Motor Cortex Microcircuits (Frontiers in Brain Microcircuits Series)
How does the motor cortex enable mammals to generate accurate, complex, and purposeful movements? A cubic millimeter of motor cortex contains roughly ~10^5 cells, an amazing ~4 Km of axons and ~0.4 Km of dendrites, somehow wired together with ~10^9 synapses. Corticospinal neurons (a.k.a. Betz cells,...
- Autores:
- Tipo de recurso:
- Book
- Fecha de publicación:
- 2015
- Institución:
- Universidad de Bogotá Jorge Tadeo Lozano
- Repositorio:
- Expeditio: repositorio UTadeo
- Idioma:
- eng
- OAI Identifier:
- oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/14444
- Acceso en línea:
- https://www.frontiersin.org/research-topics/738/motor-cortex-microcircuits-frontiers-in-brain-microcircuits-series
http://hdl.handle.net/20.500.12010/14444
- Palabra clave:
- Ciencia
Motor Cortex
Conectividad intracortical
Afinación direccional
- Rights
- License
- Abierto (Texto Completo)
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dc.title.spa.fl_str_mv |
Motor Cortex Microcircuits (Frontiers in Brain Microcircuits Series) |
title |
Motor Cortex Microcircuits (Frontiers in Brain Microcircuits Series) |
spellingShingle |
Motor Cortex Microcircuits (Frontiers in Brain Microcircuits Series) Ciencia Motor Cortex Conectividad intracortical Afinación direccional |
title_short |
Motor Cortex Microcircuits (Frontiers in Brain Microcircuits Series) |
title_full |
Motor Cortex Microcircuits (Frontiers in Brain Microcircuits Series) |
title_fullStr |
Motor Cortex Microcircuits (Frontiers in Brain Microcircuits Series) |
title_full_unstemmed |
Motor Cortex Microcircuits (Frontiers in Brain Microcircuits Series) |
title_sort |
Motor Cortex Microcircuits (Frontiers in Brain Microcircuits Series) |
dc.subject.spa.fl_str_mv |
Ciencia |
topic |
Ciencia Motor Cortex Conectividad intracortical Afinación direccional |
dc.subject.lemb.spa.fl_str_mv |
Motor Cortex Conectividad intracortical Afinación direccional |
description |
How does the motor cortex enable mammals to generate accurate, complex, and purposeful movements? A cubic millimeter of motor cortex contains roughly ~10^5 cells, an amazing ~4 Km of axons and ~0.4 Km of dendrites, somehow wired together with ~10^9 synapses. Corticospinal neurons (a.k.a. Betz cells, upper motor neurons) are a key cell type, monosynaptically conveying the output of the cortical circuit to the spinal cord circuits and lower motor neurons. But corticospinal neurons are greatly outnumbered by all the other kinds of neurons in motor cortex, which presumably also contribute crucially to the computational operations carried out for planning, executing, and guiding actions. Determining the wiring patterns, the dynamics of signaling, and how these relate to movement at the level of specific excitatory and inhibitory cell types is critically important for a mechanistic understanding of the input-output organization of motor cortex. While there is a predictive microcircuit hypothesis that relates motor learning to the operation of the cerebellar cortex, we lack such a microcircuit understanding in motor cortex and we consider microcircuits as a central research topic in the field. This Research Topic covers any issues relating to the microcircuit-level analysis of motor cortex. Contributions are welcomed from neuroscientists at all levels of investigation, from in vivo physiology and imaging in humans and monkeys, to rodent models, in vitro anatomy, electrophysiology, electroanatomy, cellular imaging, molecular biology, disease models, computational modeling, and more. |
publishDate |
2015 |
dc.date.created.none.fl_str_mv |
2015-12-03 |
dc.date.accessioned.none.fl_str_mv |
2020-10-13T23:32:26Z |
dc.date.available.none.fl_str_mv |
2020-10-13T23:32:26Z |
dc.type.local.spa.fl_str_mv |
Libro |
dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_2f33 |
format |
http://purl.org/coar/resource_type/c_2f33 |
dc.identifier.isbn.none.fl_str_mv |
978-2-889-19389-9 |
dc.identifier.issn.none.fl_str_mv |
1664-8714 |
dc.identifier.other.none.fl_str_mv |
https://www.frontiersin.org/research-topics/738/motor-cortex-microcircuits-frontiers-in-brain-microcircuits-series |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/20.500.12010/14444 |
dc.identifier.doi.none.fl_str_mv |
: 10.3389/978-2-88919-389-9 |
identifier_str_mv |
978-2-889-19389-9 1664-8714 : 10.3389/978-2-88919-389-9 |
url |
https://www.frontiersin.org/research-topics/738/motor-cortex-microcircuits-frontiers-in-brain-microcircuits-series http://hdl.handle.net/20.500.12010/14444 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.references.none.fl_str_mv |
BrechtM,HatsopoulosNG,KanekoTandShepherdGMG(2013)Motor cortexmicrocircuits.Front.NeuralCircuits 7:196. doi:10.3389/fncir.2013.00196 |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.local.spa.fl_str_mv |
Abierto (Texto Completo) |
dc.rights.creativecommons.none.fl_str_mv |
https://creativecommons.org/licenses/by/4.0/legalcode |
rights_invalid_str_mv |
Abierto (Texto Completo) https://creativecommons.org/licenses/by/4.0/legalcode http://purl.org/coar/access_right/c_abf2 |
dc.format.extent.spa.fl_str_mv |
134 páginas |
dc.format.mimetype.spa.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Frontiers Media SA |
institution |
Universidad de Bogotá Jorge Tadeo Lozano |
bitstream.url.fl_str_mv |
https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/14444/1/Motor%20Cortex%20Microcircuits%20%28Frontiers%20in%20Brain%20Microcircuits%20Series%29_76.PDF https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/14444/2/license.txt https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/14444/3/Motor%20Cortex%20Microcircuits%20%28Frontiers%20in%20Brain%20Microcircuits%20Series%29_76.PDF.jpg |
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bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositorio Institucional - Universidad Jorge Tadeo Lozano |
repository.mail.fl_str_mv |
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2020-10-13T23:32:26Z2020-10-13T23:32:26Z2015-12-03978-2-889-19389-91664-8714https://www.frontiersin.org/research-topics/738/motor-cortex-microcircuits-frontiers-in-brain-microcircuits-serieshttp://hdl.handle.net/20.500.12010/14444: 10.3389/978-2-88919-389-9134 páginasapplication/pdfengFrontiers Media SACienciaMotor CortexConectividad intracorticalAfinación direccionalMotor Cortex Microcircuits (Frontiers in Brain Microcircuits Series)Librohttp://purl.org/coar/resource_type/c_2f33Abierto (Texto Completo)https://creativecommons.org/licenses/by/4.0/legalcodehttp://purl.org/coar/access_right/c_abf2BrechtM,HatsopoulosNG,KanekoTandShepherdGMG(2013)Motor cortexmicrocircuits.Front.NeuralCircuits 7:196. doi:10.3389/fncir.2013.00196How does the motor cortex enable mammals to generate accurate, complex, and purposeful movements? A cubic millimeter of motor cortex contains roughly ~10^5 cells, an amazing ~4 Km of axons and ~0.4 Km of dendrites, somehow wired together with ~10^9 synapses. Corticospinal neurons (a.k.a. Betz cells, upper motor neurons) are a key cell type, monosynaptically conveying the output of the cortical circuit to the spinal cord circuits and lower motor neurons. But corticospinal neurons are greatly outnumbered by all the other kinds of neurons in motor cortex, which presumably also contribute crucially to the computational operations carried out for planning, executing, and guiding actions. Determining the wiring patterns, the dynamics of signaling, and how these relate to movement at the level of specific excitatory and inhibitory cell types is critically important for a mechanistic understanding of the input-output organization of motor cortex. While there is a predictive microcircuit hypothesis that relates motor learning to the operation of the cerebellar cortex, we lack such a microcircuit understanding in motor cortex and we consider microcircuits as a central research topic in the field. This Research Topic covers any issues relating to the microcircuit-level analysis of motor cortex. Contributions are welcomed from neuroscientists at all levels of investigation, from in vivo physiology and imaging in humans and monkeys, to rodent models, in vitro anatomy, electrophysiology, electroanatomy, cellular imaging, molecular biology, disease models, computational modeling, and more.Brecht, MichaelHatsopoulos, NicholasKaneko, TakehsiShepherd, Gordon M. 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