CFTR modulator therapies – Effect on life expectancy in people with cystic fibrosis

CFTR modulators have dramatically changed the clinical course of CF in those fortunate enough to receive them. Inevitably, randomised controlled trials during the development of these drugs are too short to use mortality as an outcome. Evidence for their effect on life expectancy are best gained fro...

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Autores:
Tipo de recurso:
Article of journal
Fecha de publicación:
2020
Institución:
Universidad de Bogotá Jorge Tadeo Lozano
Repositorio:
Expeditio: repositorio UTadeo
Idioma:
eng
OAI Identifier:
oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12183
Acceso en línea:
https://www.sciencedirect.com/science/article/pii/S1526054220300816?via%3Dihub
http://hdl.handle.net/20.500.12010/12183
https://doi.org/10.1016/j.prrv.2020.05.002
Palabra clave:
Fibrosis quística
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
Cystic fibrosis
Mortality
Prognosis
CFTR modulators
Rights
License
Acceso restringido
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oai_identifier_str oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12183
network_acronym_str UTADEO2
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repository_id_str
dc.title.spa.fl_str_mv CFTR modulator therapies – Effect on life expectancy in people with cystic fibrosis
title CFTR modulator therapies – Effect on life expectancy in people with cystic fibrosis
spellingShingle CFTR modulator therapies – Effect on life expectancy in people with cystic fibrosis
Fibrosis quística
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
Cystic fibrosis
Mortality
Prognosis
CFTR modulators
title_short CFTR modulator therapies – Effect on life expectancy in people with cystic fibrosis
title_full CFTR modulator therapies – Effect on life expectancy in people with cystic fibrosis
title_fullStr CFTR modulator therapies – Effect on life expectancy in people with cystic fibrosis
title_full_unstemmed CFTR modulator therapies – Effect on life expectancy in people with cystic fibrosis
title_sort CFTR modulator therapies – Effect on life expectancy in people with cystic fibrosis
dc.subject.spa.fl_str_mv Fibrosis quística
topic Fibrosis quística
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
Cystic fibrosis
Mortality
Prognosis
CFTR modulators
dc.subject.lemb.spa.fl_str_mv Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
dc.subject.keyword.spa.fl_str_mv Cystic fibrosis
Mortality
Prognosis
CFTR modulators
description CFTR modulators have dramatically changed the clinical course of CF in those fortunate enough to receive them. Inevitably, randomised controlled trials during the development of these drugs are too short to use mortality as an outcome. Evidence for their effect on life expectancy are best gained from real world registry studies specifically looking at mortality, but these are only available for ivacaftor to date. Therefore, indirect evidence must be obtained by looking at outcomes known to affect mortality and seeing the effect of these drugs on those outcomes.
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2020-08-24T23:23:16Z
dc.date.available.none.fl_str_mv 2020-08-24T23:23:16Z
dc.date.created.none.fl_str_mv 2020-05
dc.type.local.spa.fl_str_mv Artículo
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format http://purl.org/coar/resource_type/c_6501
dc.identifier.issn.spa.fl_str_mv 1526-0542
dc.identifier.other.spa.fl_str_mv https://www.sciencedirect.com/science/article/pii/S1526054220300816?via%3Dihub
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12010/12183
dc.identifier.doi.spa.fl_str_mv https://doi.org/10.1016/j.prrv.2020.05.002
identifier_str_mv 1526-0542
url https://www.sciencedirect.com/science/article/pii/S1526054220300816?via%3Dihub
http://hdl.handle.net/20.500.12010/12183
https://doi.org/10.1016/j.prrv.2020.05.002
dc.language.iso.spa.fl_str_mv eng
language eng
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_f1cf
dc.rights.local.spa.fl_str_mv Acceso restringido
rights_invalid_str_mv Acceso restringido
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dc.format.extent.spa.fl_str_mv 6 páginas
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Paediatric Respiratory Reviews
dc.source.spa.fl_str_mv reponame:Expeditio Repositorio Institucional UJTL
instname:Universidad de Bogotá Jorge Tadeo Lozano
instname_str Universidad de Bogotá Jorge Tadeo Lozano
institution Universidad de Bogotá Jorge Tadeo Lozano
reponame_str Expeditio Repositorio Institucional UJTL
collection Expeditio Repositorio Institucional UJTL
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spelling 2020-08-24T23:23:16Z2020-08-24T23:23:16Z2020-051526-0542https://www.sciencedirect.com/science/article/pii/S1526054220300816?via%3Dihubhttp://hdl.handle.net/20.500.12010/12183https://doi.org/10.1016/j.prrv.2020.05.0026 páginasapplication/pdfengPaediatric Respiratory Reviewsreponame:Expeditio Repositorio Institucional UJTLinstname:Universidad de Bogotá Jorge Tadeo LozanoFibrosis quísticaSíndrome respiratorio agudo graveCOVID-19SARS-CoV-2CoronavirusCystic fibrosisMortalityPrognosisCFTR modulatorsCFTR modulator therapies – Effect on life expectancy in people with cystic fibrosisArtículohttp://purl.org/coar/resource_type/c_6501Acceso restringidohttp://purl.org/coar/access_right/c_f1cfCFTR modulators have dramatically changed the clinical course of CF in those fortunate enough to receive them. Inevitably, randomised controlled trials during the development of these drugs are too short to use mortality as an outcome. Evidence for their effect on life expectancy are best gained from real world registry studies specifically looking at mortality, but these are only available for ivacaftor to date. Therefore, indirect evidence must be obtained by looking at outcomes known to affect mortality and seeing the effect of these drugs on those outcomes.Balfour-Lynn, I. M.King, J. 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