BMI and future risk for COVID-19 infection and death across sex, age and ethnicity: Preliminary findings from UK biobank

Aims: We examined the link between BMI and risk of a positive test for SARS-CoV-2 and risk of COVID19-related death among UK Biobank participants. Methods: Among 4855 participants tested for SARS-CoV-2 in hospital, 839 were positive and of these 189 died from COVID-19. Poisson models with penalised thin plate splines were run relating exposures of interest to test positivity and case-fatality, adjusting for confounding factors. Results: BMI was associated strongly with positive test, and risk of death related to COVID-19. The gradient of risk in relation to BMI was steeper in those under 70, compared with those aged 70 years or older for COVID-19 related death (Pinteraction ¼ 0.03). BMI was more strongly related to test positivity (Pinteraction ¼ 0.010) and death (Pinteraction ¼ 0.002) in non-whites (predominantly South Asians and AfroCaribbeans), compared with whites. Conclusions: These data add support for adiposity being more strongly linked to COVID-19-related deaths in younger people and non-white ethnicities. If future studies confirm causality, lifestyle interventions to improve adiposity status may be important to reduce the risk of COVID-19 in all, but perhaps particularly, non-white communities

• Tipo de recurso: Article of investigation
• Fecha de publicación: 2020
• Institución: Universidad de Bogotá Jorge Tadeo Lozano
• Repositorio: Expeditio: repositorio UTadeo
• Idioma: eng
• OAI Identifier: oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/13919
• Acceso en línea: https://doi.org/10.1016/j.dsx.2020.06.060; http://hdl.handle.net/20.500.12010/13919
• Palabra clave: Body mass index; COVID-19; Obesity; Síndrome respiratorio agudo grave; COVID-19; SARS-CoV-2; Coronavirus
• License: Abierto (Texto Completo)