk stratification, prevention, and treatment. |
| publishDate |
2020 |
| dc.date.accessioned.none.fl_str_mv |
2020-09-01T16:39:16Z |
| dc.date.available.none.fl_str_mv |
2020-09-01T16:39:16Z |
| dc.date.created.none.fl_str_mv |
2020 |
| dc.type.local.spa.fl_str_mv |
Artículo |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.identifier.issn.spa.fl_str_mv |
0025-6196 |
| dc.identifier.other.spa.fl_str_mv |
https://doi.org/10.1016/j.mayocp.2020.07.024 |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/20.500.12010/12552 |
| dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.1016/j.mayocp.2020.07.024 |
| identifier_str_mv |
0025-6196 |
| url |
https://doi.org/10.1016/j.mayocp.2020.07.024 http://hdl.handle.net/20.500.12010/12552 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_f1cf |
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Acceso restringido |
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Acceso restringido http://purl.org/coar/access_right/c_f1cf |
| dc.format.extent.spa.fl_str_mv |
39 páginas |
| dc.format.mimetype.spa.fl_str_mv |
image/jepg |
| dc.publisher.spa.fl_str_mv |
Mayo Clinic Proceedings |
| dc.source.spa.fl_str_mv |
reponame:Expeditio Repositorio Institucional UJTL instname:Universidad de Bogotá Jorge Tadeo Lozano |
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Universidad de Bogotá Jorge Tadeo Lozano |
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Expeditio Repositorio Institucional UJTL |
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2020-09-01T16:39:16Z2020-09-01T16:39:16Z20200025-6196https://doi.org/10.1016/j.mayocp.2020.07.024http://hdl.handle.net/20.500.12010/12552https://doi.org/10.1016/j.mayocp.2020.07.024Men are consistently overrepresented in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, and COVID (COrona- VIrus-Disease)-19 severe outcomes, including higher fatality rates. These differences are likely due to gender-specific behaviors, genetic and hormonal factors, and sex differences in biological pathways related to SARS-CoV-2 infection. Several social, behavioral and comorbid factors are implicated in the generally worse outcomes in men as compared with women. Underlying biological sex differences and their effects on COVID-19 outcomes, however, have received less attention. The present review summarizes the available literature regarding proposed molecular and cellular markers of COVID-19 infection, their associations with health outcomes, and any reported modification by sex. Biological sex differences characterized by such biomarkers exist within healthy populations and also differ with age- and sex-specific conditions, such as pregnancy and menopause. In the context of COVID-19, descriptive biomarker levels are often reported by sex, but data pertaining to the effect of patient sex on the relationship between biomarkers and COVID-19 disease severity/outcomes are scarce. Such biomarkers may offer plausible explanations for the worse COVID-19 outcomes seen in men. There is the need for larger studies with sex-specific reporting and robust analyses to elucidate how sex modifies cellular and molecular pathways associated with SARS-CoV-2. This will improve interpretation of biomarkers and clinical management of COVID-19 patients by facilitating a personalized medical approach to risk stratification, prevention, and treatment.39 páginasimage/jepgengMayo Clinic Proceedingsreponame:Expeditio Repositorio Institucional UJTLinstname:Universidad de Bogotá Jorge Tadeo LozanoCOVID-19SARS-Cov-2SexEstrogenTestosteroneAndrogenBiomarkerACE2TMPRSS2InflammationCoagulationSíndrome respiratorio agudo graveCOVID-19SARS-CoV-2CoronavirusCOVID-19 and Sex Differences: Mechanisms and BiomarkersArtículohttp://purl.org/coar/resource_type/c_2df8fbb1Acceso restringidohttp://purl.org/coar/access_right/c_f1cfHaitao, TuVermunt, JaneAbeykoon, JithmaGhamrawi, RanineGunaratne, MadugodaralalageJayachandran, MuthuvelNarang, KavitaParashuram, SantoshSuvakov, SonjaGarovic, VesnaORIGINALCaptura.PNGCaptura.PNGVer portadaimage/png90408https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12552/1/Captura.PNGd16bbd53d78251866a831da297281706MD51open accessCOVID-19-and-Sex-Differences--Mechanisms-and-Bioma_2020_Mayo-Clinic-Proceedi.pdfCOVID-19-and-Sex-Differences--Mechanisms-and-Bioma_2020_Mayo-Clinic-Proceedi.pdfArtículo reservadoapplication/pdf1106446https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12552/3/COVID-19-and-Sex-Differences--Mechanisms-and-Bioma_2020_Mayo-Clinic-Proceedi.pdf42d1a528f6aee3d1af17ca78dfafdaf4MD53embargoed access|||2200-09-01LICENSElicense.txtlicense.txttext/plain; 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