Endothelial glycocalyx damage as a systemic inflammatory microvascular endotheliopathy in COVID-19

In atherosclerosis patients, vascular endothelial dysfunction is commonly observed alongside damage of the vascular endothelial glycocalyx, an extracellular matrix bound to and encapsulating the endothelial cells lining the blood vessel wall. Although atherosclerotic risk factors have been reported...

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Autores:
Tipo de recurso:
Article of investigation
Fecha de publicación:
2020
Institución:
Universidad de Bogotá Jorge Tadeo Lozano
Repositorio:
Expeditio: repositorio UTadeo
Idioma:
spa
OAI Identifier:
oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12240
Acceso en línea:
https://doi.org/10.1016/j.bj.2020.08.007
http://hdl.handle.net/20.500.12010/12240
Palabra clave:
Vascular endothelial dysfunction
Systemic inflammatory response
Cytokine storm
ARDS
Kawasaki disease shock syndrome
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
Rights
License
Abierto (Texto Completo)
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dc.title.spa.fl_str_mv Endothelial glycocalyx damage as a systemic inflammatory microvascular endotheliopathy in COVID-19
title Endothelial glycocalyx damage as a systemic inflammatory microvascular endotheliopathy in COVID-19
spellingShingle Endothelial glycocalyx damage as a systemic inflammatory microvascular endotheliopathy in COVID-19
Vascular endothelial dysfunction
Systemic inflammatory response
Cytokine storm
ARDS
Kawasaki disease shock syndrome
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
title_short Endothelial glycocalyx damage as a systemic inflammatory microvascular endotheliopathy in COVID-19
title_full Endothelial glycocalyx damage as a systemic inflammatory microvascular endotheliopathy in COVID-19
title_fullStr Endothelial glycocalyx damage as a systemic inflammatory microvascular endotheliopathy in COVID-19
title_full_unstemmed Endothelial glycocalyx damage as a systemic inflammatory microvascular endotheliopathy in COVID-19
title_sort Endothelial glycocalyx damage as a systemic inflammatory microvascular endotheliopathy in COVID-19
dc.subject.spa.fl_str_mv Vascular endothelial dysfunction
Systemic inflammatory response
Cytokine storm
ARDS
Kawasaki disease shock syndrome
topic Vascular endothelial dysfunction
Systemic inflammatory response
Cytokine storm
ARDS
Kawasaki disease shock syndrome
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
dc.subject.lemb.spa.fl_str_mv Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
description In atherosclerosis patients, vascular endothelial dysfunction is commonly observed alongside damage of the vascular endothelial glycocalyx, an extracellular matrix bound to and encapsulating the endothelial cells lining the blood vessel wall. Although atherosclerotic risk factors have been reported in severe patients with coronavirus disease 2019 (COVID-19), the exact mechanisms are unclear. The mortality associated with the COVID-19 outbreak is increased by comorbidities, including hypertension, diabetes, obesity, chronic obstructive pulmonary disease (COPD), and cardiovascular disease. Besides, older individuals and smokers have significantly worse outcomes. Interestingly, these comorbidities and risk factors are consistent with the pathophysiology that causes vascular endothelial glycocalyx damage. Moreover, vascular glycocalyx dysfunction causes microvascular leakage, which results in interstitial pulmonary abnormal shadows (multiple patchy shadows with a ground glass inter-pneumonic appearance). This is frequently followed by severe acute respiratory distress syndrome (ARDS), closely related to coagulo-fibrinolytic changes contributing to disseminated intravascular coagulation (DIC) and Kawasaki disease shock syndrome, as well as inducing activation of the coagulation cascade, leading to thromboembolism and multiple organ failure. Notably, SARS-CoV-2, the causative virus of COVID-19, binds to ACE2, which is abundantly present not only in human epithelia of the lung and the small intestine, but also in vascular endothelial cells and arterial smooth muscle cells. Moreover, COVID-19 can induce severe septic shock, and sepsis can easily lead to systemic degradation of the vascular endothelial glycocalyx. In the current review, we propose new concepts and therapeutic goals for COVID-19-related vascular endothelial glycocalyx damage, based on previous vascular endothelial medicine research.
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2020-08-25T19:41:34Z
dc.date.available.none.fl_str_mv 2020-08-25T19:41:34Z
dc.date.created.none.fl_str_mv 2020
dc.type.local.spa.fl_str_mv Artículo
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
format http://purl.org/coar/resource_type/c_2df8fbb1
dc.identifier.issn.spa.fl_str_mv 2319-4170
dc.identifier.other.spa.fl_str_mv https://doi.org/10.1016/j.bj.2020.08.007
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12010/12240
dc.identifier.doi.spa.fl_str_mv https://doi.org/10.1016/j.bj.2020.08.007
identifier_str_mv 2319-4170
url https://doi.org/10.1016/j.bj.2020.08.007
http://hdl.handle.net/20.500.12010/12240
dc.language.iso.spa.fl_str_mv spa
language spa
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.local.spa.fl_str_mv Abierto (Texto Completo)
rights_invalid_str_mv Abierto (Texto Completo)
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dc.format.extent.spa.fl_str_mv 63 páginas
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Biomedical Journal
dc.source.spa.fl_str_mv reponame:Expeditio Repositorio Institucional UJTL
instname:Universidad de Bogotá Jorge Tadeo Lozano
instname_str Universidad de Bogotá Jorge Tadeo Lozano
institution Universidad de Bogotá Jorge Tadeo Lozano
reponame_str Expeditio Repositorio Institucional UJTL
collection Expeditio Repositorio Institucional UJTL
bitstream.url.fl_str_mv https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12240/1/1-s2.0-S2319417020301414-main.pdf
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spelling 2020-08-25T19:41:34Z2020-08-25T19:41:34Z20202319-4170https://doi.org/10.1016/j.bj.2020.08.007http://hdl.handle.net/20.500.12010/12240https://doi.org/10.1016/j.bj.2020.08.007In atherosclerosis patients, vascular endothelial dysfunction is commonly observed alongside damage of the vascular endothelial glycocalyx, an extracellular matrix bound to and encapsulating the endothelial cells lining the blood vessel wall. Although atherosclerotic risk factors have been reported in severe patients with coronavirus disease 2019 (COVID-19), the exact mechanisms are unclear. The mortality associated with the COVID-19 outbreak is increased by comorbidities, including hypertension, diabetes, obesity, chronic obstructive pulmonary disease (COPD), and cardiovascular disease. Besides, older individuals and smokers have significantly worse outcomes. Interestingly, these comorbidities and risk factors are consistent with the pathophysiology that causes vascular endothelial glycocalyx damage. Moreover, vascular glycocalyx dysfunction causes microvascular leakage, which results in interstitial pulmonary abnormal shadows (multiple patchy shadows with a ground glass inter-pneumonic appearance). This is frequently followed by severe acute respiratory distress syndrome (ARDS), closely related to coagulo-fibrinolytic changes contributing to disseminated intravascular coagulation (DIC) and Kawasaki disease shock syndrome, as well as inducing activation of the coagulation cascade, leading to thromboembolism and multiple organ failure. Notably, SARS-CoV-2, the causative virus of COVID-19, binds to ACE2, which is abundantly present not only in human epithelia of the lung and the small intestine, but also in vascular endothelial cells and arterial smooth muscle cells. Moreover, COVID-19 can induce severe septic shock, and sepsis can easily lead to systemic degradation of the vascular endothelial glycocalyx. In the current review, we propose new concepts and therapeutic goals for COVID-19-related vascular endothelial glycocalyx damage, based on previous vascular endothelial medicine research.63 páginasapplication/pdfspaBiomedical Journalreponame:Expeditio Repositorio Institucional UJTLinstname:Universidad de Bogotá Jorge Tadeo LozanoVascular endothelial dysfunctionSystemic inflammatory responseCytokine stormARDSKawasaki disease shock syndromeSíndrome respiratorio agudo graveCOVID-19SARS-CoV-2CoronavirusEndothelial glycocalyx damage as a systemic inflammatory microvascular endotheliopathy in COVID-19Artículohttp://purl.org/coar/resource_type/c_2df8fbb1Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2Yamaoka-Tojo, MinakoORIGINAL1-s2.0-S2319417020301414-main.pdf1-s2.0-S2319417020301414-main.pdfVer artículoapplication/pdf1180318https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12240/1/1-s2.0-S2319417020301414-main.pdfed4b8f34863a326922fbcfabfb7b6c0cMD51open accessLICENSElicense.txtlicense.txttext/plain; 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