Implications of sex differences in immunity for SARS-CoV-2 pathogenesis and design of therapeutic interventions

Men present more frequently with severe manifestations of COVID-19 and are at higher risk for death. The underlying mechanisms for these differences between female and male individuals infected with SARS-CoV-2 are insufficiently understood. However, studies from other viral infections have shown tha...

Full description

Autores:
Tipo de recurso:
Article of investigation
Fecha de publicación:
2020
Institución:
Universidad de Bogotá Jorge Tadeo Lozano
Repositorio:
Expeditio: repositorio UTadeo
Idioma:
eng
OAI Identifier:
oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12492
Acceso en línea:
https://doi.org/10.1016/j.immuni.2020.08.003
http://hdl.handle.net/20.500.12010/12492
Palabra clave:
SARS-CoV-2
Implications of sex differences in immunity
Pathogenesis
Therapeutic interventions
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
Rights
License
Acceso restringido
id UTADEO2_883c8a7066609857f1cc4de096185688
oai_identifier_str oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12492
network_acronym_str UTADEO2
network_name_str Expeditio: repositorio UTadeo
repository_id_str
dc.title.spa.fl_str_mv Implications of sex differences in immunity for SARS-CoV-2 pathogenesis and design of therapeutic interventions
title Implications of sex differences in immunity for SARS-CoV-2 pathogenesis and design of therapeutic interventions
spellingShingle Implications of sex differences in immunity for SARS-CoV-2 pathogenesis and design of therapeutic interventions
SARS-CoV-2
Implications of sex differences in immunity
Pathogenesis
Therapeutic interventions
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
title_short Implications of sex differences in immunity for SARS-CoV-2 pathogenesis and design of therapeutic interventions
title_full Implications of sex differences in immunity for SARS-CoV-2 pathogenesis and design of therapeutic interventions
title_fullStr Implications of sex differences in immunity for SARS-CoV-2 pathogenesis and design of therapeutic interventions
title_full_unstemmed Implications of sex differences in immunity for SARS-CoV-2 pathogenesis and design of therapeutic interventions
title_sort Implications of sex differences in immunity for SARS-CoV-2 pathogenesis and design of therapeutic interventions
dc.subject.spa.fl_str_mv SARS-CoV-2
Implications of sex differences in immunity
Pathogenesis
Therapeutic interventions
topic SARS-CoV-2
Implications of sex differences in immunity
Pathogenesis
Therapeutic interventions
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
dc.subject.lemb.spa.fl_str_mv Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
description Men present more frequently with severe manifestations of COVID-19 and are at higher risk for death. The underlying mechanisms for these differences between female and male individuals infected with SARS-CoV-2 are insufficiently understood. However, studies from other viral infections have shown that females can mount stronger immune responses against viruses than males. Emerging knowledge on the basic biological pathways that underlie differences in immune responses between women and men needs to be incorporated into research efforts on SARS-CoV-2 pathogenesis and pathology to identify targets for therapeutic interventions aimed at enhancing antiviral immune function and lung airway resilience while reducing pathogenic inflammation in COVID-19.
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2020-08-31T19:44:49Z
dc.date.available.none.fl_str_mv 2020-08-31T19:44:49Z
dc.date.created.none.fl_str_mv 2020
dc.type.local.spa.fl_str_mv Artículo
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
format http://purl.org/coar/resource_type/c_2df8fbb1
dc.identifier.issn.spa.fl_str_mv 1074-7613
dc.identifier.other.spa.fl_str_mv https://doi.org/10.1016/j.immuni.2020.08.003
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12010/12492
dc.identifier.doi.spa.fl_str_mv https://doi.org/10.1016/j.immuni.2020.08.003
identifier_str_mv 1074-7613
url https://doi.org/10.1016/j.immuni.2020.08.003
http://hdl.handle.net/20.500.12010/12492
dc.language.iso.spa.fl_str_mv eng
language eng
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_f1cf
dc.rights.local.spa.fl_str_mv Acceso restringido
rights_invalid_str_mv Acceso restringido
http://purl.org/coar/access_right/c_f1cf
dc.format.extent.spa.fl_str_mv 21 páginas
dc.format.mimetype.spa.fl_str_mv image/jepg
dc.publisher.spa.fl_str_mv Immunity
dc.source.spa.fl_str_mv reponame:Expeditio Repositorio Institucional UJTL
instname:Universidad de Bogotá Jorge Tadeo Lozano
instname_str Universidad de Bogotá Jorge Tadeo Lozano
institution Universidad de Bogotá Jorge Tadeo Lozano
reponame_str Expeditio Repositorio Institucional UJTL
collection Expeditio Repositorio Institucional UJTL
bitstream.url.fl_str_mv https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12492/1/Captura.PNG
https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12492/3/Implications-of-sex-differences-in-immunity-for-SARS-CoV-2-pathoge_2020_Immu.pdf
https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12492/2/license.txt
https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12492/4/Captura.PNG
https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12492/5/Implications-of-sex-differences-in-immunity-for-SARS-CoV-2-pathoge_2020_Immu.pdf.jpg
bitstream.checksum.fl_str_mv ddc0eb7660e41480ad45cc8c39401e41
cc0b7932ed3653f1eff31edeaea30b28
abceeb1c943c50d3343516f9dbfc110f
ddc0eb7660e41480ad45cc8c39401e41
ab1606746d593e5aac95cafee2fd56f2
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
MD5
repository.name.fl_str_mv Repositorio Institucional - Universidad Jorge Tadeo Lozano
repository.mail.fl_str_mv expeditio@utadeo.edu.co
_version_ 1812100383963611136
spelling 2020-08-31T19:44:49Z2020-08-31T19:44:49Z20201074-7613https://doi.org/10.1016/j.immuni.2020.08.003http://hdl.handle.net/20.500.12010/12492https://doi.org/10.1016/j.immuni.2020.08.003Men present more frequently with severe manifestations of COVID-19 and are at higher risk for death. The underlying mechanisms for these differences between female and male individuals infected with SARS-CoV-2 are insufficiently understood. However, studies from other viral infections have shown that females can mount stronger immune responses against viruses than males. Emerging knowledge on the basic biological pathways that underlie differences in immune responses between women and men needs to be incorporated into research efforts on SARS-CoV-2 pathogenesis and pathology to identify targets for therapeutic interventions aimed at enhancing antiviral immune function and lung airway resilience while reducing pathogenic inflammation in COVID-19.21 páginasimage/jepgengImmunityreponame:Expeditio Repositorio Institucional UJTLinstname:Universidad de Bogotá Jorge Tadeo LozanoSARS-CoV-2Implications of sex differences in immunityPathogenesisTherapeutic interventionsSíndrome respiratorio agudo graveCOVID-19SARS-CoV-2CoronavirusImplications of sex differences in immunity for SARS-CoV-2 pathogenesis and design of therapeutic interventionsArtículohttp://purl.org/coar/resource_type/c_2df8fbb1Acceso restringidohttp://purl.org/coar/access_right/c_f1cfBunders, MadeleineAltfeld, MarcusORIGINALCaptura.PNGCaptura.PNGVer portadaimage/png139854https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12492/1/Captura.PNGddc0eb7660e41480ad45cc8c39401e41MD51open accessImplications-of-sex-differences-in-immunity-for-SARS-CoV-2-pathoge_2020_Immu.pdfImplications-of-sex-differences-in-immunity-for-SARS-CoV-2-pathoge_2020_Immu.pdfArtículo reservadoapplication/pdf1154897https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12492/3/Implications-of-sex-differences-in-immunity-for-SARS-CoV-2-pathoge_2020_Immu.pdfcc0b7932ed3653f1eff31edeaea30b28MD53embargoed access|||2200-08-31LICENSElicense.txtlicense.txttext/plain; charset=utf-82938https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12492/2/license.txtabceeb1c943c50d3343516f9dbfc110fMD52open accessTHUMBNAILCaptura.PNGCaptura.PNGPortadaimage/png139854https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12492/4/Captura.PNGddc0eb7660e41480ad45cc8c39401e41MD54open accessImplications-of-sex-differences-in-immunity-for-SARS-CoV-2-pathoge_2020_Immu.pdf.jpgImplications-of-sex-differences-in-immunity-for-SARS-CoV-2-pathoge_2020_Immu.pdf.jpgIM Thumbnailimage/jpeg10548https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12492/5/Implications-of-sex-differences-in-immunity-for-SARS-CoV-2-pathoge_2020_Immu.pdf.jpgab1606746d593e5aac95cafee2fd56f2MD55open access20.500.12010/12492oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/124922020-08-31 14:46:42.575open accessRepositorio Institucional - Universidad Jorge Tadeo Lozanoexpeditio@utadeo.edu.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