Bacille Calmette Guérin (BCG) and new TB vaccines: specific, cross-myco‐ bacterial and off-target effects
The Bacille Calmette Guérin (BCG) vaccine was developed over a century ago and has become one of the most used vaccines without undergoing a modern vaccine development life cycle. Despite this, the vaccine has protected many millions from severe and disseminated forms of tuberculosis (TB). In additi...
- Autores:
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2020
- Institución:
- Universidad de Bogotá Jorge Tadeo Lozano
- Repositorio:
- Expeditio: repositorio UTadeo
- Idioma:
- eng
- OAI Identifier:
- oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12403
- Acceso en línea:
- https://doi.org/10.1016/j.prrv.2020.08.004
http://hdl.handle.net/20.500.12010/12403
- Palabra clave:
- Latent TB
Active TB
Trained immunity
COVID-19
SARS-CoV-2
COVID-19
Cross protective
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
- Rights
- License
- Acceso restringido
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dc.title.spa.fl_str_mv |
Bacille Calmette Guérin (BCG) and new TB vaccines: specific, cross-myco‐ bacterial and off-target effects |
title |
Bacille Calmette Guérin (BCG) and new TB vaccines: specific, cross-myco‐ bacterial and off-target effects |
spellingShingle |
Bacille Calmette Guérin (BCG) and new TB vaccines: specific, cross-myco‐ bacterial and off-target effects Latent TB Active TB Trained immunity COVID-19 SARS-CoV-2 COVID-19 Cross protective Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus |
title_short |
Bacille Calmette Guérin (BCG) and new TB vaccines: specific, cross-myco‐ bacterial and off-target effects |
title_full |
Bacille Calmette Guérin (BCG) and new TB vaccines: specific, cross-myco‐ bacterial and off-target effects |
title_fullStr |
Bacille Calmette Guérin (BCG) and new TB vaccines: specific, cross-myco‐ bacterial and off-target effects |
title_full_unstemmed |
Bacille Calmette Guérin (BCG) and new TB vaccines: specific, cross-myco‐ bacterial and off-target effects |
title_sort |
Bacille Calmette Guérin (BCG) and new TB vaccines: specific, cross-myco‐ bacterial and off-target effects |
dc.subject.spa.fl_str_mv |
Latent TB Active TB Trained immunity COVID-19 SARS-CoV-2 COVID-19 Cross protective |
topic |
Latent TB Active TB Trained immunity COVID-19 SARS-CoV-2 COVID-19 Cross protective Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus |
dc.subject.lemb.spa.fl_str_mv |
Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus |
description |
The Bacille Calmette Guérin (BCG) vaccine was developed over a century ago and has become one of the most used vaccines without undergoing a modern vaccine development life cycle. Despite this, the vaccine has protected many millions from severe and disseminated forms of tuberculosis (TB). In addition, BCG has cross-mycobacterial effects against non-tuberculous mycobacteria and off-target (also called non-specific or heterologous) effects against other infections and diseases. More recently, BCG’s effects on innate immunity suggest it might improve the immune response against viral respiratory infections including SARS-CoV-2. New TB vaccines, developed over the last 30 years, show promise, particularly in prevention of progression to disease from TB infection in young adults. The role of BCG in the context of new TB vaccines remains uncertain as most participants included in trials have been previously BCG immunised. BCG replacement vaccines are in efficacy trials and these may also have off-target effects. |
publishDate |
2020 |
dc.date.accessioned.none.fl_str_mv |
2020-08-28T14:19:44Z |
dc.date.available.none.fl_str_mv |
2020-08-28T14:19:44Z |
dc.date.created.none.fl_str_mv |
2020 |
dc.type.local.spa.fl_str_mv |
Artículo |
dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
format |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.identifier.issn.spa.fl_str_mv |
1526-0542 |
dc.identifier.other.spa.fl_str_mv |
https://doi.org/10.1016/j.prrv.2020.08.004 |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/20.500.12010/12403 |
dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.1016/j.prrv.2020.08.004 |
identifier_str_mv |
1526-0542 |
url |
https://doi.org/10.1016/j.prrv.2020.08.004 http://hdl.handle.net/20.500.12010/12403 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_f1cf |
dc.rights.local.spa.fl_str_mv |
Acceso restringido |
rights_invalid_str_mv |
Acceso restringido http://purl.org/coar/access_right/c_f1cf |
dc.format.extent.spa.fl_str_mv |
31 páginas |
dc.format.mimetype.spa.fl_str_mv |
text/html |
dc.publisher.spa.fl_str_mv |
Paediatric Respiratory Reviews |
dc.source.spa.fl_str_mv |
reponame:Expeditio Repositorio Institucional UJTL instname:Universidad de Bogotá Jorge Tadeo Lozano |
instname_str |
Universidad de Bogotá Jorge Tadeo Lozano |
institution |
Universidad de Bogotá Jorge Tadeo Lozano |
reponame_str |
Expeditio Repositorio Institucional UJTL |
collection |
Expeditio Repositorio Institucional UJTL |
bitstream.url.fl_str_mv |
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2020-08-28T14:19:44Z2020-08-28T14:19:44Z20201526-0542https://doi.org/10.1016/j.prrv.2020.08.004http://hdl.handle.net/20.500.12010/12403https://doi.org/10.1016/j.prrv.2020.08.004The Bacille Calmette Guérin (BCG) vaccine was developed over a century ago and has become one of the most used vaccines without undergoing a modern vaccine development life cycle. Despite this, the vaccine has protected many millions from severe and disseminated forms of tuberculosis (TB). In addition, BCG has cross-mycobacterial effects against non-tuberculous mycobacteria and off-target (also called non-specific or heterologous) effects against other infections and diseases. More recently, BCG’s effects on innate immunity suggest it might improve the immune response against viral respiratory infections including SARS-CoV-2. New TB vaccines, developed over the last 30 years, show promise, particularly in prevention of progression to disease from TB infection in young adults. The role of BCG in the context of new TB vaccines remains uncertain as most participants included in trials have been previously BCG immunised. BCG replacement vaccines are in efficacy trials and these may also have off-target effects.31 páginastext/htmlengPaediatric Respiratory Reviewsreponame:Expeditio Repositorio Institucional UJTLinstname:Universidad de Bogotá Jorge Tadeo LozanoLatent TBActive TBTrained immunityCOVID-19SARS-CoV-2COVID-19Cross protectiveSíndrome respiratorio agudo graveCOVID-19SARS-CoV-2CoronavirusBacille Calmette Guérin (BCG) and new TB vaccines: specific, cross-myco‐ bacterial and off-target effectsArtículohttp://purl.org/coar/resource_type/c_2df8fbb1Acceso restringidohttp://purl.org/coar/access_right/c_f1cfFritschi, NoraCurtis, NigelRitz, NicoleORIGINALCaptura.PNGCaptura.PNGVer portadaimage/png178040https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12403/1/Captura.PNG62a0f50851372d9de0d103866686d597MD51open accessBacille-Calmette-Gu-rin--BCG--and-new-TB-vaccines--spec_2020_Paediatric-Resp.pdfBacille-Calmette-Gu-rin--BCG--and-new-TB-vaccines--spec_2020_Paediatric-Resp.pdfArtículo reservadoapplication/pdf1487447https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12403/3/Bacille-Calmette-Gu-rin--BCG--and-new-TB-vaccines--spec_2020_Paediatric-Resp.pdf9a80ccd641f25b564ec7312402a40ad7MD53embargoed access|||2200-08-28LICENSElicense.txtlicense.txttext/plain; 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