Current approaches used in treating COVID-19 from a molecular mechanisms and immune response perspective

Coronavirus disease 2019 (COVID-19), which is caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was declared by the World Health Organization (WHO) as a global pandemic on March 11, 2020. SARS-CoV-2 targets the respiratory system, resulting in symptoms such as fever,...

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Autores:
Tipo de recurso:
Article of journal
Fecha de publicación:
2020
Institución:
Universidad de Bogotá Jorge Tadeo Lozano
Repositorio:
Expeditio: repositorio UTadeo
Idioma:
eng
OAI Identifier:
oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12873
Acceso en línea:
https://www.sciencedirect.com/science/article/pii/S1319016420302048?via%3Dihub
http://hdl.handle.net/20.500.12010/12873
https://doi.org/10.1016/j.jsps.2020.08.024
Palabra clave:
Coronavirus
Coronavirus
Investigational medications
Pandemic
Pathophysiology
Viral immune response
Rights
License
Abierto (Texto Completo)
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dc.title.spa.fl_str_mv Current approaches used in treating COVID-19 from a molecular mechanisms and immune response perspective
title Current approaches used in treating COVID-19 from a molecular mechanisms and immune response perspective
spellingShingle Current approaches used in treating COVID-19 from a molecular mechanisms and immune response perspective
Coronavirus
Coronavirus
Investigational medications
Pandemic
Pathophysiology
Viral immune response
title_short Current approaches used in treating COVID-19 from a molecular mechanisms and immune response perspective
title_full Current approaches used in treating COVID-19 from a molecular mechanisms and immune response perspective
title_fullStr Current approaches used in treating COVID-19 from a molecular mechanisms and immune response perspective
title_full_unstemmed Current approaches used in treating COVID-19 from a molecular mechanisms and immune response perspective
title_sort Current approaches used in treating COVID-19 from a molecular mechanisms and immune response perspective
dc.subject.spa.fl_str_mv Coronavirus
topic Coronavirus
Coronavirus
Investigational medications
Pandemic
Pathophysiology
Viral immune response
dc.subject.keyword.spa.fl_str_mv Coronavirus
Investigational medications
Pandemic
Pathophysiology
Viral immune response
description Coronavirus disease 2019 (COVID-19), which is caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was declared by the World Health Organization (WHO) as a global pandemic on March 11, 2020. SARS-CoV-2 targets the respiratory system, resulting in symptoms such as fever, headache, dry cough, dyspnea, and dizziness. These symptoms vary from person to person, ranging from mild to hypoxia with acute respiratory distress syndrome (ARDS) and sometimes death. Although not confirmed, phylogenetic analysis suggests that SARS-CoV-2 may have originated from bats; the intermediary facilitating its transfer from bats to humans is unknown. Owing to the rapid spread of infection and high number of deaths caused by SARS-CoV-2, most countries have enacted strict curfews and the practice of social distancing while awaiting the availability of effective U.S. Food and Drug Administration (FDA)-approved medications and/or vaccines. This review offers an overview of the various types of coronaviruses (CoVs), their targeted hosts and cellular receptors, a timeline of their emergence, and the roles of key elements of the immune system in fighting pathogen attacks, while focusing on SARS-CoV-2 and its genomic structure and pathogenesis. Furthermore, we review drugs targeting COVID-19 that are under investigation and in clinical trials, in addition to progress using mesenchymal stem cells to treat COVID-19. We conclude by reviewing the latest updates on COVID-19 vaccine development. Understanding the molecular mechanisms of how SARS-CoV-2 interacts with host cells and stimulates the immune response is extremely important, especially as scientists look for new strategies to guide their development of specific COVID-19 therapies and vaccines.
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2020-09-08T01:04:00Z
dc.date.available.none.fl_str_mv 2020-09-08T01:04:00Z
dc.date.created.none.fl_str_mv 2020-09-01
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_6501
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dc.identifier.issn.spa.fl_str_mv 1319-0164
dc.identifier.other.spa.fl_str_mv https://www.sciencedirect.com/science/article/pii/S1319016420302048?via%3Dihub
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12010/12873
dc.identifier.doi.spa.fl_str_mv https://doi.org/10.1016/j.jsps.2020.08.024
identifier_str_mv 1319-0164
url https://www.sciencedirect.com/science/article/pii/S1319016420302048?via%3Dihub
http://hdl.handle.net/20.500.12010/12873
https://doi.org/10.1016/j.jsps.2020.08.024
dc.language.iso.spa.fl_str_mv eng
language eng
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dc.format.extent.spa.fl_str_mv 53 páginas
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Saudi Pharmaceutical Journal
institution Universidad de Bogotá Jorge Tadeo Lozano
bitstream.url.fl_str_mv https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12873/2/license.txt
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spelling 2020-09-08T01:04:00Z2020-09-08T01:04:00Z2020-09-011319-0164https://www.sciencedirect.com/science/article/pii/S1319016420302048?via%3Dihubhttp://hdl.handle.net/20.500.12010/12873https://doi.org/10.1016/j.jsps.2020.08.02453 páginasapplication/pdfengSaudi Pharmaceutical JournalCoronavirusCoronavirusInvestigational medicationsPandemicPathophysiologyViral immune responseCurrent approaches used in treating COVID-19 from a molecular mechanisms and immune response perspectiveAbierto (Texto Completo)http://purl.org/coar/access_right/c_abf2Coronavirus disease 2019 (COVID-19), which is caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was declared by the World Health Organization (WHO) as a global pandemic on March 11, 2020. SARS-CoV-2 targets the respiratory system, resulting in symptoms such as fever, headache, dry cough, dyspnea, and dizziness. These symptoms vary from person to person, ranging from mild to hypoxia with acute respiratory distress syndrome (ARDS) and sometimes death. Although not confirmed, phylogenetic analysis suggests that SARS-CoV-2 may have originated from bats; the intermediary facilitating its transfer from bats to humans is unknown. Owing to the rapid spread of infection and high number of deaths caused by SARS-CoV-2, most countries have enacted strict curfews and the practice of social distancing while awaiting the availability of effective U.S. Food and Drug Administration (FDA)-approved medications and/or vaccines. This review offers an overview of the various types of coronaviruses (CoVs), their targeted hosts and cellular receptors, a timeline of their emergence, and the roles of key elements of the immune system in fighting pathogen attacks, while focusing on SARS-CoV-2 and its genomic structure and pathogenesis. Furthermore, we review drugs targeting COVID-19 that are under investigation and in clinical trials, in addition to progress using mesenchymal stem cells to treat COVID-19. We conclude by reviewing the latest updates on COVID-19 vaccine development. Understanding the molecular mechanisms of how SARS-CoV-2 interacts with host cells and stimulates the immune response is extremely important, especially as scientists look for new strategies to guide their development of specific COVID-19 therapies and vaccines.http://purl.org/coar/resource_type/c_6501Alnefaie, AlaaAlbogami, SarahLICENSElicense.txtlicense.txttext/plain; charset=utf-82938https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12873/2/license.txtabceeb1c943c50d3343516f9dbfc110fMD52open accessORIGINALCurrent-approaches-used-in-treating-COVID-19-from-a-mole_2020_Saudi-Pharmace.pdfCurrent-approaches-used-in-treating-COVID-19-from-a-mole_2020_Saudi-Pharmace.pdfVer documentoapplication/pdf2664207https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12873/1/Current-approaches-used-in-treating-COVID-19-from-a-mole_2020_Saudi-Pharmace.pdf5db58957ca010d4aa5e5d1ff2e05344dMD51open accessTHUMBNAILCurrent-approaches-used-in-treating-COVID-19-from-a-mole_2020_Saudi-Pharmace.pdf.jpgCurrent-approaches-used-in-treating-COVID-19-from-a-mole_2020_Saudi-Pharmace.pdf.jpgIM Thumbnailimage/jpeg10888https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12873/3/Current-approaches-used-in-treating-COVID-19-from-a-mole_2020_Saudi-Pharmace.pdf.jpg96d4bd547eba1cb247cf5e8ea4fbef6eMD53open access20.500.12010/12873oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/128732020-09-07 20:04:00.23open accessRepositorio Institucional - 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