Influenza A virus is transmissible via aerosolized fomites

Influenza viruses are presumed, but not conclusively known, to spread among humans by several possible routes. We provide evidence of a mode of transmission seldom considered for influenza: airborne virus transport on microscopic particles called “aerosolized fomites.” In the guinea pig model of inf...

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Autores:
Tipo de recurso:
Article of journal
Fecha de publicación:
2020
Institución:
Universidad de Bogotá Jorge Tadeo Lozano
Repositorio:
Expeditio: repositorio UTadeo
Idioma:
eng
OAI Identifier:
oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/13489
Acceso en línea:
https://www.nature.com/articles/s41467-020-17888-w
http://hdl.handle.net/20.500.12010/13489
https://doi.org/10.1038/s41467-020-17888-w
Palabra clave:
virus
via aerosolized fomites
Influenza A
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
Rights
License
Acceso restringido
id UTADEO2_316a37c19afe8c62c3692a72a7ec207d
oai_identifier_str oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/13489
network_acronym_str UTADEO2
network_name_str Expeditio: repositorio UTadeo
repository_id_str
dc.title.spa.fl_str_mv Influenza A virus is transmissible via aerosolized fomites
title Influenza A virus is transmissible via aerosolized fomites
spellingShingle Influenza A virus is transmissible via aerosolized fomites
virus
via aerosolized fomites
Influenza A
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
title_short Influenza A virus is transmissible via aerosolized fomites
title_full Influenza A virus is transmissible via aerosolized fomites
title_fullStr Influenza A virus is transmissible via aerosolized fomites
title_full_unstemmed Influenza A virus is transmissible via aerosolized fomites
title_sort Influenza A virus is transmissible via aerosolized fomites
dc.subject.spa.fl_str_mv virus
via aerosolized fomites
Influenza A
topic virus
via aerosolized fomites
Influenza A
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
dc.subject.lemb.spa.fl_str_mv Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
description Influenza viruses are presumed, but not conclusively known, to spread among humans by several possible routes. We provide evidence of a mode of transmission seldom considered for influenza: airborne virus transport on microscopic particles called “aerosolized fomites.” In the guinea pig model of influenza virus transmission, we show that the airborne particulates produced by infected animals are mainly non-respiratory in origin. Surprisingly, we find that an uninfected, virus-immune guinea pig whose body is contaminated with influenza virus can transmit the virus through the air to a susceptible partner in a separate cage. We further demonstrate that aerosolized fomites can be generated from inanimate objects, such as by manually rubbing a paper tissue contaminated with influenza virus. Our data suggest that aerosolized fomites may contribute to influenza virus transmission in animal models of human influenza, if not among humans themselves, with important but understudied implications for public health.
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2020-09-19T16:38:12Z
dc.date.available.none.fl_str_mv 2020-09-19T16:38:12Z
dc.date.created.none.fl_str_mv 2020-08-18
dc.type.local.spa.fl_str_mv Artículo
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_6501
format http://purl.org/coar/resource_type/c_6501
dc.identifier.issn.spa.fl_str_mv 2041-1723
dc.identifier.other.spa.fl_str_mv https://www.nature.com/articles/s41467-020-17888-w
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12010/13489
dc.identifier.doi.spa.fl_str_mv https://doi.org/10.1038/s41467-020-17888-w
identifier_str_mv 2041-1723
url https://www.nature.com/articles/s41467-020-17888-w
http://hdl.handle.net/20.500.12010/13489
https://doi.org/10.1038/s41467-020-17888-w
dc.language.iso.spa.fl_str_mv eng
language eng
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_16ec
dc.rights.local.spa.fl_str_mv Acceso restringido
rights_invalid_str_mv Acceso restringido
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dc.format.extent.spa.fl_str_mv 9 páginas
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Nature Communications
dc.source.spa.fl_str_mv reponame:Expeditio Repositorio Institucional UJTL
instname:Universidad de Bogotá Jorge Tadeo Lozano
instname_str Universidad de Bogotá Jorge Tadeo Lozano
institution Universidad de Bogotá Jorge Tadeo Lozano
reponame_str Expeditio Repositorio Institucional UJTL
collection Expeditio Repositorio Institucional UJTL
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spelling 2020-09-19T16:38:12Z2020-09-19T16:38:12Z2020-08-182041-1723https://www.nature.com/articles/s41467-020-17888-whttp://hdl.handle.net/20.500.12010/13489https://doi.org/10.1038/s41467-020-17888-w9 páginasapplication/pdfengNature Communicationsreponame:Expeditio Repositorio Institucional UJTLinstname:Universidad de Bogotá Jorge Tadeo Lozanovirusvia aerosolized fomitesInfluenza ASíndrome respiratorio agudo graveCOVID-19SARS-CoV-2CoronavirusInfluenza A virus is transmissible via aerosolized fomitesArtículohttp://purl.org/coar/resource_type/c_6501Acceso restringidohttp://purl.org/coar/access_right/c_16ecInfluenza viruses are presumed, but not conclusively known, to spread among humans by several possible routes. We provide evidence of a mode of transmission seldom considered for influenza: airborne virus transport on microscopic particles called “aerosolized fomites.” In the guinea pig model of influenza virus transmission, we show that the airborne particulates produced by infected animals are mainly non-respiratory in origin. Surprisingly, we find that an uninfected, virus-immune guinea pig whose body is contaminated with influenza virus can transmit the virus through the air to a susceptible partner in a separate cage. We further demonstrate that aerosolized fomites can be generated from inanimate objects, such as by manually rubbing a paper tissue contaminated with influenza virus. Our data suggest that aerosolized fomites may contribute to influenza virus transmission in animal models of human influenza, if not among humans themselves, with important but understudied implications for public health.Asadi, SimaGaaloul ben Hnia, NassimaBarre, Ramya S.Wexler, Anthony S.Ristenpart, William D.Bouvier, Nicole M.LICENSElicense.txtlicense.txttext/plain; charset=utf-82938https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/13489/2/license.txtabceeb1c943c50d3343516f9dbfc110fMD52open accessTHUMBNAILInfluenza A virus is transmissible via aerosolized fomites.pngInfluenza A virus is transmissible via aerosolized fomites.pngimage/png73363https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/13489/4/Influenza%20A%20virus%20is%20transmissible%20via%20aerosolized%20fomites.png4555986e5da45eb59b010fb27341930eMD54open accessInfluenza A virus is transmissible via aerosolized fomites.pdf.jpgInfluenza A virus is transmissible via aerosolized fomites.pdf.jpgIM Thumbnailimage/jpeg15309https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/13489/6/Influenza%20A%20virus%20is%20transmissible%20via%20aerosolized%20fomites.pdf.jpgab54f8fa095961ae2c831e06dfa0d83dMD56open accessORIGINALInfluenza A virus is transmissible via aerosolized fomites.pdfInfluenza A virus is transmissible via aerosolized fomites.pdfDocumento Reservadoapplication/pdf1020931https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/13489/5/Influenza%20A%20virus%20is%20transmissible%20via%20aerosolized%20fomites.pdfca0154553f49d0a387f5badd5a938fffMD55embargoed access|||2420-09-1920.500.12010/13489oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/134892020-09-19 11:41:33.303embargoed access|||2420-09-19Repositorio Institucional - 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