Bacille Calmette Guérin (BCG) and new TB vaccines: specific, cross-myco‐ bacterial and off-target effects

The Bacille Calmette Guérin (BCG) vaccine was developed over a century ago and has become one of the most used vaccines without undergoing a modern vaccine development life cycle. Despite this, the vaccine has protected many millions from severe and disseminated forms of tuberculosis (TB). In additi...

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Autores:
Tipo de recurso:
Article of investigation
Fecha de publicación:
2020
Institución:
Universidad de Bogotá Jorge Tadeo Lozano
Repositorio:
Expeditio: repositorio UTadeo
Idioma:
eng
OAI Identifier:
oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12403
Acceso en línea:
https://doi.org/10.1016/j.prrv.2020.08.004
http://hdl.handle.net/20.500.12010/12403
Palabra clave:
Latent TB
Active TB
Trained immunity
COVID-19
SARS-CoV-2
COVID-19
Cross protective
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
Rights
License
Acceso restringido
id UTADEO2_14726e1ff62f34c13d7060bcab85a543
oai_identifier_str oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12403
network_acronym_str UTADEO2
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repository_id_str
dc.title.spa.fl_str_mv Bacille Calmette Guérin (BCG) and new TB vaccines: specific, cross-myco‐ bacterial and off-target effects
title Bacille Calmette Guérin (BCG) and new TB vaccines: specific, cross-myco‐ bacterial and off-target effects
spellingShingle Bacille Calmette Guérin (BCG) and new TB vaccines: specific, cross-myco‐ bacterial and off-target effects
Latent TB
Active TB
Trained immunity
COVID-19
SARS-CoV-2
COVID-19
Cross protective
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
title_short Bacille Calmette Guérin (BCG) and new TB vaccines: specific, cross-myco‐ bacterial and off-target effects
title_full Bacille Calmette Guérin (BCG) and new TB vaccines: specific, cross-myco‐ bacterial and off-target effects
title_fullStr Bacille Calmette Guérin (BCG) and new TB vaccines: specific, cross-myco‐ bacterial and off-target effects
title_full_unstemmed Bacille Calmette Guérin (BCG) and new TB vaccines: specific, cross-myco‐ bacterial and off-target effects
title_sort Bacille Calmette Guérin (BCG) and new TB vaccines: specific, cross-myco‐ bacterial and off-target effects
dc.subject.spa.fl_str_mv Latent TB
Active TB
Trained immunity
COVID-19
SARS-CoV-2
COVID-19
Cross protective
topic Latent TB
Active TB
Trained immunity
COVID-19
SARS-CoV-2
COVID-19
Cross protective
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
dc.subject.lemb.spa.fl_str_mv Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
description The Bacille Calmette Guérin (BCG) vaccine was developed over a century ago and has become one of the most used vaccines without undergoing a modern vaccine development life cycle. Despite this, the vaccine has protected many millions from severe and disseminated forms of tuberculosis (TB). In addition, BCG has cross-mycobacterial effects against non-tuberculous mycobacteria and off-target (also called non-specific or heterologous) effects against other infections and diseases. More recently, BCG’s effects on innate immunity suggest it might improve the immune response against viral respiratory infections including SARS-CoV-2. New TB vaccines, developed over the last 30 years, show promise, particularly in prevention of progression to disease from TB infection in young adults. The role of BCG in the context of new TB vaccines remains uncertain as most participants included in trials have been previously BCG immunised. BCG replacement vaccines are in efficacy trials and these may also have off-target effects.
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2020-08-28T14:19:44Z
dc.date.available.none.fl_str_mv 2020-08-28T14:19:44Z
dc.date.created.none.fl_str_mv 2020
dc.type.local.spa.fl_str_mv Artículo
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dc.identifier.issn.spa.fl_str_mv 1526-0542
dc.identifier.other.spa.fl_str_mv https://doi.org/10.1016/j.prrv.2020.08.004
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12010/12403
dc.identifier.doi.spa.fl_str_mv https://doi.org/10.1016/j.prrv.2020.08.004
identifier_str_mv 1526-0542
url https://doi.org/10.1016/j.prrv.2020.08.004
http://hdl.handle.net/20.500.12010/12403
dc.language.iso.spa.fl_str_mv eng
language eng
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_f1cf
dc.rights.local.spa.fl_str_mv Acceso restringido
rights_invalid_str_mv Acceso restringido
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dc.format.extent.spa.fl_str_mv 31 páginas
dc.format.mimetype.spa.fl_str_mv text/html
dc.publisher.spa.fl_str_mv Paediatric Respiratory Reviews
dc.source.spa.fl_str_mv reponame:Expeditio Repositorio Institucional UJTL
instname:Universidad de Bogotá Jorge Tadeo Lozano
instname_str Universidad de Bogotá Jorge Tadeo Lozano
institution Universidad de Bogotá Jorge Tadeo Lozano
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collection Expeditio Repositorio Institucional UJTL
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spelling 2020-08-28T14:19:44Z2020-08-28T14:19:44Z20201526-0542https://doi.org/10.1016/j.prrv.2020.08.004http://hdl.handle.net/20.500.12010/12403https://doi.org/10.1016/j.prrv.2020.08.004The Bacille Calmette Guérin (BCG) vaccine was developed over a century ago and has become one of the most used vaccines without undergoing a modern vaccine development life cycle. Despite this, the vaccine has protected many millions from severe and disseminated forms of tuberculosis (TB). In addition, BCG has cross-mycobacterial effects against non-tuberculous mycobacteria and off-target (also called non-specific or heterologous) effects against other infections and diseases. More recently, BCG’s effects on innate immunity suggest it might improve the immune response against viral respiratory infections including SARS-CoV-2. New TB vaccines, developed over the last 30 years, show promise, particularly in prevention of progression to disease from TB infection in young adults. The role of BCG in the context of new TB vaccines remains uncertain as most participants included in trials have been previously BCG immunised. BCG replacement vaccines are in efficacy trials and these may also have off-target effects.31 páginastext/htmlengPaediatric Respiratory Reviewsreponame:Expeditio Repositorio Institucional UJTLinstname:Universidad de Bogotá Jorge Tadeo LozanoLatent TBActive TBTrained immunityCOVID-19SARS-CoV-2COVID-19Cross protectiveSíndrome respiratorio agudo graveCOVID-19SARS-CoV-2CoronavirusBacille Calmette Guérin (BCG) and new TB vaccines: specific, cross-myco‐ bacterial and off-target effectsArtículohttp://purl.org/coar/resource_type/c_2df8fbb1Acceso restringidohttp://purl.org/coar/access_right/c_f1cfFritschi, NoraCurtis, NigelRitz, NicoleORIGINALCaptura.PNGCaptura.PNGVer portadaimage/png178040https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12403/1/Captura.PNG62a0f50851372d9de0d103866686d597MD51open accessBacille-Calmette-Gu-rin--BCG--and-new-TB-vaccines--spec_2020_Paediatric-Resp.pdfBacille-Calmette-Gu-rin--BCG--and-new-TB-vaccines--spec_2020_Paediatric-Resp.pdfArtículo reservadoapplication/pdf1487447https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12403/3/Bacille-Calmette-Gu-rin--BCG--and-new-TB-vaccines--spec_2020_Paediatric-Resp.pdf9a80ccd641f25b564ec7312402a40ad7MD53embargoed access|||2200-08-28LICENSElicense.txtlicense.txttext/plain; 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