Motor Cortex Microcircuits (Frontiers in Brain Microcircuits Series)

How does the motor cortex enable mammals to generate accurate, complex, and purposeful movements? A cubic millimeter of motor cortex contains roughly ~10^5 cells, an amazing ~4 Km of axons and ~0.4 Km of dendrites, somehow wired together with ~10^9 synapses. Corticospinal neurons (a.k.a. Betz cells,...

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Autores:
Tipo de recurso:
Book
Fecha de publicación:
2015
Institución:
Universidad de Bogotá Jorge Tadeo Lozano
Repositorio:
Expeditio: repositorio UTadeo
Idioma:
eng
OAI Identifier:
oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/14444
Acceso en línea:
https://www.frontiersin.org/research-topics/738/motor-cortex-microcircuits-frontiers-in-brain-microcircuits-series
http://hdl.handle.net/20.500.12010/14444
Palabra clave:
Ciencia
Motor Cortex
Conectividad intracortical
Afinación direccional
Rights
License
Abierto (Texto Completo)
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dc.title.spa.fl_str_mv Motor Cortex Microcircuits (Frontiers in Brain Microcircuits Series)
title Motor Cortex Microcircuits (Frontiers in Brain Microcircuits Series)
spellingShingle Motor Cortex Microcircuits (Frontiers in Brain Microcircuits Series)
Ciencia
Motor Cortex
Conectividad intracortical
Afinación direccional
title_short Motor Cortex Microcircuits (Frontiers in Brain Microcircuits Series)
title_full Motor Cortex Microcircuits (Frontiers in Brain Microcircuits Series)
title_fullStr Motor Cortex Microcircuits (Frontiers in Brain Microcircuits Series)
title_full_unstemmed Motor Cortex Microcircuits (Frontiers in Brain Microcircuits Series)
title_sort Motor Cortex Microcircuits (Frontiers in Brain Microcircuits Series)
dc.subject.spa.fl_str_mv Ciencia
topic Ciencia
Motor Cortex
Conectividad intracortical
Afinación direccional
dc.subject.lemb.spa.fl_str_mv Motor Cortex
Conectividad intracortical
Afinación direccional
description How does the motor cortex enable mammals to generate accurate, complex, and purposeful movements? A cubic millimeter of motor cortex contains roughly ~10^5 cells, an amazing ~4 Km of axons and ~0.4 Km of dendrites, somehow wired together with ~10^9 synapses. Corticospinal neurons (a.k.a. Betz cells, upper motor neurons) are a key cell type, monosynaptically conveying the output of the cortical circuit to the spinal cord circuits and lower motor neurons. But corticospinal neurons are greatly outnumbered by all the other kinds of neurons in motor cortex, which presumably also contribute crucially to the computational operations carried out for planning, executing, and guiding actions. Determining the wiring patterns, the dynamics of signaling, and how these relate to movement at the level of specific excitatory and inhibitory cell types is critically important for a mechanistic understanding of the input-output organization of motor cortex. While there is a predictive microcircuit hypothesis that relates motor learning to the operation of the cerebellar cortex, we lack such a microcircuit understanding in motor cortex and we consider microcircuits as a central research topic in the field. This Research Topic covers any issues relating to the microcircuit-level analysis of motor cortex. Contributions are welcomed from neuroscientists at all levels of investigation, from in vivo physiology and imaging in humans and monkeys, to rodent models, in vitro anatomy, electrophysiology, electroanatomy, cellular imaging, molecular biology, disease models, computational modeling, and more.
publishDate 2015
dc.date.created.none.fl_str_mv 2015-12-03
dc.date.accessioned.none.fl_str_mv 2020-10-13T23:32:26Z
dc.date.available.none.fl_str_mv 2020-10-13T23:32:26Z
dc.type.local.spa.fl_str_mv Libro
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_2f33
format http://purl.org/coar/resource_type/c_2f33
dc.identifier.isbn.none.fl_str_mv 978-2-889-19389-9
dc.identifier.issn.none.fl_str_mv 1664-8714
dc.identifier.other.none.fl_str_mv https://www.frontiersin.org/research-topics/738/motor-cortex-microcircuits-frontiers-in-brain-microcircuits-series
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12010/14444
dc.identifier.doi.none.fl_str_mv : 10.3389/978-2-88919-389-9
identifier_str_mv 978-2-889-19389-9
1664-8714
: 10.3389/978-2-88919-389-9
url https://www.frontiersin.org/research-topics/738/motor-cortex-microcircuits-frontiers-in-brain-microcircuits-series
http://hdl.handle.net/20.500.12010/14444
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.references.none.fl_str_mv BrechtM,HatsopoulosNG,KanekoTandShepherdGMG(2013)Motor cortexmicrocircuits.Front.NeuralCircuits 7:196. doi:10.3389/fncir.2013.00196
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.local.spa.fl_str_mv Abierto (Texto Completo)
dc.rights.creativecommons.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/legalcode
rights_invalid_str_mv Abierto (Texto Completo)
https://creativecommons.org/licenses/by/4.0/legalcode
http://purl.org/coar/access_right/c_abf2
dc.format.extent.spa.fl_str_mv 134 páginas
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Frontiers Media SA
institution Universidad de Bogotá Jorge Tadeo Lozano
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https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/14444/2/license.txt
https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/14444/3/Motor%20Cortex%20Microcircuits%20%28Frontiers%20in%20Brain%20Microcircuits%20Series%29_76.PDF.jpg
bitstream.checksum.fl_str_mv cf79ff1ce0c7a66d3346e7c08f5e7a42
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spelling 2020-10-13T23:32:26Z2020-10-13T23:32:26Z2015-12-03978-2-889-19389-91664-8714https://www.frontiersin.org/research-topics/738/motor-cortex-microcircuits-frontiers-in-brain-microcircuits-serieshttp://hdl.handle.net/20.500.12010/14444: 10.3389/978-2-88919-389-9134 páginasapplication/pdfengFrontiers Media SACienciaMotor CortexConectividad intracorticalAfinación direccionalMotor Cortex Microcircuits (Frontiers in Brain Microcircuits Series)Librohttp://purl.org/coar/resource_type/c_2f33Abierto (Texto Completo)https://creativecommons.org/licenses/by/4.0/legalcodehttp://purl.org/coar/access_right/c_abf2BrechtM,HatsopoulosNG,KanekoTandShepherdGMG(2013)Motor cortexmicrocircuits.Front.NeuralCircuits 7:196. doi:10.3389/fncir.2013.00196How does the motor cortex enable mammals to generate accurate, complex, and purposeful movements? A cubic millimeter of motor cortex contains roughly ~10^5 cells, an amazing ~4 Km of axons and ~0.4 Km of dendrites, somehow wired together with ~10^9 synapses. Corticospinal neurons (a.k.a. Betz cells, upper motor neurons) are a key cell type, monosynaptically conveying the output of the cortical circuit to the spinal cord circuits and lower motor neurons. But corticospinal neurons are greatly outnumbered by all the other kinds of neurons in motor cortex, which presumably also contribute crucially to the computational operations carried out for planning, executing, and guiding actions. Determining the wiring patterns, the dynamics of signaling, and how these relate to movement at the level of specific excitatory and inhibitory cell types is critically important for a mechanistic understanding of the input-output organization of motor cortex. While there is a predictive microcircuit hypothesis that relates motor learning to the operation of the cerebellar cortex, we lack such a microcircuit understanding in motor cortex and we consider microcircuits as a central research topic in the field. This Research Topic covers any issues relating to the microcircuit-level analysis of motor cortex. Contributions are welcomed from neuroscientists at all levels of investigation, from in vivo physiology and imaging in humans and monkeys, to rodent models, in vitro anatomy, electrophysiology, electroanatomy, cellular imaging, molecular biology, disease models, computational modeling, and more.Brecht, MichaelHatsopoulos, NicholasKaneko, TakehsiShepherd, Gordon M. 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