COVID-19 and cardiovascular consequences: Is the endothelial dysfunction the hardest challenge?

A Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) has become a pandemic disease named Coronavirus Disease-19 (COVID-19) of epochal dimension. The clinical spectrum of COVID-19 is wide, ranging from asymptomatic forms to severe pneumonia, sepsis and multiple organ dysfunction syndromes r...

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Autores:
Tipo de recurso:
Article of investigation
Fecha de publicación:
2020
Institución:
Universidad de Bogotá Jorge Tadeo Lozano
Repositorio:
Expeditio: repositorio UTadeo
Idioma:
eng
OAI Identifier:
oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12824
Acceso en línea:
https://doi.org/10.1016/j.thromres.2020.08.039
http://hdl.handle.net/20.500.12010/12824
Palabra clave:
COVID-19
Endothelial dysfunction
Thrombosis
Inflammation
Cardiac injury
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
Rights
License
Acceso restringido
id UTADEO2_6ef493ab656df2010185a189743655ca
oai_identifier_str oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12824
network_acronym_str UTADEO2
network_name_str Expeditio: repositorio UTadeo
repository_id_str
dc.title.spa.fl_str_mv COVID-19 and cardiovascular consequences: Is the endothelial dysfunction the hardest challenge?
title COVID-19 and cardiovascular consequences: Is the endothelial dysfunction the hardest challenge?
spellingShingle COVID-19 and cardiovascular consequences: Is the endothelial dysfunction the hardest challenge?
COVID-19
Endothelial dysfunction
Thrombosis
Inflammation
Cardiac injury
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
title_short COVID-19 and cardiovascular consequences: Is the endothelial dysfunction the hardest challenge?
title_full COVID-19 and cardiovascular consequences: Is the endothelial dysfunction the hardest challenge?
title_fullStr COVID-19 and cardiovascular consequences: Is the endothelial dysfunction the hardest challenge?
title_full_unstemmed COVID-19 and cardiovascular consequences: Is the endothelial dysfunction the hardest challenge?
title_sort COVID-19 and cardiovascular consequences: Is the endothelial dysfunction the hardest challenge?
dc.subject.spa.fl_str_mv COVID-19
Endothelial dysfunction
Thrombosis
Inflammation
Cardiac injury
topic COVID-19
Endothelial dysfunction
Thrombosis
Inflammation
Cardiac injury
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
dc.subject.lemb.spa.fl_str_mv Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
description A Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) has become a pandemic disease named Coronavirus Disease-19 (COVID-19) of epochal dimension. The clinical spectrum of COVID-19 is wide, ranging from asymptomatic forms to severe pneumonia, sepsis and multiple organ dysfunction syndromes resulting in poor outcomes. Among the various consequences of severe COVID-19, cardiovascular (CV) collapse appears the most serious and potentially lethal. On the other hand, pre-existent CV comorbidities are also associated with higher mortality. The most reliable hypothetical pathogenetic mechanism for CV complications and cardiac injury in severe COVID-19 patients appears to be a sustained endothelial dysfunction, caused by the interplay of inflammation and coagulation. In this review, we survey papers addressing issues related to severe COVID-19, characterized by enhanced lung microvascular loss, hypercytokinemia, hypoxemia and thrombosis. We discuss about how the virus-induced downregulation of the angiotensin converting enzyme-2 (ACE2) receptor, used to enter the host cell, could affect the renin-angiotensin system, attempting to clarify the doubts about the use of ACE inhibitors and Angiotensin-II receptor blockers in COVID-19 patients. Finally, we point out how the delicate and physiological homeostatic function of the endothelium, which turns into a disastrous battlefield of the complex interaction between “cytokine and coagulative storms”, can be irreparably compromised and result in systemic inflammatory complications.
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2020-09-07T15:34:49Z
dc.date.available.none.fl_str_mv 2020-09-07T15:34:49Z
dc.date.created.none.fl_str_mv 2020
dc.type.local.spa.fl_str_mv Artículo
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
format http://purl.org/coar/resource_type/c_2df8fbb1
dc.identifier.issn.spa.fl_str_mv 0049-3848
dc.identifier.other.spa.fl_str_mv https://doi.org/10.1016/j.thromres.2020.08.039
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12010/12824
dc.identifier.doi.spa.fl_str_mv https://doi.org/10.1016/j.thromres.2020.08.039
identifier_str_mv 0049-3848
url https://doi.org/10.1016/j.thromres.2020.08.039
http://hdl.handle.net/20.500.12010/12824
dc.language.iso.spa.fl_str_mv eng
language eng
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_f1cf
dc.rights.local.spa.fl_str_mv Acceso restringido
rights_invalid_str_mv Acceso restringido
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dc.format.extent.spa.fl_str_mv 9 páginas
dc.format.mimetype.spa.fl_str_mv image/jepg
dc.publisher.spa.fl_str_mv Thrombosis Research
dc.source.spa.fl_str_mv reponame:Expeditio Repositorio Institucional UJTL
instname:Universidad de Bogotá Jorge Tadeo Lozano
instname_str Universidad de Bogotá Jorge Tadeo Lozano
institution Universidad de Bogotá Jorge Tadeo Lozano
reponame_str Expeditio Repositorio Institucional UJTL
collection Expeditio Repositorio Institucional UJTL
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spelling 2020-09-07T15:34:49Z2020-09-07T15:34:49Z20200049-3848https://doi.org/10.1016/j.thromres.2020.08.039http://hdl.handle.net/20.500.12010/12824https://doi.org/10.1016/j.thromres.2020.08.039A Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) has become a pandemic disease named Coronavirus Disease-19 (COVID-19) of epochal dimension. The clinical spectrum of COVID-19 is wide, ranging from asymptomatic forms to severe pneumonia, sepsis and multiple organ dysfunction syndromes resulting in poor outcomes. Among the various consequences of severe COVID-19, cardiovascular (CV) collapse appears the most serious and potentially lethal. On the other hand, pre-existent CV comorbidities are also associated with higher mortality. The most reliable hypothetical pathogenetic mechanism for CV complications and cardiac injury in severe COVID-19 patients appears to be a sustained endothelial dysfunction, caused by the interplay of inflammation and coagulation. In this review, we survey papers addressing issues related to severe COVID-19, characterized by enhanced lung microvascular loss, hypercytokinemia, hypoxemia and thrombosis. We discuss about how the virus-induced downregulation of the angiotensin converting enzyme-2 (ACE2) receptor, used to enter the host cell, could affect the renin-angiotensin system, attempting to clarify the doubts about the use of ACE inhibitors and Angiotensin-II receptor blockers in COVID-19 patients. Finally, we point out how the delicate and physiological homeostatic function of the endothelium, which turns into a disastrous battlefield of the complex interaction between “cytokine and coagulative storms”, can be irreparably compromised and result in systemic inflammatory complications.9 páginasimage/jepgengThrombosis Researchreponame:Expeditio Repositorio Institucional UJTLinstname:Universidad de Bogotá Jorge Tadeo LozanoCOVID-19Endothelial dysfunctionThrombosisInflammationCardiac injurySíndrome respiratorio agudo graveCOVID-19SARS-CoV-2CoronavirusCOVID-19 and cardiovascular consequences: Is the endothelial dysfunction the hardest challenge?Artículohttp://purl.org/coar/resource_type/c_2df8fbb1Acceso restringidohttp://purl.org/coar/access_right/c_f1cfDel Turco, SerenaVianello, AnnamariaRagusa, RosettaCaselli, ChiaraBasta, GiuseppinaLICENSElicense.txtlicense.txttext/plain; charset=utf-82938https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12824/2/license.txtabceeb1c943c50d3343516f9dbfc110fMD52open accessTHUMBNAILCaptura.PNGCaptura.PNGPortadaimage/png150788https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12824/4/Captura.PNG8a76999895db0938062bc8e479160767MD54open accessCOVID-19-and-cardiovascular-consequences--Is-the-endothelia_2020_Thrombosis-.pdf.jpgCOVID-19-and-cardiovascular-consequences--Is-the-endothelia_2020_Thrombosis-.pdf.jpgIM Thumbnailimage/jpeg14826https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12824/5/COVID-19-and-cardiovascular-consequences--Is-the-endothelia_2020_Thrombosis-.pdf.jpg07a2a1c3f86e40e0c95f9014b8a7eaa2MD55open accessORIGINALCaptura.PNGCaptura.PNGVer portadaimage/png150788https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12824/1/Captura.PNG8a76999895db0938062bc8e479160767MD51open access20.500.12010/12824oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/128242020-09-11 12:15:39.107open accessRepositorio Institucional - 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