Therapeutic promises of ginkgolide A: A literature-based review

Ginkgolide A is a highly active platelet activating factor antagonist cage molecule which was isolated from the leaves of the Ginkgo biloba L. It is known for its inflammatory and immunological potentials. This review aims to sketch a current scenario on its therapeutic activities on the basis of sc...

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Autores:
Tipo de recurso:
Article of investigation
Fecha de publicación:
2020
Institución:
Universidad de Bogotá Jorge Tadeo Lozano
Repositorio:
Expeditio: repositorio UTadeo
Idioma:
eng
OAI Identifier:
oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/15300
Acceso en línea:
https://doi.org/10.1016/j.biopha.2020.110908
http://hdl.handle.net/20.500.12010/15300
Palabra clave:
Ginkgolide A
Cancer
Inflammation
Thrombosis
Neurological activity
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
Rights
License
Abierto (Texto Completo)
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oai_identifier_str oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/15300
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dc.title.spa.fl_str_mv Therapeutic promises of ginkgolide A: A literature-based review
title Therapeutic promises of ginkgolide A: A literature-based review
spellingShingle Therapeutic promises of ginkgolide A: A literature-based review
Ginkgolide A
Cancer
Inflammation
Thrombosis
Neurological activity
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
title_short Therapeutic promises of ginkgolide A: A literature-based review
title_full Therapeutic promises of ginkgolide A: A literature-based review
title_fullStr Therapeutic promises of ginkgolide A: A literature-based review
title_full_unstemmed Therapeutic promises of ginkgolide A: A literature-based review
title_sort Therapeutic promises of ginkgolide A: A literature-based review
dc.subject.spa.fl_str_mv Ginkgolide A
Cancer
Inflammation
Thrombosis
Neurological activity
topic Ginkgolide A
Cancer
Inflammation
Thrombosis
Neurological activity
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
dc.subject.lemb.spa.fl_str_mv Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
description Ginkgolide A is a highly active platelet activating factor antagonist cage molecule which was isolated from the leaves of the Ginkgo biloba L. It is known for its inflammatory and immunological potentials. This review aims to sketch a current scenario on its therapeutic activities on the basis of scientific reports in the databases. A total 30 articles included in this review suggests that ginkgolide A has many important biological activities, including anti-inflammatory, anticancer, anxiolytic-like, anti-atherosclerosis and anti-atherombosis, neuro- and hepatoprotective effects. There is a lack of its toxicological (e.g. toxicity, cytotoxicity, genotoxicity and mutagenitcity) profile. In conclusion, ginkgolide A may be one of the potential therapeutic lead compounds, especially for the treatment of cardiovascular, hepatological, and neurological diseases and disorders. More studies are necessary on this hopeful therapeutic agent.
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2020-11-04T14:31:41Z
dc.date.available.none.fl_str_mv 2020-11-04T14:31:41Z
dc.date.created.none.fl_str_mv 2020
dc.type.local.spa.fl_str_mv Artículo
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
format http://purl.org/coar/resource_type/c_2df8fbb1
dc.identifier.issn.spa.fl_str_mv 0753-3322
dc.identifier.other.spa.fl_str_mv https://doi.org/10.1016/j.biopha.2020.110908
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12010/15300
dc.identifier.doi.spa.fl_str_mv https://doi.org/10.1016/j.biopha.2020.110908
identifier_str_mv 0753-3322
url https://doi.org/10.1016/j.biopha.2020.110908
http://hdl.handle.net/20.500.12010/15300
dc.language.iso.spa.fl_str_mv eng
language eng
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.local.spa.fl_str_mv Abierto (Texto Completo)
rights_invalid_str_mv Abierto (Texto Completo)
http://purl.org/coar/access_right/c_abf2
dc.format.extent.spa.fl_str_mv 10 páginas
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Biomedicine & pharmacotherapy
dc.source.spa.fl_str_mv reponame:Expeditio Repositorio Institucional UJTL
instname:Universidad de Bogotá Jorge Tadeo Lozano
instname_str Universidad de Bogotá Jorge Tadeo Lozano
institution Universidad de Bogotá Jorge Tadeo Lozano
reponame_str Expeditio Repositorio Institucional UJTL
collection Expeditio Repositorio Institucional UJTL
bitstream.url.fl_str_mv https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/15300/2/license.txt
https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/15300/3/Therapeutic-promises-of-ginkgolide-A--A-literatu_2020_Biomedicine---Pharmaco.pdf.jpg
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spelling 2020-11-04T14:31:41Z2020-11-04T14:31:41Z20200753-3322https://doi.org/10.1016/j.biopha.2020.110908http://hdl.handle.net/20.500.12010/15300https://doi.org/10.1016/j.biopha.2020.110908Ginkgolide A is a highly active platelet activating factor antagonist cage molecule which was isolated from the leaves of the Ginkgo biloba L. It is known for its inflammatory and immunological potentials. This review aims to sketch a current scenario on its therapeutic activities on the basis of scientific reports in the databases. A total 30 articles included in this review suggests that ginkgolide A has many important biological activities, including anti-inflammatory, anticancer, anxiolytic-like, anti-atherosclerosis and anti-atherombosis, neuro- and hepatoprotective effects. There is a lack of its toxicological (e.g. toxicity, cytotoxicity, genotoxicity and mutagenitcity) profile. In conclusion, ginkgolide A may be one of the potential therapeutic lead compounds, especially for the treatment of cardiovascular, hepatological, and neurological diseases and disorders. More studies are necessary on this hopeful therapeutic agent.10 páginasapplication/pdfengBiomedicine & pharmacotherapyreponame:Expeditio Repositorio Institucional UJTLinstname:Universidad de Bogotá Jorge Tadeo LozanoGinkgolide ACancerInflammationThrombosisNeurological activitySíndrome respiratorio agudo graveCOVID-19SARS-CoV-2CoronavirusTherapeutic promises of ginkgolide A: A literature-based reviewArtículohttp://purl.org/coar/resource_type/c_2df8fbb1Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2Sarkar, ChandanQuispe, CristinaJamaddar, SarminHossain, RajibRay, PrantaMondal, MilonMohamed, Zeinab AbdulwanisJaafaru, Mohammed SaniSalehi, BahareIslam, Muhammad TorequlRazis, Ahmad Faizal AbdullMartorell, MiquelPastene-Navarrete, EdgarSharifi-Rad, JavadLICENSElicense.txtlicense.txttext/plain; charset=utf-82938https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/15300/2/license.txtabceeb1c943c50d3343516f9dbfc110fMD52open accessTHUMBNAILTherapeutic-promises-of-ginkgolide-A--A-literatu_2020_Biomedicine---Pharmaco.pdf.jpgTherapeutic-promises-of-ginkgolide-A--A-literatu_2020_Biomedicine---Pharmaco.pdf.jpgIM Thumbnailimage/jpeg15698https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/15300/3/Therapeutic-promises-of-ginkgolide-A--A-literatu_2020_Biomedicine---Pharmaco.pdf.jpgfceef12590c320f14a637cd5dc3d58e0MD53open access20.500.12010/15300oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/153002021-03-12 17:42:45.352metadata only accessRepositorio Institucional - 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