Status of the current COVID-19 vaccine candidates: Implications in the sau- di population

Aim The purpose of this review is to discuss the current status of local and international efforts undergoing clinical trials aiming at developing a Coronavirus Disease-2019 (COVID-19) vaccine, and to highlight the anticipated challenges of this vaccine globally and in Saudi Arabia. Present Findings...

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Autores:
Tipo de recurso:
Article of investigation
Fecha de publicación:
2020
Institución:
Universidad de Bogotá Jorge Tadeo Lozano
Repositorio:
Expeditio: repositorio UTadeo
Idioma:
eng
OAI Identifier:
oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/15618
Acceso en línea:
https://doi.org/10.1016/j.jsps.2020.10.019
http://hdl.handle.net/20.500.12010/15618
Palabra clave:
COVID-19
SARS-CoV-2
Vaccines
Safety
Effectiveness
Saudi Arabia
COVID-19 (Enfermedad)
Infecciones por coronavirus
Vacunas - Pruebas
Rights
License
Abierto (Texto Completo)
id UTADEO2_5cc4e5868652ab3db7a8867bfdea710b
oai_identifier_str oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/15618
network_acronym_str UTADEO2
network_name_str Expeditio: repositorio UTadeo
repository_id_str
dc.title.spa.fl_str_mv Status of the current COVID-19 vaccine candidates: Implications in the sau- di population
title Status of the current COVID-19 vaccine candidates: Implications in the sau- di population
spellingShingle Status of the current COVID-19 vaccine candidates: Implications in the sau- di population
COVID-19
SARS-CoV-2
Vaccines
Safety
Effectiveness
Saudi Arabia
COVID-19 (Enfermedad)
Infecciones por coronavirus
Vacunas - Pruebas
title_short Status of the current COVID-19 vaccine candidates: Implications in the sau- di population
title_full Status of the current COVID-19 vaccine candidates: Implications in the sau- di population
title_fullStr Status of the current COVID-19 vaccine candidates: Implications in the sau- di population
title_full_unstemmed Status of the current COVID-19 vaccine candidates: Implications in the sau- di population
title_sort Status of the current COVID-19 vaccine candidates: Implications in the sau- di population
dc.subject.spa.fl_str_mv COVID-19
SARS-CoV-2
Vaccines
Safety
Effectiveness
Saudi Arabia
topic COVID-19
SARS-CoV-2
Vaccines
Safety
Effectiveness
Saudi Arabia
COVID-19 (Enfermedad)
Infecciones por coronavirus
Vacunas - Pruebas
dc.subject.lemb.spa.fl_str_mv COVID-19 (Enfermedad)
Infecciones por coronavirus
Vacunas - Pruebas
description Aim The purpose of this review is to discuss the current status of local and international efforts undergoing clinical trials aiming at developing a Coronavirus Disease-2019 (COVID-19) vaccine, and to highlight the anticipated challenges of this vaccine globally and in Saudi Arabia. Present Findings COVID-19 vaccine development efforts started in early January 2020 when Chinese scientists shared the Coronavirus genomic sequence in public domain. Approximately 321 research groups initiated the search for a vaccine, out of which 41 have reached phase I/II trails and 11 reached phase-III clinical trials, including approved vaccines for early to limited use. Out of these projects are two labs in the Kingdom of Saudi Arabia still in early stages of development of a COVID-19 vaccine. Several vaccine attempts are being tested from traditional, attenuated virus methods, to new nucleic acid-based designs. However, no vaccine has yet completed clinical trials and reached public domain. In spite of the challenges faced during previous vaccine trials, researchers have found that Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), the causative agent of COVID-19 is structurally similar to the (SARS-CoV-1) and the Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV), which caused epidemics in 2003 and 2012 respectively. Both SARS strains show identical affinity towards the type-II alveolar pneumocytes angiotensin converting enzyme-2 (ACE-2) receptor binding domains and therefore, similar pathogenicity. The race to develop the vaccine is predominantly for individuals at high risk of developing the infection, i.e. population groups who are most susceptible to experiencing fatal symptoms of the coronavirus. These include patients with comorbidities, above the age of 60 years and people at risk of contracting large viral loads, such as healthcare providers caring for critical admissions in inpatient wards, Intensive Care Units and Emergency Room settings. Summary Many different vaccine strategies are under development throughout different stages of the research timeline; however, it is estimated that none will show favorable results before end of 2020. For any immunization or interventional prevention/therapy system to reach the public and patients at high risk, it needs to undergo multiple phase trials to ensure safety and effectiveness. In this scoping review we aim to map the literature on COVID-19 vaccines and provide recommendations related to gaps in research, applicability and expected challenges for implementation of nationwide vaccination in Saudi Arabia.
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2020-11-11T14:39:10Z
dc.date.available.none.fl_str_mv 2020-11-11T14:39:10Z
dc.date.created.none.fl_str_mv 2020
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
format http://purl.org/coar/resource_type/c_2df8fbb1
dc.identifier.issn.spa.fl_str_mv 1319-0164
dc.identifier.other.spa.fl_str_mv https://doi.org/10.1016/j.jsps.2020.10.019
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12010/15618
dc.identifier.doi.spa.fl_str_mv https://doi.org/10.1016/j.jsps.2020.10.019
identifier_str_mv 1319-0164
url https://doi.org/10.1016/j.jsps.2020.10.019
http://hdl.handle.net/20.500.12010/15618
dc.language.iso.spa.fl_str_mv eng
language eng
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.local.spa.fl_str_mv Abierto (Texto Completo)
rights_invalid_str_mv Abierto (Texto Completo)
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dc.format.extent.spa.fl_str_mv 20 páginas
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Saudi pharmaceutical journal
institution Universidad de Bogotá Jorge Tadeo Lozano
bitstream.url.fl_str_mv https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/15618/2/license.txt
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spelling 2020-11-11T14:39:10Z2020-11-11T14:39:10Z20201319-0164https://doi.org/10.1016/j.jsps.2020.10.019http://hdl.handle.net/20.500.12010/15618https://doi.org/10.1016/j.jsps.2020.10.019Aim The purpose of this review is to discuss the current status of local and international efforts undergoing clinical trials aiming at developing a Coronavirus Disease-2019 (COVID-19) vaccine, and to highlight the anticipated challenges of this vaccine globally and in Saudi Arabia. Present Findings COVID-19 vaccine development efforts started in early January 2020 when Chinese scientists shared the Coronavirus genomic sequence in public domain. Approximately 321 research groups initiated the search for a vaccine, out of which 41 have reached phase I/II trails and 11 reached phase-III clinical trials, including approved vaccines for early to limited use. Out of these projects are two labs in the Kingdom of Saudi Arabia still in early stages of development of a COVID-19 vaccine. Several vaccine attempts are being tested from traditional, attenuated virus methods, to new nucleic acid-based designs. However, no vaccine has yet completed clinical trials and reached public domain. In spite of the challenges faced during previous vaccine trials, researchers have found that Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), the causative agent of COVID-19 is structurally similar to the (SARS-CoV-1) and the Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV), which caused epidemics in 2003 and 2012 respectively. Both SARS strains show identical affinity towards the type-II alveolar pneumocytes angiotensin converting enzyme-2 (ACE-2) receptor binding domains and therefore, similar pathogenicity. The race to develop the vaccine is predominantly for individuals at high risk of developing the infection, i.e. population groups who are most susceptible to experiencing fatal symptoms of the coronavirus. These include patients with comorbidities, above the age of 60 years and people at risk of contracting large viral loads, such as healthcare providers caring for critical admissions in inpatient wards, Intensive Care Units and Emergency Room settings. Summary Many different vaccine strategies are under development throughout different stages of the research timeline; however, it is estimated that none will show favorable results before end of 2020. For any immunization or interventional prevention/therapy system to reach the public and patients at high risk, it needs to undergo multiple phase trials to ensure safety and effectiveness. In this scoping review we aim to map the literature on COVID-19 vaccines and provide recommendations related to gaps in research, applicability and expected challenges for implementation of nationwide vaccination in Saudi Arabia.20 páginasapplication/pdfengSaudi pharmaceutical journalCOVID-19SARS-CoV-2VaccinesSafetyEffectivenessSaudi ArabiaCOVID-19 (Enfermedad)Infecciones por coronavirusVacunas - PruebasStatus of the current COVID-19 vaccine candidates: Implications in the sau- di populationAbierto (Texto Completo)http://purl.org/coar/access_right/c_abf2http://purl.org/coar/resource_type/c_2df8fbb1Raja, AlAnoud TofailAhmedAlshamsan, AwsAl-jedai, AhmedLICENSElicense.txtlicense.txttext/plain; charset=utf-82938https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/15618/2/license.txtabceeb1c943c50d3343516f9dbfc110fMD52open accessORIGINAL1-s2.0-S1319016420302619-main.pdf1-s2.0-S1319016420302619-main.pdfVer artículoapplication/pdf400087https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/15618/1/1-s2.0-S1319016420302619-main.pdf4717a93f76da737deaf0b3f68c48d0ffMD51open accessTHUMBNAIL1-s2.0-S1319016420302619-main.pdf.jpg1-s2.0-S1319016420302619-main.pdf.jpgIM Thumbnailimage/jpeg11051https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/15618/3/1-s2.0-S1319016420302619-main.pdf.jpgb974b61d19db6f7209969c72ffcf09d6MD53open access20.500.12010/15618oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/156182020-11-11 09:39:10.931open accessRepositorio Institucional - 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