Crosstalk between endoplasmic reticulum stress and anti-viral activities: A novel therapeutic target for COVID-19
The outbreak of COVID-19 caused by 2019–nCov/SARS-CoV-2 has become a pandemic with an urgent need for understanding the mechanisms and identifying a treatment. Viral infections including SARS-CoV are associated with increased levels of reactive oxygen species, disturbances of Ca++ caused by unfolded...
- Autores:
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2020
- Institución:
- Universidad de Bogotá Jorge Tadeo Lozano
- Repositorio:
- Expeditio: repositorio UTadeo
- Idioma:
- eng
- OAI Identifier:
- oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12047
- Acceso en línea:
- https://www.sciencedirect.com/science/article/pii/S0024320520305920
http://hdl.handle.net/20.500.12010/12047
https://doi.org/10.1016/j.lfs.2020.117842
- Palabra clave:
- COVID-19
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
COVID-19
2019-nCov/SARS-CoV-2
Endoplasmic reticulum stress
Unfolded protein response
Andrographolide
Melatonin
- Rights
- License
- Acceso restringido
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oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12047 |
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UTADEO2 |
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Expeditio: repositorio UTadeo |
repository_id_str |
|
dc.title.spa.fl_str_mv |
Crosstalk between endoplasmic reticulum stress and anti-viral activities: A novel therapeutic target for COVID-19 |
title |
Crosstalk between endoplasmic reticulum stress and anti-viral activities: A novel therapeutic target for COVID-19 |
spellingShingle |
Crosstalk between endoplasmic reticulum stress and anti-viral activities: A novel therapeutic target for COVID-19 COVID-19 Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus COVID-19 2019-nCov/SARS-CoV-2 Endoplasmic reticulum stress Unfolded protein response Andrographolide Melatonin |
title_short |
Crosstalk between endoplasmic reticulum stress and anti-viral activities: A novel therapeutic target for COVID-19 |
title_full |
Crosstalk between endoplasmic reticulum stress and anti-viral activities: A novel therapeutic target for COVID-19 |
title_fullStr |
Crosstalk between endoplasmic reticulum stress and anti-viral activities: A novel therapeutic target for COVID-19 |
title_full_unstemmed |
Crosstalk between endoplasmic reticulum stress and anti-viral activities: A novel therapeutic target for COVID-19 |
title_sort |
Crosstalk between endoplasmic reticulum stress and anti-viral activities: A novel therapeutic target for COVID-19 |
dc.subject.spa.fl_str_mv |
COVID-19 |
topic |
COVID-19 Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus COVID-19 2019-nCov/SARS-CoV-2 Endoplasmic reticulum stress Unfolded protein response Andrographolide Melatonin |
dc.subject.lemb.spa.fl_str_mv |
Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus |
dc.subject.keyword.spa.fl_str_mv |
COVID-19 2019-nCov/SARS-CoV-2 Endoplasmic reticulum stress Unfolded protein response Andrographolide Melatonin |
description |
The outbreak of COVID-19 caused by 2019–nCov/SARS-CoV-2 has become a pandemic with an urgent need for understanding the mechanisms and identifying a treatment. Viral infections including SARS-CoV are associated with increased levels of reactive oxygen species, disturbances of Ca++ caused by unfolded protein response (UPR) mediated by endoplasmic reticulum (ER) stress and is due to the exploitation of virus's own protein i.e., viroporins into the host cells. Several clinical trials are on-going including testing Remdesivir (anti-viral), Chloroquine and Hydroxychloroquine derivatives (anti-malarial drugs) etc. Unfortunately, each drug has specific limitations. Herein, we review the viral protein involvement to activate ER stress transducers (IRE-1, PERK, ATF-6) and their downstream signals; and evaluate combination therapies for COVID-19 mediated ER stress alterations. Melatonin is an immunoregulator, anti-pyretic, antioxidant, anti-inflammatory and ER stress modulator during viral infections. It enhances protective mechanisms for respiratory tract disorders. Andrographolide, isolated from Andrographis paniculata, has versatile biological activities including immunomodulation and determining SARS-CoV-2 binding site. Considering the properties of both compounds in terms of anti-inflammatory, antioxidant, anti-pyrogenic, anti-viral and ER stress modulation and computational approaches revealing andrographolide docks with the SARS-CoV2 binding site, we predict that this combination therapy may have potential utility against COVID-19. |
publishDate |
2020 |
dc.date.accessioned.none.fl_str_mv |
2020-08-20T22:26:12Z |
dc.date.available.none.fl_str_mv |
2020-08-20T22:26:12Z |
dc.date.created.none.fl_str_mv |
2020-08-15 |
dc.type.local.spa.fl_str_mv |
Artículo |
dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
format |
http://purl.org/coar/resource_type/c_6501 |
dc.identifier.issn.spa.fl_str_mv |
0024-3205 |
dc.identifier.other.spa.fl_str_mv |
https://www.sciencedirect.com/science/article/pii/S0024320520305920 |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/20.500.12010/12047 |
dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.1016/j.lfs.2020.117842 |
identifier_str_mv |
0024-3205 |
url |
https://www.sciencedirect.com/science/article/pii/S0024320520305920 http://hdl.handle.net/20.500.12010/12047 https://doi.org/10.1016/j.lfs.2020.117842 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_f1cf |
dc.rights.local.spa.fl_str_mv |
Acceso restringido |
rights_invalid_str_mv |
Acceso restringido http://purl.org/coar/access_right/c_f1cf |
dc.format.extent.spa.fl_str_mv |
5 Páginas |
dc.format.mimetype.spa.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Life Sciences |
dc.source.spa.fl_str_mv |
reponame:Expeditio Repositorio Institucional UJTL instname:Universidad de Bogotá Jorge Tadeo Lozano |
instname_str |
Universidad de Bogotá Jorge Tadeo Lozano |
institution |
Universidad de Bogotá Jorge Tadeo Lozano |
reponame_str |
Expeditio Repositorio Institucional UJTL |
collection |
Expeditio Repositorio Institucional UJTL |
bitstream.url.fl_str_mv |
https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12047/2/license.txt https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12047/3/Crosstalk-between-endoplasmic-reticulum-stress-and-anti-viral-a_2020_Life-Sc.pdf https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12047/4/Captura3.PNG https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12047/5/Crosstalk-between-endoplasmic-reticulum-stress-and-anti-viral-a_2020_Life-Sc.pdf.jpg |
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Repositorio Institucional - Universidad Jorge Tadeo Lozano |
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expeditio@utadeo.edu.co |
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spelling |
2020-08-20T22:26:12Z2020-08-20T22:26:12Z2020-08-150024-3205https://www.sciencedirect.com/science/article/pii/S0024320520305920http://hdl.handle.net/20.500.12010/12047https://doi.org/10.1016/j.lfs.2020.1178425 Páginasapplication/pdfengLife Sciencesreponame:Expeditio Repositorio Institucional UJTLinstname:Universidad de Bogotá Jorge Tadeo LozanoCOVID-19Síndrome respiratorio agudo graveCOVID-19SARS-CoV-2CoronavirusCOVID-192019-nCov/SARS-CoV-2Endoplasmic reticulum stressUnfolded protein responseAndrographolideMelatoninCrosstalk between endoplasmic reticulum stress and anti-viral activities: A novel therapeutic target for COVID-19Artículohttp://purl.org/coar/resource_type/c_6501Acceso restringidohttp://purl.org/coar/access_right/c_f1cfThe outbreak of COVID-19 caused by 2019–nCov/SARS-CoV-2 has become a pandemic with an urgent need for understanding the mechanisms and identifying a treatment. Viral infections including SARS-CoV are associated with increased levels of reactive oxygen species, disturbances of Ca++ caused by unfolded protein response (UPR) mediated by endoplasmic reticulum (ER) stress and is due to the exploitation of virus's own protein i.e., viroporins into the host cells. Several clinical trials are on-going including testing Remdesivir (anti-viral), Chloroquine and Hydroxychloroquine derivatives (anti-malarial drugs) etc. Unfortunately, each drug has specific limitations. Herein, we review the viral protein involvement to activate ER stress transducers (IRE-1, PERK, ATF-6) and their downstream signals; and evaluate combination therapies for COVID-19 mediated ER stress alterations. Melatonin is an immunoregulator, anti-pyretic, antioxidant, anti-inflammatory and ER stress modulator during viral infections. It enhances protective mechanisms for respiratory tract disorders. Andrographolide, isolated from Andrographis paniculata, has versatile biological activities including immunomodulation and determining SARS-CoV-2 binding site. Considering the properties of both compounds in terms of anti-inflammatory, antioxidant, anti-pyrogenic, anti-viral and ER stress modulation and computational approaches revealing andrographolide docks with the SARS-CoV2 binding site, we predict that this combination therapy may have potential utility against COVID-19.Banerjee, AditiCzinn, Steven J.Reiter, Russel J.Blanchard, Thomas G.LICENSElicense.txtlicense.txttext/plain; charset=utf-82938https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12047/2/license.txtabceeb1c943c50d3343516f9dbfc110fMD52open accessORIGINALCrosstalk-between-endoplasmic-reticulum-stress-and-anti-viral-a_2020_Life-Sc.pdfCrosstalk-between-endoplasmic-reticulum-stress-and-anti-viral-a_2020_Life-Sc.pdfDocumento reservadoapplication/pdf455009https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12047/3/Crosstalk-between-endoplasmic-reticulum-stress-and-anti-viral-a_2020_Life-Sc.pdf15b71807c6f20cfe41310fe2f332a3cdMD53embargoed access|||2220-08-19THUMBNAILCaptura3.PNGCaptura3.PNGimage/png106202https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12047/4/Captura3.PNGc0a7c764fd75600954320951e73ce668MD54open accessCrosstalk-between-endoplasmic-reticulum-stress-and-anti-viral-a_2020_Life-Sc.pdf.jpgCrosstalk-between-endoplasmic-reticulum-stress-and-anti-viral-a_2020_Life-Sc.pdf.jpgIM Thumbnailimage/jpeg21595https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12047/5/Crosstalk-between-endoplasmic-reticulum-stress-and-anti-viral-a_2020_Life-Sc.pdf.jpg9032577fd8b80f7a6b75df313264f1f8MD55open access20.500.12010/12047oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/120472020-08-20 17:27:15.338embargoed access|||2220-08-19Repositorio Institucional - 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