SARS-CoV-2-specific T-cells in unexposed humans: presence of cross-reactive memory cells does not equal protective immunity
Using human blood samples obtained from pre-pandemic donors, a recent article by Mateus et al. in Science provided new evidence that SARS-CoV-2-reactive T-cells in unexposed donors are indeed HCoV-specific T-cells.1 The rapid global spread of coronavirus disease 2019 (COVID-19), caused by the newly-...
- Autores:
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2020
- Institución:
- Universidad de Bogotá Jorge Tadeo Lozano
- Repositorio:
- Expeditio: repositorio UTadeo
- Idioma:
- eng
- OAI Identifier:
- oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/14458
- Acceso en línea:
- https://doi.org/10.1038/s41392-020-00338-w
http://hdl.handle.net/20.500.12010/14458
- Palabra clave:
- SARS-CoV-2
T-cells
Unexposed humans
Cross-reactive memory cells
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
- Rights
- License
- Abierto (Texto Completo)
| Summary: | Using human blood samples obtained from pre-pandemic donors, a recent article by Mateus et al. in Science provided new evidence that SARS-CoV-2-reactive T-cells in unexposed donors are indeed HCoV-specific T-cells.1 The rapid global spread of coronavirus disease 2019 (COVID-19), caused by the newly-emerged coronavirus SARS-CoV-2, has led to millions of infections with substantial morbidity and mortality.2 Different clinical manifestations of COVID-19 have been observed: asymptomatic infections, mild self-limiting disease, acute respiratory distress syndrome and death. The determinants underlying disease severity currently remain elusive; since severe patients often present with immune hyperresponsiveness, it is speculated that the host’ immune response could be a contributing factor to severe disease. |
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