Crosstalk between endoplasmic reticulum stress and anti-viral activities: A novel therapeutic target for COVID-19

The outbreak of COVID-19 caused by 2019–nCov/SARS-CoV-2 has become a pandemic with an urgent need for understanding the mechanisms and identifying a treatment. Viral infections including SARS-CoV are associated with increased levels of reactive oxygen species, disturbances of Ca++ caused by unfolded...

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Autores:
Tipo de recurso:
Article of journal
Fecha de publicación:
2020
Institución:
Universidad de Bogotá Jorge Tadeo Lozano
Repositorio:
Expeditio: repositorio UTadeo
Idioma:
eng
OAI Identifier:
oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12047
Acceso en línea:
https://www.sciencedirect.com/science/article/pii/S0024320520305920
http://hdl.handle.net/20.500.12010/12047
https://doi.org/10.1016/j.lfs.2020.117842
Palabra clave:
COVID-19
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
COVID-19
2019-nCov/SARS-CoV-2
Endoplasmic reticulum stress
Unfolded protein response
Andrographolide
Melatonin
Rights
License
Acceso restringido
id UTADEO2_5a1d3aa243b43a75d54e60e9cd2c4b01
oai_identifier_str oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12047
network_acronym_str UTADEO2
network_name_str Expeditio: repositorio UTadeo
repository_id_str
dc.title.spa.fl_str_mv Crosstalk between endoplasmic reticulum stress and anti-viral activities: A novel therapeutic target for COVID-19
title Crosstalk between endoplasmic reticulum stress and anti-viral activities: A novel therapeutic target for COVID-19
spellingShingle Crosstalk between endoplasmic reticulum stress and anti-viral activities: A novel therapeutic target for COVID-19
COVID-19
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
COVID-19
2019-nCov/SARS-CoV-2
Endoplasmic reticulum stress
Unfolded protein response
Andrographolide
Melatonin
title_short Crosstalk between endoplasmic reticulum stress and anti-viral activities: A novel therapeutic target for COVID-19
title_full Crosstalk between endoplasmic reticulum stress and anti-viral activities: A novel therapeutic target for COVID-19
title_fullStr Crosstalk between endoplasmic reticulum stress and anti-viral activities: A novel therapeutic target for COVID-19
title_full_unstemmed Crosstalk between endoplasmic reticulum stress and anti-viral activities: A novel therapeutic target for COVID-19
title_sort Crosstalk between endoplasmic reticulum stress and anti-viral activities: A novel therapeutic target for COVID-19
dc.subject.spa.fl_str_mv COVID-19
topic COVID-19
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
COVID-19
2019-nCov/SARS-CoV-2
Endoplasmic reticulum stress
Unfolded protein response
Andrographolide
Melatonin
dc.subject.lemb.spa.fl_str_mv Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
dc.subject.keyword.spa.fl_str_mv COVID-19
2019-nCov/SARS-CoV-2
Endoplasmic reticulum stress
Unfolded protein response
Andrographolide
Melatonin
description The outbreak of COVID-19 caused by 2019–nCov/SARS-CoV-2 has become a pandemic with an urgent need for understanding the mechanisms and identifying a treatment. Viral infections including SARS-CoV are associated with increased levels of reactive oxygen species, disturbances of Ca++ caused by unfolded protein response (UPR) mediated by endoplasmic reticulum (ER) stress and is due to the exploitation of virus's own protein i.e., viroporins into the host cells. Several clinical trials are on-going including testing Remdesivir (anti-viral), Chloroquine and Hydroxychloroquine derivatives (anti-malarial drugs) etc. Unfortunately, each drug has specific limitations. Herein, we review the viral protein involvement to activate ER stress transducers (IRE-1, PERK, ATF-6) and their downstream signals; and evaluate combination therapies for COVID-19 mediated ER stress alterations. Melatonin is an immunoregulator, anti-pyretic, antioxidant, anti-inflammatory and ER stress modulator during viral infections. It enhances protective mechanisms for respiratory tract disorders. Andrographolide, isolated from Andrographis paniculata, has versatile biological activities including immunomodulation and determining SARS-CoV-2 binding site. Considering the properties of both compounds in terms of anti-inflammatory, antioxidant, anti-pyrogenic, anti-viral and ER stress modulation and computational approaches revealing andrographolide docks with the SARS-CoV2 binding site, we predict that this combination therapy may have potential utility against COVID-19.
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2020-08-20T22:26:12Z
dc.date.available.none.fl_str_mv 2020-08-20T22:26:12Z
dc.date.created.none.fl_str_mv 2020-08-15
dc.type.local.spa.fl_str_mv Artículo
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_6501
format http://purl.org/coar/resource_type/c_6501
dc.identifier.issn.spa.fl_str_mv 0024-3205
dc.identifier.other.spa.fl_str_mv https://www.sciencedirect.com/science/article/pii/S0024320520305920
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12010/12047
dc.identifier.doi.spa.fl_str_mv https://doi.org/10.1016/j.lfs.2020.117842
identifier_str_mv 0024-3205
url https://www.sciencedirect.com/science/article/pii/S0024320520305920
http://hdl.handle.net/20.500.12010/12047
https://doi.org/10.1016/j.lfs.2020.117842
dc.language.iso.spa.fl_str_mv eng
language eng
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_f1cf
dc.rights.local.spa.fl_str_mv Acceso restringido
rights_invalid_str_mv Acceso restringido
http://purl.org/coar/access_right/c_f1cf
dc.format.extent.spa.fl_str_mv 5 Páginas
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Life Sciences
dc.source.spa.fl_str_mv reponame:Expeditio Repositorio Institucional UJTL
instname:Universidad de Bogotá Jorge Tadeo Lozano
instname_str Universidad de Bogotá Jorge Tadeo Lozano
institution Universidad de Bogotá Jorge Tadeo Lozano
reponame_str Expeditio Repositorio Institucional UJTL
collection Expeditio Repositorio Institucional UJTL
bitstream.url.fl_str_mv https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12047/2/license.txt
https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12047/3/Crosstalk-between-endoplasmic-reticulum-stress-and-anti-viral-a_2020_Life-Sc.pdf
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spelling 2020-08-20T22:26:12Z2020-08-20T22:26:12Z2020-08-150024-3205https://www.sciencedirect.com/science/article/pii/S0024320520305920http://hdl.handle.net/20.500.12010/12047https://doi.org/10.1016/j.lfs.2020.1178425 Páginasapplication/pdfengLife Sciencesreponame:Expeditio Repositorio Institucional UJTLinstname:Universidad de Bogotá Jorge Tadeo LozanoCOVID-19Síndrome respiratorio agudo graveCOVID-19SARS-CoV-2CoronavirusCOVID-192019-nCov/SARS-CoV-2Endoplasmic reticulum stressUnfolded protein responseAndrographolideMelatoninCrosstalk between endoplasmic reticulum stress and anti-viral activities: A novel therapeutic target for COVID-19Artículohttp://purl.org/coar/resource_type/c_6501Acceso restringidohttp://purl.org/coar/access_right/c_f1cfThe outbreak of COVID-19 caused by 2019–nCov/SARS-CoV-2 has become a pandemic with an urgent need for understanding the mechanisms and identifying a treatment. Viral infections including SARS-CoV are associated with increased levels of reactive oxygen species, disturbances of Ca++ caused by unfolded protein response (UPR) mediated by endoplasmic reticulum (ER) stress and is due to the exploitation of virus's own protein i.e., viroporins into the host cells. Several clinical trials are on-going including testing Remdesivir (anti-viral), Chloroquine and Hydroxychloroquine derivatives (anti-malarial drugs) etc. Unfortunately, each drug has specific limitations. Herein, we review the viral protein involvement to activate ER stress transducers (IRE-1, PERK, ATF-6) and their downstream signals; and evaluate combination therapies for COVID-19 mediated ER stress alterations. Melatonin is an immunoregulator, anti-pyretic, antioxidant, anti-inflammatory and ER stress modulator during viral infections. It enhances protective mechanisms for respiratory tract disorders. Andrographolide, isolated from Andrographis paniculata, has versatile biological activities including immunomodulation and determining SARS-CoV-2 binding site. Considering the properties of both compounds in terms of anti-inflammatory, antioxidant, anti-pyrogenic, anti-viral and ER stress modulation and computational approaches revealing andrographolide docks with the SARS-CoV2 binding site, we predict that this combination therapy may have potential utility against COVID-19.Banerjee, AditiCzinn, Steven J.Reiter, Russel J.Blanchard, Thomas G.LICENSElicense.txtlicense.txttext/plain; charset=utf-82938https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12047/2/license.txtabceeb1c943c50d3343516f9dbfc110fMD52open accessORIGINALCrosstalk-between-endoplasmic-reticulum-stress-and-anti-viral-a_2020_Life-Sc.pdfCrosstalk-between-endoplasmic-reticulum-stress-and-anti-viral-a_2020_Life-Sc.pdfDocumento reservadoapplication/pdf455009https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12047/3/Crosstalk-between-endoplasmic-reticulum-stress-and-anti-viral-a_2020_Life-Sc.pdf15b71807c6f20cfe41310fe2f332a3cdMD53embargoed access|||2220-08-19THUMBNAILCaptura3.PNGCaptura3.PNGimage/png106202https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12047/4/Captura3.PNGc0a7c764fd75600954320951e73ce668MD54open accessCrosstalk-between-endoplasmic-reticulum-stress-and-anti-viral-a_2020_Life-Sc.pdf.jpgCrosstalk-between-endoplasmic-reticulum-stress-and-anti-viral-a_2020_Life-Sc.pdf.jpgIM Thumbnailimage/jpeg21595https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12047/5/Crosstalk-between-endoplasmic-reticulum-stress-and-anti-viral-a_2020_Life-Sc.pdf.jpg9032577fd8b80f7a6b75df313264f1f8MD55open access20.500.12010/12047oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/120472020-08-20 17:27:15.338embargoed access|||2220-08-19Repositorio Institucional - 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