Potential of natural astaxanthin in alleviating the risk of cytokine storm in COVID-19

Host excessive inflammatory immune response to SARS-CoV-2 infection is thought to underpin the pathogenesis of COVID-19 associated severe pneumonitis and acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). Once an immunological complication like cytokine storm occurs, anti-viral b...

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Autores:
Tipo de recurso:
Article of investigation
Fecha de publicación:
2020
Institución:
Universidad de Bogotá Jorge Tadeo Lozano
Repositorio:
Expeditio: repositorio UTadeo
Idioma:
eng
OAI Identifier:
oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/14606
Acceso en línea:
https://doi.org/10.1016/j.biopha.2020.110886
http://hdl.handle.net/20.500.12010/14606
Palabra clave:
COVID-19
Cytokine Storm
Acute Respiratory Distress Syndrome
Astaxanthin
Antioxidant
Anti-inflammatory
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
Rights
License
Abierto (Texto Completo)
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oai_identifier_str oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/14606
network_acronym_str UTADEO2
network_name_str Expeditio: repositorio UTadeo
repository_id_str
dc.title.spa.fl_str_mv Potential of natural astaxanthin in alleviating the risk of cytokine storm in COVID-19
title Potential of natural astaxanthin in alleviating the risk of cytokine storm in COVID-19
spellingShingle Potential of natural astaxanthin in alleviating the risk of cytokine storm in COVID-19
COVID-19
Cytokine Storm
Acute Respiratory Distress Syndrome
Astaxanthin
Antioxidant
Anti-inflammatory
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
title_short Potential of natural astaxanthin in alleviating the risk of cytokine storm in COVID-19
title_full Potential of natural astaxanthin in alleviating the risk of cytokine storm in COVID-19
title_fullStr Potential of natural astaxanthin in alleviating the risk of cytokine storm in COVID-19
title_full_unstemmed Potential of natural astaxanthin in alleviating the risk of cytokine storm in COVID-19
title_sort Potential of natural astaxanthin in alleviating the risk of cytokine storm in COVID-19
dc.subject.spa.fl_str_mv COVID-19
Cytokine Storm
Acute Respiratory Distress Syndrome
Astaxanthin
Antioxidant
Anti-inflammatory
topic COVID-19
Cytokine Storm
Acute Respiratory Distress Syndrome
Astaxanthin
Antioxidant
Anti-inflammatory
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
dc.subject.lemb.spa.fl_str_mv Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
description Host excessive inflammatory immune response to SARS-CoV-2 infection is thought to underpin the pathogenesis of COVID-19 associated severe pneumonitis and acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). Once an immunological complication like cytokine storm occurs, anti-viral based monotherapy alone is not enough. Additional anti-inflammatory treatment is recommended. It must be noted that anti-inflammatory drugs such as JAK inhibitors, IL-6 inhibitors, TNF-α inhibitors, colchicine, etc., have been either suggested or are under trials for managing cytokine storm in COVID-19 infections. Natural astaxanthin (ASX) has a clinically proven safety profile and has antioxidant, anti-inflammatory, and immunomodulatory properties. There is evidence from preclinical studies that supports its preventive actions against ALI/ARDS. Moreover, ASX has a potent PPARs activity. Therefore, it is plausible to speculate that ASX could be considered as a potential adjunctive supplement. Here, we summarize the mounting evidence where ASX is shown to exert protective effect by regulating the expression of pro-inflammatory factors IL-1β, IL-6, IL-8 and TNF-α. We present reports where ASX is shown to prevent against oxidative damage and attenuate exacerbation of the inflammatory responses by regulating signaling pathways like NF-ĸB, NLRP3 and JAK/STAT. These evidences provide a rationale for considering natural astaxanthin as a therapeutic agent against inflammatory cytokine storm and associated risks in COVID-19 infection and this suggestion requires further validation with clinical studies.
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2020-10-20T19:30:18Z
dc.date.available.none.fl_str_mv 2020-10-20T19:30:18Z
dc.date.created.none.fl_str_mv 2020
dc.type.local.spa.fl_str_mv Artículo
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
format http://purl.org/coar/resource_type/c_2df8fbb1
dc.identifier.issn.spa.fl_str_mv 0753-3322
dc.identifier.other.spa.fl_str_mv https://doi.org/10.1016/j.biopha.2020.110886
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12010/14606
dc.identifier.doi.spa.fl_str_mv https://doi.org/10.1016/j.biopha.2020.110886
identifier_str_mv 0753-3322
url https://doi.org/10.1016/j.biopha.2020.110886
http://hdl.handle.net/20.500.12010/14606
dc.language.iso.spa.fl_str_mv eng
language eng
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.local.spa.fl_str_mv Abierto (Texto Completo)
rights_invalid_str_mv Abierto (Texto Completo)
http://purl.org/coar/access_right/c_abf2
dc.format.extent.spa.fl_str_mv 83 páginas
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Biomedicine & Pharmacotherapy
dc.source.spa.fl_str_mv reponame:Expeditio Repositorio Institucional UJTL
instname:Universidad de Bogotá Jorge Tadeo Lozano
instname_str Universidad de Bogotá Jorge Tadeo Lozano
institution Universidad de Bogotá Jorge Tadeo Lozano
reponame_str Expeditio Repositorio Institucional UJTL
collection Expeditio Repositorio Institucional UJTL
bitstream.url.fl_str_mv https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/14606/2/license.txt
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spelling 2020-10-20T19:30:18Z2020-10-20T19:30:18Z20200753-3322https://doi.org/10.1016/j.biopha.2020.110886http://hdl.handle.net/20.500.12010/14606https://doi.org/10.1016/j.biopha.2020.110886Host excessive inflammatory immune response to SARS-CoV-2 infection is thought to underpin the pathogenesis of COVID-19 associated severe pneumonitis and acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). Once an immunological complication like cytokine storm occurs, anti-viral based monotherapy alone is not enough. Additional anti-inflammatory treatment is recommended. It must be noted that anti-inflammatory drugs such as JAK inhibitors, IL-6 inhibitors, TNF-α inhibitors, colchicine, etc., have been either suggested or are under trials for managing cytokine storm in COVID-19 infections. Natural astaxanthin (ASX) has a clinically proven safety profile and has antioxidant, anti-inflammatory, and immunomodulatory properties. There is evidence from preclinical studies that supports its preventive actions against ALI/ARDS. Moreover, ASX has a potent PPARs activity. Therefore, it is plausible to speculate that ASX could be considered as a potential adjunctive supplement. Here, we summarize the mounting evidence where ASX is shown to exert protective effect by regulating the expression of pro-inflammatory factors IL-1β, IL-6, IL-8 and TNF-α. We present reports where ASX is shown to prevent against oxidative damage and attenuate exacerbation of the inflammatory responses by regulating signaling pathways like NF-ĸB, NLRP3 and JAK/STAT. These evidences provide a rationale for considering natural astaxanthin as a therapeutic agent against inflammatory cytokine storm and associated risks in COVID-19 infection and this suggestion requires further validation with clinical studies.83 páginasapplication/pdfengBiomedicine & Pharmacotherapyreponame:Expeditio Repositorio Institucional UJTLinstname:Universidad de Bogotá Jorge Tadeo LozanoCOVID-19Cytokine StormAcute Respiratory Distress SyndromeAstaxanthinAntioxidantAnti-inflammatorySíndrome respiratorio agudo graveCOVID-19SARS-CoV-2CoronavirusPotential of natural astaxanthin in alleviating the risk of cytokine storm in COVID-19Artículohttp://purl.org/coar/resource_type/c_2df8fbb1Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2Talukdar, JayantaBhadra, BhaskarNagle, VinodDasgupta, SantanuLICENSElicense.txtlicense.txttext/plain; charset=utf-82938https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/14606/2/license.txtabceeb1c943c50d3343516f9dbfc110fMD52open accessTHUMBNAILPotential-of-natural-astaxanthin-in-alleviating-the-r_2020_Biomedicine---Pha.pdf.jpgPotential-of-natural-astaxanthin-in-alleviating-the-r_2020_Biomedicine---Pha.pdf.jpgIM Thumbnailimage/jpeg6097https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/14606/3/Potential-of-natural-astaxanthin-in-alleviating-the-r_2020_Biomedicine---Pha.pdf.jpg12fae97b3cda21e7f31d97a2fe831b17MD53open access20.500.12010/14606oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/146062021-03-12 18:25:00.042metadata only accessRepositorio Institucional - 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