Endothelial glycocalyx damage as a systemic inflammatory microvascular endotheliopathy in COVID-19
In atherosclerosis patients, vascular endothelial dysfunction is commonly observed alongside damage of the vascular endothelial glycocalyx, an extracellular matrix bound to and encapsulating the endothelial cells lining the blood vessel wall. Although atherosclerotic risk factors have been reported...
- Autores:
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2020
- Institución:
- Universidad de Bogotá Jorge Tadeo Lozano
- Repositorio:
- Expeditio: repositorio UTadeo
- Idioma:
- spa
- OAI Identifier:
- oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12240
- Palabra clave:
- Vascular endothelial dysfunction
Systemic inflammatory response
Cytokine storm
ARDS
Kawasaki disease shock syndrome
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
- Rights
- License
- Abierto (Texto Completo)
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oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12240 |
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Expeditio: repositorio UTadeo |
repository_id_str |
|
dc.title.spa.fl_str_mv |
Endothelial glycocalyx damage as a systemic inflammatory microvascular endotheliopathy in COVID-19 |
title |
Endothelial glycocalyx damage as a systemic inflammatory microvascular endotheliopathy in COVID-19 |
spellingShingle |
Endothelial glycocalyx damage as a systemic inflammatory microvascular endotheliopathy in COVID-19 Vascular endothelial dysfunction Systemic inflammatory response Cytokine storm ARDS Kawasaki disease shock syndrome Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus |
title_short |
Endothelial glycocalyx damage as a systemic inflammatory microvascular endotheliopathy in COVID-19 |
title_full |
Endothelial glycocalyx damage as a systemic inflammatory microvascular endotheliopathy in COVID-19 |
title_fullStr |
Endothelial glycocalyx damage as a systemic inflammatory microvascular endotheliopathy in COVID-19 |
title_full_unstemmed |
Endothelial glycocalyx damage as a systemic inflammatory microvascular endotheliopathy in COVID-19 |
title_sort |
Endothelial glycocalyx damage as a systemic inflammatory microvascular endotheliopathy in COVID-19 |
dc.subject.spa.fl_str_mv |
Vascular endothelial dysfunction Systemic inflammatory response Cytokine storm ARDS Kawasaki disease shock syndrome |
topic |
Vascular endothelial dysfunction Systemic inflammatory response Cytokine storm ARDS Kawasaki disease shock syndrome Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus |
dc.subject.lemb.spa.fl_str_mv |
Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus |
description |
In atherosclerosis patients, vascular endothelial dysfunction is commonly observed alongside damage of the vascular endothelial glycocalyx, an extracellular matrix bound to and encapsulating the endothelial cells lining the blood vessel wall. Although atherosclerotic risk factors have been reported in severe patients with coronavirus disease 2019 (COVID-19), the exact mechanisms are unclear. The mortality associated with the COVID-19 outbreak is increased by comorbidities, including hypertension, diabetes, obesity, chronic obstructive pulmonary disease (COPD), and cardiovascular disease. Besides, older individuals and smokers have significantly worse outcomes. Interestingly, these comorbidities and risk factors are consistent with the pathophysiology that causes vascular endothelial glycocalyx damage. Moreover, vascular glycocalyx dysfunction causes microvascular leakage, which results in interstitial pulmonary abnormal shadows (multiple patchy shadows with a ground glass inter-pneumonic appearance). This is frequently followed by severe acute respiratory distress syndrome (ARDS), closely related to coagulo-fibrinolytic changes contributing to disseminated intravascular coagulation (DIC) and Kawasaki disease shock syndrome, as well as inducing activation of the coagulation cascade, leading to thromboembolism and multiple organ failure. Notably, SARS-CoV-2, the causative virus of COVID-19, binds to ACE2, which is abundantly present not only in human epithelia of the lung and the small intestine, but also in vascular endothelial cells and arterial smooth muscle cells. Moreover, COVID-19 can induce severe septic shock, and sepsis can easily lead to systemic degradation of the vascular endothelial glycocalyx. In the current review, we propose new concepts and therapeutic goals for COVID-19-related vascular endothelial glycocalyx damage, based on previous vascular endothelial medicine research. |
publishDate |
2020 |
dc.date.accessioned.none.fl_str_mv |
2020-08-25T19:41:34Z |
dc.date.available.none.fl_str_mv |
2020-08-25T19:41:34Z |
dc.date.created.none.fl_str_mv |
2020 |
dc.type.local.spa.fl_str_mv |
Artículo |
dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
format |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.identifier.issn.spa.fl_str_mv |
2319-4170 |
dc.identifier.other.spa.fl_str_mv |
https://doi.org/10.1016/j.bj.2020.08.007 |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/20.500.12010/12240 |
dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.1016/j.bj.2020.08.007 |
identifier_str_mv |
2319-4170 |
url |
https://doi.org/10.1016/j.bj.2020.08.007 http://hdl.handle.net/20.500.12010/12240 |
dc.language.iso.spa.fl_str_mv |
spa |
language |
spa |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.local.spa.fl_str_mv |
Abierto (Texto Completo) |
rights_invalid_str_mv |
Abierto (Texto Completo) http://purl.org/coar/access_right/c_abf2 |
dc.format.extent.spa.fl_str_mv |
63 páginas |
dc.format.mimetype.spa.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Biomedical Journal |
dc.source.spa.fl_str_mv |
reponame:Expeditio Repositorio Institucional UJTL instname:Universidad de Bogotá Jorge Tadeo Lozano |
instname_str |
Universidad de Bogotá Jorge Tadeo Lozano |
institution |
Universidad de Bogotá Jorge Tadeo Lozano |
reponame_str |
Expeditio Repositorio Institucional UJTL |
collection |
Expeditio Repositorio Institucional UJTL |
bitstream.url.fl_str_mv |
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2020-08-25T19:41:34Z2020-08-25T19:41:34Z20202319-4170https://doi.org/10.1016/j.bj.2020.08.007http://hdl.handle.net/20.500.12010/12240https://doi.org/10.1016/j.bj.2020.08.007In atherosclerosis patients, vascular endothelial dysfunction is commonly observed alongside damage of the vascular endothelial glycocalyx, an extracellular matrix bound to and encapsulating the endothelial cells lining the blood vessel wall. Although atherosclerotic risk factors have been reported in severe patients with coronavirus disease 2019 (COVID-19), the exact mechanisms are unclear. The mortality associated with the COVID-19 outbreak is increased by comorbidities, including hypertension, diabetes, obesity, chronic obstructive pulmonary disease (COPD), and cardiovascular disease. Besides, older individuals and smokers have significantly worse outcomes. Interestingly, these comorbidities and risk factors are consistent with the pathophysiology that causes vascular endothelial glycocalyx damage. Moreover, vascular glycocalyx dysfunction causes microvascular leakage, which results in interstitial pulmonary abnormal shadows (multiple patchy shadows with a ground glass inter-pneumonic appearance). This is frequently followed by severe acute respiratory distress syndrome (ARDS), closely related to coagulo-fibrinolytic changes contributing to disseminated intravascular coagulation (DIC) and Kawasaki disease shock syndrome, as well as inducing activation of the coagulation cascade, leading to thromboembolism and multiple organ failure. Notably, SARS-CoV-2, the causative virus of COVID-19, binds to ACE2, which is abundantly present not only in human epithelia of the lung and the small intestine, but also in vascular endothelial cells and arterial smooth muscle cells. Moreover, COVID-19 can induce severe septic shock, and sepsis can easily lead to systemic degradation of the vascular endothelial glycocalyx. In the current review, we propose new concepts and therapeutic goals for COVID-19-related vascular endothelial glycocalyx damage, based on previous vascular endothelial medicine research.63 páginasapplication/pdfspaBiomedical Journalreponame:Expeditio Repositorio Institucional UJTLinstname:Universidad de Bogotá Jorge Tadeo LozanoVascular endothelial dysfunctionSystemic inflammatory responseCytokine stormARDSKawasaki disease shock syndromeSíndrome respiratorio agudo graveCOVID-19SARS-CoV-2CoronavirusEndothelial glycocalyx damage as a systemic inflammatory microvascular endotheliopathy in COVID-19Artículohttp://purl.org/coar/resource_type/c_2df8fbb1Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2Yamaoka-Tojo, MinakoORIGINAL1-s2.0-S2319417020301414-main.pdf1-s2.0-S2319417020301414-main.pdfVer artículoapplication/pdf1180318https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12240/1/1-s2.0-S2319417020301414-main.pdfed4b8f34863a326922fbcfabfb7b6c0cMD51open accessLICENSElicense.txtlicense.txttext/plain; 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