Relation of statin use prior to admission to severity and recovery among COVID-19 inpatients

The impact of statins, ACE inhibitors (ACEi) and angiotensin II receptor blockers (ARBs) on COVID-19 severity and recovery is important given their high prevalence of use among individuals at risk for severe COVID-19. We studied the association between use of statin/ACEi/ARB in the month before hosp...

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Autores:
Tipo de recurso:
Article of investigation
Fecha de publicación:
2020
Institución:
Universidad de Bogotá Jorge Tadeo Lozano
Repositorio:
Expeditio: repositorio UTadeo
Idioma:
eng
OAI Identifier:
oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/13687
Acceso en línea:
https://doi.org/10.1016/j.amjcard.2020.09.012
http://hdl.handle.net/20.500.12010/13687
Palabra clave:
Coronavirus
SARS-CoV-2
Mortality
Statins
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
Rights
License
Abierto (Texto Completo)
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oai_identifier_str oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/13687
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dc.title.spa.fl_str_mv Relation of statin use prior to admission to severity and recovery among COVID-19 inpatients
title Relation of statin use prior to admission to severity and recovery among COVID-19 inpatients
spellingShingle Relation of statin use prior to admission to severity and recovery among COVID-19 inpatients
Coronavirus
SARS-CoV-2
Mortality
Statins
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
title_short Relation of statin use prior to admission to severity and recovery among COVID-19 inpatients
title_full Relation of statin use prior to admission to severity and recovery among COVID-19 inpatients
title_fullStr Relation of statin use prior to admission to severity and recovery among COVID-19 inpatients
title_full_unstemmed Relation of statin use prior to admission to severity and recovery among COVID-19 inpatients
title_sort Relation of statin use prior to admission to severity and recovery among COVID-19 inpatients
dc.subject.spa.fl_str_mv Coronavirus
SARS-CoV-2
Mortality
Statins
topic Coronavirus
SARS-CoV-2
Mortality
Statins
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
dc.subject.lemb.spa.fl_str_mv Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
description The impact of statins, ACE inhibitors (ACEi) and angiotensin II receptor blockers (ARBs) on COVID-19 severity and recovery is important given their high prevalence of use among individuals at risk for severe COVID-19. We studied the association between use of statin/ACEi/ARB in the month before hospital admission, with risk of severe outcome, and with time to severe outcome or disease recovery, among patients hospitalized for COVID-19. We performed a retrospective single-center study of all patients hospitalized at UCSD Health between February 10-June 17, 2020 (n=170 hospitalized for COVID-19, n=5281 COVID-negative controls). Logistic regression and competing risks analyses were used to investigate progression to severe disease (death or intensive care unit admission), and time to discharge without severe disease. Severe disease occurred in 53% of COVID-positive inpatients. Median time from hospitalization to severe disease was 2 days; median time to recovery was 7 days. Statin use prior to admission was associated with reduced risk of severe COVID-19 (adjusted OR 0.29, 95% CI 0.11-0.71, p<0.01) and faster time to recovery among those without severe disease (adjusted HR for recovery 2.69, 95% CI 1.36-5.33, p<0.01). The association between statin use and severe disease was smaller in the COVID-negative cohort (p for interaction=0.07). There was potential evidence of faster time to recovery with ARB use (aHR 1.92, 95% CI 0.81-4.56). In conclusion, statin use during the 30 days prior to admission for COVID-19 was associated with a lower risk of developing severe COVID-19, and a faster time to recovery among patients without severe disease.
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2020-09-23T16:24:40Z
dc.date.available.none.fl_str_mv 2020-09-23T16:24:40Z
dc.date.created.none.fl_str_mv 2020
dc.type.local.spa.fl_str_mv Artículo
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format http://purl.org/coar/resource_type/c_2df8fbb1
dc.identifier.issn.spa.fl_str_mv 0002-9149
dc.identifier.other.spa.fl_str_mv https://doi.org/10.1016/j.amjcard.2020.09.012
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12010/13687
dc.identifier.doi.spa.fl_str_mv https://doi.org/10.1016/j.amjcard.2020.09.012
identifier_str_mv 0002-9149
url https://doi.org/10.1016/j.amjcard.2020.09.012
http://hdl.handle.net/20.500.12010/13687
dc.language.iso.spa.fl_str_mv eng
language eng
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.local.spa.fl_str_mv Abierto (Texto Completo)
rights_invalid_str_mv Abierto (Texto Completo)
http://purl.org/coar/access_right/c_abf2
dc.format.extent.spa.fl_str_mv 20 páginas
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv The American Journal of Cardiology
dc.source.spa.fl_str_mv reponame:Expeditio Repositorio Institucional UJTL
instname:Universidad de Bogotá Jorge Tadeo Lozano
instname_str Universidad de Bogotá Jorge Tadeo Lozano
institution Universidad de Bogotá Jorge Tadeo Lozano
reponame_str Expeditio Repositorio Institucional UJTL
collection Expeditio Repositorio Institucional UJTL
bitstream.url.fl_str_mv https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/13687/1/1-s2.0-S0002914920309474-main.pdf
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spelling 2020-09-23T16:24:40Z2020-09-23T16:24:40Z20200002-9149https://doi.org/10.1016/j.amjcard.2020.09.012http://hdl.handle.net/20.500.12010/13687https://doi.org/10.1016/j.amjcard.2020.09.012The impact of statins, ACE inhibitors (ACEi) and angiotensin II receptor blockers (ARBs) on COVID-19 severity and recovery is important given their high prevalence of use among individuals at risk for severe COVID-19. We studied the association between use of statin/ACEi/ARB in the month before hospital admission, with risk of severe outcome, and with time to severe outcome or disease recovery, among patients hospitalized for COVID-19. We performed a retrospective single-center study of all patients hospitalized at UCSD Health between February 10-June 17, 2020 (n=170 hospitalized for COVID-19, n=5281 COVID-negative controls). Logistic regression and competing risks analyses were used to investigate progression to severe disease (death or intensive care unit admission), and time to discharge without severe disease. Severe disease occurred in 53% of COVID-positive inpatients. Median time from hospitalization to severe disease was 2 days; median time to recovery was 7 days. Statin use prior to admission was associated with reduced risk of severe COVID-19 (adjusted OR 0.29, 95% CI 0.11-0.71, p<0.01) and faster time to recovery among those without severe disease (adjusted HR for recovery 2.69, 95% CI 1.36-5.33, p<0.01). The association between statin use and severe disease was smaller in the COVID-negative cohort (p for interaction=0.07). There was potential evidence of faster time to recovery with ARB use (aHR 1.92, 95% CI 0.81-4.56). In conclusion, statin use during the 30 days prior to admission for COVID-19 was associated with a lower risk of developing severe COVID-19, and a faster time to recovery among patients without severe disease.20 páginasapplication/pdfengThe American Journal of Cardiologyreponame:Expeditio Repositorio Institucional UJTLinstname:Universidad de Bogotá Jorge Tadeo LozanoCoronavirusSARS-CoV-2MortalityStatinsSíndrome respiratorio agudo graveCOVID-19SARS-CoV-2CoronavirusRelation of statin use prior to admission to severity and recovery among COVID-19 inpatientsArtículohttp://purl.org/coar/resource_type/c_2df8fbb1Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2Daniels, Lori B.Sitapati, Amy M.Zhang, JingZou, JingjingBui, Quan M.Ren, JuntingLonghurst, Christopher A.Criqui, Michael H.Messer, KarenORIGINAL1-s2.0-S0002914920309474-main.pdf1-s2.0-S0002914920309474-main.pdfVer artículoapplication/pdf674137https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/13687/1/1-s2.0-S0002914920309474-main.pdf0f7ea716d2b6f422da8e6f016bbf2384MD51open accessLICENSElicense.txtlicense.txttext/plain; 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