Correlation of D-xylose with severity and morbidity-related factors of COVID-19 and possible therapeutic use of D-xylose and antibiotics for COVID-19

The SARS-Cov-2 pandemic that currently affects the entire world has been shown to be especially dangerous in the elderly (≥65 years) and in smokers, with notably strong comorbidity in patients already suffering from chronic diseases, such as Type 2 diabetes, cancers, chronic respiratory diseases, ob...

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Autores:
Tipo de recurso:
Article of investigation
Fecha de publicación:
2020
Institución:
Universidad de Bogotá Jorge Tadeo Lozano
Repositorio:
Expeditio: repositorio UTadeo
Idioma:
eng
OAI Identifier:
oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12363
Acceso en línea:
https://doi.org/10.1016/j.lfs.2020.118335
http://hdl.handle.net/20.500.12010/12363
Palabra clave:
Xylose
Xylitol, SARS-Cov-2
Inflammatory
Lung
Acute kidney injury
Diabetes
Scurvy
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
Rights
License
Acceso restringido
id UTADEO2_6109fab1323ac34ea8a12e4f0b7959ad
oai_identifier_str oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12363
network_acronym_str UTADEO2
network_name_str Expeditio: repositorio UTadeo
repository_id_str
dc.title.spa.fl_str_mv Correlation of D-xylose with severity and morbidity-related factors of COVID-19 and possible therapeutic use of D-xylose and antibiotics for COVID-19
title Correlation of D-xylose with severity and morbidity-related factors of COVID-19 and possible therapeutic use of D-xylose and antibiotics for COVID-19
spellingShingle Correlation of D-xylose with severity and morbidity-related factors of COVID-19 and possible therapeutic use of D-xylose and antibiotics for COVID-19
Xylose
Xylitol, SARS-Cov-2
Inflammatory
Lung
Acute kidney injury
Diabetes
Scurvy
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
title_short Correlation of D-xylose with severity and morbidity-related factors of COVID-19 and possible therapeutic use of D-xylose and antibiotics for COVID-19
title_full Correlation of D-xylose with severity and morbidity-related factors of COVID-19 and possible therapeutic use of D-xylose and antibiotics for COVID-19
title_fullStr Correlation of D-xylose with severity and morbidity-related factors of COVID-19 and possible therapeutic use of D-xylose and antibiotics for COVID-19
title_full_unstemmed Correlation of D-xylose with severity and morbidity-related factors of COVID-19 and possible therapeutic use of D-xylose and antibiotics for COVID-19
title_sort Correlation of D-xylose with severity and morbidity-related factors of COVID-19 and possible therapeutic use of D-xylose and antibiotics for COVID-19
dc.subject.spa.fl_str_mv Xylose
Xylitol, SARS-Cov-2
Inflammatory
Lung
Acute kidney injury
Diabetes
Scurvy
topic Xylose
Xylitol, SARS-Cov-2
Inflammatory
Lung
Acute kidney injury
Diabetes
Scurvy
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
dc.subject.lemb.spa.fl_str_mv Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
description The SARS-Cov-2 pandemic that currently affects the entire world has been shown to be especially dangerous in the elderly (≥65 years) and in smokers, with notably strong comorbidity in patients already suffering from chronic diseases, such as Type 2 diabetes, cancers, chronic respiratory diseases, obesity, and hypertension. Inflammation of the lungs is the main factor leading to respiratory distress in patients with chronic respiratory disease and in patients with severe COVID-19. Several studies have shown that inflammation of the lungs in general and Type 2 diabetes are accompanied by the degradation of glycosaminoglycans (GAGs), especially heparan sulfate (HS). Several studies have also shown the importance of countering the degradation of HS in lung infections and Type 2 diabetes. D-xylose, which is the initiating element for different sulfate GAG chains (especially HS), has shown regeneration properties for GAGs. D-xylose and xylitol have demonstrated antiinflammatory, antiglycemic, antiviral, and antibacterial properties in lung infections, alone or in combination with antibiotics. Considering the existing research on COVID-19 and related to D-xylose/xylitol, this review offers a perspective on why the association between D-xylose and antibiotics may contribute to significantly reducing the duration of treatment of COVID-19 patients and why some anti-inflammatory drugs may increase the severity of COVID-19. A strong correlation with scurvy, based on gender, age, ethnicity, smoking status, and obesity status, is also reviewed. Related to this, the effects of treatment with plants such as Artemisia are also addressed.
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2020-08-27T19:53:19Z
dc.date.available.none.fl_str_mv 2020-08-27T19:53:19Z
dc.date.created.none.fl_str_mv 2020
dc.type.local.spa.fl_str_mv Artículo
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format http://purl.org/coar/resource_type/c_2df8fbb1
dc.identifier.issn.spa.fl_str_mv 0024-3205
dc.identifier.other.spa.fl_str_mv https://doi.org/10.1016/j.lfs.2020.118335
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12010/12363
dc.identifier.doi.spa.fl_str_mv https://doi.org/10.1016/j.lfs.2020.118335
identifier_str_mv 0024-3205
url https://doi.org/10.1016/j.lfs.2020.118335
http://hdl.handle.net/20.500.12010/12363
dc.language.iso.spa.fl_str_mv eng
language eng
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dc.rights.local.spa.fl_str_mv Acceso restringido
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dc.format.extent.spa.fl_str_mv 12 páginas
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dc.publisher.spa.fl_str_mv Life Sciences
dc.source.spa.fl_str_mv reponame:Expeditio Repositorio Institucional UJTL
instname:Universidad de Bogotá Jorge Tadeo Lozano
instname_str Universidad de Bogotá Jorge Tadeo Lozano
institution Universidad de Bogotá Jorge Tadeo Lozano
reponame_str Expeditio Repositorio Institucional UJTL
collection Expeditio Repositorio Institucional UJTL
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spelling 2020-08-27T19:53:19Z2020-08-27T19:53:19Z20200024-3205https://doi.org/10.1016/j.lfs.2020.118335http://hdl.handle.net/20.500.12010/12363https://doi.org/10.1016/j.lfs.2020.118335The SARS-Cov-2 pandemic that currently affects the entire world has been shown to be especially dangerous in the elderly (≥65 years) and in smokers, with notably strong comorbidity in patients already suffering from chronic diseases, such as Type 2 diabetes, cancers, chronic respiratory diseases, obesity, and hypertension. Inflammation of the lungs is the main factor leading to respiratory distress in patients with chronic respiratory disease and in patients with severe COVID-19. Several studies have shown that inflammation of the lungs in general and Type 2 diabetes are accompanied by the degradation of glycosaminoglycans (GAGs), especially heparan sulfate (HS). Several studies have also shown the importance of countering the degradation of HS in lung infections and Type 2 diabetes. D-xylose, which is the initiating element for different sulfate GAG chains (especially HS), has shown regeneration properties for GAGs. D-xylose and xylitol have demonstrated antiinflammatory, antiglycemic, antiviral, and antibacterial properties in lung infections, alone or in combination with antibiotics. Considering the existing research on COVID-19 and related to D-xylose/xylitol, this review offers a perspective on why the association between D-xylose and antibiotics may contribute to significantly reducing the duration of treatment of COVID-19 patients and why some anti-inflammatory drugs may increase the severity of COVID-19. A strong correlation with scurvy, based on gender, age, ethnicity, smoking status, and obesity status, is also reviewed. Related to this, the effects of treatment with plants such as Artemisia are also addressed.12 páginasimage/jepgengLife Sciencesreponame:Expeditio Repositorio Institucional UJTLinstname:Universidad de Bogotá Jorge Tadeo LozanoXyloseXylitol, SARS-Cov-2InflammatoryLungAcute kidney injuryDiabetesScurvySíndrome respiratorio agudo graveCOVID-19SARS-CoV-2CoronavirusCorrelation of D-xylose with severity and morbidity-related factors of COVID-19 and possible therapeutic use of D-xylose and antibiotics for COVID-19Artículohttp://purl.org/coar/resource_type/c_2df8fbb1Acceso restringidohttp://purl.org/coar/access_right/c_f1cfCheudjeu, AntonyORIGINALCaptura.PNGCaptura.PNGVer portadaimage/png171004https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12363/1/Captura.PNGc06f947be37ab8fffc2f5c7b1a1c9216MD51open accessCorrelation-of-D-xylose-with-severity-and-morbidity-related-facto_2020_Life-.pdfCorrelation-of-D-xylose-with-severity-and-morbidity-related-facto_2020_Life-.pdfArtículo reservadoapplication/pdf784369https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12363/3/Correlation-of-D-xylose-with-severity-and-morbidity-related-facto_2020_Life-.pdf6b01afec13cec3fbeb3c164e3ad47dddMD53embargoed access|||2200-08-27LICENSElicense.txtlicense.txttext/plain; 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