Efficacy and safety of disinfectants for decontamination of N95 and sn95 filtering facepiece respirators: a Systematic review
Background: Decontaminating and re-using filtering facepiece respirators (FFRs) for healthcare workers is a potential solution to address inadequate FFR supply during a global pandemic. Aim: The objective of this review was to synthesize existing data on the effectiveness and safety of using chemica...
- Autores:
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2020
- Institución:
- Universidad de Bogotá Jorge Tadeo Lozano
- Repositorio:
- Expeditio: repositorio UTadeo
- Idioma:
- eng
- OAI Identifier:
- oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12500
- Acceso en línea:
- https://doi.org/10.1016/j.jhin.2020.08.005
http://hdl.handle.net/20.500.12010/12500
- Palabra clave:
- PPE
Decontamination
Respirator
N95
Disinfectants
COVID-19
Pandemic
FFR
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
- Rights
- License
- Acceso restringido
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dc.title.spa.fl_str_mv |
Efficacy and safety of disinfectants for decontamination of N95 and sn95 filtering facepiece respirators: a Systematic review |
title |
Efficacy and safety of disinfectants for decontamination of N95 and sn95 filtering facepiece respirators: a Systematic review |
spellingShingle |
Efficacy and safety of disinfectants for decontamination of N95 and sn95 filtering facepiece respirators: a Systematic review PPE Decontamination Respirator N95 Disinfectants COVID-19 Pandemic FFR Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus |
title_short |
Efficacy and safety of disinfectants for decontamination of N95 and sn95 filtering facepiece respirators: a Systematic review |
title_full |
Efficacy and safety of disinfectants for decontamination of N95 and sn95 filtering facepiece respirators: a Systematic review |
title_fullStr |
Efficacy and safety of disinfectants for decontamination of N95 and sn95 filtering facepiece respirators: a Systematic review |
title_full_unstemmed |
Efficacy and safety of disinfectants for decontamination of N95 and sn95 filtering facepiece respirators: a Systematic review |
title_sort |
Efficacy and safety of disinfectants for decontamination of N95 and sn95 filtering facepiece respirators: a Systematic review |
dc.subject.spa.fl_str_mv |
PPE Decontamination Respirator N95 Disinfectants COVID-19 Pandemic FFR |
topic |
PPE Decontamination Respirator N95 Disinfectants COVID-19 Pandemic FFR Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus |
dc.subject.lemb.spa.fl_str_mv |
Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus |
description |
Background: Decontaminating and re-using filtering facepiece respirators (FFRs) for healthcare workers is a potential solution to address inadequate FFR supply during a global pandemic. Aim: The objective of this review was to synthesize existing data on the effectiveness and safety of using chemical disinfectants to decontaminate N95 FFRs. Methods: We conducted a systematic review on disinfectants to decontaminate N95 FFRs using Embase, Medline, Global Health, Google Scholar, WHO feed, and MedRxiv. Two reviewers independently determined study eligibility and extracted predefined data fields. Original research reporting on N95 FFR function, decontamination, safety, or FFR fit following decontamination with a disinfectant was included. Findings and Conclusions: A single cycle of vaporized hydrogen peroxide (H2O2) successfully removes viral pathogens without affecting airflow resistance or fit, and maintains an initial filter penetration of <5%, with little change in FFR appearance. Residual hydrogen peroxide levels following decontamination were within safe limits. More than one decontamination cycle of vaporized H2O2 may be possible but further information is required on how multiple cycles would affect FFR fit in a real world setting before the upper limit can be established. Although immersion in liquid H2O2 does not appear to adversely affect FFR function, there is no available data on its ability to remove infectious pathogens from FFRs or its impact on FFR fit. Sodium hypochlorite, ethanol, isopropyl alcohol and ethylene oxide are not recommended due to safety concerns or negative effects on FFR function. |
publishDate |
2020 |
dc.date.accessioned.none.fl_str_mv |
2020-08-31T20:36:14Z |
dc.date.available.none.fl_str_mv |
2020-08-31T20:36:14Z |
dc.date.created.none.fl_str_mv |
2020 |
dc.type.local.spa.fl_str_mv |
Artículo |
dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
format |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.identifier.issn.spa.fl_str_mv |
0195-6701 |
dc.identifier.other.spa.fl_str_mv |
https://doi.org/10.1016/j.jhin.2020.08.005 |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/20.500.12010/12500 |
dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.1016/j.jhin.2020.08.005 |
identifier_str_mv |
0195-6701 |
url |
https://doi.org/10.1016/j.jhin.2020.08.005 http://hdl.handle.net/20.500.12010/12500 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_f1cf |
dc.rights.local.spa.fl_str_mv |
Acceso restringido |
rights_invalid_str_mv |
Acceso restringido http://purl.org/coar/access_right/c_f1cf |
dc.format.extent.spa.fl_str_mv |
46 páginas |
dc.format.mimetype.spa.fl_str_mv |
image/jepg |
dc.publisher.spa.fl_str_mv |
Journal of Hospital Infection |
dc.source.spa.fl_str_mv |
reponame:Expeditio Repositorio Institucional UJTL instname:Universidad de Bogotá Jorge Tadeo Lozano |
instname_str |
Universidad de Bogotá Jorge Tadeo Lozano |
institution |
Universidad de Bogotá Jorge Tadeo Lozano |
reponame_str |
Expeditio Repositorio Institucional UJTL |
collection |
Expeditio Repositorio Institucional UJTL |
bitstream.url.fl_str_mv |
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spelling |
2020-08-31T20:36:14Z2020-08-31T20:36:14Z20200195-6701https://doi.org/10.1016/j.jhin.2020.08.005http://hdl.handle.net/20.500.12010/12500https://doi.org/10.1016/j.jhin.2020.08.005Background: Decontaminating and re-using filtering facepiece respirators (FFRs) for healthcare workers is a potential solution to address inadequate FFR supply during a global pandemic. Aim: The objective of this review was to synthesize existing data on the effectiveness and safety of using chemical disinfectants to decontaminate N95 FFRs. Methods: We conducted a systematic review on disinfectants to decontaminate N95 FFRs using Embase, Medline, Global Health, Google Scholar, WHO feed, and MedRxiv. Two reviewers independently determined study eligibility and extracted predefined data fields. Original research reporting on N95 FFR function, decontamination, safety, or FFR fit following decontamination with a disinfectant was included. Findings and Conclusions: A single cycle of vaporized hydrogen peroxide (H2O2) successfully removes viral pathogens without affecting airflow resistance or fit, and maintains an initial filter penetration of <5%, with little change in FFR appearance. Residual hydrogen peroxide levels following decontamination were within safe limits. More than one decontamination cycle of vaporized H2O2 may be possible but further information is required on how multiple cycles would affect FFR fit in a real world setting before the upper limit can be established. Although immersion in liquid H2O2 does not appear to adversely affect FFR function, there is no available data on its ability to remove infectious pathogens from FFRs or its impact on FFR fit. Sodium hypochlorite, ethanol, isopropyl alcohol and ethylene oxide are not recommended due to safety concerns or negative effects on FFR function.46 páginasimage/jepgengJournal of Hospital Infectionreponame:Expeditio Repositorio Institucional UJTLinstname:Universidad de Bogotá Jorge Tadeo LozanoPPEDecontaminationRespiratorN95DisinfectantsCOVID-19PandemicFFRSíndrome respiratorio agudo graveCOVID-19SARS-CoV-2CoronavirusEfficacy and safety of disinfectants for decontamination of N95 and sn95 filtering facepiece respirators: a Systematic reviewArtículohttp://purl.org/coar/resource_type/c_2df8fbb1Acceso restringidohttp://purl.org/coar/access_right/c_f1cfO’Hearn, KatieGertsman, ShiraWebster, RichardTsampalieros, AnneNg, RhiannonGibson, JessSampson, MargaretSikora, LindseyDayre McNally, JamesORIGINALCaptura.PNGCaptura.PNGVer portadaimage/png103495https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12500/1/Captura.PNGf18487f0b72340c13ea847949d6990fbMD51open accessEfficacy-and-Safety-of-Disinfectants-for-Decontamination-_2020_Journal-of-Ho.pdfEfficacy-and-Safety-of-Disinfectants-for-Decontamination-_2020_Journal-of-Ho.pdfArtículo reservadoapplication/pdf1532091https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12500/3/Efficacy-and-Safety-of-Disinfectants-for-Decontamination-_2020_Journal-of-Ho.pdfd12370b3a326cfe5b868292b5528f9c9MD53embargoed access|||2200-08-31LICENSElicense.txtlicense.txttext/plain; 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