Development and clinical application of phosphorus-containing drugs

Phosphorus-containing drugs belong to an important class of therapeutic agents and are widely applied in daily clinical practices. Structurally, the phosphorus-containing drugs can be classified into phosphotriesters, phosphonates, phosphinates, phosphine oxides, phosphoric amides, bisphosphonates,...

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Autores:
Tipo de recurso:
Article of investigation
Fecha de publicación:
2020
Institución:
Universidad de Bogotá Jorge Tadeo Lozano
Repositorio:
Expeditio: repositorio UTadeo
Idioma:
eng
OAI Identifier:
oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12223
Acceso en línea:
https://doi.org/10.1016/j.medidd.2020.100063
http://hdl.handle.net/20.500.12010/12223
Palabra clave:
Phosphorus-containing drugs
Prodrugs
Drug modification
Phosphite, phosphate
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
Rights
License
Abierto (Texto Completo)
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dc.title.spa.fl_str_mv Development and clinical application of phosphorus-containing drugs
title Development and clinical application of phosphorus-containing drugs
spellingShingle Development and clinical application of phosphorus-containing drugs
Phosphorus-containing drugs
Prodrugs
Drug modification
Phosphite, phosphate
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
title_short Development and clinical application of phosphorus-containing drugs
title_full Development and clinical application of phosphorus-containing drugs
title_fullStr Development and clinical application of phosphorus-containing drugs
title_full_unstemmed Development and clinical application of phosphorus-containing drugs
title_sort Development and clinical application of phosphorus-containing drugs
dc.subject.spa.fl_str_mv Phosphorus-containing drugs
Prodrugs
Drug modification
Phosphite, phosphate
topic Phosphorus-containing drugs
Prodrugs
Drug modification
Phosphite, phosphate
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
dc.subject.lemb.spa.fl_str_mv Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
description Phosphorus-containing drugs belong to an important class of therapeutic agents and are widely applied in daily clinical practices. Structurally, the phosphorus-containing drugs can be classified into phosphotriesters, phosphonates, phosphinates, phosphine oxides, phosphoric amides, bisphosphonates, phosphoric anhydrides, and others; functionally, they are often designed as prodrugs with improved selectivity and bioavailability, reduced side effects and toxicity, or biomolecule analogues with endogenous materials and antagonistic endoenzyme supplements. This review summarized the phosphorus-containing drugs currently on the market as well as a few promising molecules at clinical studies, with particular emphasis on their structural features, biological mechanism, and indications.
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2020-08-25T17:06:24Z
dc.date.available.none.fl_str_mv 2020-08-25T17:06:24Z
dc.date.created.none.fl_str_mv 2020
dc.type.local.spa.fl_str_mv Artículo
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
format http://purl.org/coar/resource_type/c_2df8fbb1
dc.identifier.issn.spa.fl_str_mv 2590-0986
dc.identifier.other.spa.fl_str_mv https://doi.org/10.1016/j.medidd.2020.100063
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12010/12223
dc.identifier.doi.spa.fl_str_mv https://doi.org/10.1016/j.medidd.2020.100063
identifier_str_mv 2590-0986
url https://doi.org/10.1016/j.medidd.2020.100063
http://hdl.handle.net/20.500.12010/12223
dc.language.iso.spa.fl_str_mv eng
language eng
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.local.spa.fl_str_mv Abierto (Texto Completo)
rights_invalid_str_mv Abierto (Texto Completo)
http://purl.org/coar/access_right/c_abf2
dc.format.extent.spa.fl_str_mv 30 páginas
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Medicine in Drug Discovery
dc.source.spa.fl_str_mv reponame:Expeditio Repositorio Institucional UJTL
instname:Universidad de Bogotá Jorge Tadeo Lozano
instname_str Universidad de Bogotá Jorge Tadeo Lozano
institution Universidad de Bogotá Jorge Tadeo Lozano
reponame_str Expeditio Repositorio Institucional UJTL
collection Expeditio Repositorio Institucional UJTL
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spelling 2020-08-25T17:06:24Z2020-08-25T17:06:24Z20202590-0986https://doi.org/10.1016/j.medidd.2020.100063http://hdl.handle.net/20.500.12010/12223https://doi.org/10.1016/j.medidd.2020.100063Phosphorus-containing drugs belong to an important class of therapeutic agents and are widely applied in daily clinical practices. Structurally, the phosphorus-containing drugs can be classified into phosphotriesters, phosphonates, phosphinates, phosphine oxides, phosphoric amides, bisphosphonates, phosphoric anhydrides, and others; functionally, they are often designed as prodrugs with improved selectivity and bioavailability, reduced side effects and toxicity, or biomolecule analogues with endogenous materials and antagonistic endoenzyme supplements. This review summarized the phosphorus-containing drugs currently on the market as well as a few promising molecules at clinical studies, with particular emphasis on their structural features, biological mechanism, and indications.30 páginasapplication/pdfengMedicine in Drug Discoveryreponame:Expeditio Repositorio Institucional UJTLinstname:Universidad de Bogotá Jorge Tadeo LozanoPhosphorus-containing drugsProdrugsDrug modificationPhosphite, phosphateSíndrome respiratorio agudo graveCOVID-19SARS-CoV-2CoronavirusDevelopment and clinical application of phosphorus-containing drugsArtículohttp://purl.org/coar/resource_type/c_2df8fbb1Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2Yu, HanxiaoYang, HeShi, EnxueTang, WenjunORIGINAL1-s2.0-S2590098620300506-main.pdf1-s2.0-S2590098620300506-main.pdfVer artículoapplication/pdf3409604https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12223/1/1-s2.0-S2590098620300506-main.pdf6fd807837d5b242326b09875c76df6faMD51open accessLICENSElicense.txtlicense.txttext/plain; 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