SARS-CoV-2 seroprevalence among health care workers in a new york city hospital: A cross-sectional analysis during the COVID-19 pandemic

Background New York City (NYC) has endured the greatest burden of COVID-19 infections in the US. Health inequities in South Bronx predisposed this community to a greater number of infections cases, hospitalisations and mortality. Health Care Workers (HCWs) are at high-risk of exposure to the infecti...

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Autores:
Tipo de recurso:
Article of investigation
Fecha de publicación:
2020
Institución:
Universidad de Bogotá Jorge Tadeo Lozano
Repositorio:
Expeditio: repositorio UTadeo
Idioma:
eng
OAI Identifier:
oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/14660
Acceso en línea:
https://doi.org/10.1016/j.ijid.2020.10.036
http://hdl.handle.net/20.500.12010/14660
Palabra clave:
Seroprevalence
Health care workers
Antibody
Exposure
SARS-CoV-2 PCR
COVID-19
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
Rights
License
Abierto (Texto Completo)
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dc.title.spa.fl_str_mv SARS-CoV-2 seroprevalence among health care workers in a new york city hospital: A cross-sectional analysis during the COVID-19 pandemic
title SARS-CoV-2 seroprevalence among health care workers in a new york city hospital: A cross-sectional analysis during the COVID-19 pandemic
spellingShingle SARS-CoV-2 seroprevalence among health care workers in a new york city hospital: A cross-sectional analysis during the COVID-19 pandemic
Seroprevalence
Health care workers
Antibody
Exposure
SARS-CoV-2 PCR
COVID-19
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
title_short SARS-CoV-2 seroprevalence among health care workers in a new york city hospital: A cross-sectional analysis during the COVID-19 pandemic
title_full SARS-CoV-2 seroprevalence among health care workers in a new york city hospital: A cross-sectional analysis during the COVID-19 pandemic
title_fullStr SARS-CoV-2 seroprevalence among health care workers in a new york city hospital: A cross-sectional analysis during the COVID-19 pandemic
title_full_unstemmed SARS-CoV-2 seroprevalence among health care workers in a new york city hospital: A cross-sectional analysis during the COVID-19 pandemic
title_sort SARS-CoV-2 seroprevalence among health care workers in a new york city hospital: A cross-sectional analysis during the COVID-19 pandemic
dc.subject.spa.fl_str_mv Seroprevalence
Health care workers
Antibody
Exposure
SARS-CoV-2 PCR
COVID-19
topic Seroprevalence
Health care workers
Antibody
Exposure
SARS-CoV-2 PCR
COVID-19
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
dc.subject.lemb.spa.fl_str_mv Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
description Background New York City (NYC) has endured the greatest burden of COVID-19 infections in the US. Health inequities in South Bronx predisposed this community to a greater number of infections cases, hospitalisations and mortality. Health Care Workers (HCWs) are at high-risk of exposure to the infection. This study aims to assess seroprevalence and associated characteristics of consenting HCWs from a NYC public hospital. Methods Cross sectional study including serum samples for qualitative SARS-CoV-2 antibody testing with nasopharyngeal swabs for SARS-CoV-2 PCR and completion of an online survey capturing demographics, COVID-19 symptoms during the preceding months on duty, details of healthcare and community exposure, and travel history were collected from consenting participants in May 2020. Participants’ risk of exposure to COVID-19 infection in hospital and in the community was defined based on CDC guidelines. Travel history to high-risk areas was also considered an additional risk. The Odds Ratio with bivariable and multivariable logistic regression was used to assess characteristics associated with seroprevalence. Results A total of 500 HCW were tested, 137 (27%) tested positive for SARS-CoV-2 antibody. Symptomatic participants had a 75% (98/130) rate of seroconversion compared to those without symptoms. Subjects with anosmia and ageusia had increased odds of seroconversion in comparison to those without these symptoms. Community exposure was 34% (44/130) among those who had positive antibodies. Conclusion Seroprevalence among HCWs was high compared to the community at the epicenter of the pandemic. Further studies to evaluate sustained adaptive immunity in this high-risk group will guide our response to a future surge.
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2020-10-21T17:24:35Z
dc.date.available.none.fl_str_mv 2020-10-21T17:24:35Z
dc.date.created.none.fl_str_mv 2020
dc.type.local.spa.fl_str_mv Artículo
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
format http://purl.org/coar/resource_type/c_2df8fbb1
dc.identifier.issn.spa.fl_str_mv 1201-9712
dc.identifier.other.spa.fl_str_mv https://doi.org/10.1016/j.ijid.2020.10.036
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12010/14660
dc.identifier.doi.spa.fl_str_mv https://doi.org/10.1016/j.ijid.2020.10.036
identifier_str_mv 1201-9712
url https://doi.org/10.1016/j.ijid.2020.10.036
http://hdl.handle.net/20.500.12010/14660
dc.language.iso.spa.fl_str_mv eng
language eng
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.local.spa.fl_str_mv Abierto (Texto Completo)
rights_invalid_str_mv Abierto (Texto Completo)
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dc.format.extent.spa.fl_str_mv 24 páginas
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv International Journal of Infectious Diseases
dc.source.spa.fl_str_mv reponame:Expeditio Repositorio Institucional UJTL
instname:Universidad de Bogotá Jorge Tadeo Lozano
instname_str Universidad de Bogotá Jorge Tadeo Lozano
institution Universidad de Bogotá Jorge Tadeo Lozano
reponame_str Expeditio Repositorio Institucional UJTL
collection Expeditio Repositorio Institucional UJTL
bitstream.url.fl_str_mv https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/14660/2/license.txt
https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/14660/3/SARS-CoV-2-Seroprevalence-Among-Health-Care-Workers-i_2020_International-Jou.pdf.jpg
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spelling 2020-10-21T17:24:35Z2020-10-21T17:24:35Z20201201-9712https://doi.org/10.1016/j.ijid.2020.10.036http://hdl.handle.net/20.500.12010/14660https://doi.org/10.1016/j.ijid.2020.10.036Background New York City (NYC) has endured the greatest burden of COVID-19 infections in the US. Health inequities in South Bronx predisposed this community to a greater number of infections cases, hospitalisations and mortality. Health Care Workers (HCWs) are at high-risk of exposure to the infection. This study aims to assess seroprevalence and associated characteristics of consenting HCWs from a NYC public hospital. Methods Cross sectional study including serum samples for qualitative SARS-CoV-2 antibody testing with nasopharyngeal swabs for SARS-CoV-2 PCR and completion of an online survey capturing demographics, COVID-19 symptoms during the preceding months on duty, details of healthcare and community exposure, and travel history were collected from consenting participants in May 2020. Participants’ risk of exposure to COVID-19 infection in hospital and in the community was defined based on CDC guidelines. Travel history to high-risk areas was also considered an additional risk. The Odds Ratio with bivariable and multivariable logistic regression was used to assess characteristics associated with seroprevalence. Results A total of 500 HCW were tested, 137 (27%) tested positive for SARS-CoV-2 antibody. Symptomatic participants had a 75% (98/130) rate of seroconversion compared to those without symptoms. Subjects with anosmia and ageusia had increased odds of seroconversion in comparison to those without these symptoms. Community exposure was 34% (44/130) among those who had positive antibodies. Conclusion Seroprevalence among HCWs was high compared to the community at the epicenter of the pandemic. Further studies to evaluate sustained adaptive immunity in this high-risk group will guide our response to a future surge.24 páginasapplication/pdfengInternational Journal of Infectious Diseasesreponame:Expeditio Repositorio Institucional UJTLinstname:Universidad de Bogotá Jorge Tadeo LozanoSeroprevalenceHealth care workersAntibodyExposureSARS-CoV-2 PCRCOVID-19Síndrome respiratorio agudo graveCOVID-19SARS-CoV-2CoronavirusSARS-CoV-2 seroprevalence among health care workers in a new york city hospital: A cross-sectional analysis during the COVID-19 pandemicArtículohttp://purl.org/coar/resource_type/c_2df8fbb1Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2Venugopal, UshaJilani, NargisRabah, SamiShariff, Masood A.Jawed, MuzamilMendez Batres, AstridAbubacker, MuhamedMenon, SharikaPillai, AnjanaShabarek, NehadKasubhai, MoizDimitrov, VihrenMenon, VidyaLICENSElicense.txtlicense.txttext/plain; charset=utf-82938https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/14660/2/license.txtabceeb1c943c50d3343516f9dbfc110fMD52open accessTHUMBNAILSARS-CoV-2-Seroprevalence-Among-Health-Care-Workers-i_2020_International-Jou.pdf.jpgSARS-CoV-2-Seroprevalence-Among-Health-Care-Workers-i_2020_International-Jou.pdf.jpgIM Thumbnailimage/jpeg6186https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/14660/3/SARS-CoV-2-Seroprevalence-Among-Health-Care-Workers-i_2020_International-Jou.pdf.jpg15ef3a70d89a77086c3b9d603dfa1545MD53open access20.500.12010/14660oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/146602021-03-12 18:15:19.644metadata only accessRepositorio Institucional - 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