Efficacy and safety of disinfectants for decontamination of N95 and sn95 filtering facepiece respirators: a Systematic review

Background: Decontaminating and re-using filtering facepiece respirators (FFRs) for healthcare workers is a potential solution to address inadequate FFR supply during a global pandemic. Aim: The objective of this review was to synthesize existing data on the effectiveness and safety of using chemica...

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Autores:
Tipo de recurso:
Article of investigation
Fecha de publicación:
2020
Institución:
Universidad de Bogotá Jorge Tadeo Lozano
Repositorio:
Expeditio: repositorio UTadeo
Idioma:
eng
OAI Identifier:
oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12500
Acceso en línea:
https://doi.org/10.1016/j.jhin.2020.08.005
http://hdl.handle.net/20.500.12010/12500
Palabra clave:
PPE
Decontamination
Respirator
N95
Disinfectants
COVID-19
Pandemic
FFR
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
Rights
License
Acceso restringido
id UTADEO2_4ab4f4978ccda94f30705c0779321ce9
oai_identifier_str oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12500
network_acronym_str UTADEO2
network_name_str Expeditio: repositorio UTadeo
repository_id_str
dc.title.spa.fl_str_mv Efficacy and safety of disinfectants for decontamination of N95 and sn95 filtering facepiece respirators: a Systematic review
title Efficacy and safety of disinfectants for decontamination of N95 and sn95 filtering facepiece respirators: a Systematic review
spellingShingle Efficacy and safety of disinfectants for decontamination of N95 and sn95 filtering facepiece respirators: a Systematic review
PPE
Decontamination
Respirator
N95
Disinfectants
COVID-19
Pandemic
FFR
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
title_short Efficacy and safety of disinfectants for decontamination of N95 and sn95 filtering facepiece respirators: a Systematic review
title_full Efficacy and safety of disinfectants for decontamination of N95 and sn95 filtering facepiece respirators: a Systematic review
title_fullStr Efficacy and safety of disinfectants for decontamination of N95 and sn95 filtering facepiece respirators: a Systematic review
title_full_unstemmed Efficacy and safety of disinfectants for decontamination of N95 and sn95 filtering facepiece respirators: a Systematic review
title_sort Efficacy and safety of disinfectants for decontamination of N95 and sn95 filtering facepiece respirators: a Systematic review
dc.subject.spa.fl_str_mv PPE
Decontamination
Respirator
N95
Disinfectants
COVID-19
Pandemic
FFR
topic PPE
Decontamination
Respirator
N95
Disinfectants
COVID-19
Pandemic
FFR
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
dc.subject.lemb.spa.fl_str_mv Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
description Background: Decontaminating and re-using filtering facepiece respirators (FFRs) for healthcare workers is a potential solution to address inadequate FFR supply during a global pandemic. Aim: The objective of this review was to synthesize existing data on the effectiveness and safety of using chemical disinfectants to decontaminate N95 FFRs. Methods: We conducted a systematic review on disinfectants to decontaminate N95 FFRs using Embase, Medline, Global Health, Google Scholar, WHO feed, and MedRxiv. Two reviewers independently determined study eligibility and extracted predefined data fields. Original research reporting on N95 FFR function, decontamination, safety, or FFR fit following decontamination with a disinfectant was included. Findings and Conclusions: A single cycle of vaporized hydrogen peroxide (H2O2) successfully removes viral pathogens without affecting airflow resistance or fit, and maintains an initial filter penetration of <5%, with little change in FFR appearance. Residual hydrogen peroxide levels following decontamination were within safe limits. More than one decontamination cycle of vaporized H2O2 may be possible but further information is required on how multiple cycles would affect FFR fit in a real world setting before the upper limit can be established. Although immersion in liquid H2O2 does not appear to adversely affect FFR function, there is no available data on its ability to remove infectious pathogens from FFRs or its impact on FFR fit. Sodium hypochlorite, ethanol, isopropyl alcohol and ethylene oxide are not recommended due to safety concerns or negative effects on FFR function.
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2020-08-31T20:36:14Z
dc.date.available.none.fl_str_mv 2020-08-31T20:36:14Z
dc.date.created.none.fl_str_mv 2020
dc.type.local.spa.fl_str_mv Artículo
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dc.identifier.issn.spa.fl_str_mv 0195-6701
dc.identifier.other.spa.fl_str_mv https://doi.org/10.1016/j.jhin.2020.08.005
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12010/12500
dc.identifier.doi.spa.fl_str_mv https://doi.org/10.1016/j.jhin.2020.08.005
identifier_str_mv 0195-6701
url https://doi.org/10.1016/j.jhin.2020.08.005
http://hdl.handle.net/20.500.12010/12500
dc.language.iso.spa.fl_str_mv eng
language eng
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dc.rights.local.spa.fl_str_mv Acceso restringido
rights_invalid_str_mv Acceso restringido
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dc.format.extent.spa.fl_str_mv 46 páginas
dc.format.mimetype.spa.fl_str_mv image/jepg
dc.publisher.spa.fl_str_mv Journal of Hospital Infection
dc.source.spa.fl_str_mv reponame:Expeditio Repositorio Institucional UJTL
instname:Universidad de Bogotá Jorge Tadeo Lozano
instname_str Universidad de Bogotá Jorge Tadeo Lozano
institution Universidad de Bogotá Jorge Tadeo Lozano
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collection Expeditio Repositorio Institucional UJTL
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spelling 2020-08-31T20:36:14Z2020-08-31T20:36:14Z20200195-6701https://doi.org/10.1016/j.jhin.2020.08.005http://hdl.handle.net/20.500.12010/12500https://doi.org/10.1016/j.jhin.2020.08.005Background: Decontaminating and re-using filtering facepiece respirators (FFRs) for healthcare workers is a potential solution to address inadequate FFR supply during a global pandemic. Aim: The objective of this review was to synthesize existing data on the effectiveness and safety of using chemical disinfectants to decontaminate N95 FFRs. Methods: We conducted a systematic review on disinfectants to decontaminate N95 FFRs using Embase, Medline, Global Health, Google Scholar, WHO feed, and MedRxiv. Two reviewers independently determined study eligibility and extracted predefined data fields. Original research reporting on N95 FFR function, decontamination, safety, or FFR fit following decontamination with a disinfectant was included. Findings and Conclusions: A single cycle of vaporized hydrogen peroxide (H2O2) successfully removes viral pathogens without affecting airflow resistance or fit, and maintains an initial filter penetration of <5%, with little change in FFR appearance. Residual hydrogen peroxide levels following decontamination were within safe limits. More than one decontamination cycle of vaporized H2O2 may be possible but further information is required on how multiple cycles would affect FFR fit in a real world setting before the upper limit can be established. Although immersion in liquid H2O2 does not appear to adversely affect FFR function, there is no available data on its ability to remove infectious pathogens from FFRs or its impact on FFR fit. Sodium hypochlorite, ethanol, isopropyl alcohol and ethylene oxide are not recommended due to safety concerns or negative effects on FFR function.46 páginasimage/jepgengJournal of Hospital Infectionreponame:Expeditio Repositorio Institucional UJTLinstname:Universidad de Bogotá Jorge Tadeo LozanoPPEDecontaminationRespiratorN95DisinfectantsCOVID-19PandemicFFRSíndrome respiratorio agudo graveCOVID-19SARS-CoV-2CoronavirusEfficacy and safety of disinfectants for decontamination of N95 and sn95 filtering facepiece respirators: a Systematic reviewArtículohttp://purl.org/coar/resource_type/c_2df8fbb1Acceso restringidohttp://purl.org/coar/access_right/c_f1cfO’Hearn, KatieGertsman, ShiraWebster, RichardTsampalieros, AnneNg, RhiannonGibson, JessSampson, MargaretSikora, LindseyDayre McNally, JamesORIGINALCaptura.PNGCaptura.PNGVer portadaimage/png103495https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12500/1/Captura.PNGf18487f0b72340c13ea847949d6990fbMD51open accessEfficacy-and-Safety-of-Disinfectants-for-Decontamination-_2020_Journal-of-Ho.pdfEfficacy-and-Safety-of-Disinfectants-for-Decontamination-_2020_Journal-of-Ho.pdfArtículo reservadoapplication/pdf1532091https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12500/3/Efficacy-and-Safety-of-Disinfectants-for-Decontamination-_2020_Journal-of-Ho.pdfd12370b3a326cfe5b868292b5528f9c9MD53embargoed access|||2200-08-31LICENSElicense.txtlicense.txttext/plain; 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