SARS-CoV-2-specific T-cells in unexposed humans: presence of cross-reactive memory cells does not equal protective immunity

Using human blood samples obtained from pre-pandemic donors, a recent article by Mateus et al. in Science provided new evidence that SARS-CoV-2-reactive T-cells in unexposed donors are indeed HCoV-specific T-cells.1 The rapid global spread of coronavirus disease 2019 (COVID-19), caused by the newly-emerged coronavirus SARS-CoV-2, has led to millions of infections with substantial morbidity and mortality.2 Different clinical manifestations of COVID-19 have been observed: asymptomatic infections, mild self-limiting disease, acute respiratory distress syndrome and death. The determinants underlying disease severity currently remain elusive; since severe patients often present with immune hyperresponsiveness, it is speculated that the host’ immune response could be a contributing factor to severe disease.

• Tipo de recurso: Article of investigation
• Fecha de publicación: 2020
• Institución: Universidad de Bogotá Jorge Tadeo Lozano
• Repositorio: Expeditio: repositorio UTadeo
• Idioma: eng
• OAI Identifier: oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/14458
• Acceso en línea: https://doi.org/10.1038/s41392-020-00338-w; http://hdl.handle.net/20.500.12010/14458
• Palabra clave: SARS-CoV-2; T-cells; Unexposed humans; Cross-reactive memory cells; Síndrome respiratorio agudo grave; COVID-19; SARS-CoV-2; Coronavirus
• License: Abierto (Texto Completo)