The hammer and the dance of cell cycle control

Cell cycle checkpoints secure ordered progression from one cell cycle phase to the next. They are important to signal cell stress and DNA lesions and to stop cell cycle progression when severe problems occur. Recent work suggests, however, that the cell cycle control machinery responds in more subtl...

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Autores:
Tipo de recurso:
Article of investigation
Fecha de publicación:
2020
Institución:
Universidad de Bogotá Jorge Tadeo Lozano
Repositorio:
Expeditio: repositorio UTadeo
Idioma:
eng
OAI Identifier:
oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/16411
Acceso en línea:
https://doi.org/10.1016/j.tibs.2020.11.002
http://hdl.handle.net/20.500.12010/16411
Palabra clave:
Cell cycle control
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
Rights
License
Abierto (Texto Completo)
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oai_identifier_str oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/16411
network_acronym_str UTADEO2
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repository_id_str
dc.title.spa.fl_str_mv The hammer and the dance of cell cycle control
title The hammer and the dance of cell cycle control
spellingShingle The hammer and the dance of cell cycle control
Cell cycle control
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
title_short The hammer and the dance of cell cycle control
title_full The hammer and the dance of cell cycle control
title_fullStr The hammer and the dance of cell cycle control
title_full_unstemmed The hammer and the dance of cell cycle control
title_sort The hammer and the dance of cell cycle control
dc.subject.spa.fl_str_mv Cell cycle control
topic Cell cycle control
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
dc.subject.lemb.spa.fl_str_mv Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
description Cell cycle checkpoints secure ordered progression from one cell cycle phase to the next. They are important to signal cell stress and DNA lesions and to stop cell cycle progression when severe problems occur. Recent work suggests, however, that the cell cycle control machinery responds in more subtle and sophisticated ways when cells are faced with naturally occurring challenges, such as replication impediments associated with endogenous replication stress. Instead of following a stop and go approach, cells use fine-tuned deceleration and brake release mechanisms under the control of ataxia telangiectasia and Rad3-related protein kinase (ATR) and checkpoint kinase 1 (CHK1) to more flexibly adapt their cell cycle program to changing conditions. We highlight emerging examples of such intrinsic cell cycle checkpoint regulation and discuss their physiological and clinical relevance.
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2020-12-09T17:09:45Z
dc.date.available.none.fl_str_mv 2020-12-09T17:09:45Z
dc.date.created.none.fl_str_mv 2020
dc.type.local.spa.fl_str_mv Artículo
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
format http://purl.org/coar/resource_type/c_2df8fbb1
dc.identifier.issn.spa.fl_str_mv 1097-4172
dc.identifier.other.spa.fl_str_mv https://doi.org/10.1016/j.tibs.2020.11.002
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12010/16411
dc.identifier.doi.spa.fl_str_mv https://doi.org/10.1016/j.tibs.2020.11.002
identifier_str_mv 1097-4172
url https://doi.org/10.1016/j.tibs.2020.11.002
http://hdl.handle.net/20.500.12010/16411
dc.language.iso.spa.fl_str_mv eng
language eng
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.local.spa.fl_str_mv Abierto (Texto Completo)
rights_invalid_str_mv Abierto (Texto Completo)
http://purl.org/coar/access_right/c_abf2
dc.format.extent.spa.fl_str_mv 14 páginas
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Cell press
dc.source.spa.fl_str_mv reponame:Expeditio Repositorio Institucional UJTL
instname:Universidad de Bogotá Jorge Tadeo Lozano
instname_str Universidad de Bogotá Jorge Tadeo Lozano
institution Universidad de Bogotá Jorge Tadeo Lozano
reponame_str Expeditio Repositorio Institucional UJTL
collection Expeditio Repositorio Institucional UJTL
bitstream.url.fl_str_mv https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/16411/2/license.txt
https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/16411/3/The-Hammer-and-the-Dance-of-Cell-Cycle-Cont_2020_Trends-in-Biochemical-Scien.pdf.jpg
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spelling 2020-12-09T17:09:45Z2020-12-09T17:09:45Z20201097-4172https://doi.org/10.1016/j.tibs.2020.11.002http://hdl.handle.net/20.500.12010/16411https://doi.org/10.1016/j.tibs.2020.11.002Cell cycle checkpoints secure ordered progression from one cell cycle phase to the next. They are important to signal cell stress and DNA lesions and to stop cell cycle progression when severe problems occur. Recent work suggests, however, that the cell cycle control machinery responds in more subtle and sophisticated ways when cells are faced with naturally occurring challenges, such as replication impediments associated with endogenous replication stress. Instead of following a stop and go approach, cells use fine-tuned deceleration and brake release mechanisms under the control of ataxia telangiectasia and Rad3-related protein kinase (ATR) and checkpoint kinase 1 (CHK1) to more flexibly adapt their cell cycle program to changing conditions. We highlight emerging examples of such intrinsic cell cycle checkpoint regulation and discuss their physiological and clinical relevance.14 páginasapplication/pdfengCell pressreponame:Expeditio Repositorio Institucional UJTLinstname:Universidad de Bogotá Jorge Tadeo LozanoCell cycle controlSíndrome respiratorio agudo graveCOVID-19SARS-CoV-2CoronavirusThe hammer and the dance of cell cycle controlArtículohttp://purl.org/coar/resource_type/c_2df8fbb1Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2Panagopoulos, AndreasAltmeyer, MatthiasLICENSElicense.txtlicense.txttext/plain; charset=utf-82938https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/16411/2/license.txtabceeb1c943c50d3343516f9dbfc110fMD52open accessTHUMBNAILThe-Hammer-and-the-Dance-of-Cell-Cycle-Cont_2020_Trends-in-Biochemical-Scien.pdf.jpgThe-Hammer-and-the-Dance-of-Cell-Cycle-Cont_2020_Trends-in-Biochemical-Scien.pdf.jpgIM Thumbnailimage/jpeg17805https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/16411/3/The-Hammer-and-the-Dance-of-Cell-Cycle-Cont_2020_Trends-in-Biochemical-Scien.pdf.jpg4a061e3a7074fb30b6540c7e314d04b4MD53open access20.500.12010/16411oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/164112021-03-12 16:39:47.394metadata only accessRepositorio Institucional - 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