Gene delivery to the skin – how far have we come?
Gene therapies are powerful tools to prevent, treat, and cure human diseases. The application of gene therapies for skin diseases received little attention so far, despite the easy accessibility of skin and the urgent medical need. A major obstacle is the unique barrier properties of human skin, whi...
- Autores:
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2020
- Institución:
- Universidad de Bogotá Jorge Tadeo Lozano
- Repositorio:
- Expeditio: repositorio UTadeo
- Idioma:
- eng
- OAI Identifier:
- oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12798
- Acceso en línea:
- https://doi.org/10.1016/j.tibtech.2020.07.012
http://hdl.handle.net/20.500.12010/12798
- Palabra clave:
- Gene delivery
Skin
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
- Rights
- License
- Acceso restringido
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oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12798 |
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| dc.title.spa.fl_str_mv |
Gene delivery to the skin – how far have we come? |
| title |
Gene delivery to the skin – how far have we come? |
| spellingShingle |
Gene delivery to the skin – how far have we come? Gene delivery Skin Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus |
| title_short |
Gene delivery to the skin – how far have we come? |
| title_full |
Gene delivery to the skin – how far have we come? |
| title_fullStr |
Gene delivery to the skin – how far have we come? |
| title_full_unstemmed |
Gene delivery to the skin – how far have we come? |
| title_sort |
Gene delivery to the skin – how far have we come? |
| dc.subject.spa.fl_str_mv |
Gene delivery Skin |
| topic |
Gene delivery Skin Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus |
| dc.subject.lemb.spa.fl_str_mv |
Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus |
| description |
Gene therapies are powerful tools to prevent, treat, and cure human diseases. The application of gene therapies for skin diseases received little attention so far, despite the easy accessibility of skin and the urgent medical need. A major obstacle is the unique barrier properties of human skin, which significantly limits the absorption of biomacromolecules, and thus hampers the efficient delivery of nucleic acid payloads. In this review, we discuss current approaches, successes, and failures of cutaneous gene therapy and provide guidance toward the development of next-generation concepts. We specifically allude to the delivery strategies as the major obstacle that prevents the full potential of gene therapies – not only for skin disorders but also for almost any other human disease. |
| publishDate |
2020 |
| dc.date.accessioned.none.fl_str_mv |
2020-09-07T13:57:07Z |
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2020-09-07T13:57:07Z |
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2020 |
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Artículo |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.identifier.issn.spa.fl_str_mv |
0167-7799 |
| dc.identifier.other.spa.fl_str_mv |
https://doi.org/10.1016/j.tibtech.2020.07.012 |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/20.500.12010/12798 |
| dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.1016/j.tibtech.2020.07.012 |
| identifier_str_mv |
0167-7799 |
| url |
https://doi.org/10.1016/j.tibtech.2020.07.012 http://hdl.handle.net/20.500.12010/12798 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
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http://purl.org/coar/access_right/c_f1cf |
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Acceso restringido |
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Acceso restringido http://purl.org/coar/access_right/c_f1cf |
| dc.format.extent.spa.fl_str_mv |
14 páginas |
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text/html |
| dc.publisher.spa.fl_str_mv |
Trends in Biotechnology |
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reponame:Expeditio Repositorio Institucional UJTL instname:Universidad de Bogotá Jorge Tadeo Lozano |
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Universidad de Bogotá Jorge Tadeo Lozano |
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2020-09-07T13:57:07Z2020-09-07T13:57:07Z20200167-7799https://doi.org/10.1016/j.tibtech.2020.07.012http://hdl.handle.net/20.500.12010/12798https://doi.org/10.1016/j.tibtech.2020.07.012Gene therapies are powerful tools to prevent, treat, and cure human diseases. The application of gene therapies for skin diseases received little attention so far, despite the easy accessibility of skin and the urgent medical need. A major obstacle is the unique barrier properties of human skin, which significantly limits the absorption of biomacromolecules, and thus hampers the efficient delivery of nucleic acid payloads. In this review, we discuss current approaches, successes, and failures of cutaneous gene therapy and provide guidance toward the development of next-generation concepts. We specifically allude to the delivery strategies as the major obstacle that prevents the full potential of gene therapies – not only for skin disorders but also for almost any other human disease.14 páginastext/htmlengTrends in Biotechnologyreponame:Expeditio Repositorio Institucional UJTLinstname:Universidad de Bogotá Jorge Tadeo LozanoGene deliverySkinSíndrome respiratorio agudo graveCOVID-19SARS-CoV-2CoronavirusGene delivery to the skin – how far have we come?Artículohttp://purl.org/coar/resource_type/c_2df8fbb1Acceso restringidohttp://purl.org/coar/access_right/c_f1cfUl Ain, QurratCampos, Estefania V.R.Huynh, ArielWitzigmann, DominikTHUMBNAILCaptura.PNGCaptura.PNGPortadaimage/png204635https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12798/4/Captura.PNG06d6930f837a9236d4681d94f0dddc47MD54open accessGene-Delivery-to-the-Skin---How-Far-Have-We-Come_2020_Trends-in-Biotechnolog.pdf.jpgGene-Delivery-to-the-Skin---How-Far-Have-We-Come_2020_Trends-in-Biotechnolog.pdf.jpgIM Thumbnailimage/jpeg22690https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12798/5/Gene-Delivery-to-the-Skin---How-Far-Have-We-Come_2020_Trends-in-Biotechnolog.pdf.jpg2347a467a743711579a8d00f49ecd8b8MD55open accessORIGINALCaptura.PNGCaptura.PNGVer portadaimage/png204635https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12798/1/Captura.PNG06d6930f837a9236d4681d94f0dddc47MD51open accessLICENSElicense.txtlicense.txttext/plain; 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